Abnormal expression of CCND1 and RB1 in resection margin epithelia of lung cancer patients

British Journal of Cancer

Volumn 75, Issue 12, 1997, Pages 1761-1768

  Betticher, D C ^a,b   Heighway, J ^a   Thatcher, N ^a   Hasleton, P S ^c  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BERN   (Switzerland)

^c WYTHENSHAWE HOSPITAL   (United Kingdom)

Author keywords

Carcinogenesis; Carcinoma in situ; CCND1; Cyclin D1; Non small cell lung cancer; RB1; Retinoblastoma protein

Indexed keywords

CYCLIN D1; RETINOBLASTOMA PROTEIN;

ADULT; AGED; ARTICLE; BRONCHUS MUCOSA; CANCER SURGERY; CARCINOMA IN SITU; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; LUNG CANCER; LUNG NON SMALL CELL CANCER; MALE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0030969154     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.300     Document Type: Article

References (54)

1. Arber N, Gammon M, Hibshoosh H, Lightdale C, Britton J, Zhang Y, Neugut A, Heitjan D, Yap E, Rotterdam H, Holt P and Weistein IB (1996) Increased expression of cyclin D1 is an early event in esophageal and gastric tumors. Proc Am Assoc Cancer Res 37: 8 (A55)
2. Auerbach O, Stout AP, Hammond C and Garfinkel L (1961) Changes in bronchial epithelium in relation to cigarette smoking and in relation to lung cancer. N Engl J Med 265: 255-267
3. Auerbach O, Stout AP, Hammond C and Garfinkel L (1962a) Bronchial epithelium in former smokers. N Engl J Med 267: 119-125
4. Auerbach O, Stout AP, Hammond C and Garfinkel L (1962b) Changes in bronchial epithelium in relation to sex, age, residence, smoking and pneumonia. N Engl J Med 267: 111-119
5. Auerbach O, Garfinkel L and Parks VR (1975) Histologic type of lung cancer in relation to smoking habits, year of diagnosis and sites of metastases. Chest 67: 382-387
6. Banno S, Yoshikawa K, Nakamura S, Yamamoto K, Seito T, Nitta M, Takahashi T, Ueda R and Seto M (1994) Monoclonal antibody against PRAD1/cyclin D1 stains nuclei of tumor cells with translocation or amplification at BCL-1 locus. Jpn J Cancer Res 85: 918-926
7. Bartek J, Vojtesek B, Grand RJA, Gallimore PH and Lane DP (1992) Cellular localization and T antigen binding of the retinoblastoma protein. Oncogene 7: 101-108
8. Bartkova J, Lukas J, Strauss M and Bartek J (1994a) The PRAD-1/Cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas. Int J Cancer 58: 568-573
9. Bartkova J, Lukas J, Müller H, Lützhoft D, Strauss M and Bartek J (1994b) Cyclin D1 protein expression and function in human breast cancer. Int J Cancer 57: 353-361
10. Bartkova J, Lukas J, Strauss M and Bartek J (1994c) Cell cycle-related variation and tissue-restricted expression of human cyclin D1 protein. J Pathol 172: 237-245
11. Bartkova J, Lukas J, Strauss M and Bartek J (1995) Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene 10: 775-778
12. Betticher DC, Thatcher N, Altermatt HJ, Hoban P, Ryder WDJ and Heighway J (1995) Alternate splicing produces a novel cyclin D1 transcript. Oncogene 11: 1005-1011
13. Betticher DC, Heighway J, Hasleton PS, Altermatt HJ, Ryder WDJ, Cerny T and Thatcher N (1996) Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small cell lung cancer. Br J Cancer 73: 294-300
14. Bringuier PP, Tamimi Y, Schuuring E and Schalken J (1996) Expression of cyclin D1 and EMS1 in bladder tumours: relationship with chromosome 11q13 amplification. Oncogene 12: 1747-1753
15. Carbone DP and Minna JD (1992) The molecular genetics of lung cancer. Adv Int Med 37: 153-171
