Molecular pathogenesis of lung cancer

Journal of Thoracic and Cardiovascular Surgery

Volumn 118, Issue 6, 1999, Pages 1136-1152

  Fong, K M ^a   Sekido, Y ^a   Minna, J D ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GROWTH; CANCER INVASION; CANCER PREVENTION; EARLY DIAGNOSIS; LUNG CANCER; METASTASIS; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; REVIEW; SIGNAL TRANSDUCTION; SMOKING; TUMOR SUPPRESSOR GENE;

EID: 0032697386     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5223(99)70121-2     Document Type: Article

References (207)

1. C Lengauer KW Kinzler B. Vogelstein Genetic instabilities in human cancers Nature 396 1998 643 649
2. NA Levin PM Brzoska ML Warnock JW Gray MF. Christman Identification of novel regions of altered DNA copy number in small cell lung tumors Genes Chromosomes Cancer 13 1995 175 178
3. I Petersen M Bujard S Petersen G Wolf A Goeze A Schwendel Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung Cancer Res 57 1997 2331 2335
4. Y Sekido KM Fong JD. Minna Progress in understanding the molecular pathogenesis of human lung cancer Biochem Biophys Acta 1378 1998 F21 F59
5. D Ryberg BA Lindstedt S Zienolddiny A. Haugen A hereditary genetic marker closely associated with microsatellite instability in lung cancer Cancer Res 55 1995 3996 3999
6. R Rosell A Pifarré M Monzó J Astudillo MP López-Cabrerizo R Calvo Reduced survival in patients with stage-I non-small-cell lung cancer associated with DNA-replication errors Int J Cancer 74 1997 330 334
7. J Adachi M Shiseki T Okazaki G Ishimaru M Noguchi S Hirohashi Microsatellite instability in primary and metastatic lung carcinomas Genes Chromosomes Cancer 14 1995 301 306
8. S Chevillard JP Radicella C Levalois J Lebeau M-F Poupon S Oudard Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human and kidney tumors Oncogene 16 1998 3083 3086
9. M Esteller SR Hamilton PC Burger SB Baylin JG. Herman Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia Cancer Res 59 1999 793 797
10. JR Spurzem SI Rennard DJ. Romberger Bombesin-like peptides and airway repair: a recapitulation of lung development Am J Respir Cell Mol Biol 16 1997 209 211
11. GE Richardson BE. Johnson The biology of lung cancer Semin Oncol 20 1993 105 127
12. Z Fathi JW Way MH Corjay J Viallet EA Sausville JF. Battey Bombesin receptor structure and expression in human lung carcinoma cell lines J Cell Biochem Suppl 24 1996 237 246
13. JM Siegfried AT Gillespie R Mera TJ Casey P Keohavong JR Testa Prognostic value of specific KRAS mutations in lung adenocarcinomas Cancer Epidemiol Biomarkers Prev 6 1997 841 847
14. F Cuttitta DN Carney J Mulshine TW Moody J Fedorko A Fischler Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer Nature 316 1985 823 826
15. G Halmos AV. Schally Reduction in receptors for bombesin and epidermal growth factor in xenografts of human small-cell lung cancer after treatment with bombesin antagonist RC-3095 Proc Natl Acad Sci U S A 94 1997 956 960
16. MJ Kelley RI Linnoila IL Avis MS Georgiadis F Cuttitta JL Mulshine Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer Chest 112 1997 256 261
17. neu) in human non-small cell carcinomas of the lung Cancer Res 50 1990 421 425
18. WJ Rachwal PF Bongiorno MB Orringer RI Whyte SP Ethier DG. Beer Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas Br J Cancer 72 1995 56 64
19. M Noguchi M Murakami W Bennett R Lupu F Hui Jr CC Harris Biological consequences of overexpression of a transfected c- erb B-2 gene in immortalized human bronchial epithelial cells Cancer Res 53 1993 2035 2043
20. JA Kern L Torney D Weiner A Gazdar HM Shepard B. Fendly Inhibition of human lung cancer cell line growth by an anti-p185HER2 antibody Am J Respir Cell Mol Biol 9 1993 448 454
21. C-M Tsai K-T Chang L-H Wu J-Y Chen AF Gazdar T Mitsudomi Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines Cancer Res 56 1996 206 209
22. D Yu S-S Wang KM Dulski C-M Tsai GL Nicolson M-C Hung c- erb B-2/ neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastasis-associated properties Cancer Res 54 1994 3260 3266
23. JA Kern RJC Slebos B Top S Rodenhuis D Lager RA Robinson C- erb B-2 expression and codon 12 K- ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas J Clin Invest 93 1994 516 520
