Allelic exclusion of the T cell receptor β locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein

Journal of Experimental Medicine

Volumn 190, Issue 8, 1999, Pages 1093-1102

  Aifantis, Iannis ^a   Pivniouk, Vadim I ^b   Gärtner, Frank ^b   Feinberg, Jacqueline ^a   Swat, Wojciech ^b   Alt, Frederick W ^b   Von Boehmer, Harald ^a   Geha, Raif S ^b  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Allelic exclusion; Pre TCR; SLP 76; TCR signaling; Thymocyte development

Indexed keywords

ADAPTOR PROTEIN; SECRETORY PROTEIN; T LYMPHOCYTE RECEPTOR;

ALLELE; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; ENDOPLASMIC RETICULUM; GENE LOCATION; GENE REARRANGEMENT; GENETIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLELES; ANIMALS; ANTIGENS, CD; CELL LINE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; MICE; MICE, TRANSGENIC; PHOSPHOPROTEINS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

EID: 0032729007     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.8.1093     Document Type: Article

References (44)

1. von Boehmer, H., and H.J. Fehling. 1997. Structure and function of the pre-T cell receptor. Annu. Rev. Immunol. 15: 433-452.
2. Fehling, H.J., A. Krotkova, C. Saint-Ruf, and H. von Boehmer. 1995. Crucial role of the pre-T-cell receptor a gene in development of αβ but not γδ T cells. Nature. 375:795-798.
3. Malissen, M., A. Gillet, B. Rocha, J. Trucy, E. Vivier, C. Boyer, F. Kontgen, N. Brun, G. Mazza, E. Spanopoulo, et al. 1993. T cell development in mice lacking the CD3 ζ/η gene. EMBO (Eur. Mol. Biol. Organ.) J. 12:4347-1355.
4. Mombaerts, P., A.R. Clarke, M.A. Rudnicki, J. Iacomini, S. Itohara, J.J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M.L. Hooper, et al. 1992. Mutations in T-cell antigen receptor genes a and β block thymocyte development at different stages. Nature. 360:225-231.
5. Molina, T.J., K. Kishihara, D.H. Siderovski, W. van Ewijk, A. Narendran, E. Timms, A. Wakeham, C.J. Paige, K.-U. Hartmann, A. Veilette, et al. 1992. Profound block in thymocyte development in mice lacking p56lck. Nature. 357: 161-164.
6. van Oers, N.S.C., B. Lowin-Kropf, D. Finlay, K. Connolly, and A. Weis. 1996. αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity. 5:429-436.
7. O'Shea, C.C., A.P. Thornell, I.R. Rosewell, B. Hayes, and M.J. Owen. 1997. Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion in immature thymocytes. Immunity. 7:591-599.
8. Irving, B.A., F.W. Alt, and N. Killeen. 1998. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science. 280:905-908.
9. Strasser, A., A.W. Harris, L.M. Corcoran, and S. Cory. 1994. Bcl-2 expression promotes B-but not T-lymphoid development in scid mice. Nature. 368:457-160.
10. + stage during positive selection and promotes thymocyte differentiation at several control points. Immunity. 1:197-205.
11. Alt, F.W., G.D. Yancopoulos, T.K. Blackwell, C. Wood, E. Thomas, M. Boss, R. Coffman, N. Rosenberg, S. Tonegawa, and D. Baltimore. 1984. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO (Eur. Mol. Biol. Organ.) J. 3:1209-1219.
12. Aifantis, I., J. Buer, H. von Boehmer, and O. Azogui. 1997. Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus. Immunity. 7:601-607.
13. Krotkova, A., H. von Boehmer, and H.J. Fehling. 1997. Allelic exclusion in pTα-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-β chains, but less efficient inhibition of endogeneous Vβ→(D)Jβ rearrangements in the presence of a functional TCR-β transgene. J. Exp. Med. 186:767-775.
14. Ardouin, L., J. Ismaili, B. Malissen, and M. Malissen. 1998. The CD3-γδε and CD3-ζ/η modules are each essential for allelic exclusion at the T cell receptor β locus are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-β, -γ, and -δ loci. J. Exp. Med. 187:105-116.
15. Anderson, S.J., S.D. Levin, and R.M. Perlmutter. 1993. Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes. Nature. 365:552-554.
16. Gartner, F., F.W. Alt, R. Monroe, M. Chu, B.P. Sleckman, L. Davidson, and W. Swat. 1999. Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion. Immunity. 10:537-546.
17. Pivniouk, V., E. Tsitsikov, P. Swinton, G. Rathbun, F.W. Alt, and R.S. Geha. 1998. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell. 94:229-238.
18. Clements, J.L., B. Yang, S.E. Ross-Barta, S.L. Eliason, R.F. Hrstka, R.A. Williamson, and G.A. Koretzky. 1998. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science, 281:416-419.