16. Chiba I, Takahashi T, Nau M, D'Amico D, Curiel DT, Mitsudomi T, Buchhagen DL, Carbone D, Piantadosi S, Koga H, Reissman PT, Slamon DJ, Homes EC and Minna JD (1990) Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Oncogene 5: 1603-1610
17. Cordon-Cardo C and Richon VM (1994) Expression of the retinoblastoma protein is regulated in normal human tissues. Am J Pathol 144: 500-510
18. Geradts J, Hu SX, Lincoln CE, Benedict WF and Xu HJ (1994) Aberrant RB gene expression in routinely processed archival tumor tissues determined by three different anti-RB antibodies. Int J Cancer 58: 161-167
19. Gillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C, Barnes D and Peters G (1994) Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res 54: 1812-1817
20. Gillett C, Smith P, Gregory W, Richards M, Millis R, Peters G and Barnes D (1996) Cyclin D1 and prognosis in human breast cancer. Int J Cancer 69: 92-99
21. Heighway J (1991) Hae III polymorphism within the 3′ untranslated region of PRAD1. Nucleic Acids Res 19: 5451
22. Higashiyama M, Doi O, Kodama K, Yokuchi H and Tateishi R (1994) Retinoblastoma protein expression in lung cancer: an immunohistochemical analysis. Oncology 51: 544-551
23. Hirama T and Koeffler HP (1995) Role of the cyclin-dependent kinase inhibitors in the development of cancer. Blood 86: 841-854
24. Izzo J, Papadimitrakopoulou V, Lee JS, Ro JY, Li XQ, Hong WK and Hittelman WN (1996) Role of cyclin D1 (CCND1) in the multistep tumorigenesis process of head and neck squamous cell carcinomas (HNSCC). Proc Am Assoc Cancer Res 37: 539(A3687)
25. Jiang W, Zhang YJ, Kahn SM, Hollstein MC, Santella RM, Lu SH, Harris CC, Montesano R and Weinstein IB (1993) Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc Natl Acad Sci USA 90: 9026-9030
26. Kishimoto Y, Sugio K, Hung JY, Virmani AK, McIntire DD, Minna JD and Gazdar AF (1995) Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers. J Natl Cancer Inst 87: 1224-1229
27. Kuroda H, Komatsu H, Nakamura S, Niitsu Y, Takahashi T, Ueda R and Seto M (1995) The positive nuclear staining observed with monoclonal antibody against PRAD1/Cyclin D1 correlates with mRNA expression in mantle cell lymphoma. Jpn J Cancer Res 86: 890-898
28. Kurzrock R, Ku S and Talpaz M (1995) Abnormalities in the Prad1 (Cyclin D1/BCL-1) oncogene are frequent in cervical and vulvar squamous cell carcinoma cell lines. Cancer 75: 584-590
29. Lukas J, Pagano M, Staskova Z, Draetta G and Bartek J (1994) Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene 9: 707-718
30. McDowell EM and Beals TF (1986) Hyperplasia, metaplasia and carcinoma in situ. In Biopsy Pathology of the Bronchi. pp. 264-307. Chapman and Ha ll: London
31. Michalides R, Van Veelen N, Hart A, Loftus B, Wientjens E and Balm A (1995) Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squamous cell carcinomas of the head and neck. Cancer Res 55: 975-978
32. Naitoh H, Shibata J, Kawaguchi A, Kodama M and Hattori T (1995) Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer. Am J Pathol 146: 1161-1169
33. Nakagawa H, Zukerberg L, Togawa K, Meltzer SJ, Nishihara T and Rustgi AK (1995) Human cyclin D1 oncogene in esophageal squamous cell carcinomas. Cancer 76: 541-549
34. Nakamura S, Seto M, Banno S, Suzuki S, Koshikawa T, Kitoh K, Kagami Y, Ogura M, Yatabe Y, Kojima M, Mutoori T, Takahashi T, Uead R and Suchi T (1994) Immunohistochemical analysis of cyclin D1 protein in hematopoietic neoplasms with special reference to mantle cell lymphoma. Jpn J Cancer Res 85: 1270-1279
35. Nishida N, Fukuda Y, Komeda T, Kita R, Sando T, Furukawa M, Amenomori M, Shibagaki I, Nakao K, Ikenaga M and Ishizaki K (1994) Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res 54: 3107-3110
