Associations of CYP1A1, GSTM1, and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens

Cancer Research

Volumn 58, Issue 21, 1998, Pages 4858-4863

  Le Marchand, Loïc ^a   Sivaraman, Lakshmi ^a,b   Pierce, Lisa ^a   Seifried, Ann ^a   Lum, Annette ^a   Wilkens, Lynne R ^a   Lau, Alan F ^a  

^a UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGEN; DIMETHYLNITROSAMINE DEMETHYLASE; ETHOXYRESORUFIN DEETHYLASE; NITROSAMINE; POLYCYCLIC AROMATIC HYDROCARBON;

ADULT; AGED; ARTICLE; CANCER RISK; CHEMICAL CARCINOGENESIS; CIGARETTE SMOKING; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; ENZYME ACTIVITY; ENZYME POLYMORPHISM; ENZYME SPECIFICITY; FEMALE; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REGRESSION ANALYSIS;

ADULT; AGED; ALLELES; CARCINOGENS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2E1; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; LUNG NEOPLASMS; MIDDLE AGED; PLANTS, TOXIC; POLYCYCLIC HYDROCARBONS, AROMATIC; TOBACCO;

EID: 0032211358     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Travis, W. D., Travis, L. B., and Devesa, S. S. Lung cancer [published erratum appears in Cancer (Phila.), 75: 2979, 1995]. Cancer (Phila.), 74: 191-205, 1995.
2. Thun, M. J., Lally, C. A., Flannery, J. T., Calle, E. E., Flanders, W. D., and Heath, C. W., Jr. Cigarette smoking and changes in the histopathology of lung cancer. J. Natl. Cancer Inst., 89: 1580-1586, 1997.
3. Wynder, E. L., and Hoffmann, D. Smoking and lung cancer: scientific challenges and opportunities. Cancer Res., 54: 5284-5295, 1997.
4. United States Department of Health and Human Services. Reducing the Health Consequences of Smoking: 25 Years of Progress. A Report of the Surgeon General pp. 89-8411. Rockville, MD: United States Department of Health and Human Services, 1989.
5. Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54: 4855-4878, 1994.
6. Denissenko, M. F., Pao, A., Tang, M-S., and Pfeifer, G. P. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in p53. Science (Washington DC), 274: 430-432, 1996.
7. Hoffmann, D., Rivenson, A., Murphy, S. E., Chung, F-L., Amin, S., and Hecht, S. S. Cigarette smoking and adenocarcinoma of the lung: the relevance of nicotine-derived N-nitrosamines. J. Smoking Rel. Disord., 4: 165-190, 1993.
8. Kadlubar, F. F., and Hammons, G. J. Role of cytochrome P-450 in metabolism of chemical carcinogens. In: F. P. Guengerich (ed.), Mammalian Cytochromes P-450, Vol. 2, pp. 81-130. Boca Raton FL: CRC Press, 1987.
9. Ketterer, B., Harris, J. M., Talaska, G., Meyer, D. J., Pemble, S. E., Taylor, J. B., Lang, N. P., and Kadlubar, F. F. The human glutathione S-transferase supergene family, its polymorphism, and its effects on susceptibility to lung cancer. Environ. Health Perspect., 98: 87-94, 1992.
10. Kawajiri, K., Nakachi, K., Imai, K., Yoshii, A., Shinoda, N., and Watanabe, J. Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P4501A1 gene. FEBS Lett., 263: 131-133, 1990.
11. Hayashi, S., Watanabe, J., Nakachi, K., and Kawajiri, K. Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P4501A1 gene. J. Biochem., 110: 407-411, 1991.
12. Okada, T., Kawashima, K., Fukushi, S., Minakuchi, T., and Nishimura, S. Association between a cytochrome P450 CYP1A1 genotype and incidence of lung cancer. Pharmacogenetics, 4: 333-340, 1994.
13. Hirvonen, A., Husgafvel-Pursiainen, K., Karjalainen, A., Anttila, S., and Vainio, H. Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population. Cancer Epidemiol. Biomark. Prev., 1: 485-489, 1992.
14. 1450) gene: lack of association between the MspI restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population. Pharmacogenetics, 1: 20-25, 1991.