24. P Pfeiffer PP Clausen K Andersen C. Rose Lack of prognostic significance of epidermal growth factor receptor and the oncoprotein p 185HER-2 in patients with systemically untreated non-small-cell lung cancer: an immunohistochemical study on cryosections Br J Cancer 74 1996 86 91
25. V Rusch J Baselga C Cordon-Cardo J Orazem M Zaman S Hoda Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung Cancer Res 53 1993 2379 2385
26. M Tateishi T Ishida T Mitsudomi S Kaneko K. Sugimachi Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung Cancer Res 50 1990 7077 7080
27. L Damstrup K Rygaard M Spang-Thomsen HS. Poulsen Expression of the epidermal growth factor receptor in human small cell lung cancer cell lines Cancer Res 52 1992 3089 3093
28. H Ohmichi U Koshimizu K Matsumoto T. Nakamura Hepatocyte growth factor (HGF) acts as a mesenchyme-derived morphogenic factor during fetal lung development Development 125 1998 1315 1324
29. K Yanagita K Matsumoto K Sekiguchi H Ishibashi Y Niho T. Nakamura Hepatocyte growth factor may act as a pulmotrophic factor on lung regeneration after acute lung injury J Biol Chem 268 1993 21212 21217
30. P Harvey A Warn P Newman LJ Perry RY Ball RM. Warn Immunoreactivity for hepatocyte growth factor/scatter factor and its receptor, met, in human lung carcinomas and malignant mesotheliomas J Pathol 180 1996 389 394
31. M Olivero M Rizzo R Madeddu C Casadio S Pennacchietti MR Nicotra Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas Br J Cancer 74 1996 1862 1868
32. JM Siegfried LA Weissfeld P Singh-Kaw RJ Weyant JR Testa RJ. Landreneau Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer Cancer Res 57 1997 433 439
33. Y Sekido T Takahashi R Ueda M Takahashi H Suzuki K Nishida Recombinant human stem cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c- kit protooncogene Cancer Res 53 1993 1709 1714
34. GW Krystal SJ Hines CP Organ Autocrine growth of small cell lung cancer mediated by coexpression of c- kit and stem cell factor Cancer Res 56 1996 370 376
35. KA Quinn AM Treston EJ Unsworth MJ Miller M Vos C Grimley Insulin-like growth factor expression in human cancer cell lines J Biol Chem 271 1996 11477 11483
36. HN Antoniades T Galanopoulos J Neville-Golden CJ O’Hara Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein products Proc Natl Acad Sci U S A 89 1992 3942 3946
37. R Maneckjee JD. Minna Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines Proc Natl Acad Sci U S A 87 1990 3294 3298
38. R Maneckjee JD. Minna Opioids induce while nicotine suppresses apoptosis in human lung cancer cells Cell Growth Differ 5 1994 1033 1040
39. CA Cooper FA Carey VJ Bubb D Lamb KM Kerr AH Wyllie The pattern of K- ras mutation in pulmonary adenocarcinoma defines a new pathway of tumour development in the human lung J Pathol 181 1997 401 404
40. E Tsuchiya R Furuta N Wada K Nakagawa Y Ishikawa B Kawabuchi High K- ras mutation rates in goblet-cell-type adenocarcinomas of the lungs J Cancer Res Clin Oncol 121 1995 577 581
41. RJ Slebos RH Hruban O Dalesio WJ Mooi GJ Offerhaus S. Rodenhuis Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung J Natl Cancer Inst 83 1991 1024 1027
42. MS Greenblatt WP Bennett M Hollstein CC Harris Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis Cancer Res 54 1994 4855 4878
43. RJ Slebos RE Kibbelaar O Dalesio A Kooistra J Stam CJLM Meijer K- ras oncogene activation as a prognostic marker in adenocarcinoma of the lung N Engl J Med 323 1990 561 565
44. T Mitsudomi SM Steinberg HK Oie JL Mulshine R Phelps J Viallet ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent Cancer Res 51 1991 4999 5002
45. R Rosell S Li Z Skacel JL Mate J Maestre M Canela Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients Oncogene 8 1993 2407 2412
46. SL Graziano GP Gamble NB Newman LZ Abbott M Rooney S Mookherjee Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer J Clin Oncol 17 1999 668 675
47. C-M Tsai K-T Chang R-P Perng T Mitsudomi M-H Chen C Kadoyama Correlation of intrinsic chemoresistance of non-small-cell lung cancer cell lines with HER-2/neu gene expression but not with ras gene mutations J Natl Cancer Inst 85 1993 897 901
48. S Rodenhuis L Boerrigter B Top RJ Slebos WJ Mooi L van’t Veer Mutational activation of the K- ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study J Clin Oncol 15 1997 285 291
49. MM Nau BJ Brooks J Battey E Sausville AF Gazdar IR Kirsch L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer Nature 318 1985 69 73
