PIM1 reconstitutes thymus cellularity in interleukin 7- and common γ chain-mutant mice and permits thymocyte maturation in rag- but not CD3γ- deficient mice

Journal of Experimental Medicine

Volumn 190, Issue 8, 1999, Pages 1059-1068

  Jacobs, Heinz ^a   Krimpenfort, Paul ^b   Haks, Mariëlle ^c   Allen, John ^b   Blom, Bianca ^c   Démollière, Corinne ^a   Kruisbeek, Ada ^c   Spits, Hergen ^c   Berns, Anton ^b  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Common chain; IL 7; Lymphomagenesis; Pre T cell development; Proviral tagging; Rag

Indexed keywords

CD3 ANTIGEN; HEMOGLOBIN GAMMA CHAIN; INTERLEUKIN 7;

ANIMAL CELL; ARTICLE; CELL COMPOSITION; CELL MATURATION; CELL PROLIFERATION; COMPLEMENT ACTIVATION; EFFECTOR CELL; ENZYME RECONSTITUTION; GENE EXPRESSION REGULATION; GENE INSERTION; LYMPHOMA; MOUSE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; SIGNAL TRANSDUCTION; THYMOCYTE;

ANIMALS; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; FLOW CYTOMETRY; IMMUNOGLOBULIN GAMMA-CHAINS; INTERLEUKIN-7; LYMPHOMA, T-CELL; MICE; MICE, TRANSGENIC; MOLONEY MURINE LEUKEMIA VIRUS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-PIM-1; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0032753239     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.8.1059     Document Type: Article

References (51)

