메뉴 건너뛰기




Volumn 69, Issue , 1998, Pages 309-352

Accessibility control of V(D)J recombination: Lessons from gene targeting

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ANTIGEN RECOGNITION; ENHANCER REGION; GENE CONTROL; GENE REARRANGEMENT; GENE STRUCTURE; GENE TARGETING; GENETIC RECOMBINATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REVIEW;

EID: 0031866349     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review
Times cited : (44)

References (182)
  • 1
    • 0030887862 scopus 로고    scopus 로고
    • RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
    • Agrawal, A., and Schatz, D. G. (1997). RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell (Cambridge, Mass.) 89, 43-53.
    • (1997) Cell (Cambridge, Mass.) , vol.89 , pp. 43-53
    • Agrawal, A.1    Schatz, D.G.2
  • 3
    • 0023513107 scopus 로고
    • Development of the primary antibody repertoire
    • Alt, F. W., Blackwell, T., and Yancopoulos, G. D. (1987). Development of the primary antibody repertoire. Science 238, 1079-1087.
    • (1987) Science , vol.238 , pp. 1079-1087
    • Alt, F.W.1    Blackwell, T.2    Yancopoulos, G.D.3
  • 5
    • 0029095840 scopus 로고
    • V(D)J recombination and allelic exclusion of a TCR /3-chain minilocus occurs in the absence of a functional promoter
    • Alvarez, J. D., Anderson, S. J., and Loh, D. Y. (1995). V(D)J recombination and allelic exclusion of a TCR /3-chain minilocus occurs in the absence of a functional promoter. J. Immunol. 155, 1191-1202.
    • (1995) J. Immunol. , vol.155 , pp. 1191-1202
    • Alvarez, J.D.1    Anderson, S.J.2    Loh, D.Y.3
  • 6
    • 0027466448 scopus 로고
    • Immunoglobulin heavy chain enhancer is located near or in an initiation zone of chromosomal DNA replication
    • Ariizumi, K., Wang, Z., and Tucker, P. W. (1993). Immunoglobulin heavy chain enhancer is located near or in an initiation zone of chromosomal DNA replication. Proc. Natl. Acad. Sci. U.S.A. 90, 3695-3699.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 3695-3699
    • Ariizumi, K.1    Wang, Z.2    Tucker, P.W.3
  • 7
    • 0027316203 scopus 로고
    • Site-directed point mutations in embryonic stem cells: A gene-targetting Tag-and exchange strategy
    • Askew, G. R., Doetschman, T., and Lingrel, J. (1993). Site-directed point mutations in embryonic stem cells: A gene-targetting Tag-and exchange strategy. Mol. Cell. Biol. 13, 4115-4124.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4115-4124
    • Askew, G.R.1    Doetschman, T.2    Lingrel, J.3
  • 9
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin Κ gene: Critical role for the intron enhancer /matrix attachment region
    • Betz, A. G., Milstein, C., Gonzales-Fernadez, A., Pannell, R., Larson, T., and Neuberger, M. S. (1994). Elements regulating somatic hypermutation of an immunoglobulin Κ gene: critical role for the intron enhancer /matrix attachment region. Cell (Cambridge, Mass.) 77, 239-248.
    • (1994) Cell (Cambridge, Mass.) , vol.77 , pp. 239-248
    • Betz, A.G.1    Milstein, C.2    Gonzales-Fernadez, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 10
    • 0026653420 scopus 로고
    • The essentials of DNA methylation
    • Bird, A. (1992). The essentials of DNA methylation. Cell (Cambridge, Mass.) 70, 5-8.
    • (1992) Cell (Cambridge, Mass.) , vol.70 , pp. 5-8
    • Bird, A.1
  • 11
    • 0022385704 scopus 로고
    • Specific 5' and 3' regions of the μ-chain gene are undermethylated at distinct stages of B-cell differentiation
    • Blackman, M. A., and Koshland, M. E. (1985). Specific 5' and 3' regions of the μ-chain gene are undermethylated at distinct stages of B-cell differentiation. Proc. Natl. Acad. Sci. U.S.A. 82, 3809-3813.
    • (1985) Proc. Natl. Acad. Sci. U.S.A. , vol.82 , pp. 3809-3813
    • Blackman, M.A.1    Koshland, M.E.2
  • 12
    • 0029886929 scopus 로고    scopus 로고
    • Mechanism of V(D)J recombination
    • Bogue, M., and Roth, D. B. (1996). Mechanism of V(D)J recombination. Curr. Biol. 8, 175-180.