50. BE Johnson E Russell AM Simmons R Phelps SM Steinberg DC Ihde MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer J Cell Biochem Suppl 24 1996 210 217
51. X Ou S Campau R Slusher RK Jasti M Mabry GP Kalemkerian Mechanism of all- trans -retinoic acid-mediated L- myc gene regulation in small cell lung cancer Oncogene 13 1996 1893 1899
52. T Takahashi MM Nau I Chiba MJ Birrer RK Rosenberg M Vinocour p53: a frequent target for genetic abnormalities in lung cancer Science 246 1989 491 494
53. WP Bennett SP Hussain KH Vahakangas MA Khan PG Shields CC. Harris Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer J Pathol 187 1999 8 18
54. MF Denissenko A Pao M Tang GP Pfeifer Preferential formation of benzo[ a ]pyrene adducts at lung cancer mutational hotspots in P53 Science 274 1996 430 432
55. G Casey ME Lopez JC Ramos SJ Plummer MJ Arboleda M Shaughnessy DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignancies Oncogene 13 1996 1971 1981
56. E Brambilla A Negoescu S Gazzeri S Lantuejoul D Moro C Brambilla Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors Am J Pathol 149 1996 1941 1952
57. M Nishio T Koshikawa T Kuroishi M Suyama K Uchida Y Takagi Prognostic significance of abnormal p53 accumulation in primary, resected non-small-cell lung cancers J Clin Oncol 14 1996 497 502
58. J Geradts KM Fong PV Zimmerman R Maynard JD. Minna Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small cell lung cancers Clin Cancer Res 5 1999 791 800
59. SL. Graziano Non-small cell lung cancer: clinical value of new biological predictors Lung Cancer 17 1997 S37 S58
60. D Kandioler-Eckersberger S Kappel M Mittlböck G Dekan C Ludwig E Janschek The TP53 genotype but not immunohistochemical result is predictive of response to cisplatin-based neoadjuvant therapy in stage III non–small cell lung cancer J Thorac Cardiovasc Surg 117 1999 744 750
61. D Matsuzoe T Hideshima A Kimura K Inada K Watanabe Y Akita p53 mutations predict non-small cell lung carcinoma response to radiotherapy Cancer Lett 135 1999 189 194
62. J Adachi K Ookawa M Shiseki T Okazaki S Tsuchida K Morishita Induction of apoptosis but not G1 arrest by expression of the wild-type p53 gene in small cell lung carcinoma Cell Growth Differ 7 1996 879 886
63. JA Roth D Nguyen DD Lawrence BL Kemp CH Carrasco DZ Ferson Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer Nature Med 2 1996 985 991
64. Y Zou G Zong YH Ling MM Hao G Lozano WK Hong Effective treatment of early endobronchial cancer with regional administration of liposome-p53 complexes [see comments] J Natl Cancer Inst 90 1998 1130 1137
65. R Lubin G Zalcman L Bouchet J Tredanel Y Legros D Cazals Serum p53 antibodies as early markers of lung cancer Nature Med 1 1995 701 702
66. MR Rosenfeld N Malats L Schramm F Graus F Cardenal N Vinolas Serum anti-p53 antibodies and prognosis of patients with small-cell lung cancer J Natl Cancer Inst 89 1997 381 385
67. T Mitsudomi S Suzuki Y Yatabe M Nishio M Kuwabara K Gotoh Clinical implications of p53 autoantibodies in the sera of patients with non-small-cell lung cancer J Natl Cancer Inst 90 1998 1563 1568
68. CL Lai CM Tsai TT Tsai BI Kuo KT Chang HT Fu Presence of serum antip53 antibodies is associated with pleural effusion and poor prognosis in lung cancer patients Clin Cancer Res 4 1998 3025 3030
69. G Zalcman B Schlichtholz J Tredaniel T Utban Monitoring of p53 autoantibodies in lung cancer during therapy: relationship to treatment Clin Cancer Res 4 1998 1359 1366
70. JM Silva R Gonzalez G Dominguez JM Garcia P España F Bonilla TP53 gene mutations in plasma DNA of cancer patients Genes Chromosomes Cancer 24 1999 160 161
71. M Osada M Ohba C Kawahara C Ishioka R Kanamaru T Katoh Cloning and functional analysis of human p51, which structurally and functionally resembles p53 Nature Med 4 1998 839 843
72. S Nomoto N Haruki M Kondo H Konishi T Takahashi T Takahashi Search for mutations and examination of allelic expression imbalance of the p73 gene at lp36.33 in human lung cancers Cancer Res 58 1998 1380 1383
73. H Yoshikawa M Nagashima MA Khan MG McMenamin K Hagiwara CC. Harris Mutational analysis of p73 and p53 in human cancer cell lines Oncogene 18 1999 3415 3421
74. M Mai A Yokomizo C Qian P Yang DJ Tindall DI Smith Activation of p73 silent allele in lung cancer Cancer Res 58 1998 2347 2349
