Rb and p16(INK4a) expression in resected non-small cell lung tumors

Cancer Research

Volumn 56, Issue 15, 1996, Pages 3415-3420

  Kratzke, Robert A ^a,b   Greatens, Todd M ^b   Rubins, Jeffrey B ^b   Maddaus, Michael A ^b   Niewoehner, Dennis E ^b   Niehans, Gloria A ^b   Geradts, Joseph ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; PROTEIN KINASE INHIBITOR; RETINOBLASTOMA PROTEIN; CARRIER PROTEIN; PROTEIN P16INK4A;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CARCINOGENESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THORACOTOMY; ADENOCARCINOMA; BIOSYNTHESIS; CANCER STAGING; GENE EXPRESSION; LUNG TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS;

ADENOCARCINOMA; AGED; CARCINOMA, NON-SMALL-CELL LUNG; CARRIER PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE EXPRESSION; HUMANS; LUNG NEOPLASMS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RETINOBLASTOMA PROTEIN;

EID: 0029665043     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Parker, S. L., Tong, T., Bolden, S., and Wingo, P. A Cancer statistics, 1996. CA Cancer J. Clin., 46: 5-28, 1996.
2. Kratzke, R. A., Shimizu, E., and Kaye, F. J. Oncogenes in human lung cancer Cancer Treat. Res., 63: 61-85, 1992.
3. Rodenhuis, S., van de Wetering, M., Mooi, W., Wagenaar, S., Van Bodegom, P., and Bos, J. Mutational activation of the K-ras oncogene: A possible pathogenetic factor in adenocarcinoma of the lung. N. Engl. J. Med., 317: 929-935, 1987.
4. Yokota, J., Wada, M., Yoshida, T., Noguchi, M., Terasaki, T., Shimosato, Y., Sugimura, T., and Terada, M. Heterogeneity of lung cancer cells with respect to the amplification and rearrangement of myc family oncogenes. Oncogene, 2: 607-611, 1988.
5. Ihde, D. C., and Minna, J. D. Non-small cell lung cancer. Part I: biology, diagnosis, and staging. Curr. Probl. Cancer, 15: 61-104, 1991.
6. Otterson, G. A., Kratzke, R. A., Coxon, A., Kim, Y. W., and Kaye, F. J. Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retain wildtype RB. Oncogene, 9: 3375-3378, 1994.
7. Serrano, M., Hannon, G. J., and Beach, D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (Lond.), 366: 704-707, 1993.
8. 1 phase progression: cycling on cue. Cell, 79: 561-565, 1994.
9. Hinds, P. W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S. I., and Weinberg, R. A. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell, 70: 993-1006, 1992.
10. Dowdy, S. F., Hinds, P. W., Louie, K., Reed, S. I., Arnold, A., and Weinberg, R. A. Physical interaction of the retinoblastoma protein with human D cyclins Cell, 73: 499-511, 1993.
11. INK4a expression in primary lung cancers and cell lines Cancer Res., 55: 505-509, 1995.
12. Washimi, O., Nagatake, M., Osada, H., Ueda, R., Koshikawa, T., Seki, T., Takahashi, T., and Takahasi, T. In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small cell lung cancers. Cancer Res., 55: 514-517, 1995.
13. Sakaguchi, M., Fujii, Y., Hirabayashi, H., Yoon, H. E., Komoto, Y. Oue, T., Kusafuka, T., Okada, A., and Matsuda, H. Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: an immunohistochemical study. Int. J. Cancer, 65: 442-445, 1996.
14. Geradts, J., Kratzke, R. A., Crush-Stanton, S., Wen, S. F., and Lincoln, C. E. Wild-type and mutant retinoblastoma protein in paraffin sections. Mod. Pathol., 9: 339-347, 1996.
15. INK4A in archival human solid tumors: correlation with retinoblastoma protein expression. Cancer Res., 55: 6006-6011, 1995.
16. Kratzke, R., Otterson, G. A., Lincoln, C. E., Ewing, S., Oie, H., Geradts, J., and Kaye, F. J. Immunohistochemical analysis of the p16INK4 cyclin dependent kinase inhibitor in malignant mesothelioma. J. Natl. Cancer Inst., 87: 1870-1875, 1995.
17. Xu, H., Quinlan, D. C., Davidson, A. G., Hu, S. X., Summers, C. L., Li, J., and Benedict, W. F. Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung cancer. J. Natl. Cancer Inst., 86: 695-699, 1994.
18. Shimizu, E., Coxon, A., Otterson, G. A., Steinberg, S. M., Kratzke, R. A., Kim, Y. W., Fedorko, J., Oie, H., Johnson, B. E., Mulshine, J. L., Minna, J. D., Gazdar, A. F., and Kaye, F. J. RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. Oncogene, 9: 2441-2448, 1994.
19. Nakagawa, K., Conrad, N. K., Williams, J. P., Johnson, B. E., and Kelley, M. J. Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. Oncogene, 11: 1843-1851, 1995.
20. Xu, H. J., Hu, S. X., Cagle, P. T., Moore, G. E., and Benedict, W. F. Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas. Cancer Res., 51: 2735-2739, 1991.
21. Kishimoto, Y., Sugio, K., Hung, J. Y., Virmani, A. K., McIntire, D. D., Minna, J. D., and Gazdar, A. F. Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers. J. Natl. Cancer Inst., 87: 1224-1229, 1995.
22. Wolfel, T., Hauer, M., Schneider, J., Serrano, M., Wolfel, C., Klehmann, H. E., De, P. E., Hankeln, T., Meyer zum Buschenfelde, K., and Beach, D. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science (Washington DC), 269: 1281-1284, 1995.
23. Betticher, D. C., Heighway, J., Hasleton, P. S., Altermatt, H. J., Ryder, W. D., Cerny, T., and Thatcher, N. Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer. Br. J. Cancer, 73: 294-300, 1996.
24. Roth, J., Fossella, F., Kornaki, R., Ryan, M. B., Putnam, J. B., Jr., Lee, J. S., Dhingra, H., De Caro, L., Chasen, M., McGavran, M., Atkinson, E. N., and Hong, W. K. A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage III non-small cell lung cancer. J. Natl. Cancer Inst., 86: 673-680, 1994.
25. Rosell, R., Gomez, C. J., Camps, C., Maestre, J., Padille, J., Canto, A., Mate, J. L., Li, S., Roig, J., Olazabal, A. Canela, M., Ariza, A., Skacel, Z., Morera-Prat, J., and Abad, A. A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. N Engl. J. Med., 330: 153-158, 1994.
26. Rosell, R., Li, S., Skacel, Z., Mate, J. L., Maestre, J., Canela, M., Tolosa, E., Armengol, P., Barnadas, A., and Ariza, A. Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients Oncogene, 8: 2407-2412, 1993.