Pim-1 kinase and p100 cooperate to enhance c-Myb activity

Molecular Cell

Volumn 2, Issue 4, 1998, Pages 417-425

  Leverson, Joel D ^a,e   Koskinen, Päivi J ^b   Orrico, Frank C ^a   Rainio, Eeva Marja ^b   Jalkanen, Katriina J ^b   Dash, Ajeeta B ^a,f   Eisenman, Robert N ^c   Ness, Scott A ^d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF TURKU   (Finland)

^c USA   (United States)

^d UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

^e SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; MIM 1 PROTEIN, GALLUS GALLUS; MIM-1 PROTEIN, GALLUS GALLUS; NUCLEAR PROTEIN; ONCOPROTEIN; PIM1 PROTEIN, MOUSE; PROTEIN; PROTEIN C MYB; PROTEIN KINASE PIM 1; PROTEIN SERINE THREONINE KINASE; RAS PROTEIN; SND1 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL; ARTICLE; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROMOTER REGION; SIGNAL TRANSDUCTION;

ACETYLTRANSFERASES; ANIMALS; BASE SEQUENCE; CELLS, CULTURED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYB; PROTO-ONCOGENE PROTEINS C-PIM-1; RAS PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 0032185769     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80141-0     Document Type: Article

References (48)