    • (1996) Curr. Biol. , vol.8 , pp. 175-180
    • Bogue, M.1    Roth, D.B.2
  • 13
    • 0030837472 scopus 로고    scopus 로고
    • V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formation
    • Bogue, M. A., Wang, C., Zhu, C., and Roth, D. B. (1997). V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formation. Immunity 7, 37-47.
    • (1997) Immunity , vol.7 , pp. 37-47
    • Bogue, M.A.1    Wang, C.2    Zhu, C.3    Roth, D.B.4
  • 14
    • 0029819322 scopus 로고    scopus 로고
    • Gene-targeted deletion and replacement mutations of the T-cell receptor β-chain enhancer: The role of enhancer elements in controlling V(D)J recombinational accessibility
    • Bories, J. C, Demengeot, J., Davidson, L., and Alt, F. W. (1996). Gene-targeted deletion and replacement mutations of the T-cell receptor β-chain enhancer: The role of enhancer elements in controlling V(D)J recombinational accessibility. Proc. Natl. Acad. Sci. U.S.A. 93, 7871-7876.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 7871-7876
    • Bories, J.C.1    Demengeot, J.2    Davidson, L.3    Alt, F.W.4
  • 15
    • 0023886164 scopus 로고
    • Rearrangement of IgH genes in normal thymocyte development
    • Born, W., White, J., Kappler, J., and Marrack, P. (1988). Rearrangement of IgH genes in normal thymocyte development. J. Immunol. 140, 3228-3232.
    • (1988) J. Immunol. , vol.140 , pp. 3228-3232
    • Born, W.1    White, J.2    Kappler, J.3    Marrack, P.4
  • 17
    • 0025187182 scopus 로고
    • Protective methylation of immunoglobulin and T cell receptor (TcR) gene loci prior to induction of class switch and TcR recombination
    • Burger, C., and Radbruch, A. (1990). Protective methylation of immunoglobulin and T cell receptor (TcR) gene loci prior to induction of class switch and TcR recombination. Eur. J. Immunol. 20, 2285-2291.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 2285-2291
    • Burger, C.1    Radbruch, A.2
  • 18
    • 0343812092 scopus 로고    scopus 로고
    • IL-7 receptor and VDJ recombination: Trophic versus mechanistic actions
    • Candéias, S., Muegge, K., and Durum, S. K. (1997a). IL-7 receptor and VDJ recombination: Trophic versus mechanistic actions. Immunity 6, 501-508.
    • (1997) Immunity , vol.6 , pp. 501-508
    • Candéias, S.1    Muegge, K.2    Durum, S.K.3
  • 19
    • 0030877757 scopus 로고    scopus 로고
    • Defective T-cell receptor γ gene rearrangement in interleukin-7 receptor knockout mice
    • Candéias, S., Peschon, J. J., Muegge, K., and Durum, S. K. (1997b). Defective T-cell receptor γ gene rearrangement in interleukin-7 receptor knockout mice. Immunol. Lett. 57, 9-14.
    • (1997) Immunol. Lett. , vol.57 , pp. 9-14
    • Candéias, S.1    Peschon, J.J.2    Muegge, K.3    Durum, S.K.4
  • 20
    • 0024328536 scopus 로고
    • Altering the genome by homologous recombination
    • Capecchi, M. R. (1989). Altering the genome by homologous recombination. Science 244, 1288-1292.
    • (1989) Science , vol.244 , pp. 1288-1292
    • Capecchi, M.R.1
  • 21
    • 0027508340 scopus 로고
    • TCRβ and TCRα gene enhancers confer tissue- And stage-specificity on V(D)J recombination events
    • Capone, M., Watrin, F., Femex, C., Horvat, B., Krippl, B., Scollay, R., and Ferrier, P. (1993). TCRβ and TCRα gene enhancers confer tissue- and stage-specificity on V(D)J recombination events. EMBO J. 12, 4335-4346.
    • (1993) EMBO J , vol.12 , pp. 4335-4346
    • Capone, M.1    Watrin, F.2    Femex, C.3    Horvat, B.4    Krippl, B.5    Scollay, R.6    Ferrier, P.7
  • 23
    • 0027215522 scopus 로고
    • RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development
    • Chen, J., Lansford, R., Stewart, V., Young, F., and Alt, F. W. (1993a). RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development. Proc. Natl. Acad. Sci. U.S.A. 90, 4528-4532.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 4528-4532
    • Chen, J.1    Lansford, R.2    Stewart, V.3    Young, F.4    Alt, F.W.5
  • 25
    • 0029954710 scopus 로고    scopus 로고
    • Transcriptional control of lymphoid development: Lessons from gene targeting
    • Clevers, H. C, and Grosschedl, R. (1996). Transcriptional control of lymphoid development: Lessons from gene targeting. Immunol. Today 17, 336-343.
