Proliferation kinetics associated with T cell receptor-β chain selection of fetal murine thymocytes

Journal of Experimental Medicine

Volumn 184, Issue 6, 1996, Pages 2327-2339

  Falk, Ingrid ^a   Biro, Judit ^a   Kohler, Hubertus ^a   Eichmann, Klaus ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DIVISION; CONTROLLED STUDY; FETUS; FETUS DEVELOPMENT; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE;

ANIMALS; FETUS; FLOW CYTOMETRY; GENE REARRANGEMENT, B-LYMPHOCYTE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; ORGAN CULTURE TECHNIQUES; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0030472679     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.6.2327     Document Type: Article

References (50)

1. Godfrey, D.I., and A. Zlotnik. 1993. Control points in early T-cell development. Immunol. Today. 14:547-554.
2. Robey, E., and B.J. Fowlkes. 1994. Selective events in T cell development. Ann. Rev. Immunol. 12:675-705.
3. Groettrup, M., K. Ungewiss, O. Azogui, R. Palacios, M.J. Owen, A.C. Hayday, and H. von Boehmer. 1993. A novel disulphide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kD glycoprotein. Cell. 75: 283-294.
4. Saint-Ruf, C., K. Ungewiss, M. Groettrup, L. Bruno, H.L. Fehling, and H. von Boehmer. 1994. Analysis and expression of a pre-T cell receptor gene. Science (Wash. DC). 266:1208-1212.
5. Groettrup, M., and H. von Boehmer. 1993. Role for a pre-T cell receptor in T cell development. Immunol. Today. 14: 610-614.
6. Levelt, C.N., and K. Eichmann. 1993. Parallel development of the T cell and its receptor. The Immunologist. 1:151-154.
7. Levelt, C.N., and K. Eichmann. 1995. Receptors and signals in early thymic selection. Immunity. 3:667-672.
8. Tanaka, Y., L. Ardouin, A. Gillet, S.Y. Lin, A. Magnan, B. Malissen, and M. Malissen. 1995. Early T-cell development in CD3-deficient mice. Immunol. Rev. 148:171-199.
9. Zunicka-Pflücker, J.L., and M.J. Lenardo. 1996. Regulation of thymocyte development from immature progenitors. Curr. Opin. Immunol. 8:215-224.
10. Von Boehmer, H. 1990. Developmental biology of T cells in T cell-receptor transgenic mice. Annu. Rev. Immunol. 8: 531-556.
11. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150:4244-4252.
12. - thymocyte differentiation. J. Immunol. 152:4783-4792.
13. Dudley, E.C., H.T. Petrie, L.M. Shah, M.J. Owen, and A.C. Hayday. 1994. T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity. 1:83-92.
14. Mallick, C.A., E.C. Dudley, J.L. Viney, M.J. Owen, and A.C. Hayday. 1993. Rearrangement and diversity of T cell receptor β chain genes in thymocytes, a critical role for the β chain in development. Cell. 73:513-519.
15. Petrie, T., F. Livak, D.G. Schatz, A. Strasser, I.N. Crispe, and K. Shortman. 1993. Multiple rearrangements in T cell receptor a chain genes maximize the production of useful thymocytes. J. Exp. Med. 178:615-622.
16. Boismenu, R., M. Rhein, W.H. Fischer, and W.L. Havran. 1996. A role for CD81 in early T cell development. Science (Wash. DC). 271:198-200.
17. + thymocytes. Nature (Lond.). 333:742-746.
18. Rothenberg, E.V. 1994. Signaling mechanisms in thymocyte selection. Curr. Opin. Immunol. 6:257-265.
19. Malissen, M., J. Tracy, E. Janvin-Marche, P.A. Cazenave, R. Scollay, and B. Malissen. 1992. Regulation of TCRα and β gene allelic exclusion during T cell development. Immunol. Today. 13:315-322.
20. Levelt, C.N., B. Wang, A. Ehrfeld, C. Terhorst, and K. Eichmann. 1995. Regulation of T cell receptor (TCR)-β locus allelic exclusion and initiation of TCRβ locus rearrangement in immature thymocytes by signaling through the CD3 complex. Eur. J. Immunol. 25:1257-1261.
21. Capone, M., F. Watrin, C. Fernex, B. Horvat, B. Krippl, L. Wu, E. Scollay, and P. Ferner. 1993. TCR β and TCR α gene enhancers confer tissue- and stage-specificity on V(D)J recombination events. EMBO (Eur. Mol. Biol. Organ.) J. 12: 4335-4346.
22. Wilson, A., W. Held, and H.R. MacDonald. 1994. Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179:1355-1360.
23. Levelt, C.N., A. Ehrfeld, and K. Eichmann. 1993. Regulation of thymocyte development through CD3. I. Timepoint of ligation of CD3∈ determines clonal deletion or induction of developmental program. J. Exp. Med. 177:707-716.
24. Levelt, C.N., P. Mombaerts, A. Iglesias, S. Tonegawa, and K. Eichmann. 1993. Restoration of early thymocyte differentiation in T-cell receptor β-chain deficient mutant mice by transmembrane signaling through CD3∈. Proc. Natl. Acad. Sci. USA. 90:11401-11405.
