Domains of the TCRβ-chain required for early thymocyte development

Journal of Experimental Medicine

Volumn 184, Issue 5, 1996, Pages 1833-1843

  Jacobs, Heinz ^a,c   Iacomini, John ^b,d   Van De Ven, Marion ^a   Tonegawa, Susumu ^b   Berns, Anton ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF COLOGNE   (Germany)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; DNA; RNA; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL SURFACE; CONTROLLED STUDY; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING; THYMOCYTE; TRANSGENE;

EID: 0029845009     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.5.1833     Document Type: Article

References (56)

1. Von Boehmer, H. 1990. Developmental biology of T cells in T-cell receptor transgenic mice. Annu. Rev. Immunol. 8: 531-556.
2. Philpott, K.L., J.L. Viney, G. Kay, S. Rastan, E.M. Gardiner, S. Chae, A.C. Mayday, and M.J. Owen. 1992. Lymphoid development in mice congenitally lacking T cell receptor αβ-expressing cells. Science (Wash. DC). 256:1448-1452.
3. Mombaerts, P., A.R. Clarke, M.A. Rudnicki, J. Iacomini, S. Itohara, J.J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M.L. Hooper, and S. Tonegawa. 1992. Mutations in T-cell antigen receptor genes a and β block thymocyte development at different stages. Nature (Lond.). 360:225-231.
4. Davis, M.M., and P.J. Bjorkman. 1988. T-cell antigen receptor genes and T-cell recognition. Nature (Lond.). 334:395-402.
5. Mombaerts, P., J. Iacomini, R.S. Johnson, K. Herrup, S. Tonegawa, and V.E. Papaioannou. 1992. RAG-1 deficient mice have no mature B and T lymphocytes. Cell. 68:869-877.
6. Shinkai, Y., G. Rathbun, K.-P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A.M. Stall, and F.W. Alt. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68:855-867.
7. Furley, A.J., S. Mizutani, K. Weilbaecher, H.S. Dhaliwal, A.M. Ford, L.C. Chan, H.V. Molgaard, B. Toyonaga, T. Mak, P. Van den Elsen et al. 1986. Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex. Cell. 46:75-87.
8. Born, W., E. Harris, and C. Hannum. 1987. Ontogeny of T-cell receptor gene expression. Trends Genet. 3:132-136.
9. Uematsu, Y., S. Ryser, Z. Dembic, P. Borgulya, P. Krimpenfort, A. Berns, H. von Boehmer, and M. Steinmetz. 1988. In transgenic mice the introduced functional T cell receptor β gene prevents expression of endogenous β genes. Cell. 52: 831-841.
10. Krimpenfort, P., F. Ossendorp, J. Borst, C. Melief, and A. Berns. 1989. T cell depletion in transgenic mice carrying a mutant gene for TCR-β. Nature (Lond.). 341:742-746.
11. Ossendorp, F., H. Jacobs, G. Van der Horst, E. De Vries, A. Berns, and J. Borst. 1992. T cell receptor-αβ lacking the β-chain V domain can be expressed at the cell surface but prohibits T cell maturation. J. Immunol. 148:3714-3722.
12. Yancopoulos, G.D., and F.W. Alt. 1985. Developmentally controlled and tissue specific expression of unrearranged VH gene segments. Cell. 40:271-281.
13. Pillai, S., and D. Baltimore. 1987. Formation of disulfide-linked μ2φ2 tetramers in pre-B cells by the 18k φ-immunoglobulin light chain. Nature (Lond.). 329:172-174.
14. Tsubata, T., and M. Reth. 1990. The products of pre-B cell-specific genes (λ5 and VpreB) and the Immunoglobulin μ chain form a complex that is transported to the cell surface. J. Exp. Med. 172:973-976.
15. Karasuyama, H., A. Kudo, and F. Melchers. 1990. The proteins encoded by the Vpreli and λ5 pre-B cell-specific genes can associate with each other and with μ heavy chain. J. Exp. Med. 172:969-972.
