Signals involved in CD4/CD8 lineage commitment: Current concepts and potential mechanisms

Seminars in Immunology

Volumn 11, Issue 4, 1999, Pages 273-281

  Singer, Alfred ^a   Bosselut, Remy ^b   Bhandoola, Avinash ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NONE

Author keywords

Coreceptor; Signaling; T cell development; Thymus

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

REVIEW; T LYMPHOCYTE; THYMOCYTE;

EID: 0033178645     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1999.0183     Document Type: Article

References (62)

1. Shortman K, Egerton M, Spangrude GJ, Scollay R (1990) The generation and fate of thymocytes. Semin Immunol 2:3-12
2. Egerton M, Scollay R, Shortman K (1990) Kinetics of mature T-cell development in the thymus. Proc Natl Acad Sci USA 87:2579-2582
3. Lundberg K, Shortman K (1994) Small cortical thymocytes are subject to positive selection. J Exp Med 179:1475-1483
4. + cells by CD4. Science 249:1558-1561
5. + thymocytes by p56lck tyrosine kinase: Basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J Exp Med 178:1701-1712
6. + thymocytes as a consequence of intrathymic interactions that diminish available p56lck. Immunity 4:495-504
7. + thymocytes. Proc Natl Acad Sci USA 90:10534-10538
8. Kisielow P, Teh HS, Bluthmann H, von Boehmer H (1988) Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature 335:730-733
9. Sha WC, Nelson CA, Newberry RD, Kranz DM, Russell JH, Loh DY (1988) Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature 335:271-274
10. Sha WC, Nelson CA, Newberry RD, Kranz DM, Russell JH, Loh DY (1988) Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature 336:73-76
11. Teh HS, Kisielow P, Scott B, Kishi H, Uematsu Y, Bluthmann H, von Boehmer H (1988) Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 335:229-233
12. Scott B, Bluthmann H, Teh HS, von Boehmer H (1989) The generation of mature T cells requires interaction of the alpha beta T-cell receptor with major histocompatibility antigens. Nature 338:591-593
13. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341:746-749
14. Berg LJ, Pullen AM, Fazekas de St Groth B, Mathis D, Benoist C, Davis MM (1989) Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 58:1035-1046
15. Borgulya P, Kishi H, Muller U, Kirberg J, von Boehmer H (1991) Development of the CD4 and CD8 lineage of T cells: Instruction versus selection. Embo J 10:913-918
16. Seong RH, Chamberlain JW, Parnes JR (1992) Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail. Nature 356:718-720
17. Itano A, Salmon P, Kioussis D, Tolaini M, Corbella P, Robey E (1996) The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J Exp Med 183:731-741
18. + T lymphocytes. Eur J Immunol 23:2834-2840
19. Itano A, Cado D, Chan FK, Robey E (1994) A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection. Immunity 1:287-290
20. Sebzda E, Choi M, Fung-Leung WP, Mak TW, Ohashi PS (1997) Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner. Immunity 6:643-653
21. + T cells. Science 248:1227-1230
22. + cytolytic T cells. Nature 344:742-746
23. + T cells in major histocompatibility complex class II-deficient mice. Science 253:1417-1420
24. Cosgrove D, Gray D, Dierich A, Kaufman J, Lemeur M, Benoist C, Mathis D (1991) Mice lacking MHC class II molecules. Cell 66:1051-1066
25. Chan SH, Cosgrove D, Waltzinger C, Benoist C, Mathis D (1993) Another view of the selective model of thymocyte selection. Cell 73:225-236
26. + thymocytes: Selection rather than instruction? Science 261:911-915
27. Chan SH, Waltzinger C, Baron A, Benoist C, Mathis D (1994) Role of coreceptors in positive selection and lineage commitment. Embo J 13:4482-4489
28. Itano A, Kioussis D, Robey E (1994) Stochastic component to development of class I major histocompatibility complex-specific T cells. Proc Natl Acad Sci USA 91:220-224
29. + helper T cells in class II major histocompatibility complex mutant mice. J Exp Med 179:1997-2004
