메뉴 건너뛰기




Volumn 122, Issue 6, 1996, Pages 319-327

Lessons from the p53 mutant mouse

Author keywords

Apoptosis; Cancer genetics; Gene targeting; Mouse knockouts; p53; Tumor suppressor genes

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; PROTEIN P53;

EID: 0029967219     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01220798     Document Type: Review
Times cited : (38)

References (79)
  • 5
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles C, Helmberg A , Karin M (1994) p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370:220-223
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 6
    • 0028959978 scopus 로고
    • DCC:linking tumor suppressor genes and altered cell surface interactions in cancer?
    • Cho KR, Fearon ER (1995) DCC:linking tumor suppressor genes and altered cell surface interactions in cancer? Curr Opin Genet Dev 5:72-78
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 72-78
    • Cho, K.R.1    Fearon, E.R.2
  • 9
    • 0027251720 scopus 로고
    • Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
    • Debbas M, White E (1993) Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev 7:546-554
    • (1993) Genes Dev , vol.7 , pp. 546-554
    • Debbas, M.1    White, E.2
  • 10
    • 0028978183 scopus 로고
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82:675-684
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.4    Leder, P.5
  • 17
    • 0025887476 scopus 로고
    • Wild-type p53 can down-modulate the activity of various promoters
    • Ginsberg D, Mechta F, Yaniv M, Oren M (1991) Wild-type p53 can down-modulate the activity of various promoters. Proc Natl Acad Sci USA 88:9979-9983
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9979-9983
    • Ginsberg, D.1    Mechta, F.2    Yaniv, M.3    Oren, M.4
  • 18
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4855-4878
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 19
    • 0028988697 scopus 로고
    • Effects of heterozygosity for the Rb-1t19neo allele in the mouse
    • Harrison DJ, Hooper ML, Armstrong JF, Clarke AR (1995) Effects of heterozygosity for the Rb-1t19neo allele in the mouse. Oncogene 10:1615-1620
    • (1995) Oncogene , vol.10 , pp. 1615-1620
    • Harrison, D.J.1    Hooper, M.L.2    Armstrong, J.F.3    Clarke, A.R.4
  • 21
    • 0028587166 scopus 로고
    • The genetics of Wilms' tumor - A case of disrupted development
    • Hastie ND (1994) The genetics of Wilms' tumor - a case of disrupted development. Annu Rev Genet 28:523-558
    • (1994) Annu Rev Genet , vol.28 , pp. 523-558
    • Hastie, N.D.1
  • 22
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by trans-activation-deficient p53
    • Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M (1995) Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev 9:2170-2183
    • (1995) Genes Dev , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, K.H.4    Oren, M.5
  • 23
    • 0028171968 scopus 로고
    • Mediation of c-myc-induced apoptosis by p53
    • Hermeking H, Eick D (1994) Mediation of c-myc-induced apoptosis by p53. Science 265:2091-2093
    • (1994) Science , vol.265 , pp. 2091-2093
    • Hermeking, H.1    Eick, D.2
  • 24
    • 0028227260 scopus 로고
    • Apoptosis or retinoblastoma: Alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53
    • Howes KA, Ransom N, Papermaster DS, Lasudry JGH, Albert DM, Windle JJ (1994). Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Genes Dev 8:1300-1310
    • (1994) Genes Dev , vol.8 , pp. 1300-1310
    • Howes, K.A.1    Ransom, N.2    Papermaster, D.S.3    Lasudry, J.G.H.4    Albert, D.M.5    Windle, J.J.6
  • 25
    • 0028174064 scopus 로고
    • Heterozygous Rb-1 delta 20/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance
    • Hu N, Gutsmann A, Herbert DC, Bradley A, Lee WH, Lee EY-HP (1994) Heterozygous Rb-1 delta 20/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene 9:1021-1027
    • (1994) Oncogene , vol.9 , pp. 1021-1027
    • Hu, N.1    Gutsmann, A.2    Herbert, D.C.3    Bradley, A.4    Lee, W.H.5    Lee, E.Y.-H.P.6
  • 32
    • 0028168643 scopus 로고
    • p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis
    • Kemp CJ, Wheldon T, Balmain A. (1994) p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat Genet 8:66-69.
    • (1994) Nat Genet , vol.8 , pp. 66-69