75. A Marchetti C Doglioni M Barbareschi F Buttitta S Pellegrini G Bertacca p21 RNA and protein expression in non-small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiation Oncogene 12 1996 1319 1324
76. M Caputi V Esposito A Baldi LA De C Dean G Signoriello p21wafl/cip1mda-6 expression in non-small-cell lung cancer: relationship to survival Am J Respir Cell Mol Biol 18 1998 213 217
77. WP Bennett WS El-Deiry WL Rush DGJ Guinee p21 waf1/cip1 and transforming growth factor β1 protein expression correlate with survival in non-small cell lung cancer Clin Cancer Res 4 1998 1499 1506
78. M Higashiyama O Doi K Kodama H Yokouchi T Kasugai S Ishiguro MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation Br J Cancer 75 1997 1302 1308
79. JW Harbour SL Lai J Whang-Peng AF Gazdar ID Minna FJ. Kaye Abnormalities in structure and expression of the human retinoblastoma gene in SCLC Science 241 1988 353 357
80. PT Reissmann H Koga R Takahashi RA Figlin EC Holmes S Piantadosi Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer Oncogene 8 1993 1913 1919
81. PT Cagle AK El-Naggar H-J Xu S-X Hu WF. Benedict Differential retinoblastoma protein expression in neuroendocrine tumors of the lung: potential diagnostic implications Am J Pathol 150 1997 393 400
82. H Dosaka-Akita S-X Hu M Fujino M Harada I Kinoshita H-J Xu Altered retinoblastoma protein expression in nonsmall cell lung cancer: its synergistic effects with altered ras and p53 protein status on prognosis Cancer 79 1997 1329 1337
83. H-J Xu DC Quinlan AG Davidson S-X Hu CL Summers J Li Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma J Natl Cancer Inst 86 1994 695 699
84. INK4a expression in resected non-small cell lung tumors Cancer Res 56 1996 3415 3420
85. K Ookawa M Shiseki R Takahashi Y Yoshida M Terada J Yokota Reconstitution of the RB gene suppresses the growth of small-cell lung carcinoma cells carrying multiple genetic alterations Oncogene 8 1993 2175 2181
86. BM Sanders M Jay GJ Draper EM. Roberts Non-ocular cancer in relatives of retinoblastoma patients Br J Cancer 60 1989 358 365
87. C Minimo M Bibbo PP Claudio A De Luca A. Giordano The role of pRb2/pl30 protein in diagnosing lung carcinoma on fine needle aspiration biopsies Pathol Res Pract 195 1999 67 70
88. DC Betticher J Heighway PS Hasleton HJ Altermatt WD Ryder T Cerny Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer Br J Cancer 73 1996 294 300
89. T Mishina H Dosaka-Akita I Kinoshita F Hommura T Morikawa H Katoh Cyclin D1 expression in non-small-cell lung cancers: its association with altered p53 expression, cell proliferation and clinical outcome Br J Cancer 80 1999 1289 1295
90. M Caputi AM Groeger V Esposito C Dean A De Luca C Pacilio Prognostic role of cyclin D1 in lung cancer: relationship to proliferating cell nuclear antigen Am J Respir Cell Mol Biol 20 1999 746 750
91. B Driscoll L Wu S Buckley FL Hall KD Anderson D. Warburton Cyclin D1 antisense RNA destabilizes pRb and retards lung cancer cell growth Am J Physiol 273 1997 L941 L949
92. A Merlo E Gabrielson F Askin D. Sidransky Frequent loss of chromosome 9 in human primary non-small cell lung cancer Cancer Res 54 1994 640 642
93. INK4B and p18 genes in primary non-small-cell lung cancers Int J Cancer 65 1996 734 739
94. A Marchetti F Buttitta S Pellegrini G Bertacca A Chella V Carnicelli Alterations of P16 (MTS1) in node-positive non-small cell lung carcinomas J Pathol 181 1997 178 182
95. A Merlo JG Herman L Mao DJ Lee E Gabrielson PC Burger 5'CpG island methylation is associated with transcriptional silencing of the tumour suppressor pl6/CDKN2/MTS1 in human cancers Nature Med 1 1995 686 692
96. INK4 protein induction by 5-aza 2'deoxycytidine Oncogene 11 1995 1211 1216
97. INK4A inactivation in non-small cell lung cancer cell lines Cancer Res 55 1995 6200 6209
98. INK4 in human cancer Proc Natl Acad Sci U S A 91 1994 11045 11049
99. K Nakagawa NK Conrad JP Williams BE Johnson MJ Kelley Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage Oncogene 11 1995 1843 1851
100. MJ Kelley K Nakagawa SM Steinberg JL Mulshine A Kamb BE. Johnson Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines J Natl Cancer Inst 87 1995 756 761
101. INK4 and retinoblastoma protein status in non-small cell lung cancer: potential synergistic effect with altered p53 protein on proliferative activity Cancer Res 56 1996 5557 5562
102. INK4 expression in primary lung cancers and cell lines Cancer Res 55 1995 503 509