    • (1996) Immunol. Today , vol.17 , pp. 336-343
    • Clevers, H.C.1    Grosschedl, R.2
  • 28
    • 0031214080 scopus 로고    scopus 로고
    • Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
    • Critchlow, S. E., Bowater, R. P., and Jackson, S. P. (1997). Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr. Biol. 7, 588-598.
    • (1997) Curr. Biol. , vol.7 , pp. 588-598
    • Critchlow, S.E.1    Bowater, R.P.2    Jackson, S.P.3
  • 29
    • 0028307661 scopus 로고
    • Analysis of regions of RAG-2 important for V(D)J recombination
    • Cuomo, C. A., and Oettinger, M. A. (1994). Analysis of regions of RAG-2 important for V(D)J recombination. Nucleic Acids Res. 22, 1810-1814.
    • (1994) Nucleic Acids Res , vol.22 , pp. 1810-1814
    • Cuomo, C.A.1    Oettinger, M.A.2
  • 30
    • 0029814965 scopus 로고    scopus 로고
    • DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences
    • Cuomo, C. A., Mundy, C. L., and Oettinger, M. A. (1996). DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences. Mol. Cell. Biol. 16, 5683-5690.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5683-5690
    • Cuomo, C.A.1    Mundy, C.L.2    Oettinger, M.A.3
  • 31
    • 0029791450 scopus 로고    scopus 로고
    • Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes
    • Danska, J. S., Holland, D. P., Mariathasan, S., Williams, K. M., and Guidos, C. J. (1996). Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes. Mol. Cell. Biol. 16, 5507-5517.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5507-5517
    • Danska, J.S.1    Holland, D.P.2    Mariathasan, S.3    Williams, K.M.4    Guidos, C.J.5
  • 33
    • 0027262971 scopus 로고
    • Functional characterization of the promoter for the human germ-line T cell receptor J alpha (TEA) transcript
    • de Chasseval, R., and De Villartay, J. P. (1993). Functional characterization of the promoter for the human germ-line T cell receptor J alpha (TEA) transcript. Eur. J. Immunol. 23, 1294-1298.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1294-1298
    • de Chasseval, R.1    de Villartay, J.P.2
  • 34
    • 0029584058 scopus 로고
    • Promotion of V(D)J recombinational accessibility by the intronic Eκ element: Role of the ΚB motif
    • Demengeot, J., Oltz, E. M., and Alt, F. W. (1995). Promotion of V(D)J recombinational accessibility by the intronic Eκ element: Role of the ΚB motif. Int. Immunol. 7, 1995-2003.
    • (1995) Int. Immunol. , vol.7 , pp. 1995-2003
    • Demengeot, J.1    Oltz, E.M.2    Alt, F.W.3
  • 36
    • 0028446580 scopus 로고
    • A locus control region in the T cell receptor α/δ locus
    • Diaz, P., Cado, D., and Winoto, A. (1994). A locus control region in the T cell receptor α/δ locus. Immunity 1, 207-217.
    • (1994) Immunity , vol.1 , pp. 207-217
    • Diaz, P.1    Cado, D.2    Winoto, A.3
  • 38
    • 0029864993 scopus 로고    scopus 로고
    • Initiation of V(D)J recombination in vitro obeying the 12/23 rule
    • Eastman, Q. M., Leu, T. M. J., and Schatz, D. G. (1996). Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature (London) 380, 85-88.
    • (1996) Nature (London) , vol.380 , pp. 85-88
    • Eastman, Q.M.1    Leu, T.M.J.2    Schatz, D.G.3
  • 39
    • 0027476466 scopus 로고
    • Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development
    • Ehlich, A., Schaal, S., Gu, H., Kitamura, D., and Rajewsky, K. (1993). Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell (Cambridge, Mass.) 72, 695-704.
    • (1993) Cell (Cambridge, Mass.) , vol.72 , pp. 695-704
    • Ehlich, A.1    Schaal, S.2    Gu, H.3    Kitamura, D.4    Rajewsky, K.5
  • 40
    • 0027396509 scopus 로고
    • Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate
    • Engler, P., Weng, A., and Storb, U. (1993). Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate. Mol. Cell. Biol. 13, 571-577.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 571-577
    • Engler, P.1    Weng, A.2    Storb, U.3
  • 41
    • 0028903049 scopus 로고
    • Combinatorial regulation of transcription I: General aspects of transcriptional control
    • Ernst, P., and Smale, S. T. (1995a). Combinatorial regulation of transcription I: General aspects of transcriptional control. Immunity 2, 311-319.