1. Rodewald, H.R., and H.J. Fehling. 1998. Molecular and cellular events in early thymocyte development. Adv. Immunol. 69:1-112.
2. Febling, H.J., and H. von Boehmer. 1997. Early alpha beta T cell development in the thymus of normal and genetically manipulated mice. Curr. Opin. Immunol. 9:263-275.
3. Leonard, W.J., E.W. Shores, and P.E. Love. 1995. Role of the cytokine receptor γ chain in cytokine signaling and lymphoid development. Immunol. Rev. 148:97-114.
4. Sugamura, K., H. Asao, M. Kondo, N. Tanaka, N. Ishii, M. Nakamura, and T. Takeshita. 1995. The common gamma-chain for multiple cytokine receptors. Adv. Immunol. 59: 225-277.
5. Cao, X., E.W. Shores, J. Hu-Li, M.R. Anver, B.L. Kelsall, S.M. Russell, J. Drago, M. Noguchi, A. Grinberg, E.T. Bloom, et al. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity. 2:223-238.
6. DiSanto, J.P., W. Müller, D. Guy Grand, A. Fischer, and K. Rajewsky. 1995. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc. Natl. Acad. Sci. USA. 92:377-381.
7. Maki, K., S. Sunaga, Y. Komagata, Y. Kodaira, A. Mabuchi, H. Karasuyama, K. Yokomuro, J.I. Miyazaki, and K. Ikuta. 1996. Interleukin 7 receptor-deficient mice lack γδ T cells. Proc. Natl. Acad. Sci. USA. 93:7172-7177.
8. Ohbo, K., T. Suda, M. Hashiyama, A. Mantani, M. Ikebe, K. Miyakawa, M. Moriyama, M. Nakamura, M. Katsuki, K. Takahashi, et al. 1996. Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain. Blood. 87:956-967.
9. Peschon, J.J., P.J. Morrissey, K.H. Grabstein, F.J. Ramsdell, E. Maraskovsky, B.C. Gliniak, L.S. Park, S.F. Siegler, D.E. Williams, C.B. Ware, et al. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180:1955-1960.
10. von Freeden-Jeffry, U., P. Vieira, L.A. Lucian, T. McNeil, S.E. Burdach, and R. Murray. 1995. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181:1519-1526.
11. Mallick, C.A., E.C. Dudley, J.L. Viney, M.J. Owen, and A.C. Hayday. 1993. Rearrangement and diversity of T cell receptor β chain genes in thymocytes: a critical role for the β chain in development. Cell. 73:513-519.
12. von Boehmer, H. 1990. Developmental biology of T cells in T cell receptor transgenic mice. Annu. Rev. Immunol. 8:531-556.
13. Mombaerts, P., J. Iacomini, R.S. Johnson, K. Herrup, S. Tonegawa, and V.E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 68:869-877.
14. Shinkai, Y., G. Rathbum, K.P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A.M. Stall, et al. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68: 855-867.
15. Molina, T.J., K. Kishihara, D.P. Siderovski, W. van Ewijk, A. Narendran, E. Timms, A. Wakeham, C.J. Paige, K.U. Hartmann, A. Veillette, et al. 1992. Profound block in thymocyte development in mice lacking p56lck. Nature. 357: 161-164.
16. Levin, S.D., S.J. Anderson, K.A. Forbush, and R.M. Perimutter. 1993. A dominant-negative transgene defines a role for p56lck in thymopoiesis. EMBO (Eur. Mol. Biol. Organ.) J. 12:1671-1680.
17. Mombaerts, P., S.J. Anderson, R.M. Perlmutter, T.W. Mak, and S. Tonegawa. 1994. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1:261-267.
18. Berns, A., M. Breuer, S. Verbeek, and M. van Lohuizen. 1989. Transgenic mice as a means to study synergism between oncogenes. Int. J. Cancer Suppl. 4:22-25.
19. Jonkers, J., and A. Berns. 1996. Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochimica et Biophysica Acta. 1287:29-57.
20. van der Lugt, N.M.T., J. Domen, E. Verhoeven, K. Linders, H. van der Gulden, J. Allen, and A. Berns. 1995. Proviral tagging in Eμ-myc transgenic mice lacking the Pim-1 protooncogene leads to compensatory activation of Pim-2. EMBO (Eur. Mol. Biol. Organ.) J. 14:2536-2544.
21. Feldman, J.D., D. Vician, M. Crispino, G. Tocco, V.L. Marcheselli, N.G. Bazan, M. Baudry, and H.R. Herschmann. 1998. KID-1, a protein kinase induced by depolarization in brain. J. Biol. Chem. 273:16535-16543.
22. Allen, J.D., E. Verhoeven, J. Domen, M. van der Valk, and A. Berns. 1997. Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc. Oncogene. 15:1133-1141.
23. Verbeek, S., M. van Lohuizen, M. van der Valk, J. Domen, G. Kraal, and A. Berns. 1991. Mice bearing the Eμ-myc and Eμ-pim-1 transgenes develop pre-B-cell leukemia prenatally. Mol. Cell. Biol. 11:1176-1179.
24. Domen, J., N.M. van der Lugt, D. Acton, P.W. Laird, K. Linders, and A. Berns. 1993. Pim-1 levels determine the size of early B lymphoid compartments in bone marrow. J. Exp. Med. 178:1665-1673.
25. Domen, J., N.M. van der Lugt, P.W. Laird, C.J. Saris, A.R. Clarke, M.L. Hooper, and A. Berns. 1993. Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells. Blood. 82:1445-1452.