103. INK4B/ MTS2, and p18 genes in primary and metastatic lung cancer Cancer Res 55 1995 1448 1451
104. INK4 expression in nonsmall cell lung carcinoma Cancer 80 1997 389 395
105. S Gazzeri V Della Valle L Chaussade C Brambilla CJ Larsen E. Brambilla The human p19ARF protein encoded by the beta transcript of the pl6INK4a gene is frequently lost in small cell lung cancer Cancer Res 58 1998 3926 3931
106. V Esposito A Baldi A De Luca AM Groger M Loda GG Giordano Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer Cancer Res 57 1997 3381 3385
107. KIP1 in human lung cancers: differential changes in small cell and non-small cell carcinomas. Cancer Res 58 1998 1042 1047
108. KIP2 gene at 11p15.5 Oncogene 12 1996 1365 1368
109. H Ohata M Emi Y Fujiwara K Higashino K Nakagawa R Futagami Deletion mapping of the short arm of chromosome 8 in non-small cell lung carcinoma Genes Chromosomes Cancer 7 1993 85 88
110. S Sato Y Nakamura E. Tsuchiya Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung Cancer Res 54 1994 5652 5655
111. M Shiseki T Kohno R Nishikawa Y Sameshima H Mizoguchi J. Yokota Frequent allelic losses on chromosomes 2q, 18q, and 22q in advanced non-small cell lung carcinoma Cancer Res 54 1994 5643 5648
112. T Otsuka T Kohno M Mori M Noguchi S Hirohashi J. Yokota Deletion mapping of chromosome 2 in human lung carcinoma Genes Chromosomes Cancer 16 1996 113 119
113. KC O’Briant G Bepler Delineation of the centromeric and telomeric chromosome segment 11p15.5 lung cancer suppressor regions LOH11A and LOH11B Genes Chromosomes Cancer 18 1997 111 114
114. K Ueno T Kumagai T Kijima T Kishimoto S. Hosoe Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer Hum Genet 102 1998 63 68
115. AK Virmani KM Fong D Kodagoda D McIntire J Hung V Tonk Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types Genes Chromosomes Cancer 21 1998 308 319
116. II Wistuba C Behrens AK Virmani S Milchgrub S Syed S Lam Allelic losses at chromosome 8p21-23 are early and frequent events in the pathogenesis of lung cancer Cancer Res 59 1999 1973 1979
117. F Lerebours S Olschwang B Thuille A Schmitz P Fouchet B Buecher Fine deletion mapping of chromosome 8p in non-small-cell lung carcinoma Int J Cancer 81 1999 854 858
118. N Shivapurkar AK Virmani II Wistuba S Milchgrub B Mackay JD Minna Deletions of chromosome 4 at multiple sites are frequent in malignant mesothelioma and small cell lung carcinoma Clin Cancer Res 5 1999 17 23
119. K Kok SL Naylor CH. Buys Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes Adv Cancer Res 71 1997 27 92
120. K Hibi T Takahashi K Yamakawa R Ueda Y Sekido Y Ariyoshi Three distinct regions involved in 3p deletion in human lung cancer Oncogene 7 1992 445 449
121. G Sozzi ML Veronese M Negrini R Baffa MG Cotticelli H Inoue The FHIT gene 3p14.2 is abnormal in lung cancer Cell 85 1996 17 26
122. KM Fong EJ Biesterveld A Virmani I Wistuba Y Sekido SA Bader FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations Cancer Res 57 1997 2256 2267
123. Y Tokuchi Y Kobayashi S Hayashi M Hayashi K Tanimoto T Hashimoto Abnormal FHIT transcripts found in both lung cancer and normal lung tissue Genes Chromosomes Cancer 24 1999 105 111
124. G Sozzi S Tornielli E Tagliabue L Sard F Pezzella U Pastorino Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities Cancer Res 57 1997 5207 5212
125. G Sozzi L Sard L De Gregorio A Marchetti K Musso F Buttitta Association between cigarette smoking and FHIT gene alterations in lung cancer Cancer Res 57 1997 2121 2123
126. L Burke MA Khan AN Freedma A Gemma M Rusin Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer Cancer Res 58 1998 2533 2536
127. Z Siprashvili G Sozzi LD Barnes P McCune AK Robinson V Eryomin Replacement of Fhit in cancer cells suppresses tumorigenicity Proc Natl Acad Sci U S A 94 1997 13771 13776
128. L Ji B Fang N Yen K Fong JD Minna JA. Roth Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression [In Process Citation] Cancer Res 59 1999 3333 3339
129. GA Otterson GH Xiao J Geradts F Jin WD Chen W Niklinska Protein expression and functional analysis of the FHIT gene in human tumor cells J Natl Cancer Inst 90 1998 426 432
130. K Kok A van den Berg PMJF Veldhuis AY van der Veen M Franke EFPM Schoenmakers A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosomes Cancer Res 54 1994 4183 4187
131. M-H Wei F Latif S Bader V Kashuba J-Y Chen F-M Duh Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG Cancer Res 56 1996 1487 1492
