Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer

British Journal of Cancer

Volumn 75, Issue 4, 1997, Pages 477-481

  Koukourakis, M I ^a   Giatromanolaki, A ^a,b   O'Byrne, K J ^a   Comley, M ^b   Whitehouse, R M ^a   Talbot, D C ^a   Gatter, K C ^b   Harris, A L ^a,b  

^a UNIVERSITY HOSPITAL OF IRAKLION   (Greece)

^b OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Lung cancer; Platelet derived endothelial cell growth factor; Thymidine phosphorylase; Vascular grade

Indexed keywords

ENDOTHELIAL CELL GROWTH FACTOR; PYRIMIDINE; THYMIDINE PHOSPHORYLASE;

ANGIOGENESIS; ANIMAL TISSUE; ARTICLE; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS;

EID: 0031045574     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.83     Document Type: Article

References (36)

1. Altman DG (1991) Practical Statistics for Medical Research. Chapman & Hall: London.
2. Barton GJ, Ponting CP, Spraggon G, Finnis C and Sleep D (1992) Human platelet-derived endothelial cell growth factor is homologous to Escherichia coli thymidine phosphorylase. Protein Sci 1: 688-690
3. Brown RA and Weiss JB (1988) Neovascularisation and ils role in the ostoarthritic process. Ann Rheum Dis 47: 881-885
4. Cox DR (1972) Regression models and life lables (with discussion). J R Stat Soc 34: 187-220
5. Eda H, Fujimoto K, Watanabe S, Ura M, Hino A, Tanaka Y, Wada K and Ishitsuka H (1993) Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5′-deoxy-5-fluorouridine. Cancer Chemother Pharmacol 32: 333-338
6. Fox SB, Moghaddam A, Westwood M, Turley H, Bicknell R, Gatler KC and Harris AL (1995) Platelet derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study. J Pathol 176: 183-190
7. Fox SB, Westwood M, Moghaddam A, Comley M, Turley H, Whitehouse RM, Bicknell R, Gatter KC and Harris AL (1996) The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase is up-regulated in breast cancer epithelium and endothelium. Hr J Cancer 73: 275-280
8. Furukawa T, Yoshimura A, Sumizawa T, Haraguchi M, Akiyama S, Fukui K, Ishizawa M and Yamada Y (1992) Angiogenic factor (letter), Nature 356: 668
9. Giatromanolaki A, Koukourakis M, O'Byrne K, Fox S, Whitehouse R, Talbot DC, Harris AL and Gatter KC (1996) Prognostic value of angiogenesis in operable non small cell lung cancer. J Pathol 179: 80-88
10. Haraguchi M, Furukawa T, Sumizawa T and Akiyama S (1993) Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites. Cancer Res 53: 5680-5682
11. Haraguchi M, Miyadera K, Uemura K, Sumizawa T, Furukawa T, Yamada K and Akiyama S-I (1994) Angiogenic activity of enzymes. Nature 368: 198
12. Heldin NE, Usuki K, Bergh J, Westermark B and Heldin CH (1993) Differential expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human lung carcinoma cell lines. Br J Cancer 68: 708-711
13. Horak ER, Leek R, Klenk N, Lejeune S, Smith K, Stuart N, Greenall M, Stepniewska K and Harris AL (1992) Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet 340: 1120-1124
14. Ishikawa F, Miyazono K, Hellman U, Dexler H, Wernstedt C, Hagiwara K, Usuki K, Takaku F, Risau W and Heldin CH (1989) Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature 338: 557-562
15. Kaplan E and Meier P (1958) Non-parametric estimation from incomplete observations. J Am Stat Assoc 53: 457-481
16. Koch AE, Harlow LA, Haines GK, Amento, EP, Unemori EN, Wong WL, Pope, RM and Ferrara N (1994) Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol 152: 4149-4156
17. Kono A, Hara Y, Sugata S, Matsushima Y and Ueda T (1984) Substrate specificity of a thymidine phosphorylase in human liver tumor. Chem Pharm Bull 32: 1919-1921
