Cyclin D1 expression in non-small-cell lung cancers: Its association with altered p53 expression, cell proliferation and clinical outcome

British Journal of Cancer

Volumn 80, Issue 8, 1999, Pages 1289-1295

  Mishina, T ^a   Dosaka Akita, H ^a   Kinoshita, I ^a   Hommura, F ^a   Morikawa, T ^a   Katoh, H ^a   Kawakami, Y ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Clinical outcome; Cyclin D1; Ki 67 index; Non small cell lung cancers; p16 RB pathway; p53

Indexed keywords

CYCLIN D1; KI 67 ANTIGEN; PROTEIN P16; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ADULT; AGED; ARTICLE; CANCER SURGERY; CANCER SURVIVAL; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SOUTHERN BLOTTING; TREATMENT OUTCOME;

AGED; CARCINOMA, NON-SMALL-CELL LUNG; CELL DIVISION; CYCLIN D1; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; KI-67 ANTIGEN; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033057640     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6990500     Document Type: Article

References (47)

1. Åkervall JA, Michalides RJAM, Mineta H, Balm A, Borg A, Dictor M, Jin Y, Loftus B, Mertens F and Wennerberg JP (1997) Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression. Cancer 79: 38-389
2. Rartkova J, Lukas J, Strauss M and Bartek J (1994) Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein. J Pathol 172: 237-245
3. Beahrs OH, Henson DE, Hutter RVP and Kennedy BJ (1992) Lung. In: Manual for Staging of Cancer, 4th edn. American Joint Commitee on Cancer Chicago: 115-122
4. Betticher DC, Heighway J, Hasleton PS, Altermatt HJ, Ryder WDJ, Cerny T and Thatcher N (1996) Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer. Br J Cancer 73: 294-300
5. Betticher DC, White GRM, Vonlanthen S, Liu X, Kappeler A, Altermatt H, Thatcher N and Heighway J (1997) G1 control gene status is frequently altered in resectable non-small-cell lung cancer. Int J Cancer 74: 556-562
6. Buckley MF, Sweeney KJE, Hamilton JA, Sini RL, Manning DL, Nicholson RI, deFazio A, Watts CKW, Musgrove EA and Sutherland RL (1993) Expression and amplification of cyclin genes in human breast cancer. Oncogene 8: 2127-2133
7. Chen X, Bargonetti J and Prives C (1995) p53, through p21 (WAF1/CIP1 ), induces cyclin D1 synthesis. Cancer Res 55: 4257-4263
8. Del Sal G, Murphy M, Ruaro E, Lazarevic D, Levine A and Schneider C (1996) Cyclin D1 and p21/waf1 are involved in p53 growth suppression. Oncogene 12: 177-185
9. Fearon ER and Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61: 759-767
10. Filmus J, Robles AI, Shi W, Wong MJ, Colombo LL and Conti C (1994) Induction of cyclin D1 overexpression by activated ras. Oncogene 9: 3627-3633
11. Gerdes J, Lemke H, Baisch H, Wacker H, Schwab U and Stein H (1984) Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133: 1710-1715
12. INK4A is a potential effector of TGF-β-induced cell cycle arrest. Nature 371: 257-261
13. Harada M, Dosaka-Akita H, Miyamoto H, Kuzumaki N and Kawakami Y (1992) Prognostic significance of the expression of ras oncogene product in non-small-cell lung cancer. Cancer 69: 72-77
14. Hinds PW, Dowdy SF, Eaton EN, Arnold A and Weinberg RA (1994) Function of a human cyclin gene as an oncogene. Proc Natl Acad Sci USA 91: 709-713
15. Jiang W, Tomita N, Zhang Y, Lu S and Weinstein B (1992) Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res 52: 2980-2983
16. Jiang W, Kahn SM, Zhou P, Zhang Y, Cacace AM, Infante AS, Doi S, Santella RM and Weinstein IB (1993) Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene 8: 3447-3457
17. INK4 and retinoblastoma protein status in non small-cell lung cancer: potential synergistic effect with altered p53 protein on proliferative activity. Cancer Res 56: 5557-5562
18. Lovec H, Sewing A, Lucibello FC, Müller R and Möröy T (1994) Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation. Oncogene 9: 323-326
19. Lukas J, Pagano M, Staskova Z, Draetta G and Bartek J (1994a) Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene 9: 707-718
20. Lukas J, Müller H, Bartkova J, Spitkovsky D, Kjerulff AA, Jansen-Durr P, Strauss M and Bartek J (1994b) DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. J Cell Biol 125: 625-638
21. Lukas J, Parrr D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G and Bartek J (1995) Retinoblastoma-protein dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375: 503-506
22. McIntosh GG, Anderson JJ, Milton I, Steward M, Parr AH, Thomas MD, Henry JA, Angus B, Lennard TWJ and Horne CHW (1995) Determination of the prognostic value of cyclin D1 overexpression in breast cancer. Oncogene 11: 885-891
