MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex

Journal of Molecular Biology

Volumn 273, Issue 5, 1997, Pages 993-1003

  Alkema, Mark J ^a   Jacobs, Jacqueline ^a   Voncken, Jan Willem ^a   Jenkins, Nancy A ^b   Copeland, Neal G ^b   Satijn, David P E ^a   Otte, Arie P ^a   Berns, Anton ^a   Van Lohuizen, Maarten ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Bmi1; Chromosomal localization; Nuclear distribution; Polycomb; Transcriptional repressor

Indexed keywords

HYBRID PROTEIN; ONCOPROTEIN; PROTEIN;

ANIMAL CELL; ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 11; CONTROLLED STUDY; DROSOPHILA; EMBRYO; FEMALE; GENE CONSTRUCT; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; TRANSCRIPTION REGULATION;

EID: 0031567787     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1372     Document Type: Article

References (39)

1. Akasaka, T., Kanno, M., Balling, R., Miesa, M. A., Taniguchi, M. & Koseki, H. (1996). A role for mel-18, a Polycomb group related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development, 122, 1513-1522.
2. Alkema, M. J., Wiegant, J., Raap, A. K., Berns, A. & van Lohuizen, M. (1993). Characterization and chromosomal localization of the human proto-oncogene BMI-1. Humun Mol .Genet. 2, 1597-1603.
3. Alkema, M. J., van der Lugt, N. M., Bobeldijk, R. C., Berns, A. & van Lohuizen, M. (1995). Transformation of axial skeleton due to overexpression of Bmi-1 in transgenic mice. Nature, 374, 724-727.
4. Alkema, M. J., Bronk, M., Verhoeven, E., Otte, A. P., van't, Veer L. J., Berns, A. & van Lohuizen, M. (1997). Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex. Genes Dev. 11, 226-240.
5. Brunk, B. P., Martin, E. C. & Adler, P. N. (1991). Drosophila genes posterior sex combs and suppressor two of zeste encode proteins with homology to the murine Bmi-1 oncogene. Nature, 353, 351-353.
6. Bunker, C. A. & Kingston, R. E. (1994). Transcriptional repression by Drosophila and mammalian polycomb group proteins in transfected mammalian cells. Mol. Cell. Biol. 14, 1721-1732.
7. Cohen, K. J., Hanna, J. S., Prescott, J. E. & Dang, C. V. (1996). Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity. Mol. Cell. Biol. 16, 5527-5535.
8. Copeland, N. G. & Jenkins, N. A. (1991). Development and application of a molecular genetic linkage map of the mouse genome. Trends Genet. 7, 113-118.
9. Coré, N., Bel, S., Gaunt, S. J., Aurrand-Lions, M., Pearce, J., Fisher, A. & Djabali, M. (1997). Altered cellular proliferation and mesoderm patterning in polycomb-M33-deficient mice. Development, 124, 721-729.
10. Franke, A., DeCamillis, M., Zink, D., Cheng, N., Brock, H. W. & Paro, R. (1992). Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J. 11, 2941-2950.
11. Franke, A., Messmer, S. & Paro, R. (1995). Mapping functional domains of the polycomb protein of Drosophila melanogaster. Chromosome Res. 3, 351-360.
12. Gecz, J., Gaunt, S. J., Passage, E., Burton, R. D., Cudrey, C., Pearce, J. J. & Fontes, M. (1995). Assignment of a polycomb-like chromobox gene (CBX2) to human chromosome 17q25. Genomics, 26, 130-133.
13. Goodrich, J., Puangsomlee, P., Martin, M., Long, D., Meyerowitz, E. M. & Coupland, G. (1997). A polycomb-group gene regulates homeotic gene expression in Arabidopsis. Nature, 386, 44-51.
14. Gunster, M. J., Satijn, D. P. E., Hamer, K. M., den Blaauwen, J. L., de Bruijn, D., Alkema, M. J., van Lohuizen, M., van Driel, R. & Otte, A. P. (1997). Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and the human homologs of polyhomeotic. Mol. Cell. Biol. 17, 2326-2335.
15. Robert, O., Jallal, B. & Ullrich, A. (1996). Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. Mol. Cell. Biol. 16, 3066-3073.
16. Hustert, E., Scherer, G., Olowson, M., Guenet, J.-L. & Balling, R. (1996). Rbt (rabo torcido), a new mouse skeletal mutation involved in ateroposterior patterning of the axial skeleton, maps close to the Ts (Tail-short) locus and distal to the Sox9 locus on chromosome 11. Mammalian Genome, 7, 881-885.
