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The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
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The FHITgene at 3p14.2 is abnormal in lung cancer
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Sozzi, G., Veronese, M. L., Negrini, M., Baffa, R., Cotticelli, M. G., Inoue, H., Tornielli, S., Pilotti, S., DeGregorio, L., Pastorino, U., Pierotti, M. A., Ohta, M., Huebner, K., and Croce, C. M. The FHITgene at 3p14.2 is abnormal in lung cancer. Cell, 85: 17-26, 1996.
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FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations
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Fong, K. M., Biesterveld, E. J., Virmani, A., Wistuba, I., Sekido, Y., Bader, S. A., Ahmadian, M., Ong, S. T., Rassool, F. V., Zimmerman, P. V., Ciaccone, G., Gazdar, A. F., and Minna, J. A. FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations. Cancer Res., 57: 2256-2267, 1997.
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Druck, T., Hadaczek, P., Fu, T-B., Ohta, M., Siprashvili, Z., Baffa, R., Negrini, M., Kastury, K., Veronese, M. L., Rosen, D., Rothstein, J., McCue, P., Cotticelli, M. G., Inoue, H., Croce, C. M., and Huebner, K. Structure and expression of the human FHIT gene in normal and tumor cells. Cancer Res., 57: 504-512, 1997.
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Thiagalingam, S., Lisitsyn, N. A., Hamguchi, M., Wigler, M. H., Willson, J. K. V., Markowitz, S. D., Leach, F. S., Kinzler, K. W., and Vogelstein, B. Evaluation of the FHIT gene in colorectal cancers. Cancer Res., 56: 2936-2939, 1996.
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Variable FHIT transcripts in non-neoplastic tissues
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Replacement of Fhit in cancer cells suppresses tumorigenicity
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Siprashvili, Z., Sozzi, G., Barnes, L. D., McCue, P., Robinson, A. K., Eryomin, V., Sard, L., Tagliabue, E., Greco, A., Fusetti, L., Schwartz, G., Pierotti, M. A., Croce, C. M., and Huebner, K. Replacement of Fhit in cancer cells suppresses tumorigenicity. Proc. Natl. Acad. Sci. USA, in press.
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Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization
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FHIT gene alterations in head and neck squamous cell carcinomas
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Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B
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Boldog, F., Gemmill, R. M., West, J., Robinson, M., Robinson, L., Li, E., Roche, J., Todd, S., Waggoner, B., Lundstrom, R., Jacobson, J., Mullokandov, M. R., Klinger, H., and Drabkin, H. A. Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B. Hum. Mol. Genet., 6: 193-203, 1997.
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The FHIT gene at 3p14.2 is abnormal in breast carcinomas
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Negrini, M., Monaco, C., Vorechovsky, I., Ohta, M., Druck, T., Baffa, R., Huebner, K., and Croce, C. M. The FHIT gene at 3p14.2 is abnormal in breast carcinomas. Cancer Res., 56: 3173-3179, 1996.
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The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated with familial breast cancer and cytogenetic rearrangements of chromosome band 3p14
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Panagopoulos, I., Pandis, N., Thelin, S., Petersson, C., Mertens, F., Borg, A., Kristoffersson, U., Mitelman, F., and Aman, P. The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated with familial breast cancer and cytogenetic rearrangements of chromosome band 3p14. Cancer Res., 56: 4871-4875, 1996.
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