    • Kemp, C.J.1    Wheldon, T.2    Balmain, A.3
  • 34
    • 0029147430 scopus 로고
    • Binding of the von-Hippel-Lindau tumor suppressor protein to Elongin B and C
    • Kibel A, Iliopaoulos O, DeCaprio JA, Kaelin WG (1995) Binding of the von-Hippel-Lindau tumor suppressor protein to Elongin B and C. Science 269:1444-1446
    • (1995) Science , vol.269 , pp. 1444-1446
    • Kibel, A.1    Iliopaoulos, O.2    DeCaprio, J.A.3    Kaelin, W.G.4
  • 36
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson JAG (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820-823
    • (1971) Proc Natl Acad Sci USA , vol.68 , pp. 820-823
    • Knudson, J.A.G.1
  • 39
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane DP (1992) p53, guardian of the genome. Nature 358:15-16
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 41
    • 0026801062 scopus 로고
    • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    • Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD (1992) Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70:923-935
    • (1992) Cell , vol.70 , pp. 923-935
    • Livingstone, L.R.1    White, A.2    Sprouse, J.3    Livanos, E.4    Jacks, T.5    Tlsty, T.D.6
  • 42
    • 0027262606 scopus 로고
    • Stabilization of the p53 tumor suppressor is induced by adenovirus-5 E1A and accompanies apoptosis
    • Lowe SW, Ruley HE (1993) Stabilization of the p53 tumor suppressor is induced by adenovirus-5 E1A and accompanies apoptosis. Genes Dev 7:535-545
    • (1993) Genes Dev , vol.7 , pp. 535-545
    • Lowe, S.W.1    Ruley, H.E.2
  • 43
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytoxicity of anticancer agents
    • Lowe SM, Ruley HE, Jacks T, Housman DE (1993a) p53-dependent apoptosis modulates the cytoxicity of anticancer agents. Cell 74:957-967
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.M.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 44
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe SW, Schmitt ES, Smith SW, Osborne BA, Jacks T (1993b) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847-849.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.S.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 46
    • 0028323294 scopus 로고
    • Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells
    • Lowe SW, Jacks T, Housman DE, Ruley HE (1994b) Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Nat Acad Sci USA 91:2026-2030
    • (1994) Proc Nat Acad Sci USA , vol.91 , pp. 2026-2030
    • Lowe, S.W.1    Jacks, T.2    Housman, D.E.3    Ruley, H.E.4
  • 47
    • 0027318117 scopus 로고
    • Specific repression of TATA-mediated but not intiator-mediated transcription by wild-type p53
    • Mack DH, Vartikar J, Pipas JM, Laimins LA (1993) Specific repression of TATA-mediated but not intiator-mediated transcription by wild-type p53. Nature 363:281-283
    • (1993) Nature , vol.363 , pp. 281-283
    • Mack, D.H.1    Vartikar, J.2    Pipas, J.M.3    Laimins, L.A.4
  • 48
    • 0027315653 scopus 로고
    • p53 and the Li-Fraumeni syndrome
    • Malkin D (1993) p53 and the Li-Fraumeni syndrome. Cancer Genet Cytogenet 66:83-92
    • (1993) Cancer Genet Cytogenet , vol.66 , pp. 83-92
    • Malkin, D.1
  • 50
    • 0028047723 scopus 로고
    • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
    • Merritt AJ, Potten CS, Kemp CJ, Hickman JA, Balmain A, Lane D, Hall PA (1994) The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 54:614-617
    • (1994) Cancer Res , vol.54 , pp. 614-617
    • Merritt, A.J.1    Potten, C.S.2    Kemp, C.J.3    Hickman, J.A.4    Balmain, A.5    Lane, D.6    Hall, P.A.7
  • 53
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T, Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 54
    • 0027408679 scopus 로고
    • DNA tumor virus transforming proteins and the cell cycle
    • Moran E (1993) DNA tumor virus transforming proteins and the cell cycle. Curr Opin Genet Dev 3:63-70
    • (1993) Curr Opin Genet Dev , vol.3 , pp. 63-70
    • Moran, E.1
  • 55
    • 0027934570 scopus 로고
    • p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • Morgenbesser SD, Williams BO, Jacks T, DePinho RA (1994) p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371:72-74
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    DePinho, R.A.4
  • 56
    • 0025015168 scopus 로고
    • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    • Moser AR, Pilot HC, Dove WF (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247:322-324
    • (1990) Science , vol.247 , pp. 322-324
    • Moser, A.R.1    Pilot, H.C.2    Dove, W.F.3
  • 57
    • 0027944251 scopus 로고
    • Cyclin G is a transcriptional target of the tumor suppressor protein p53
    • Okamoto K, Beach D (1994) Cyclin G is a transcriptional target of the tumor suppressor protein p53. EMBO J 13:4816-4823
    • (1994) EMBO J , vol.13 , pp. 4816-4823
    • Okamoto, K.1    Beach, D.2
  • 59
    • 0028334011 scopus 로고
    • Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
    • Pan H, Griep A (1994) Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev 8:1285-1299
    • (1994) Genes Dev , vol.8 , pp. 1285-1299
    • Pan, H.1    Griep, A.2
  • 60
    • 0029093605 scopus 로고
    • Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development
    • Pan H, Griep AE (1995) Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development. Genes Dev 9:2157-2169
    • (1995) Genes Dev , vol.9 , pp. 2157-2169
    • Pan, H.1    Griep, A.E.2
  • 61
    • 0028957642 scopus 로고
    • Mutations in the APC gene and their implications for protein structure and function
    • Polakis P (1995) Mutations in the APC gene and their implications for protein structure and function. Curr Opin Genet Dev 5:66-71
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 66-71
    • Polakis, P.1
  • 63
    • 0029143395 scopus 로고
    • Essential role for p53-mediated transcription in E1A-induced apoptosis
    • Sabbatini P, Lin J, Levine AJ, White E (1995) Essential role for p53-mediated transcription in E1A-induced apoptosis. Genes Dev 9:2184-2192
    • (1995) Genes Dev , vol.9 , pp. 2184-2192
    • Sabbatini, P.1    Lin, J.2    Levine, A.J.3    White, E.4
  • 65
    • 0025775929 scopus 로고
    • Reppression of the interleukine 6 promoter by p53 and the retinoblastoma susceptibility gene product
    • Santhanam U, Ray A, Sehgal PB (1991) Reppression of the interleukine 6 promoter by p53 and the retinoblastoma susceptibility gene product. Proc Natl Acad Sci USA 88: 7605-7609
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7605-7609
    • Santhanam, U.1    Ray, A.2    Sehgal, P.B.3
  • 66
    • 0029057336 scopus 로고
    • A single ataxia telangiectasia gene with a product similar to P1-3 kinase
    • Savitsky K, et al. (1995) A single ataxia telangiectasia gene with a product similar to P1-3 kinase. Science 268:1749-1753
    • (1995) Science , vol.268 , pp. 1749-1753
    • Savitsky, K.1
  • 67
    • 0028072523 scopus 로고
    • DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
    • Strasser A, Harris AW, Jacks T, Cory S (1994) DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 79:329-339
    • (1994) Cell , vol.79 , pp. 329-339
    • Strasser, A.1    Harris, A.W.2    Jacks, T.3    Cory, S.4
  • 74
    • 0028034199 scopus 로고
    • myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21 waf1/cip1
    • Wagner AJ, Kokontis JM, Hay N (1994) myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21 waf1/cip1. Genes Dev 8:2817-2830
    • (1994) Genes Dev , vol.8 , pp. 2817-2830
    • Wagner, A.J.1    Kokontis, J.M.2    Hay, N.3
  • 75
    • 0001655748 scopus 로고
    • Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity and association with ERCC3
    • Wang XW, Forrester K, Yeh H, Feitelson MA, Gu JR, Harris CC (1994) Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity and association with ERCC3. Proc Natl Acad Sci USA 91:2230-2234
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2230-2234
    • Wang, X.W.1    Forrester, K.2    Yeh, H.3    Feitelson, M.A.4    Gu, J.R.5    Harris, C.C.6
  • 76
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323-330
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 78
    • 0026801977 scopus 로고
    • Wild-type p53 restores cells cycle control and inhibits gene amplification in cells with mutant p53 alleles
    • Yin Y, Tainksy MA, Bischoff FZ, Strong LC, Wahl GM (1992) Wild-type p53 restores cells cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70: 937-948
    • (1992) Cell , vol.70 , pp. 937-948
    • Yin, Y.1    Tainksy, M.A.2    Bischoff, F.Z.3    Strong, L.C.4    Wahl, G.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.