Cloning and functional analysis of human p51, which structurally and functionally resembles p53

Nature Medicine

Volumn 4, Issue 7, 1998, Pages 839-843

  Osada, Motonobu ^a   Ohba, Mai ^a   Kawahara, Chikashi ^a   Ishioka, Chikashi ^a   Kanamaru, Ryunosuke ^a   Katoh, Iyoko ^b   Ikawa, Yoji ^b   Nimura, Yoshinori ^c   Nakagawara, Akira ^c   Obinata, Masuo ^a   Ikawa, Shuntaro ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c CHIBA CANCER CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21; PROTEIN P53;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CARCINOGENESIS; EPIDERMOID TUMOR; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; MOLECULAR CLONING; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TISSUE SPECIFICITY; TUMOR SUPPRESSOR GENE;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CATS; CELL DIVISION; CHICKENS; CLONING, MOLECULAR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROMOTER REGIONS (GENETICS); SALMON; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0031852337     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0798-839     Document Type: Article

References (20)

1. Morgan, S.E. & Kastan, M.B. p53 and ATM: cell cycle, cell death, and cancer. Adv. Cancer Res. 71, 1-25 (1997).
2. Wang, X.W. & Harris, C.C. p53 tumor-suppressor gene: clues to molecular carcinogenesis. J. Cell. Physiol. 173, 247-255 (1997).
3. Kaghad, M. et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90, 809-819 (1997).
4. Jost, C.A., Marin, M.C. & Kaelin, W.G., Jr. p73 is a human p53-related protein that can induce apoptosis [see comments]. Nature 389, 191-194 (1997).
5. Hansen, R. & Oren, M. p53; from inductive signal to cellular effect. Curr. Opin. Gen. Develop. 7, 46-51 (1997).
6. Levine, A.J. p53, the cellular gatekeeper for growth and division. Cell 88, 323-331 (1997).
7. Sidle, A. et al. Activity of the retinoblastoma family proteins, pRB, p107, and p130, during cellular proliferation and differentiation. Crit. Rev. Biochem. Mol. Biol. 31, 237-271 (1996).
8. Oren, M. Lonely no more: p53 finds its kin in a tumor suppressor haven. Cell 90, 829-832 (1997).
9. Dickman, S. First p53 relative may be a new tumor suppressor [news]. Science 277, 1605-1606 (1997).
10. Schmale, H. & Bamberger, C. A novel protein with strong homology to the tumor suppressor p53. Oncogene 15, 1363-1367 (1997).
11. Xu, X. et al. A mouse erythroleukemia cell line possessing friend spleen focus-forming virus gp55 transgene and temperature-sensitive mutant p53 gene. Jpn. J. Cancer Res. 86, 284-291 (1995).
12. Pietenpol, J.A. et al. Sequence-specific transcriptional activation is essential for growth suppression by p53. Proceedings of the National Academyof Sciences of the United States of America 91, 1998-2002 (1994).
13. El Deiry, W. S. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825 (1993).
14. Canman, C.E. & Kastan, M.B. Role of p53 in apoptosis. Adv. Pharmacol. 41, 429-460 (1997).
15. Jia, L.Q. et al. Screening the p53 status of human cell lines using a yeast functional assay. Mol. Carcinog. 19, 243-253 (1997).
16. Kern, S.E. et al. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256, 827-830 (1992).
17. Chen, C. & Okayama, H. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7, 2745-2752 (1987).
18. Newell, M.K., Haughn, L.J., Maroun, C.R. & Julius, M.H. Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen. Nature 347, 286-289 (1990).
19. Frebourg, T. et al. A functional screen for germ line p53 mutations based on transcriptional activation. Cancer Res. 52, 6976-6978 (1992).
20. Takahashi, H. et al. Mutation, allelotying, and transciption analyses of p73 gene in prostatic carcinoma. Cancer Res. (in press).