132. K Yamakawa T Takahashi Y Horio Y Murata E Takahashi K Hibi Frequent homozygous deletions in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22 Oncogene 8 1993 327 330
133. J Li C Yen D Liaw K Podsypanina S Bose SI Wang PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer Science 275 1997 1943 1947
134. E Forgacs EJ Biesterveld Y Sekido K Fong S Muneer II Wistuba Mutation analysis of the PTEN/MMAC1 gene in lung cancer Oncogene 17 1998 1557 1565
135. W Wu BL Kemp ML Proctor AF Gazdar JD Minna WK Hong Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer Cancer Res 59 1999 1846 1851
136. SS Wang A Virmani AF Gazdar JD Minna GA. Evans Refined mapping of two regions of loss of heterozygosity on chromosome band 11q23 in lung cancer Genes Chromosomes Cancer 25 1999 154 159
137. SS Wang ED Esplin JL Li L Huang A Gazdar J Minna Alterations of the PPP2R1B gene in human lung and colon cancer Science 282 1998 284 287
138. SX Jiang T Kameya Y Sato N Yanase H Yoshimura T. Kodama Bcl-2 protein expression in lung cancer and close correlation with neuroendocrine differentiation Am J Pathol 148 1996 837 846
139. F Pezzella H Turley I Kuzu MF Tungekar MS Dunnill CB Pierce bcl -2 protein in non-small-cell lung carcinoma N Engl J Med 329 1993 690 694
140. M Higashiyama O Doi K Kodama H Yokouchi S Nakamori R Tateishi bcl-2 oncoprotein in surgically resected nonsmall cell lung cancer: possibly favorable prognostic factor in association with low incidence of distant metastasis J Surg Oncol 64 1997 48 54
141. RM Apolinario P van der Valk JS de Jong W Deville J van Ark-Otte AM Dingemans Prognostic value of the expression of p53, bcl -2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancer J Clin Oncol 15 1997 2456 2466
142. U Kaiser M Schilli U Haag K Neumann H Kreipe E Kogan Expression of bcl-2–protein in small cell lung cancer Lung Cancer 15 1996 31 40
143. G Fontanini S Vignati D Bigini A Mussi M Lucchi CA Angeletti Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer Br J Cancer 71 1995 1003 1007
144. RC Anton RW Brown M Younes MM Gondo MA Stephenson PT. Cagle Absence of prognostic significance of bcl-2 immunopositivity in non-small cell lung cancer: analysis of 427 cases Hum Pathol 28 1997 1079 1082
145. GA Niehans T Brunner SP Frizelle JC Liston CT Salerno DJ Knapp Human lung carcinomas express Fas ligand Cancer Res 57 1997 1007 1012
146. Y Nambu SJ Hughes A Rehemtulla D Hamstra MB Orringer DG. Beer Lack of cell surface Fas/APO-1 expression in pulmonary adenocarcinomas J Clin Invest 101 1998 1102 1110
147. K Hiyama E Hiyama S Ishioka M Yamakido K Inai AF Gazdar Telomerase activity in small-cell and non-small-cell lung cancers J Natl Cancer Inst 87 1995 895 902
148. J Albanell F Lonardo V Rusch M Engelhardt J Langenfeld W Han High telomerase activity in primary lung cancers: association with increased cell proliferation rates and advanced pathologic stage J Natl Cancer Inst 89 1997 1609 1615
149. K Yashima LA Litzky L Kaiser T Rogers S Lam II Wistuba Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas Cancer Res 57 1997 2373 2377
150. SA Belinsky KJ Nikula WA Palmisano R Michels G Saccomanno E Gabrielson Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis Proc Natl Acad Sci 95 1998 11891 11896
151. M Esteller M Sanchez-Cespedes R Rosell D Sidransky SB Baylin JG. Herman Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients Cancer Res 59 1999 67 70
152. M Makos BD Nelkin MI Lerman F Latif B Zbar SB. Baylin Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer Proc Natl Acad Sci 89 1992 1929 1933
153. T Kohno M Kawanishi J Inazawa J. Yokota Identification of CpG islands hypermethylated in human lung cancer by the arbitrarily primed-PCR method Hum Genet 102 1998 258 264
154. H Suzuki R Ueda T Takahashi T. Takahashi Altered imprinting in lung cancer Nature Genet 6 1994 332 333
155. M Kondo H Suzuki R Ueda H Osada K Takagi T Takahashi Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers Oncogene 10 1995 1193 1198
156. CA Angeletti M Lucchi G Fontanini A Mussi A Chella A Ribechini Prognostic significance of tumoral angiogenesis in completely resected late stage lung carcinoma (stage IIIA-N2): impact of adjuvant therapies in a subset of patients at high risk of recurrence Cancer 78 1996 409 415