15. Shields, P. G., Caporaso, N. E., Falk, R. T., Sugimura, H., Trivers, G. E., Trump, B. F., Hoover, R. N., Weston, A., and Harris, C. C. Lung cancer, race, and a CYP1A1 genetic polymorphism. Cancer Epidemiol. Biomark. Prev., 2: 481-485, 1993.
16. Drakoulis, N., Cascorbi, I., Brockmoller, J., Gross, C. R., and Roots, I. Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon 7 mutation (4889 A to G) and a T to C mutation in the 3′-flanking region. Clin. Investig., 72: 240-248, 1994.
17. Xu, X., Kelsey, K. T., Wiencke, J. K., Wain, J. C., and Christiani, D. C. Cytochrome P450 CYP1A1 MspI polymorphism and lung cancer susceptibility. Cancer Epidemiol. Biomark. Prev., 5: 687-692, 1996.
18. Ishibe, N., Wiencke, J. K., Zuo, Z-F., McMillan, A., Spitz, M., and Kelsey, K. T. Susceptibility to lung cancer in light smokers associated with CYP1A1 polymorphisms in Mexican- and African-Americans. Cancer Epidemiol. Biomark. Prev., 6: 1075-1080, 1997.
19. Uematsu, F., Kikuchi, H., Motomiya, M., Abe, T., Sagami, I., Ohmachi, T., Wakui, A., Kanamaru, R., and Watanabe, M. Association between restriction fragment length polymorphism of the human cytochrome P450IIE1 gene and susceptibility to lung cancer. Jpn. J. Cancer Res., 82: 254-256, 1991.
20. Hirvonen, A., Husgafvel-Pursiainen, K., Anttila, S., Karjalainen, A., and Vainio, H. The human CYP2E1 gene and lung cancer: DraI and RsaI restriction fragment length polymorphisms in a Finnish study population. Carcinogenesis (Lond.), 14: 85-88, 1993.
21. Persson, I., Johansson, I., Bergling, H., Dahl, M-L., Seidegard, J., Rylander, R., Rannug, A., Hogberg, J., and Sundberg, M. I. Genetic polymorphism of cytochrome P4502E1 in a Swedish population; relationship to incidence of lung cancer. FEBS Lett., 319: 207-211, 1993.
22. Kato, S., Shields, P. G., Caporaso, N. E., Sugimura, H. Trivers, G. E., Tucker, M. A., Trump, B. F., Weston, A., and Harris, C. C. Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer. Cancer Epidemiol. Biomark. Prev., 3: 515-518, 1994.
23. Wu, X., Shi, H., Jiang, H., Kemp, B., Hong, W. K., Delclos, G. L., and Spitz, M. R. Associations between cytochrome P4502E1 genotype, mutagen sensitivity, cigarette smoking and susceptibility to lung cancer. Carcinogenesis (Lond.), 18: 967-973, 1997.
24. Wu, X. F., Amos, C. I., Kemp, B. L., Shi, H. H., Jiang, H., Wan, Y., and Spitz, M. R. Cytochrome P450 2E1 DraI polymorphism in lung cancer in minority populations. Cancer Epidemiol. Biomark. Prev., 7: 13-18, 1998.
25. Watanabe, J., Yang, J-P., Eguchi, H., Hayashi, S., Imai, K., Nakachi, K., and Kawajiri, K. An RsaI polymorphism in the CYP1E1 gene does not affect lung cancer risk in a Japanese population. Jpn. J. Cancer Res., 86: 245-248, 1995.
26. Hankin, J. H. A diet history method for research, clinical and community use. 23rd Lenna Frances Cooper Memorial Lecture. J. Am. Diet. Assoc., 86: 868-872, 1986.
27. Hankin, J. H., Wilkens, L. R., Kolonel, L. N., and Yoshizawa, C. N. Validation of a quantitative diet history method in Hawaii. Am. J. Epidemiol., 133: 616-628, 1991.
28. United States Department of Agriculture. Nutrient Database for Standard Reference, Release 10. Bethesda, MD: Human Nutrition Information Service, United States Department of Agriculture, 1992.
29. Maniatis, T., Frisch, E. F., and Sambrook, K. J. Molecular Cloning: A Laboratory Manual, pp. 458-459. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1982.
30. Lum, A., and Le Marchand, L. A simple mouthwash method for obtaining genomic DNA in molecular epidemiological studies. Cancer Epidemiol. Biomark. Prev., 7: 719-724, 1998.
31. Kim, R. B., O'Shea, D., and Wilkinson, G. R. Relationship in healthy subjects between CYP2E1 genetic polymorphisms and the 6-hydroxylation of chlorzoxasone: a putative measure of CYP2E1 activity. Pharmacogenetics, 4: 162-165, 1994.
