Prognostic role of the cyclin-dependent kinase inhibitor p27 in non- small cell lung cancer

Cancer Research

Volumn 57, Issue 16, 1997, Pages 3381-3385

  Esposito, Vincenzo ^a,b   Baldi, Alfonso ^a,e   De Luca, Antonio ^a   Groger, Angela M ^a,f   Loda, Massimo ^c   Giordano, Giovan Giacomo ^b   Caputi, Mario ^b   Baldi, Feliciano ^b   Pagano, Michele ^d   Giordano, Antonio ^a,g  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^e Laboratory of Neuroscience   (Italy)

^f UNIVERSITY OF VIENNA   (Austria)

^g THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEASOME;

ADULT; ARTICLE; CANCER SURVIVAL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SURVIVAL TIME; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NEOPLASM PROTEINS; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 14444268041     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. MacLachlan, T. K., Sang, N., and Giordano, A. Cyclins, cyclin-dependent kinases and Cdk inhibitors: implication in cell cycle control and cancer. Crit. Rev. Eukaryotic Gene Expression, 5: 127-156, 1995.
2. Paggi, M. G., Baldi, A., Bonetto, F., and Giordano, A. Retinoblastoma protein family in cell cycle and cancer: a review. J. Cell Biochem., 62: 418-430, 1996.
3. Koff, A., Cross, F., Fisher, A., Schumacher, J., Leguellec, K., Philippe, M., and Roberts, J. M. Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell, 66: 1217-1228, 1991.
4. Polyak, K., Lee, M. H., Erdjement-Bromage, H., Koff, A., Roberts, J. M., Tempst, P., and Massagué, J. Cloning of p27/kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell, 79: 59-66, 1994.
5. Toyoshima, T., and Hunter, T. p27, a novel inhibitor of G1-cyclin-cdk protein kinase activity, is related to p21. Cell, 78: 67-74, 1994.
6. Nourse, J., Firpo, E., Flanagan, M., Coats, S., Polyak, C., Lee, M., Massagué, J., Crabtree, G., and Roberts, J. Interleukin-2-mediated elimination of p27kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature (Lond.), 372: 570-573, 1994.
7. Hengst, L., and Reed, S. Translation control of p27kip1 accumulation during the cell cycle. Science (Washington, DC), 271: 1861-1864, 1996.
8. Pagano, M., Beer-Romero, P., Glass, S., Tam, S. W., Theodoras, A., Rolfe, M., and Draetta, G. Targeting ubiquitin-mediated degradation for proliferation inhibitors. In: E. Mihich and D. Housman (eds.), Cancer Genes, New York: Plenum Publishing Corp., pp. 255-268, 1997.
9. Pagano, M., Tam, S. W., Theodoras, A. M., Romero-Beer, P., Del Sal, G., Chau, V., Yew, R., Draetta, G., and Rolfe, M. Role of the ubiquitin-proteasomc pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science (Washington, DC), 269: 682-685, 1995.
10. Shottenfeld, D. Epidemiology of lung cancer. In: H. Pass, J. B. Mitchell, D. H. Johnson, and A. T. Turrisi, Lung Cancer: Principles and Practice. Lippincott-Raven Publishers, Philadelphia, 1996.
11. Cordon-Cardo, C. Mutation of cell cycle regulators: biological and clinical implications for human neoplasia. Am. J. Pathol., 147: 1-16, 1995.
12. Bullrich, F., MacLachlan, T. K., Sang, N., Druck, T., Veronese, M. L., Chiorazzi, N., Koff, A., Huebner, K., Croce, C. M., and Giordano, A. Mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE and PITALRE and a cdk inhibitor, p27Kip1, to regions involved in human cancer. Cancer Res., 55: 1199-1205, 1995.