157. G Fontanini M Lucchi S Vignati A Mussi F Ciardiello M De Laurentiis Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: a prospective study J Natl Cancer Inst 89 1997 881 886
158. U Pastorino S Andreola E Tagliabue F Pezzella M Incarbone G Sozzi Immunocytochemical markers in stage I lung cancer: relevance to prognosis J Clin Oncol 15 1997 2858 2865
159. LM Chandrachud N Pendleton DM Chisholm MA Horan AM. Schor Relationship between vascularity, age and survival in non-small-cell lung cancer Br J Cancer 76 1997 1367 1375
160. D Hanahan J. Folkman Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis Cell 86 1996 353 364
161. J Mattern R Koomägi M Volm Association of vascular endothelial growth factor expression with intratumoral microvessel density and turnout cell proliferation in human epidermoid lung carcinoma Br J Cancer 73 1996 931 934
162. G Fontanini S Vignati M Lucchi A Mussi A Calcinai L Boldrini Neoangiogenesis and p53 protein in lung cancer: their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression Br J Cancer 75 1997 1295 1301
163. S Ambs WP Bennett WG Merriam MO Ogunfusika SM Oser MA Khan Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53 Br J Cancer 78 1998 233 239
164. Y Ohta Y Watanabe S Murakami M Oda Y Hayashi A Nonomura Vascular endothelial growth factor and lymph node metastasis in primary lung cancer Br J Cancer 76 1997 1041 1045
165. M Volm R Koomägi J Mattern Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer Int J Cancer 74 1997 64 68
166. A Kieser HA Weich G Brandner D Marme W. Kolch Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression Oncogene 9 1994 963 969
167. D Mukhopadhyay L Tsiokas VP. Sukhatme Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression Cancer Res 55 1995 6161 6165
168. I Takanami T Imamura T Hashizume K Kikuchi Y Yamamoto T Yamamoto Immunohistochemical detection of basic fibroblast growth factor as a prognostic indicator in pulmonary adenocarcinoma Jpn J Clin Oncol 26 1996 293 297
169. M Volm R Koomägi J Mattern G Stammler Prognostic value of basic fibroblast growth factor and its receptor (FGFR-1) in patients with non-small cell lung carcinomas Eur J Cancer 33 1997 691 693
170. MI Koukourakis A Giatromanolaki KJ O’Byrne M Comley RM Whitehouse DC Talbot Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer Br J Cancer 75 1997 477 481
171. DA Arenberg MP Keane B DiGiovine SL Kunkel SB Morris YY Xue Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer J Clin Invest 102 1998 465 472
172. DA Arenberg SL Kunkel PJ Polverini M Glass MD Burdick RM. Strieter Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice J Clin Invest 97 1996 2792 2802
173. DA Arenberg SL Kunkel PJ Polverini SB Morris MD Burdick MC Glass Interferon-γ-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases J Exp Med 184 1996 981 992
174. MA Sulzer MP Leers JA van Noord EC Bollen PH. Theunissen Reduced E-cadherin expression is associated with increased lymph node metastasis and unfavorable prognosis in non-small cell lung cancer Am J Respir Crit Care Med 157 1998 1319 1323
175. WR Smythe E LeBel JE Bavaria LR Kaiser SM. Albelda Integrin expression in non-small cell carcinoma of the lung Cancer Metastasis Rev 14 1995 229 239
176. M Adachi T Taki C Huang M Higashiyama O Doi T Tsuji Reduced integrin alpha3 expression as a factor of poor prognosis of patients with adenocarcinoma of the lung J Clin Oncol 16 1998 1060 1067
177. T Hirata T Fukuse H Naiki S Hitomi H. Wada Expression of CD44 variant exon 6 in stage I non-small cell lung carcinoma as a prognostic factor Cancer Res 58 1998 1108 1110
178. MR Clarke RJ Landreneau SD Finkelstein TT Wu P Ohori SA. Yousem Extracellular matrix expression in metastasizing and nonmetastasizing adenocarcinomas of the lung Hum Pathol 28 1997 54 59
179. N Kawano H Osawa T Ito Y Nagashima F Hirahara Y Inayama Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms: an immunohistochemical study Hum Pathol 28 1997 613 622
180. M Tokuraku H Sato S Murakami Y Okada Y Watanabe M. Seiki Activation of the precursor of gelatinase A/72 kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasis Int J Cancer 64 1995 355 359
181. IC Anderson DJ Sugarbaker RK Ganju DG Tsarwhas WG Richards M Sunday Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts Cancer Res 55 1995 4120 4126
182. T Hirano B Franzén H Kato Y Ebihara G Auer Genesis of squamous cell lung carcinoma: sequential changes of proliferation, DNA ploidy, and p53 expression Am J Pathol 144 1994 296 302