18. Mclaren R, Kuzu I, Dunnil M, Harris AL, Lane D and Gatter KC (1992) The relationship of p53 immunostaining to survival in carcinoma of the lung. Br J Cancer 66: 735-738
19. Maeda K, Chung YS, Ogawa Y, Takatsuka S, Sawada T, Onoda N, Nitta A, Arimoto Y and Sowa M (1995) Malignancy of gastric cancer analyzed by the expression of thymidine phosphorylase. Gan To Kagaku Ryoho 22: 679-682
20. Mantel N (1966) Evaluation of survival data and two new rank statistics arising in is consideration. Cancer Chemother Rep 50: 163-170
21. Moghaddam A and Bicknell R (1992) Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity. Biochemistry 31: 12141-12146
22. Moghaddam A, Zhang HT, Fan TPD, HU D-E, Lees V, Turley H, Fox SB, Gatter KC, Harris AL and Bicknell R (1995) Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc Natl Acad Sci USA 92: 998-1002
23. Mountain CF (1986) A new international staging system for lung cancer. Chest 89 (suppl.): 225-233
24. Miyazono K, Okabe T, Urabe A, Takaku F and Heldin CH (1987) Purification and properties of an endothelial cell growth factor from human platelets. J Biol Chem 262: 4098-4103
25. Parums DV, Cordell JL, Micklem K, Heryet AR, Gatter KC and Mason DY (1990) JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections. J Clin Pathol 43: 752-757
26. Patterson A, Zhang H, Moghaddam A, Bicknell R, Talbot D, Stratford J and Harris A (1995) Increased sensitivity to the pro-drug 5′-deoxy-5-fluorouridine and modulation of 5′-fluoro-2′-deoxyuridine sensitivity in MCF-7 cell transfected with thymidine phosphorylase. Br J Cancer 72: 669-675
27. Pauly JL, Schuller MG, Zelcer AA, Kirss TA, Gore SS and Germain MJ (1977) Identification and comparative analysis of thymidine phosphorylase in the plasma of healthy subjects and cancer patients. J Natl Cancer Inst 58: 1587-1590
28. Schwartz EL., Baptiste N, O'Connor CJ, Wadler S and Otter BA (1994) Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine phosphorylase. Cancer Res 54; 1472-1478
29. Sotos GA, Grogan L and Allegra CJ (1994) Preclinical and clinical aspecls oF biomodulation of 5-fluorouracil. Cancer Treat Rev 20: 11-49
30. Takeuchi M, Otsuku T, Matsui N, Asai K, Hirano T, Moriyuma A, Isobi I, Eksiogui YZ, Maksukawa K, Kato T and Tada T (1994) Aberrant production of gliostatin/platelet derived endothelial cell growth factor in rheumatoid synovium. Arthritis Rheum 37; 662-672
31. Toi M, Hoshina S, Taniguchi T, Yamamoto Y, Ishitsuka H and Tominaga T (1995) Expression of platelet-derived endothelial cell growth factor/thymidine phospshorylase in human breast cancer. Int J Cancer 64: 79-82
32. Tungekar MF, Gatter KC, Dunnil MS and Mason DY (1991) Ki-67 immunostaining and survival in operable lung cancer. Histopathology 19: 545-550
33. Usuki K, Saras J, Waltenberger J, Miyazono K, Pierce G Thomason A and Heldin CH (1992) Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. Biophys Res Commun 184: 1311-1316
34. Veale D, Aschroft T, Gibson, GJ and Harris AL (1987) Epidermal growth factor receptors in non small cell lung cancer. Br J Cancer 55: 513-516
35. Vertongen F, Fondu P, Van Den Heule B, Cauchie C and Mandelbaum IM (1984) Thymidine kinase and thymidine phosphorylase activities in various types of leukemia and lymphoma. Tumour Biol 5: 303-311
36. Yoshimura A, Kuwazuru Y, Furukawa T, Yoshida H, Yamada K and Akiyama S (1990) Purification and tissue distribution of human thymidine phosphorylase: high expression in lymphocytes, reticulocytes and tumors. Biochim Biophys Acta 1034: 107-113