The role of SLP-76 and LAT in lymphocyte development

Current Opinion in Immunology

Volumn 12, Issue 2, 2000, Pages 173-178

  Pivniouk, Vadim I ^a   Geha, Raif S ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; MEMBRANE PROTEIN; T LYMPHOCYTE RECEPTOR;

LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PROLYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE RECEPTOR GENE; THYMOCYTE;

EID: 0034093661     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(99)00068-0     Document Type: Review

References (72)

1. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J Immunol. 150:1993;4244-4253.
2. von Boehmer H., Fehling H.J. Structure and function of the pre-T cell receptor. Annu Rev Immunol. 15:1997;433-452.
3. Shortman K., Wu L. Early T lymphocyte progenitors. Annu Rev Immunol. 14:1996;29-47.
4. Mombaerts P., Iacomini J., Johnson R.S., Herrup K., Tonegawa S., Papaioannou V.E. RAG-1 deficient mice have no mature B and T lymphocytes. Cell. 68:1992;869-877.
5. Shinkai Y., Rathbun G., Lam K.P., Oltz E.M., Stewart V., Mendelsohn M., Charron J., Datta M., Young F., Stall A.M., Alt F.W. RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68:1992;855-867.
6. Fehling H.J., Krotkova A., Saint-Ruf C., von Boehmer H. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature. 375:1995;795-798.
7. Malissen M., Gillet A., Ardouin L., Trucy J., Ferrier P., Vivier E., Malissen B. Altered T cell development in mice with a targeted mutation of the CD3-ε gene. EMBO J. 14:1995;4641-4653.
8. Haks M.C., Krimpenfort P., Borst J., Kruisbeek A.M. The CD3gamma chain is essential for development of both the TCR alpha beta and TCR gamma delta lineages. EMBO J. 17:1998;1871-1882.
9. Malissen M., Gillet A., Rocha B., Trucy J., Vivier E., Boyer C., Kontgen F., Brun N., Mazza G., Spanopoulo E., Malissen B. T cell development in mice lacking the CD3ζ/η gene. EMBO J. 12:1993;4347-4355.
10. Mombaerts P., Clarke A.R., Rudnicki M.A., Iacomini J., Itohara S., Lafaille J.J., Wang L., Ichikawa Y., Jaenisch R., Hooper M.L., Tonegawa S. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature. 360:1992;225-231.
11. lck. Nature. 357:1992;161-164.
12. lck in thymopoiesis. EMBO J. 12:1993;1671-1680.
13. Cantrell D. T cell antigen receptor signal transduction pathways. Annu Rev Immunol. 14:1996;259-274.
14. da Silva A.J., Raab M., Li Z., Rudd C.E. TcR zeta/CD3 signal transduction in T-cells: downstream signalling via ZAP-70, SLP-76 and FYB. Biochem Soc Trans. 25:1997;361-366.
15. Raab M., da Silva A.J., Findell P.R., Rudd C.E. Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. Immunity. 6:1997;155-164.
16. Wardenburg J.B., Fu C., Jackman J.K., Flotow H., Wilkinson S.E., Williams D.H., Johnson R., Kong G., Chan A.C., Findell P.R. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function. J Biol Chem. 271:1996;19641-19644.
17. Zhang W., Sloan-Lancaster J., Kitchen J., Trible R., Samelson L. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell. 92:1998;83-10392. This paper reports the cloning and initial characterization of LAT.
18. Tuosto L., Michel F., Acuto O. p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. J Exp Med. 184:1996;1161-1166.
19. Wardenburg J.B., Pappu R., Bu J.Y., Mayer B., Chernoff J., Straus D., Chan A.C. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity. 9:1998;607-616. First report on association between SLP-76 and Nck. Possible role of this interaction was analyzed and SLP-76 was implicated in yet another signaling pathway.
20. Wunderlich L., Farago A., Downward J., Buday L. Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes. Eur J Immunol. 29:1999;1068-1075.