183. DC Betticher J Heighway N Thatcher PS Hasleton Abnormal expression of CCND1 and RB1 in resection margin epithelia of lung cancer patients Br J Cancer 75 1997 1761 1768
184. Y Satoh Y Ishikawa K Nakagawa T Hirano E. Tsuchiya A follow-up study of progression from dysplasia to squamous cell carcinoma with immunohistochemical examination of p53 protein overexpression in the bronchi of ex-chromate workers Br J Cancer 75 1997 678 683
185. ZH Li J Zheng LM Weiss D Shibata c-k- ras and p53 mutations occur very early in adenocarcinoma of the lung Am J Pathol 144 1994 303 309
186. E Brambilla S Gazzeri S Lantuejoul JL Coll D Moro A Negoescu p53 mutant immunophenotype and deregulation of p53 transcription pathway (Bcl2, Bax, and Waf1) in precursor bronchial lesions of lung cancer Clin Cancer Res 4 1998 1609 1618
187. J Hung Y Kishimoto K Sugio A Virmani DD McIntire JD Minna Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma JAMA 273 1995 558 563
188. Y Kishimoto K Sugio JY Hung AK Virmani DD McIntire JD Minna Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers J Natl Cancer Inst 87 1995 1224 1229
189. K Sugio Y Kishimoto AK Virmani JY Hung AF Gazdar K- ras mutations are a relatively late event in the pathogenesis of lung carcinomas Cancer Res 54 1994 5811 5815
190. II Wistuba C Behrens S Milchgrub D Bryant J Hung JD Minna Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma Oncogene 18 1999 643 650
191. WH Westra IO Baas RH Hruban FB Askin K Wilson GJ Offerhaus K- ras oncogene activation in atypical alveolar hyperplasias of the human lung Cancer Res 56 1996 2224 2228
192. L Mao JS Lee JM Kurie YH Fan SM Lippman JJ Lee Clonal genetic alterations in the lungs of current and former smokers [see comments] J Natl Cancer Inst 89 1997 857 862
193. II Wistuba S Lam C Behrens AK Virmani KM Fong J LeRiche Molecular damage in the bronchial epithelium of current and former smokers J Natl Cancer Inst 89 1997 1366 1373
194. AL Smith J Hung L Walker TE Rogers F Vuitch E Lee Extensive areas of aneuploidy are present in the respiratory epithelium of lung cancer patients Br J Cancer 73 1996 203 209
195. WA Franklin AF Gazdar J Haney II Wistuba FG La Rosa T Kennedy Widely dispersed p53 mutation in respiratory epithelium: a novel mechanism for field carcinogenesis J Clin Invest 100 1997 2133 2137
196. SD Spivack MJ Fasco VE Walker LS. Kaminsky The molecular epidemiology of lung cancer Crit Rev Toxicol 27 1997 319 365
197. GK Tokuhata AM. Lilienfeld Familial aggregation of lung cancer among hospital patients Public Health Rep 78 1963 277 283
198. WL Ooi RC Elston VW Chen JE Bailey-Wilson H. Rothschild Increased familial risk for lung cancer J Natl Cancer Inst 76 1986 217 222
199. CR Wolf CA Smith D. Forman Metabolic polymorphisms in carcinogen metabolising enzymes and cancer susceptibility Br Med Bull 50 1994 718 731
200. N Jourenkova-Mironova H Wikman C Bouchardy A Voho P Dayer S Benhamou Role of glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes in modulating susceptibility to smoking-related lung cancer Pharmacogenetics 8 1998 495 502
201. L Le Marchand L Sivaraman L Pierce A Seifried A Lum LR Wilkens Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens Cancer Res 58 1998 4858 4863
202. X Wu Y Zhao SE Honn GE Tomlinson JD Minna WK Hong Benzo[a]pyrene diol epoxide-induced 3p21.3 aberrations and genetic predisposition to lung cancer Cancer Res 58 1998 1605 1608
203. S Sone S Takashima F Li Z Yang T Honda Y Maruyama Mass screening for lung cancer with mobile spiral computed tomography scanner [see comments] Lancet 351 1998 1242 1245
204. CI Henschke DI McCauley DF Yankelevitz DP Naidich G McGuinness OS Miettinen Early Lung Cancer Action Project: overall design and findings from baseline screening [see comments] Lancet 354 1999 99 105
205. SA Ahrendt JT Chow LH Xu SC Yang CF Eisenberger M Esteller Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer [see comments] J Natl Cancer Inst 91 1999 332 339
206. M Younes RW Brown M Stephenson M Gondo PT. Cagle Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival Cancer 80 1997 104651
207. T Ito Y Noguchi S Satoh H Hayashi Y Inayama H. Kitamura Expression of facilitative glucose transporter isoforms in lung carcinomas: its relation to histologic type, differentiation grade, and tumor stage [see comments] Mod Pathol 11 1998 437 443