25. -/- mice in the absence of TCR β chain expression. Int. Immunol. 6:995-1001.
26. lck and CD3ζ in early thymic selection. Immunity. 3:215-222.
27. Mombaerts, P., A.R. Clarke, M.A. Rudnicki, J. Iacomini, S. Itohara, J.J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M.L. Hooper, and S. Tonegawa. 1992. Mutations in T cell antigen receptor genes α and β block thymocyte development at different stages. Nature (Lond.). 360:225-231.
28. Mombaerts, P., J. Iacomini, R.S. Johnson, K. Herup, S. Tonegawa, and V.E. Papaicannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 68:869-877.
29. Shinkai, Y., S. Koyeau, K. Nakayama, K.M. Murphy, D.Y. Loh, E.L. Reinherz, and F.W. Alt. 1992. Restoration of T cell development in RAG2-deficient mice by functional TCR transgenes. Science (Wash. DC). 259:822-825.
30. Shinkai, Y., G. Rathbun, K.P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A.M. Stall, and F.W. Alt. 1992. RAG2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68:855-867.
31. Shores, E.W., S.O. Sharrow, I. Uppenkamp, and A. Singer. 1990. T cell receptor negative thymocytes from Seid mice can be induced to enter the CD4/CD8 differentiation pathway. Eur. J. Immunol. 20:69-75.
32. Habu, S., M. Kimura, M. Katsuki, K. Hioki, and T. Nomuta. 1987. Correlation of T cell receptor gene rearrangements to T cell surface antigen expression and to serum immunoglobulin level in Scid mice. Eur. J. Immunol. 17:1467-1471.
33. Fehling, J.J., A. Krotkova, C. Saint-Ruf, and H.v. Boehmer. 1995. Crucial role of the pre-T cell receptor a gene in the development of αβ but not of γδ cells. Nature (Lond.). 375: 795-798.
34. Jacobs, H., D. Vandeputte, L. Tolkamp, E. de Vries, J. Borel, and A. Berns. 1994. CD3 components at the cell surface of pro-T cells can mediate pre-T cell development in vivo. Eur. J. Immunol. 24:934-939.
35. Shortman, K., M. Egerton, G.J. Spangrude, and K. Scollay. 1990. The generation and fate of thymocytes. Semin. Immunol. 2:3-12.
36. +) thymocytes in normal and genetically modified mice. J. Immunol. 154:5103-5113.
37. Hoffman, E.G., L. Passoni, T. Crompton, T.M.J. Len, D.G. Schatz, A. Kaff, M.J. Owen, and A.J. Hayday. 1996. Productive T cell receptor β chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 10:984-962.
38. Parkin, I.G., J.J.T. Owen, and E.J. Jenkinson. 1988. Proliferation of thymocytes in relation to T-cell receptor β chain expression. Immunology. 64:97-99.
39. - thymocytes: in vivo development kinetics on T cell receptor β chain rearrangement status. J. Exp. Med. 177:1079-1092.
40. Hozumi, K., A. Kobori, T. Sato, H. Nozaki, S-L. Nishikawa, T. Nishimura, and S. Habu. 1994. Pro-T cells in fetal thymus express c-kit and RAG-2 do not rearrange the gene encoding the T cell receptor βchain. Eur. J. Immunol. 24:1339-1344.
41. Cristanti, X., A. Colantani, R. Snodgrass, and H. von Boehmer. 1986. Expression of T cell receptors by thymocytes: in situ staining and biochemical analysis. EMBO (Eur. Mol. Biol. Organ.) J. 5:2837-2843.
42. + stage are highly correlated in individual thymocytes. J. Exp. Med. 178:1867-1875.
43. Hoy, C.A., L.L. Seamer, and R.T. Schimke. 1989. Thermal denaturation of DNA for immuno-chemical staining of incorporated bromodeoxyuridine (BrdUrd): critical factors that affect the amount of fluorescence and the shape of BrdUrd/ DNA histogram. Cytometry. 10:718-725.
44. Casanova, J.L., P. Romero, C. Widmann, P. Kourilsky, and J.L. Maryansky. 1991. T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire. J. Exp. Med. 174:1371-1383.
45. lck. EMBO (Eur. Mol. Biol. Organ.) J. 11:4877-4886.
46. Egerton, M., K. Shortman, and R. Scollay. 1990. The kinetics of immature murine thymocyte development in vivo. Int. Immunol. 2:501-507.
47. Cao, X., E.W. Shores, J. Hu-Li, M.R. Anver, B.L. Kelsall, S.M. Russell, J. Drago, M. Noguchi, A. Grinberg, E.T. Bloom, W.E. Paul, S.I. Katz, P.E. Love, and W.J. Leonard. 1995. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain. Immunity. 2:223-238.
48. DiSanto, J.P., W. Muller, D. Guy-Grand, A. Fischer, and K. Rajewsky. 1995. Lymphoid development in mice with a targeted deletion of the interleukin-2 receptor γ chain. Proc. Natl. Acad. Sci. USA. 92:377-381.
49. Park, S.Y., K. Saijo, T. Takahashi, M. Osawa, H. Arase, N. Hirayama, K. Miyake, H. Nakauchi, T. Shirasawa, and T. Saito. 1995. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity. 3:771-782.
50. + stage of thymocyte differentiation in the absence of T cell receptor rearrangement. J. Exp. Med. 183:1923-1928.