21. Jackman J.K., Motto D.G., Sun Q., Tanemoto M., Turck C.W., Peltz G.A., Koretzky G.A., Findell P.R. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J Biol Chem. 270:1995;7029-7032.
22. ••]) on a Grb-2 analog that actually binds SLP-76 in vivo. Unlike Grb-2, Gads does not bind SOS.
23. ••].
24. Sanzenbacher R., Kabelitz D., Janssen O. SLP-76 binding to p56lck: a role for SLP-76 in CD4-induced desensitization of the TCR/CD3 signaling complex. J Immunol. 163:1999;3143-3152. The original study, the importance of which is appropriately expressed in its title.
25. da Silva A.J., Li Z., de Vera C., Canto E., Findell P., Rudd C.E. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain- containing leukocyte protein 76 and modulates interleukin 2 production. Proc Natl Acad Sci USA. 94:1997;7493-7498.
26. Musci M.A., Hendricks-Taylor L.R., Motto D.G., Paskind M., Kamens J., Turck C.W., Koretzky G.A. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. J Biol Chem. 272:1997;11674-11677.
27. Koretzky G. The role of Grb2-associated proteins in T-cell activation. Immunol Today. 18:1997;401-406.
28. Clements J.L., Ross-Barta S.E., Tygrett L.T., Waldschmidt T.J., Koretzky G.A. SLP-76 expression is restricted to hemopoietic cells of monocyte, granulocyte, and T lymphocyte lineage and is regulated during T cell maturation and activation. J Immunol. 161:1998;3880-3889. Analysis of SLP-76 expression by flow-cytometry using intracellular staining with specific antibodies.
29. •]) on cloning the B cell homologue of SLP-76.
30. •].
31. Motto D.G., Ross S.E., Wu J., Hendricks-Taylor L.R., Koretzky G.A. Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. J Exp Med. 183:1996;1937-1943.
32. Zhang W., Trible R.P., Samelson L.E. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity. 9:1998;239-246. This paper reports an important feature of LAT that enables its proper localization.
33. •].
34. Facchetti F., Chan J.K., Zhang W., Tironi A., Chilosi M., Parolini S., Notarangelo L.D., Samelson L.E. Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions. Am J Pathol. 154:1999;1037-1046.
35. •].
36. 2+ flux in response to TCR crosslinking and appears to have deficient expression of LAT.
37. Crespo P., Schuebel K.E., Ostrom A.A., Gutkind J.S., Bustelo X.R. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature. 385:1997;169-172.
38. Han J., Das B., Wei W., Van Aelst L., Mosteller R.D., Khosravi-Far R., Westwick J.K., Der C.J., Broek D. Lck regulates Vav activation of members of the Rho family of GTPases. Mol Cell Biol. 17:1997;1346-1353.
39. Crespo P., Bustelo X.R., Aaronson D.S., Coso O.A., Lopez-Barahona M., Barbacid M., Gutkind J.S. Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene. 13:1996;455-460.
40. Symons M., Derry J.M.J., Kariak B., Jiang S., Lemahieu V., McCormick F., Francke U., Abo A. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell. 84:1996;723-734.
41. Tarakhovsky A., Turner M., Schaal S., Mee P.J., Duddy L.P., Rajewsky K., Tybulewicz V.L.J. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature. 374:1995;467-470.
42. Turner M., Mee P.J., Walters A.E., Quinn M.E., Mellor A.L., Zamoyska R., Tybulewicz V.L.J. A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity. 7:1997;451-460.
43. Zhang R., Alt F.W., Davidson L., Orkin S.H., Swat W. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature. 374:1995;470-473.
44. Wu J., Motto D.G., Koretzky G.A., Weiss A. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity. 4:1996;593-602.
45. Alberola-Ila J., Takaki S., Kerner J.D., Perlmutter R.M. Differential signaling by lymphocyte antigen receptors. Annu Rev Immunol. 15:1997;125-154.
46. Yablonski D., Kane L.P., Qian D., Weiss A. A nck-pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK. EMBO J. 17:1998;5647-5657.