30. Davis CB, Killeen N, Crooks ME, Raulet D, Littman DR (1993) Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73:237-247
31. + cells in beta 2-microglobulin-deficient mice. Eur J Immunol 24:1933-1936
32. Chan S, Correia-Neves M, Dierich A, Benoist C, Mathis D (1998) Visualization of CD4/CD8 T cell commitment. J Exp Med 188:2321-2333
33. + T cell lineages: A new perspective on thymic commitment and selection. Immunity 2:413-425
34. + thymocytes has selectively terminated CD4 or CD8 synthesis. J Exp Med 184:2091-2099
35. +TCRhi thymocytes. J Exp Med 181:1643-1651
36. Benveniste P, Knowles G, Cohen A (1996) CD8/CD4 lineage commitment occurs by an instructional/default process followed by positive selection. Eur J Immunol 26:461-471
37. + T cells by TCR ligation without aggregation even in the absence of MHC. Nature 371:67-70
38. Muller KP, Kyewski BA (1993) T cell receptor targeting to thymic cortical epithelial cells in vivo induces survival, activation and differentiation of immature thymocytes. Eur J Immunol 23:1661-1670
39. Bommhardt U, Cole MS, Tso JY, Zamoyska R (1997) Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus. Eur J Immunol 27:1152-1163
40. Cibotti R, Punt JA, Dash KS, Sharrow SO, Singer A (1997) Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals. Immunity 6:245-255
41. + thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chains. J Exp Med 186:17-23
42. Zerrahn J, Held W, Raulet DH (1997) The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88:627-636
43. + thymic selection in humans lacking zap-70 kinase. Cell 76:947-958
44. Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG (1994) Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 264:1596-1599
45. Robey EA, Fowlkes BJ, Gordon JW, Kioussis D, von Boehmer H, Ramsdell F, Axel R (1991) Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell 64:99-107
46. + thymocytes. Immunity 7:243-254
47. Robey E, Chang D, Itano A, Cado D, Alexander H, Lans D, Weinmaster G, Salmon P (1996) An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87:483-492
48. Hedrick SM, Sharp LL (1998) T-cell fate. Immunol Rev 165:95-110
49. Jehn BM, Bielke W, Pear WS, Osborne BA (1999) Protective effects of notch-1 on TCR-induced apoptosis. J Immunol 162:635-638
50. Kim HK, Siu G (1998) The notch pathway intermediate HES-1 silences CD4 gene expression. Mol Cell Biol 18:7166-7175
51. Robey E, Fowlkes BJ (1994) Selective events in T cell development. Annu Rev Immunol 12:675-705
52. Sharp LL, Schwarz DA, Bott CM, Marshall CJ, Hedrick SM (1997) The influence of the MAPK pathway on T cell lineage commitment. Immunity 7:609-618
53. Matechak EO, Killeen N, Hedrick SM, Fowlkes BJ (1996) MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent. Immunity 4:337-347
54. Levin SD, Anderson SJ, Forbush KA, Perlmutter RM (1993) A dominant-negative transgene defines a role for p56lck in thymopoiesis. Embo J 12:1671-1680
55. Hashimoto K, Sohn SJ, Levin SD, Tada T, Perlmutter RM, Nakayama T (1996) Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection. J Exp Med 184:931-943
56. Killeen N, Littman DR (1993) Helper T-cell development in the absence of CD4-p56lck association. Nature 364:729-732
57. + T cells by TCR-specific antibodies requires low valency TCR cross-linking: Implications for repertoire selection in the thymus. Eur J Immunol 28:3252-3258
58. Albert Basson M, Bommhardt U, Cole MS, Tso JY, Zamoyska R (1998) CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity. J Exp Med 187:1249-1260
59. + stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1:197-205
60. Deftos ML, He YW, Ojala EW, Bevan MJ (1998) Correlating notch signaling with thymocyte maturation. Immunity 9:777-786
61. Dave VP, Allman D, Keefe R, Hardy RR, Kappes DJ (1998) HD mice: A novel mouse mutant with a specific defect in the generation of CD4(+) T cells. Proc Natl Acad Sci USA 95:8187-8192
62. - thymocytes dominate the fetal thymus treated with a combination of anti-T cell receptor-beta and anti-CD4 antibodies. J Immunol 151:1290-1302