19. Clements, J.L., and G.A. Koretzky. 1999. Recent developments in lymphocyte activation: linking kinases to downstream signaling events. J. Clin. Invest. 103:925-929.
20. Koretzky, G. 1997. The role of Grb2-associated proteins in T-cell activation. Immunol. Today. 18:401-406.
21. Motto, D.G., S.E. Ross, J. Wu, L.R. Hendricks-Taylor, and G.A. Koretzky. 1996. Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. J. Exp. Med. 183:1937-1943.
22. Yablonski, D., M.R. Kuhne, T. Kadlecek, and A. Weiss. 1998. Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in an SLP-76-deficient T cell. Science. 281:413-416.
23. Groettrup, M., K. Ungewiss, O. Azogui, R. Palacios, M.J. Owen, A.C. Hayday, and H. von Boehmer. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein. Cell. 75: 283-294.
24. Aifantis, I., O. Azogui, J. Feinberg, C. Saint-Ruf, J. Buer, and H. von Boehmer. 1998. On the role of the pre-T cell receptor in αβ versus γδ T lineage commitment. Immunity. 9:649-655.
25. Buer, J., I. Aifantis, J.P. DiSanto, H.J. Fehling, and H. von Boehmer. 1997. T-cell development in the absence of the pre-T-cell receptor. Immunol. Lett. 57:5-8.
26. Hollander, G., E. Castigli, R. Kulback, M. Su, S. Burakoff, J.-C. Gutierrez-Ramos, and R. Geha. 1996. Induction of alloantigen-specific tolerance by B cells from CD40 deficient mice. Proc. Natl. Acad. Sci. USA. 93:4994-4998.
27. Shinkai, Y., G. Rathbun, K.P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A.M. Stall, et al. 1992. RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68: 855-867.
28. lo thymocytes in vivo. Science. 250:1720-1723.
29. Laird, P.W., A. Zijderveld, K. Linders, M.A. Rudnicki, R. Jaenisch, and A. Berns. 1991. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19:4293.
30. Loffert, D., A. Ehlich, W. Muller, and K. Rajewsky. 1996. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity. 4:133-144.
31. von Boehmer, H., I. Aifantis, J. Feinberg, O. Lechner, C. Saint-Ruf, U. Walter, J. Buer, and O. Azogui. 1999. Pleiotropic changes controlled by the pre-T cell receptor. Curr. Opin. Immunol. 11:135-142.
32. Aifantis, I., J. Feinberg, H.J. Fehling, J.P. Di Santo, and H. von Boehmer. 1999. Early T cell receptor β gene expression is regulated by the pre-T cell receptor-CD3 complex. J. Exp. Med. 190:141-144.
33. von Boehmer, H. 1990. Developmental biology of T cells in T cell receptor transgenic mice. Annu. Rev. Immunol. 8:531-556.
34. Shinkai, Y., S. Koyasu, K. Nakayama, K.M. Murphy, D.Y. Loh, E.L. Reinherz, and F.W. Alt. 1993. Restoration of T cell development in RAG2-deficient mice by functional TCR transgenes. Science. 259:822-825.
35. Malissen, M., J. Trucy, E. Jouvin-Marche, P.A. Cazenave, R. Scollay, and B. Malissen. 1992. Regulation of TCR alpha and beta gene allelic exclusion during T-cell development. Immunol. Today. 13:315-322.
36. Xu, Y., L. Davidson, F.W. Alt, and D. Baltimore. 1996. Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus. Proc. Natl. Acad. Sci. USA. 93:2169-2173.
37. van Meerwijk, J.P., H. Bluthmann, and M. Steinmetz. 1990. T-cell specific rearrangement of T-cell receptor β transgenes in mice. EMBO (Eur. Mol. Biol. Organ.) J. 9:1057-1062.
38. Luton, F., V. Legendre, J.P. Gorvel, A.M. Schmitt-Verhulst, and C. Boyer. 1997. Tyrosine and serine protein kinase activities associated with ligand-induced internalized TCR/ CD3 complexes. J. Immunol. 158:3140-3147.
39. + thymocytes. Proc. Natl. Acad. Sci. USA. 93: 4683-4687.
40. Uematsu, Y., S. Ryser, Z. Dembic, P. Borgulya, P. Krimpenfort, A. Berns, H. von Boehmer, and M. Steinmetz. 1988. In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes. Cell. 52:831-841.
41. Sleckman, B.P., B. Khor, R. Monroe, and F.W. Alt. 1998. Assembly of productive T cell receptor 8 variable region genes exhibits allelic inclusion. J. Exp. Med. 188:1465-1471.
42. Arden, B., S.P. Clark, D. Kabelitz, and T.W. Mak. 1995. Mouse T-cell receptor variable gene segment families. Immunogenetics. 42:501-530.
43. Clark, S.P., Y. Yoshikai, S. Taylor, G. Siu, L. Hood, and T.W. Mak. 1984. Identification of a diversity segment of human T-cell receptor beta-chain, and comparison with the analogous murine element. Nature. 311:387-389.
44. Malissen, M., K. Minard, S. Mjolsness, M. Kronenberg, J. Goverman, T. Hunkapiller, M.B. Prystowsky, Y. Yoshikai, F. Fitch, T.W. Mak, et al. 1984. Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide. Cell. 37:1101-1110.