16. Brouns, G.S., E. De Vries, C.J.M. Van Noesel, D.Y. Mason, R.A.W. Van Lier, and J. Borst. 1993. The structure of the μ/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction. Eur. J. Immunol. 23:1088-1097.
17. Ferner, P., B. Krippl, T.K. Blackwell, A.J.W. Furley, H. Suh, A. Winoto, W.D. Cook, L. Hood, F. Costantini, and F.W. Alt. 1990. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO (Eur. Mol. Biol. Organ.) J. 9:117-125.
18. Serwe, M., and F. Sablitzky. 1993. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain enhancer. EMBO (Eur. Mol. Biol. Organ.) J. 12:2321-2327.
19. Lauster, R., C.A. Reynaud, I.L. Martensson, A. Peter, D. Bucchini, J. Jami, and J.C. Weill. 1993. Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene. EMBO (Eur. Mol. Biol. Organ.) J. 12: 4615-4623.
20. H locus. EMBO (Eur. Mol. Biol. Organ.) J. 12:4635-4645.
21. Punt, J.A., R.T. Kubo, T. Saito, T.H. Finkel, S. Kathiresan, K.J. Blank, and Y. Hashimoto.1991. Surface expression of a T cell receptor (TCR-β) chain in the absence of TCR-α, -δ, -γ proteins. J. Exp. Med. 174:775-783.
22. Kishi, H., P. Borguyla, B. Scott, K. Karjalainen, A. Traunecker, J. Kaufman, and H. von Boehmer. 1991. Surface expression of the β T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells. EMBO (Eur. Mol. Biol. Organ.) J. 10:93-100.
23. Groettrup, M., A. Baron, G. Griffiths, R. Palacios, and H. Von Boehmer. 1992. T cell receptor (TCR) β chain homodimers on the surface of immature but not mature α, γ, δ chain deficient T cell lines. EMBO (Eur. Mol. Biol. Organ.) J. 11:2735-2746.
24. Borst, J., H. Jacobs, and G. Brouns. 1996. Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes. Cur. Opin. Immunol. 132:49-84.
25. Shinkai, Y., S. Koyasu, K. Nakayama, K.M. Murphy, D.Y. Loh, E.L. Reinherz, and F.W. Alt. 1993. Restoration of T cell development in RAG-2 deficient mice by functional TCR transgenes. Science (Wash. DC). 259:822-825.
26. Jacobs, H., D. Vandeputte, L. Tolkamp, E. de Vries, J. Borst, and A. Berns. 1994. CD3 components at the surface of pro-T cells can mediate pre-T cell development. Eur. J. Immunol. 24:934-939.
27. Groettrup, M., K. Ungewiss, O. Azogui, R. Palacios, M.J. Owen, A.C. Hayday, and H. von Boehmer. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the TCR β chain and a 33 kD glycoprotein. Cell. 75:283-294.
28. Saint-Ruf, C., K. Ungewiss, M. Groettrup, L. Bruno, H.J. Fehling, and H. von Boehmer. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science (Wash. DC). 266:1208-1212.
29. Fehling, H.J., A. Krotkova, C. Samt-Ruf, and H. von Boehmer. 1995. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature (Lond.). 375: 795-798.
30. Levelt, C.N., P. Mombaerts, A. Iglesias, S. Tonegawa, and K. Eichmann. 1993. Restoration of early thymocyte differentiation in T cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε. Proc. Natl. Acad. Sci. USA. 90:11401-11405.
31. -/- mice in the absence of TCRβ chain expression. Int. Immun. 6:995-1001.
32. Winoto, A., S. Mjolsness, and L. Hood. 1985. Genomic organization of the genes encoding mouse T-cell receptor α-chain. Nature (Lond.). 316:837-840.
33. Lataille, J.J., K. Nagashima, M. Katsuki, and S. Tonegawa. 1994. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell. 78:399-408.
34. Hogan, B., F. Constantini, and E. Lacy. 1986. Manipulating the mouse embryo. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
35. Laird, P.W., A. Zijdeveld, K. Linders, M.A. Rudnicki, R. Jaenisch, and A. Berns. 1991. Simplified mammalian DNA isolation procedure. Nucleic Acid Res. 19:4293.