36. Pelosio P, Barbareschi M, Bonoldi E, Marchetti A, Verderio P, Caffo O, Bevilacqua P, Boracchi P, Buttitta F, Barbazza R, Dalla Palma P and Gasparini G (1996) Clinical significance of cyclin D1 expression in patients with node-positive breast carcinoma treated with adjuvant therapy. Ann Oncol 7: 695-703
37. Reissmann PT, Koga H, Takahashi R, Figlin RA, Homes EC, Piantadois S, Cordon-Cardo C and Slamon DJ (1993) Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. Oncogene 8: 1913-1919
38. Robles AI and Conti CJ (1995) Early overexpression of cyclin D1 protein in mouse skin carcinogenesis. Carcinogenesis 16: 781-786
39. Rodenhuis S, Van De Wetering ML, Mooi WJ, Evers SG, Van Zandwijk N and Bos JL (1987) Mutational activation of the K-RAS oncogene. A possible pathogenetic factor in adenocarcinoma of the lung. N Engl J Med 317: 929-935
40. Saccomanno G, Archer VE, Auerbach O, Saunders RP and Brennan LM (1974) Development of carcinoma of the lung as reflected in exfoliated cells. Cancer 33: 256-270
41. Schauer IE, Siriwardana S, Langan TA and Sclafani RA (1994) Cyclin D1 overexpression vs. retinoblastoma inactivation: implications for growth control evasion in non-small cell and small cell lung cancer. Proc Natl Acad Sci USA 91: 7827-7831
42. Shapiro GI, Edwards CD, Kobzik L, Godleski J, Richards W, Sugarbaker DJ and Rollins BJ (1995) Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. Cancer Res 55: 505-509
43. Sidransky D (1995) Importance of chromosome 9p loss in human lung cancer. J Natl Cancer Inst 87: 1201-1202
44. Swerdlow SH, Yang WI, Zukerberg LR, Harris NL, Arnold A and Williams ME (1995) Expression of cyclin D1 protein in centrocytic/mantle cell lymphomas with and without rearrangements of the BCL1/cyclin D1 gene. Hum Pathol 26: 999-1004
45. Thiberville L, Payne P, Vieklinds J, Leriche J, Horsman D, Nouvet G, Palcic B and Lam S (1995) Evidence of cumulative gene losses with progression of premalignant epithelial lesions to carcinoma of the bronchus. Cancer Res 55: 5133-5139
46. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, Nakamura Y, White R, Smits AMM and Bos JL (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319: 525-532
47. Weinstat-Saslow D, Merino MJ, Manrow RE, Lawrence JA, Bluth RE, Wittenbel KD, Simpson JF, Page DL and Steeg PS (1995) Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Nature Med 1: 1257-1260
48. WHO (1981) Histological Typing of Lung Tumours, 2nd edn. World Health Organization: Geneva
49. Xu HJ, Hu SX, Cagle PT, Moore GE and Benedict WF (1991) Absence of retinoblastoma protein expression in primary non-small cell lung carcinoma. Cancer Res 51: 2735-2739
50. Xu HJ, Quinlan DC, Davidson AG, Hu SX, Summers CL, Li J and Benedict WF (1994) Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma. J Natl Cancer Inst 86: 695-699
51. Xu HJ (1995) Altered retinoblastoma (Rb) protein expression in human malignancies. Adv Anat Pathol 2: 213-226
52. Zhang SY, Caamano J, Cooper F, Guo X and Klein-Szanto AJP (1994) Immunohistochemistry of cyclin D1 in human breast cancer. Am J Clin Pathol 102: 695-698
53. Zhang T, Nanney L, Ko TC, Luongo C, Dubois RN and Beauchamp RD (1996) Overexpression of cyclin D1 in intestinal polyposis in Min mice and human familial adenomatous polyposis subjects. Proc Am Assoc Cancer Res 37: 112 (A775)
54. Zhang YJ, Jiang W, Chien CJ, Lee CS, Kahn SM, Santella RM and Weinstein IB (1993) Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma. Biochem Biophys Res Commun 196: 1010-1016