17. Jenkins, N. A., Copeland, N. G., Taylor, B. A. & Lee, B. K. (1982). Organization, distribution and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J. Virol. 43, 26-36.
18. Kennison, J. A. (1993). Trascriptional activation of Drosophila homeotic genes from distant regulator elements. Trends Genet. 9, 75-79.
19. Kuziora, M. A. & McGinnis, W. (1988). Different transcripts of the Drosophila Abd-B gene correlate with distinct genetic sub-functions. EMBO J. 7, 3233-3244.
20. Messmer, S., Franke, A. & Paro, R. (1992). Analysis of the functional role of the polycomb chromo domain in Drosophila melanogaster. Genes Dev. 6, 1241-1254.
21. Morishige, K.-L, Takahashi, Findlay I., Koyama, H., Zanelli, J. S., Peterson, C., Jenkins, N. A., Copeland, N. G., Mori, N. & Kurachi, Y. (1993). Molecular cloning, functional expression and localization of an inward rectifier potassium channel in the mouse brain. FEBS Letters, 336, 375-380.
22. Morgan, W. C. (1950). A new tail-short mutation in the mouse. J. Hered. 41, 208-215.
23. Müller, J., Gaunt, S. & Lawrence, P. A. (1995). Function of the polycomb protein is conserved in mice and flies. Development, 121, 2847-2852.
24. Nagasawa, M., Sakimura, K., Mori, K. J., Bedell, M. A., Copeland, N. G., Jenkins, N. A. & Mishina, M. (1996). Gene structure and chromosomal localization of the mouse NMDA receptor channel subunits. Mol. Brain Res. 36, 1-11.
25. Paro, R. (1993). Mechanisms of heritable gene repression during development of Drosophila. Curr. Opin. Cell Biol. 5, 999-1005.
26. Paro, R. & Hogness, D. S. (1991). The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila. Proc. Natl Acad. Sci. USA, 88, 263-267.
27. Pearce, J. J., Singh, P. B. & Gaunt, S. J. (1992). The mouse has a polycomb-like chromobox gene. Development, 114, 921-929.
28. Pirrotta, V. (1995). Chromatin complexes regulating gene expression in Drosophila. Curr. Opin. Genet. Dev. 5, 466-472.
29. Platero, J. S., Sharp, E. J., Adler, P. N. & Eissenberg, J. C. (1996). In vivo assay for protein-protein interactions using Drosophila chromosomes. Chromosoma, 104, 393-404.
30. Reijnen, M. J., Hamer, K. M., den Blaauwen, J. L., Lambrechts, C., Schoneveld, I., van Driel, R. & Otte, A. P. (1995). Polycomb and bmi-1 homologs are expressed in overlapping patterns in Xenopus embryos and are able to interact with each other. Mech. Dev. 53, 35-46.
31. Satijn, D. P. E., Gunster, M. J., van der Vlag, J., Hamer, K. M., Schul, W., Alkema, M. J., Saurin, A. J., Freemont, P. S., van Driel, R. & Otte, A. P. (1997). Mol. Cell. Biol. 17, 4105-4113.
32. Schumacher, A., Faust, C. & Magnuson, T. (1996). Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature, 383, 250-253.
33. Tagawa, M., Sakamoto, T., Shigemoto, K., Matsubara, H., Tamura, Y., Ito, T., Nakamura, I., Okitsu, A., Imai, K. & Taniguchi, M. (1990). Expression of novel DNA-binding protein with zinc finger structure in various tumor cells. J. Biol. Chem. 265, 20021-20026.
34. van der Lugt, N. M. T., Domen, J., Linders, K., van Roon, M., Robanus, Maandag E., te, Riele H., van der Valk, M., Deschamps, J., Sofroniew, M., van Lohuizen, M. & Berns, A. (1994). Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the Bmi-1 proto-oncogene. Genes Dev. 8, 757-769.
35. van der Lugt, N. M. T., Alkema, M. J., Berns, A. & Deschamps, J. (1996). The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. Mech. Dev. 58, 153-164.
36. van Lohuizen, M., Frasch, M., Wientjens, E. & Berns, A. (1991). Sequence similarity between the mammalian Braz-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature, 353, 353-355.
37. Wedeen, C., Harding, K. & Levine, M. (1986). Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila. Cell, 44, 739-748.
38. Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A. & Harlow, E. (1988). Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature, 334, 124-129.
39. Yu, B. D., Hess, J. L., Horning, S. E., Brown, G. A. & Korsmeyer, S. J. (1995). Altered Hox expression and segmental identity in Mll-mutant mice. Nature, 378, 505-508.