36. Cuypers, H.T., G. Selten, W. Quint, M. Zijstra, E.R. Maandag, W. Boelens, P. van Wezenberg, C. Melief, and A. Berns. 1984. Murine leukemia virus-induced T-cell lymphomagenesis: integration of provirusses in a distinct chromosomal region. Cell. 37:141-150.
37. Lai, E., R. Barth, and L.E. Hood. 1987. Genomic organization of the mouse T-cell receptor β gene family. Prof. Natl. Acad. Sci. USA. 84:3846-3850.
38. Chien, Y., N.R.J. Gascoigne, J. Kavaler, N.E. Lee, and M.M. Davis. 1984. Somatic recombination in a murine T cell receptor gene. Nature (Lond.). 309:322-326.
39. Maniatis, T., E.F. Fritsch., and J. Sambrook. 1982. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
40. Saito, H., D.M. Kranz, Y. Tagagaki, A.C. Hayday, H.N. Eisen, and S. Tonegawa. 1984. A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature (Lond.). 312:36-40.
41. Hedrick, S.M., E.A. Nielsen, J. Kavaler, D.I. Cohen, M.M. Davis. 1994. Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature (Lond.). 308:153-158.
42. Dodemont, H.J., P. Soriano, W.J. Quax., F. Ramaekers, J.A. Lenstra, M.A. Groenen, G. Bernardi, and H. Bloemendahl. 1982. The genes coding for the cytoskeletal proteins actin and vimentinin in warmblooded vertebrates. EMBO (Eur. Mol. Biol. Organ.) J. 1:167-171.
43. Leo, O., M. Foo, D.H. Sachs, L.E. Samelson, and J.A. Bluestone. 1987. Identification of monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA. 84: 1374-1378.
44. Kubo, R. T., W. Born, J.W. Kappler, P. Marrack, and M. Pigeon. 1989. Characterization of a monoclonal antibody which detects all murine αβ T cell receptors. J. Immunol. 142:2736-2742.
45. b6 of the murine T-cell receptor. Proc. Natl. Acad. Sci. USA. 85:7695-7698.
46. Haskins, K., C. Hannum, J. White, N. Roehm, R. Kubo, J. Kappler, and P. Marrack. 1984. The antigen-specific, major-histocompatibility complex-restricted receptor on T cells. J. Exp. Med. 160:452-471.
47. Staerz, U.D., H.J. Rammensee, J.D. Benedetto, and M.J. Bevan. 1988. Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor. J. Immunol. 134:3994-4000.
48. Ashwell, J.D., and Klausner, R.D. 1990. Genetic and mutational analysis of the T cell antigen receptor. Annu. Rev. Immunol. 8:139-168.
49. Klausner, R.D., J. Lippincott-Schwartz, and J.S. Bonnofacino. 1990. The T cell antigen receptor. Insights into organelle biology. Annu. Rev. Cell. Biol. 6:403-431.
50. Nilsson, T., P.A. Jackson, and P.A. Peterson. 1989. Short cytoplasinic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum. Cell. 58:707-718.
51. Jackson, M.R., T. Nilsson, and P.A. Peterson. 1990. Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum. EMBO (Eur. Mol. Biol. Organ.) J. 9:3153-3162.
52. Wilson, R.K., E. Lai, P. Concannon, R.K. Barth, and L.E. Hood. 1988. Structure, organization and polymorphism of murine and human T-cell receptor α and β chain gene families. Immunol. Rev. 101:149-172.
53. Yancopoulos, G.D., S.V. Desiderio, M. Paskind, J.F. Kearney, D. Baltimore, and F.W. Alt. 1984. Preferential utilization of the most J(H) proximal V(H) gene segments in pre-B cell lines. Nature (Lond.). 311:727-733.
54. Perlmutter, R.M., J.F. Kearney, S.P. Chang, and L.E. Hood. 1985. Developmentally controlled expression of immunoglobulin VH genes. Science (Wash. DC). 227:1597-1601.
55. Yancopoulos, G.D., B.A. Malynn, and F.W. Alt. 1988. Developmentally regulated and strain-specific expression of murine VH gene families. J. Exp. Med. 168:417-435.
56. Freitas, A.A., L. Andrade, M.P. Lembezat, and A. Coutinho. 1990. Expression of VH gene repertoires: Differentiating B cells of adult bone marrow mimic fetal development. Int. Immunol. 2:15-21.