26. Domen, J., N.M. van der Lugt, P.W. Laird, C.J. Saris, and A. Berns. 1993. Analysis of Pim-1 function in mutant mice. Leukemia. 7:108-112.
27. Schmidt, T., H. Karsunky, B. Rödel, B. Zevnik, H.-P. Elsässer, and T. Möröy. 1998. Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with β-selection. EMBO (Eur. Mol. Biol. Organ.) J. 17:5349-5369.
28. Selten, G., H.T. Cuypers, and A. Berns. 1985. Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas. EMBO (Eur. Mol. Biol. Organ.) J. 4:1793-1798.
29. Selten, G., H.T. Cuypers, W. Boelens, E. Robanus-Maandag, J. Verbeek, J. Domen, C. van Beveren, and A. Berns. 1986. The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases. Cell. 46: 603-611.
30. Hooper, M.L. 1992. Embryonal stem cells. In Modern Genetics. H.J. Evans, editor. Hatwood Academics Publishers GmbH, Switzerland. 147 pp.
31. Robanus-Maandag, E.C., M. van der Valk, M. Vlaar, C. Feltkamp, J. O'Brien, M. van Roon, N.M. van der Lugt, A. Berns, and H. Riele. 1994. Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice. EMBO (Eur. Mol. Biol. Organ.) J. 13:4260-4268.
32. Haks, M.C., P. Krimpenfort, J. Borst, and A.M. Kruisbeek. 1998. The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages. EMBO (Eur. Mol. Biol. Organ.) J. 17:1871-1882.
33. Van Lohuizen, M., S. Verbeek, P. Krimpenfort, J. Domen, C. Saris, T. Radaszkiewicz, and A. Berns. 1989. Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation in murine leukemia virus-induced tumors. Cell. 56: 673-682.
34. McDonnell, T.J., N. Deane, F.M. Platt, G. Nunez, U. Jaeger, J.P. McKearn, and S.J. Korsmeyer. 1989. Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 57:79-88.
35. Selten, G., H.T. Cuypers, M. Zijlstra, C. Melief, and A. Berns. 1984. Involvement of c-myc in MuLV-induced T cell lymphomas in mice: frequency and mechanisms of activation. EMBO (Eur. Mol. Biol. Organ.) J. 3:3215-3222.
36. Scheijen, B., J. Jonkers, D. Acton, and A. Berns. 1997. Characterization of pal-1, a common proviral insertion site in murine leukemia virus induced lymphomas of c-myc and pim-1 transgenic mice. J. Virol. 7:9-16.
37. Jacobs, H., J. Iacomini, M. van de Ven, S. Tonegawa, and A. Berns. 1996. Domains of the TCR beta-chain required for early thymocyte development. J. Exp. Med. 184:1833-1843.
38. Jacobs, H. 1996. Control of T Cell Development in TCR Mutant Mice. Thesis in Medical Science. University of Amsterdam, The Netherlands. 196 pp.
39. Malissen, B., and M. Malissen. 1996. Functions of TCR and pre-TCR subunits: lessons from gene ablation. Curr. Opin. Immunol. 8:383-393.
40. Rohwer, F., S. Todd, and K.L. McGuire. 1996. The effect of IL-2 treatment on transcriptional attenuation in proto-oncogenes pim-1 and c-myb in human thymic blasts. J. Immunol. 157:643-649.
41. Muli, A.L., H. Wakao, T. Kinoshita, T. Kitamura, and A. Miyajima. 1996. Suppression of interleukin-3 induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO (Eur. Mol. Biol. Organ.) J. 15:2425-2433.
42. Di Santo, J.P., and H.-R. Rodewald. 1998. In vivo roles of receptor tyrosine kinases and cytokine receptors in early thymocyte development. Curr. Opin. Immunol. 10:196-207.
43. Kondo, M., K. Akashi, J. Domen, K. Sugamura, and I.L. Weissman. 1997. Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain deficient mice. Immunity. 7:155-162.
44. Jacobs, H., D. Vandeputte, L. Tolkamp, E. de Vries, J. Borst, and A. Berns. 1994. CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Eur. J. Immunol. 24:934-939.
45. Levelt, C.N., P. Mombaerts, A. Iglesias, S. Tonegawa, and K. Eichmann. 1993. Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon. Proc. Natl. Acad. Sci. USA. 90:11401-11405.
46. -/- mice in the absence of TCR beta chain expression. Int. Immunol. 6:995-1001.
47. Shortman, K., and L. Wu. 1996. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14:29-47.
48. Leverson, J.D., P.J. Koskinen, F.C. Orrico, E.-M. Rainio, K.J. Jalkanen, A.B. Dash, R.N. Eisenman, and S.A. Ness. 1998. Pim-1 kinase and p100 cooperate to enhance c-Myb activity. Mol. Cell. 2:417-425.
49. Shinkai, Y., A. Ma, H.L. Cheng, and F.W. Alt. 1995. CD3 epsilon and CD3 zeta cytoplasmic domains can independently generate signals for T cell development and function. Immunity. 2:401-411.
50. Di Santo, J.P., I. Aifantis, E. Rosmaraki, C. Garcia, J. Feinberg, H.J. Fehling, A. Fischer, H. von Boehmer, and B. Rocha. 1999. The common cytokine receptor γ chain and the pre-T cell receptor provide independent but critically overlapping signals in early α/β T cell development. J. Exp. Med. 189:563-574.
51. Rodewald, H.R., M. Ogawa, C. Haller, C. Waskow, and J.P. DiSanto. 1997. Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation. Immunity. 6:265-272.