Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung carcinoma

British Journal of Cancer

Volumn 73, Issue 7, 1996, Pages 931-934

  Mattern, J ^a   Koomagi R ^a,b   Volm, M ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF TARTU   (Estonia)

Author keywords

Angiogenesis; Lung carcinoma; Proliferation; Vascular endothelial growth factor (VEGF)

Indexed keywords

CYCLINE; POLYCLONAL ANTIBODY; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ARTICLE; CAPILLARY DENSITY; CELL PROLIFERATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CARCINOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR VASCULARIZATION;

EID: 0029988680     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.166     Document Type: Article

References (31)

1. BECKER D, MEIER CB AND HERLYN M. (1989). Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides against basic fibroblast growth factor. EMBO J., 8, 3685-3691.
2. BOOCOCK CA, CARNOCK-JONES DS, SHARKEY AM, MCLAREN J, BARKER PJ, WRIGHT KA, TWENTYMAN PR AND SMITH SK (1995). Expression of vascular endothelial growth factor and its receptors fit and KDR in ovarian carcinoma. J. Natl Cancer Inst., 87, 506-516.
3. CARR DT AND MOUNTAIN CF. (1977). Staging lung cancer. In Lung Cancer, Straus MJ (ed) pp. 151-161. Clinical Diagnosis and Treatment. Grune and Stratton: New York.
4. CONOLLY DT, HEUVELMAN DM, NELSON R, OLANDER JV, EPPLEY BL, DELFINO JJ, SIEGEL NR, LEIMGRUBER RM AND FEDER J. (1989). Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J. Clin. Invest., 84, 1470-1478.
5. CRICKARD K, GROSS JL, CRICKARD U, YOONESSI M, LELE S, HERBLIN WF AND EIDSVOOG K. (1994). Basic fibroblast growth factor and receptor expression in human ovarian cancer. Gynecol. Oncol., 55, 277-284.
6. FERRARA N, HOUCK K, JAKEMAN L AND LEUNG DW. (1992). Molecular and biological properties of the vascular endothelial-growth-factor family of proteins. Endocrine Rev., 13, 18-32.
7. FOLKMAN J AND KLAGSBRUN M. (1987). Angiogenic factors. Science, 235, 442-447.
8. FOLKMAN J AND SHING Y. (1992). Angiogenesis. J. Biol. Chem., 267, 10931-10934.
9. FOX SB, GATTER KC, BICKNELL R, GOING JJ, STANTON P, COOKE TG AND HARRIS AL (1993). Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer. Cancer Res. 53, 4161-4163.
10. GITAY-GOREN H, SOKER S, VLODAVSKY I AND NEUFELD G. (1992). The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules. J. Biol. Chem., 267, 6093-6098.
11. GITAY-GOREN H, HALABAN R AND NEUFELD G. (1993). Human melanoma cells but not normal melanocytes express vascular endothelial growth factor receptors. Biochem. Biophys. Res. Commun., 190, 702-709.
12. GOTO F, GOTO K, WEINDEL K AND FOLKMAN J. (1993). Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab. Invest., 69, 508-517.
13. HOLLANDER M AND WOLFE DA. (1973). Nonparametric Statistical Methods. Wiley: New York.
14. KONDO S, ASANO M AND SUZUKI H. (1993). Significance of vascular endothelial growth factor/vascular permeability factor for solid tumor growth, and its inhibition by the antibody. Biochem. Biophys. Res. Commun., 190, 1234-1241.
15. MACCHIARINI P, FONTANINI G, HARDIN MJ, SQUARTINI F AND ANGELETTI CA. (1992). Relation of neovascularization to metastasis of non-small cell lung cancer. Lancet, 340, 145-146.
16. PORSCHEN R, CLASSEN S, POINTEK M AND BORCHARD F (1994). Vascularization of carcinomas of the esophagus and its correlation with tumor proliferation. Cancer Res., 54, 587-591.
17. ROOS G, LANDBERG G, HUFF J, HOUGHTEN P, TAKASAKI Y AND TAN EM. (1993). Analysis of the epitopes of proliferating cell nuclear antigen recognized by monoclonal antibodies. Lab. Invest., 68, 204-210.
18. SCHWEIGERER L, NEUFELD G, MERGIA A, ABRAHAM JA, FIDDES JC AND GOSPODAROWICZ D. (1987). Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors. Proc. Natl Acad. Sci. USA, 84, 842-846.
19. SENGER DR, VAN DE WATER L, BROWN LF, NAGY JA, YEO K-T, YEO T-K, BERSE B, JACKMAN RW, DVORAK AM AND DVORAK HF. (1993). Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metast. Rev., 12, 303-324.
20. SPORN MB AND ROBERTS AB. (1985). Autocrine growth factors and cancer. Nature, 313, 745-747.
21. SRIVASTAVA A, LAIDLER P, DAVIES R, HORGAN K AND HUGHES LE. (1988). The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. Am. J. Pathol., 133, 419-423.
22. TANNOCK IF. (1968). The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumor. Br. J. Cancer, 22, 258-273.
23. TOI M, KASHITANI J AND TOMINAGA T. (1993). Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma. Int. J. Cancer, 55, 371-374.
24. VARTANIAN RK AND WEIDNER N. (1994). Correlation of intratumoral endothelial cell proliferation with microvessel density (tumor angiogenesis) and tumor cell proliferation in breast carcinoma. Am. J. Pathol., 144, 1188-1194.
25. VERMEULEN PB, VERHOEVEN D, HUBENS G, VAN MARCK E, GOOVAFRTS G, HUYGHE M, DE BRUIJN EA, VAN OOSTEROM AT AND DIRIX LY. (1995). Microvessel density, endothelial cell proliferation and tumor cell proliferation in human colorectal adenocarcinomas. Ann. Oncol., 6, 59-64.
26. VOLM M, MATTERN J AND SAMSEL B. (1991). Overexpression of P-glycoprotein and glutathione S-transferase-π in resistant non-small-cell lung carcinomas of smokers. Br. J. Cancer, 64, 700-704.
27. WEIDNER N, SEMPLE JP, WELCH WR AND FOLKMAN J. (1991). Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N. Engl. J. Med., 324, 1-8.
28. WEIDNER N, CARROLL PR, FLAX J, BLUMENFELD W AND FOLKMAN J. (1993). Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am. J. Pathol., 143, 401-409.
29. WORLD HEALTH ORGANIZATION. (1981). Histological typing of lung tumors. Tumori, 6, 253-272.
30. YAMAZAKI K, ABE S, TAKEKAWA H, SUKOH N, WATANABE N, OGURA S, NAKAJIMA I, ISOBE H, INOUE K AND KAWAKAMI Y (1994). Tumor angiogenesis in human lung adenocarcinoma. Cancer, 74, 2245-2250.
31. ZHANG HT, CRAFT P, SCOTT PAE, ZICHE M, WEICH HA, HARRIS AL AND BICKNELL R. (1995). Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells. J. Natl Cancer Inst., 87, 213-219.