32. Hayashi, S., Watanabe, J., and Kawajiri, K. Genetic polymorphisms in the 5′-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J. Biochem., 110: 559-565, 1991.
33. Bell, D. A., Thompson, C. L., Taylor, J., Miller, C. R., Perera, F., Hsieh, L. L., and Lucier, G. W. Genetic monitoring of human polymorphic cancer susceptibility genes by polymerase chain reaction: application to glutathione transferase μ. Environ. Health Perspect., 98: 113-117, 1992.
34. Fleiss, J. L. Statistical Methods for Rates and Proportions. New York: John Willey & Sons, 1981.
35. Breslow, N. E., and Day, N. E. Statistical Methods for Cancer Epidemiology. The Analysis of Case-Control Studies, Vol. I. Lyon, France: IARC, 1980.
36. Willett, W. C., and Stampfer, M. J. Total energy intake: implications for epidemiologic analyses. Am J. Epidemiol., 124: 17-27, 1986.
37. Le Marchand, L., Yoshizawa, C. N., Kolonel, L. N., Hankin, J. H., and Goodman, M. T. Vegetable consumption and lung cancer risk: a population-based case-control study in Hawaii. J. Natl. Cancer Inst., 81: 1158-1164, 1989.
38. Goodman, M. T., Hankin, J. H., Wilkens, L. R., and Kolonel, L. N. High-fat foods and the risk of lung cancer. Epidemiology, 3: 288-299, 1992.
39. Deutsch-Wenzel, R., Brune, H., Grimmer, G., Dettbarn, G., and Misfeld, J. Experimental studies in rat lungs on the carcinogenicity and dose-response relationships of eight frequently occurring environmental polycyclic aromatic hydrocarbons. J. Natl. Cancer Inst., 71: 539-544, 1983.
40. Rannug, A., Alexandrie, A-K., Persson, I., and Ingelman-Sundberg, M. Genetic polymorphism of cytochromes P450 1A1, 2D6 and 2E1: regulation and toxicological significance. J. Occup. Environ. Med., 37: 25-36, 1995.
41. Sabadie, N., Richter-Reichhelm, H. B., Saracci, R., Mohr, U., and Bartsch, H. Interindividual differences in oxidative benzo(a)pyrene metabolism by normal and tumorous surgical lung specimens from 105 lung cancer patients. Int. J. Cancer, 27: 417-425, 1981.
42. Nowak, D., Schmidt-Preuss, U., Jorres, R., Liebke, F., and Rudiger, H. W. Formation of DNA adducts and water-soluble metabolites of benzo(a)pyrene in human monocytes is genetically controlled. Int. J. Cancer, 41: 169-173, 1988.
43. McLemore, T. L., Adelberg, A., Liu, M. C., McMahon, N. A., Yu, S. J., Hubbard, W. C., Czerwinski, M., Wood, T. G., Storeng, R., Lubek, R. A., Eggleson, J. C., Boyd, M. R., and Hines, R. N. Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas. J. Natl. Cancer Inst., 82: 1333-1339, 1990.
44. Kouri, R. E., McKinney, C. E., Slomiany, D. J., Snodgrass, D. R., Wray, N. P., and McLemore, T. L. Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes. Cancer Res., 42: 5030-5037, 1982.
45. Hawke, L. J., and Farrell, G. C. Increased binding of benzo(a)pyrene metabolites to lymphocytes from patients with lung cancer. Cancer Lett., 30: 289-297, 1986.
46. Law, M. R. Genetic predisposition to lung cancer. Br. J. Cancer, 61: 195-206, 1990.
47. Petersen, D. D., McKinney, C. E., Ikeya, K., Smith, H. H., Bale, A. E., McBride, O. W., and Nebert, D. W. Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP. Am. J. Hum. Genet., 48: 720-725, 1991.
48. Landi, M. T., Bertazzi, P. A., Shields, P. G., Clark, G., Lucier, G. W., Garte, S. J., Cosma, G., and Caporaso, N. E. Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans. Pharmacogenetics, 4: 242-246, 1994.
49. Crofts, F., Taioli, E., Trachman, J., Cosma, G. N., Currie, D., Toniolo, P., and Garte, S. J. Functional significance of different human CYP1A1 genotypes. Carcinogenesis (Lond.), 15: 2961-2963, 1994.