1. Amson, R., Sigaux, F., Przedborski, S., Flandrin, G., Givol, D., and Telerman, A. (1989). The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias. Proc. Natl. Acad. Sci. USA 86, 8857-8861.
2. Aziz, N., Miglarese, M.R., Hendrickson, R.C., Shabanowitz, J., Sturgill, T.W., Hunt, D.F., and Bender, T.P. (1995). Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain. Proc. Natl. Acad. Sci. USA 92, 6429-6433.
3. Badiani, P., Corbella, P., Kioussis, D., Marvel, J., and Weston, K. (1994). Dominant interfering alleles define a role for c-Myb in T-cell development. Genes Dev. 8, 770-782.
4. Badiani, P.A., Kioussis, D., Swirsky, D.M., Lampert, I.A., and Weston, K. (1996). T-cell lymphomas in v-Myb transgenic mice. Oncogene 13, 2205-2212.
5. Bishop, J.M. (1991). Molecular themes in oncogenesis. Cell 64, 235-248.
6. Bruder, J.T., Heidecker, G., and Rapp, U.R. (1992). Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev. 6, 545-556.
7. Cuypers, H.T., Selten, G., Quint, W., Zijlstra, M., Maandag, E.R., Boelens, W., van Wezenbeek, P., Melief, C., and Berns, A. (1984). Murine leukemia virus-induced T-cell lymphomagenesis: integration of proviruses in a distinct chromosomal region. Cell 37, 141-150.
8. Dash, A.B., Orrico, F.C., and Ness, S.A. (1996). The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb. Genes Dev. 10, 1858-1869.
9. Dautry, F., Weil, D., Yu, J., and Dautry-Varsat, A. (1988). Regulation of pim and myb mRNA accumulation by interleukin 2 and interleukin 3 in murine hematopoietic cell lines. J. Biol. Chem. 263, 17615-17620.
10. DeLorbe, W.J., Luciw, P.A., Goodman, H.M., Varmus, H.E., and Bishop, J.M. (1980). Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J. Virol. 36, 50-61.
11. Devereux, J., Haeberli, P., and Smithies, O. (1984). A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12, 387-395.
12. Dini, P.W., and Lipsick, J.S. (1993). Oncogenic truncation of the first repeat of c-Myb decreases DNA binding in vitro and in vivo. Mol. Cell. Biol. 13, 7334-7348.
13. Dubendorff, J.W., Whittaker, L.J., Eltman, J.T., and Lipsick, J.S. (1992). Carboxy-terminal elements of c-Myb negatively regulate transcriptional activation in cis and in frans. Genes Dev. 6, 2524-2535.
14. Durfee, T., Becherer, K., Chen, P.L., Yeh, S.H., Yang, Y., Kilburn, A.E., Lee, W.H., and Elledge, S.J. (1993). The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7, 555-569.
15. Friedmann, M., Nissen, M.S., Hoover, D.S., Reeves, R., and Magnuson, N.S. (1992). Characterization of the proto-oncogene pim-1: kinase activity and substrate recognition sequence. Arch. Biochem. Biophys. 298, 594-601.
16. Graf, T. (1998). Leukemogenesis: small differences in Myb have large effects. Curr. Biol. 8, R353-R355.
17. Hayman, M.J., Meyer, S., Martin, F., Steinlein, P., and Beug, H. (1993). Self-renewal and differentiation of normal avian erythroid progenitor cells: regulatory roles of the TGFα/c-ErbB and SCF/c-Kit receptors. Cell 74, 157-169.
18. Hedge, S.P., Kumar, A., Kurschner, C., and Shapiro, L.H. (1998). c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation. Mol. Cell. Biol. 18, 2729-2737.
19. Hollenberg, S.M., Sternglanz, R., Cheng, P.F., and Weintraub, H. (1995). Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol. 15, 3813-3822.
20. Hoover, D., Friedmann, M., Reeves, R., and Magnuson, N.S. (1991). Recombinant human pim-1 protein exhibits serine/threonine kinase activity. J. Biol. Chem. 266, 14018-14023.
21. Howe, L.R., Leevers, S.J., Gómez, N., Nakielny, S., Cohen, P., and Marshall, C.J. (1992). Activation of the MAP kinase pathway by the protein kinase raf. Cell 71, 335-342.
22. Hunter, T. (1998). Prolyl isomerases and nuclear function. Cell 92, 141-143.
23. Joneja, B., and Wojchowski, D.M. (1997). Mitogenic signaling and inhibition of apoptosis via the erythropoietin receptor Box-1 domain. J. Biol. Chem. 272, 11176-11184.
24. Jonkers, J., and Berns, A. (1996). Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochem. Biophys. Acta 1287, 29-57.
25. Klempnauer, K.-H., Symonds, G., Evans, G.I., and Bishop, J.M. (1984). Subcellular localization of proteins encoded by oncogenes of avian myeloblastosis virus and avian leukemia virus E26 and by the chicken c-myb gene. Cell 37, 537-547.
26. Kohlhuber, F., Strobl, L.J., and Eick, D. (1993). Early down-regulation of c-myc in dimethylsulfoxide-induced mouse erythroleukemia (MEL) cells is mediated at the P1/P2 promoters. Oncogene 8, 1099-1102.
27. Kowenz-Leutz, E., Herr, P., Niss, K., and Leutz, A. (1997).The homeo-box gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation. Cell 91, 185-195.
28. Lachman, H.M., and Skoultchi, A.I. (1984). Expression of c-myc changes during differentiation of mouse erythroleukaemia cells. Nature 310, 992-994.
29. Leverson, J.D., and Ness, S.A. (1998). Point mutations in v-Myb disrupt acyclophilin-catalyzed negative regulatory mechanism. Mol. Cell 1, 203-211.
30. Liang, H., Hittelman, W., and Nagarajan, L. (1996). Ubiquitous expression and cell cycle regulation of the protein kinase PIM-1. Arch. Biochem. Biophys. 330, 259-265.
31. Lilly, M., Le, T., Holland, P., and Hendrickson, S.L. (1992). Sustained expression of the pim-1 kinase is specifically induced in myeloid cells by cytokines whose receptors are structurally related. Oncogene 7, 727-732.
32. Lüscher, B., Christenson, E., Litchfield, D.W., Krebs, E.G., and Eisenman, R.N. (1990). Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation. Nature 344, 517-522.
33. Meeker, T.C., Loeb, J., Ayres, M., and Sellers, W. (1990). The human Pim-1 gene is selectively transcribed in different hemato-lymphoid cell lines in spite of a G + C-rich housekeeping promoter. Mol. Cell. Biol. 10, 1680-1688.
34. Moroy, T., Grzeschiczek, A., Petzold, S., and Hartmann, K.U. (1993). Expression of a Pim-1 transgene accelerates lymphoproliferation and inhibits apoptosis in lpr/lpr mice. Proc. Natl. Acad. Sci. USA 90, 10734-10738.
35. Mucenski, M.L., McLain, K., Kier, A.B., Swerdlow, S.H., Schreiner, C.M., Miller, T.A., Pietryga, D.W., Scott, W.J., and Potter, S.S. (1991). A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65, 677-689.
36. Nagata, Y., and Todokoro, K. (1995). Thrombopoietin induces activation of at least two distinct signaling pathways. FEBS Lett. 377, 497-501.
37. Ness, S.A. (1996). The myb oncoprotein: regulating a regulator. BBA Rev. Cancer 1288, F123-F139.
38. Ness, S.A., Beug, H., and Graf, T. (1987). v-myb dominance over v-myc in doubly transformed chick myelomonocytic cells. Cell 51, 41-50.
39. Ness, S.A., Marknell, Å., and Graf, T. (1989). The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene. Cell 59, 1115-1125.
40. Ness, S.A., Kowenz-Leutz, E., Casini, T., Graf, T., and Leutz, A. (1993). Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. Genes Dev. 7, 749-759.
41. Oelgeschläger, M., Krieg, J., Lüscher-Firzlaff, J.M., and Lüscher, B. (1995). Casein kinase II phosphorylation site mutations in c-Myb affect DNA binding and transcriptional cooperativity with NF-M. Mol. Cell. Biol. 15, 5966-5974.
42. Oelgeschläger, M., Janknecht, R., Krieg, J., Schreek, S., and Lüscher, B. (1996). Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transcription and on the cooperativity with NF-M. EMBO J. 15, 2771-2780.
43. Sakai, I., and Kraft, A.S. (1997). The kinase domain of Jak2 mediates induction of bcl-2 and delays cell death in hematopoietic cells. J. Biol. Chem. 272, 12350-12358.
44. Saris, C.J., Domen, J., and Berns, A. (1991). The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG. EMBO J. 10, 655-664.
45. Stewart, B.E., and Rice, R.H. (1995). Differentiation-associated expression of the proto-oncogene pim-1 in cultured human keratino-cytes. J. Invest. Dermat. 105, 699-703.
46. Tavner, F.J., Simpson, R., Tashiro, S., Favier, D., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Macmillan, E.M., Lutwyche, J., Keough, R.A., et al. (1998). Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by Myb. Mol. Cell. Biol. 18, 989-1002.
47. Tong, X., Drapkin, R., Yalamanchili, R., Mosialos, G., and Kieff, E. (1995). The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. Mol. Cell. Biol. 15, 4735-4744.
48. Wingett, D., Reeves, R., and Magnuson, N.S. (1992). Characterization of the testes-specific pim-1 transcript in rat. Nucleic Acids Res. 20, 3183-3189.