13. Kawamata, A., Morosetti, R., Miller, C., Park, D., Spirin, K., Nakamaki, T., Takeuchi, S., Hatta, Y., Simpson, J., and Wilczynski, S. Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies. Cancer Res., 55: 2266-2269, 1995.
14. Pietenpol, J. A., Bohlander, S. K., Sato, Y., Papadopoulos, N., Liu, B., Friedman, C., Trask, B. J., Roberts, J. M., Kinzler, K. W., Rowley, J. D., and Vogelstein, B. Assignment of the p27 kip1 gene to 12p13 and its analysis in leukemias. Cancer Res., 55: 1206-1210, 1995.
15. Ponce-Castañeda, M. V., Lee, M. H., Latres, E., Polyak, K., Lacombe, L., Montgomery, K., Mathew, S., Krauter, K., Sheinfeld, J., Massagué, J., and Cordon-Cardo, C. p27 Kip1: chromosomal mapping to 12q12 and absence of mutations in human tumors. Cancer Res., 55: 1211-1214, 1995.
16. Stegmaier, K., Takeuchi, S., Golub, T. R., Bhohlander, S. K., Bartram, C. R., and Koeffler, P. Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia. Cancer Res., 56: 1413-1417, 1996.
17. World Health Organization. Histological Typing of Lung Tumors, Ed. 2, pp. 25-26. Geneva: WHO, 1981.
18. Beahrs, O. H., Henson, D. E., Hutter, R. V. P., and Kennedy, B. J. Lung. In: Manual for Staging of Cancer, Ed. 4, pp. 115-122. Chicago: American Joint Committee on Cancer, 1992.
19. Loda, M., Cukor, B., Tam, S. W., Lavin, P., Fiorentino, M., Draetta, G., Jessup, J. M., and Pagano, M. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat. Med., 3: 152-154, 1997.
20. Claudio, P. P., Howard, C. M., Baldi, A., De Luca, A., Fu. Y., Condorelli, G., Sun, Y., Colburn, N., Calabretta, B., and Giordano, A. pRb2/p130 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res., 54: 5556-5560, 1994.
21. Sheaff, R. J., and Roberts, J. M. Lesson in p16 from phylum Falcomiun. Current Biol., 5: 28-31, 1995.
22. DiGiuseppe, J. A., Redston, S. M., Yeo, J. C., Kern, S. E., and Hruban, R. H. p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma. Am. J. Pathol., 147: 884-888, 1995.
23. el-Deiry, W., Tokino, T., Waldman, T., Oliner, J. D., Velculescu, V. E., Burrel, M., Hill, D. E., Healy, E., Rees, J. I., Hamilton, S. R., Kinzler, K. W., and Vogelstein, B. Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res., 55: 2910-2919, 1995.
24. Marchetti, A., Doglioni, C., Barbareschi, M., Buttitta, F., Pellegrini, S., Bertacca, G., Chella, A., Merlo, G., Angeletti, C. A., Dalla Palma, P., and Bevilacqua, G. p21 RNA and protein expression in non small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiation. Oncogene, 12: 1319-1324, 1996.
25. Fero, M., Rivkin, M., Tasch, M., Porter, P., Carow, C., Firpo, E., Polyak, K., Tsai, L., Broudy, V., Perlmutter, R., Kaushansky, K., and Roberts, J. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis and female sterility in p27kip1-deficient mice. Cell, 85: 733-744, 1996.
26. Kiyokawa, H., Kineman, R., Manova-Todorova, K., Soares, V., Hoffman, E., Ono, M., Khanam, D., Hayday, A., Frohman, L., and Koff, A. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell, 85: 721-732, 1996.
27. Mal, A., Poon, R., Howe, P., Toyoshima, H., Hunter, T., and Harter, M. Inactivation of p27kip1 by the viral E1A oncoprotein in TGF β-treated cells. Nature (Lond.), 380: 262-265, 1996.
28. Zerfass-Thome, K., Zwerschkle, W., Mannhardt, B., Tindle. R., Botz, J. W., and Jansen-Durr, P. Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type16 E7 oncoprotein. Oncogene, 2323-2330, 1996.