50. Kiyohara, C., Hirohata, T., and Inutsuka, S. The relationship between aryl hydrocarbon hydroxylase and polymorphisms of the CYP1A1 gene. Jpn. J. Cancer Res., 87: 18-24, 1996.
51. Nakachi, K., Imai, K., Hayashi, S., Watanabe, J., and Kawajiri, K. Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose. Cancer Res., 51: 5177-5180, 1991.
52. Nakachi, K., Hayashi, S., Kawajiri, K., and Imai, K. Association of cigarette smoking and CYP1A1 polymorphisms with adenocarcinomas of the lung by grades of differentiation. Carcinogenesis (Lond.), 16: 2209-2213, 1995.
53. Hayashi, S., Watanabe, J., and Kawajiri, K. High susceptibility to lung cancer analyzed in terms of combined genotypes P4501A1 and μ-class glutathione S-transferase genes. Jpn. J. Cancer Res., 83: 866-870, 1992.
54. Nakachi, K., Imai, K., Hayashi, S., and Kawajiri, K. Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population. Cancer Res., 53: 2994-2999, 1993.
55. Kihara, M., Kihara, M., and Noda, K. Risk of smoking for squamous and small cell carcinomas of the lung modulated by combinations of CYP1A1 and GSTM1 gene polymorphisms in a Japanese population. Carcinogenesis (Lond.), 16: 2331-2336, 1995.
56. Alexandrie, A. K., Sundberg, M. I., Seidegard, J., Tornling, G., and Rannug, A. Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types. Carcinogenesis (Lond.), 15: 1785-1790, 1994.
57. Garcia-Closas. M., Kelsey, K. T., Wiencke, J. K., Xu, X., Wain, J. C., and Christiani, D. C. A case-control study of cytochrome P4501A1, glutathione S-transferase M1, cigarette smoking and lung cancer susceptibility (Massachusetts, United States). Cancer Causes Control, 8: 544-553, 1997.
58. London, S. J., Daly, A. K., Cooper, J., Navidi, W. C., Carpenter, C. L., and Idle, J. R. Polymorphism of glutathione S-transferase M1 and lung cancer risk in African-Americans and Caucasians in Los Angeles County, California. J. Natl. Cancer Inst., 87: 1246-1253, 1995.
59. Carmella, S. G., Kagan, S. S., Kagan, M., Foiles, P. G., Palladino, G., Quart, A. M., Quart, E., and Hecht, S. S. Mass spectrometric analyses of tobacco-specific nitrosamine hemoglobin adducts in snuff dippers, smokers and nonsmokers. Cancer Res., 50: 5438-5445, 1990.
60. Ronai, Z. A., Gradia, S., Peterson, L. A., and Hecht, S. S. G to A transition and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents. Carcinogenesis (Lond.), 14: 2419-2422, 1993.
61. Rodenhuis, S., and Slesbos, R. J. Clinical significance of ras oncogene activation in human lung cancer. Cancer Res., 52: 2665s-2669s, 1992.
62. Ekström, G., and Ingelman-Sundberg, M. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P450 (P-450 IIE1). Biochem. Pharmacol., 38: 1313-1319, 1989.
63. Lucas, D., Ménez, C., Girre, C., Berthou, F., Bodénez, P., Joannet, I., Hispard, E., Bardou, L-G., and Ménez, J-F. Cytochrome P4502E1 genotype and chlorzoxazone metabolism in healthy and alcoholic Caucasian subjects. Pharmacogenetics, 5: 298-304, 1995.
64. Kim, R. B., Yamazaki, H., Chiba, K., O'Shea, D., Mimura, M., Guengerich, F. P., Ishizaki, T., Shimada, T., and Wilkinson, G. R. In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians. J. Pharmacol. Exp. Ther., 279: 4-11, 1996.
65. Le Marchand, L., Wilkens, L. R., and Kolonel, L. N. Ethnic differences in the lung cancer risk associated with smoking. Cancer Epidemiol. Biomark. Prev., 1: 103-107, 1992.
66. Cascorbi, I., Brockmoller, J., and Roots, I. A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. Cancer Res., 56: 4965-4969, 1996.
67. Hu, Y., Oscarson, M., Johansson, I., Yue, Q-Y., Dahl, M-L., Tabone, M., Arinco, S., Albano, E., and Ingelman-Sundberg, M. Genetic polymorphism of human CYP2E1: characterization of two variant alleles. Mol. Pharmacol., 51: 370-376, 1997.