47. Raab M., Kang H., da Silva A., Zhu X., Rudd C.E. FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells. J Biol Chem. 274:1999;21170-21179.
48. •], this manuscript implicates Vav in regulation of the actin cytoskeleton.
49. •].
50. Snapper S.B., Rosen F.S., Mizoguchi E., Cohen P., Khan W., Liu C.H., Hagemann T.L., Kwan S.P., Ferrini R., Davidson L.et al. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity. 9:1998;81-91. This paper demonstrates the role of WASP in T cell activation, further suggesting a link between the TCR and the cytoskeleton.
51. ••], presents an analysis of SLP-76 deficient mice and suggests a central role for SLP-76 in T cell development.
52. ••].
53. -/- mice.
54. Levelt C.N., Mombaerts P., Inglesias A., Tonegawa S., Eichmann K. Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε Proc Nat Acad Sci USA. 90:1993;11401-11406.
55. -/- mice in the absence of TCRβ chain expression. Int Immunol. 6:1994;995-1001.
56. Fehling H.J., Iritani B.M., Krotkova A., Forbush K.A., Laplace K., Perlmutter R., von Boehmer H. Restoration of thymopoiesis in pTα-/- mice by anti-CD3ε antibody treatment or with transgenes encoding activated LCK or tailless pTα Immunity. 6:1997;703-714.
57. lck and CD3ζ in early thymic selection. Immunity. 3:1995;215-222.
58. -/- mice.
59. Shinkai Y., Koyasu S., Nakayama K., Murphy K.M., Loh D.Y., Reinherz E.L., Alt F.W. Restoration of T cell development in RAG2-deficient mice by functional TCR transgenes. Science. 259:1993;822-825.
60. Krotkova A., von Boehmer H., Fehling H.J. Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta→ (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene. J Exp Med. 186:1997;767-775.
61. -/- mice by introduction of a p53 null mutation.
62. Peterson E.J., Clements J.L., Ballas Z.K., Koretzky G.A. NK cytokine secretion and cytotoxicity occur independently of the SLP-76 adaptor protein. Eur J Immunol. 29:1999;2223-2232. Here, normal function of NK cells in SLP-76 deficient mice is reported.
63. -/- platelets through the collagen receptor.
64. Pivniouk V.I., Martin T.R., Lu-Kuo J.M., Katz H.R., Oettgen H.C., Geha R.S. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J Clin Invest. 103:1999;1737-1743. The significance of this paper is expressed in the title.
65. von Boehmer H., Aifantis I., Feinberg J., Lechner O., Saint-Ruf C., Walter U., Buer J., Azogui O. Pleiotropic changes controlled by the pre-T cell receptor. Curr Opin Immunol. 11:1999;135-142.
66. Aifantis I., Buer J., von Boehmer H., Azogui O. Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus. Immunity. 7:1997;601-607.
67. Ardouin L., Ismaili J., Malissen B., Malissen M. The CD3-γδε and CD3-ζ/η modules but are each essential for allelic exclusion at the T cell receptor β locus are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-β, -γ, and -δ loci. J Exp Med. 187:1998;105-116. This manuscript provides analysis on the role for the different CD3 proteins in allelic exclusion.
68. Wallace V.A., Kawai K., Levelt C.N., Kishihara K., Molina T., Timms E., Pircher H., Penninger J., Ohashi P.S., Eichmann K.et al. T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes. Eur J Immunol. 25:1995;1312-1318.
69. Uematsu Y., Ryser S., Dembic Z., Borgulya P., Krimpenfort P., Berns A., von Boehmer H., Steinmetz M. In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes. Cell. 52:1988;831-841.
70. Anderson S.J., Abraham K.M., Nakayama T., Singer A., Perlmutter R.M. Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck. EMBO J. 11:1992;4877-4886.
71. ••]) indicating that some functional bifurcation of the signaling pathways exists downstream of the TCR.
72. ••].