23. Marchetti A, Doglioni C, Barbareschi M, Buttitta F, Pellegrini S, Gaeta P, La Rocca R, Merlo G, Chella A, Angeletti CA, Palma PD and Bevilacqua G (1998) Cyclin D1 and retinoblastoma susceptibility gene alterations in non-small-cell lung cancer. Int J Cancer 75: 187-192
24. Marhin WW, Hei Y, Chen S, Jiang Z, Gallie BL, Phillips RA and Penn LZ (1996) Loss of Rb and myc activation co-operate to suppress cyctin D1 and contribute to transformation. Oncogene 12: 43-52
25. Mate JL, Ariza A, Aracil C, Lopez D, Isamat M, Perez-Piteira J and Navas-Palacios JJ (1996) Cyclin D1 overexpression in non-small-cell lung carcinoma: correlation with Ki-67 labelling index and poor cytoplasmic differentiation. J Pathol 180: 395-399
26. Matsushime H, Roussel MF, Ashmun RA and Sherr CJ (1991) Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65: 701-713
27. Mineta H, Borg Å, Dictor M, Wahlberg P and Wennerberg J (1997) Correlation between p53 mutation and cyclin D1 amplification in head and neck squamous cell carcinoma. Oral Oncol 33: 42-46
28. Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM and Arnold A (1991 ) A novel cyclin encoded by a bcl-1-linked candidate oncogene. Nature 350: 512-515
29. Müller H, Lukas J, Schneider A, Warthoe P, Bartek J, Eilers M and Strauss M (1994) Cyclin D1 expression is regulated by the retinoblastoma protein. Proc Natl Acad Sci USA 91: 2945-2949
30. Naitoh H, Shibata J, Kawaguchi A, Kodama M and Hattori T (1995) Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer. Am J Pathol 146: 1161-1169
31. Nakagawa H, Wang TC, Zukerberg L, Odze R, Togawa K, May GHW, Wilson J and Rustgi AK (1997) The targeting of the cyclin D1 oncogene by an Epstein Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach. Oncogene 14: 1185-1190
32. Nikaido T, Li S, Shiozawa T and Fujii S (1996) Coabnormal expression of cyclin D1 and p53 protein in human uterine endometrial carcinomas. Cancer 78: 1248-1253
33. Nishida N, Fukuda Y, Komeda T, Kita R, Sando T, Furukawa M, Amenomori M, Shibagaki I, Nakao K, Ikenaga M and Ishizaki K (1994) Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res 54: 3107-3110
34. Nishio M, Koshikawa T, Yatabe Y, Kuroishi T, Suyama M, Nagatake M, Sugiura T, Ariyoshi Y, Mitsudomi T, Takahashi T and Takahashi TA (1997) Prognostic significance of cyclin D1 and retinoblastoma expression in combination with p53 abnormalities in primary, resected non-small-cell lung cancers. Clin Cancer Res 3: 1051-1058
35. Peeper DS, Upton TM, Ladha MH, Neuman E, Zalvide J, Bernards R, DeCaprio JA and Ewen M (1997) Ras signalling linked to the cell-cycle machinery by the rennoblastoma protein. Nature 386: 177-181
36. Ravitz MJ, Yan S, Dolce C, Kinniburgh AJ and Wenner CE (1996) Differential regulation of p27 and cyclin D1 by TGF-β and EGF in C3H 10T1/2 mouse fibroblast. J Cell Physiol 168: 510-520
37. Serrano M, Hannon GJ and Beach D (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707
38. INK4 expression in primary lung cancers and cell lines. Cancer Res 55: 505-509
39. Sherr CJ (1996) Cancer cell cycles. Science 274: 1672-1677
40. Sofer-Levi Y and Resnitsky D (1996) Apoptosis induced hy ectopic expression of cyclin D1 but not cyclin E. Oncogene 13: 2431-2437
41. Spitkovsky D, Steiner, Gopalkrishnan RV, Eilers M and Jansen-Dürr P (1995) The role of p53 in coordinated regulation of cyclin D1 and p21 gene expression by the adenovirus EIA and EIB oncogenes. Oncogene 10: 2421-2425
42. Tanaka H, Fujii Y, Hirabayashi H, Miyoshi S, Sakaguchi M, Yoon H and Matsuda H (1998) Disruption of the RB pathway and cell-proliferative activity in non-small-cell lung cancers. Int J Cancer 79: 111-115
43. Uchimura K, Endo K, Fujinuma H, Zukerberg L, Arnold A and Motokura T (1996) Oncogenic collaboration of the cyclin D1 (PRAD1, bcl-1) gene with a mutated p53 and an activated ras oncogene in neoplastic transformation. Jpn J Cancer Res 87: 459-465
44. Wang TC, Cardiff RD, Zukerberg L, Lees E, Arnold A and Schmidt EV (1994) Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 369: 669-671
45. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81: 323-330
46. WHO (1982) Histological Typing of Lung Tumor, 2nd edn. pp. 25-26. World Health Organisation: Geneva
47. Zhu X, Ohtsubo M, Böhmer RM, Roberts JM and Assoian RK (1996) Adhesion dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-edk2, and phosphorylation of the retinoblastoma protein. J Cell Biol 133: 391-403