    • (1995) Immunity , vol.2 , pp. 311-319
    • Ernst, P.1    Smale, S.T.2
  • 42
    • 0029020682 scopus 로고
    • Combinatorial regulation of transcription II: The immunoglobulin μ heavy chain gene
    • Ernst, P., and Smale, S. T. (1995b). Combinatorial regulation of transcription II: The immunoglobulin μ heavy chain gene. Immunity 2, 427-438.
    • (1995) Immunity , vol.2 , pp. 427-438
    • Ernst, P.1    Smale, S.T.2
  • 43
    • 0028956147 scopus 로고
    • Assymetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination
    • Ezekiel, U. R., Engler, P., Stern, D., and Storb, U. (1995). Assymetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination. Immunity 2, 381-389.
    • (1995) Immunity , vol.2 , pp. 381-389
    • Ezekiel, U.R.1    Engler, P.2    Stern, D.3    Storb, U.4
  • 44
    • 0030984706 scopus 로고    scopus 로고
    • The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences
    • Ezekiel, U. R., Sun, T., Bozek, G., and Storb, U. (1997). The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences. Mol. Cell Biol. 17, 4191-4197.
    • (1997) Mol. Cell Biol. , vol.17 , pp. 4191-4197
    • Ezekiel, U.R.1    Sun, T.2    Bozek, G.3    Storb, U.4
  • 45
    • 0029030481 scopus 로고
    • The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate
    • Fernex, C., Capone, M., and Ferrier, P. (1995). The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate. Mol. Cell. Biol. 15, 3217-3226.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3217-3226
    • Fernex, C.1    Capone, M.2    Ferrier, P.3
  • 46
    • 0029983577 scopus 로고    scopus 로고
    • Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster
    • Ferradini, L., Gu, H., De Smet, A., Rajewsky, K., Reynaud, C. A., and Weill, J. C. (1996). Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster. Science 271, 1416-1420.
    • (1996) Science , vol.271 , pp. 1416-1420
    • Ferradini, L.1    Gu, H.2    de Smet, A.3    Rajewsky, K.4    Reynaud, C.A.5    Weill, J.C.6
  • 47
    • 0024433760 scopus 로고
    • T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line
    • Ferrier, P., Covey, L. R., Suh, H., Winoto, A., Hood, L., and Alt, F. W. (1989a). T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line. Int. Immunol. 1, 66-74.
    • (1989) Int. Immunol. , vol.1 , pp. 66-74
    • Ferrier, P.1    Covey, L.R.2    Suh, H.3    Winoto, A.4    Hood, L.5    Alt, F.W.6
  • 50
    • 0029091902 scopus 로고
    • Targeted deletion of 5'HS2 of the murine β-globin LCR reveals that it is not essential for proper regulation of the β-globin locus
    • Fiering, S., Epner, E., Robinson, K., Zhuang, Y., Telling, A., Hu, M., Martin, D. I. K., Enver, T., Ley, T. T., and Groudine, M. (1995). Targeted deletion of 5'HS2 of the murine β-globin LCR reveals that it is not essential for proper regulation of the β-globin locus. Genes Dev. 9, 2203-2213.
    • (1995) Genes Dev , vol.9 , pp. 2203-2213
    • Fiering, S.1    Epner, E.2    Robinson, K.3    Zhuang, Y.4    Telling, A.5    Hu, M.6    Martin, D.I.K.7    Enver, T.8    Ley, T.T.9    Groudine, M.10
  • 51
    • 0026504462 scopus 로고
    • Transcription of germ line Vα segments correlates with ongoing T-cell receptor α-chain rearrangement
    • Fondell, J. D., and Marcu, K. B. (1992). Transcription of germ line Vα segments correlates with ongoing T-cell receptor α-chain rearrangement. Mol. Cell. Biol. 12, 1480-1489.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 1480-1489
    • Fondell, J.D.1    Marcu, K.B.2
  • 52
    • 0030966099 scopus 로고    scopus 로고
    • Recent advances in understanding V(D)J recombination
    • Gellert, M. (1997). Recent advances in understanding V(D)J recombination. Adv. Immunol. 64, 39-64.
    • (1997) Adv. Immunol. , vol.64 , pp. 39-64
    • Gellert, M.1
  • 53
    • 0030993348 scopus 로고    scopus 로고
    • Transcription factors required for lymphoid lineage commitment
    • Georgopoulos, K. (1997). Transcription factors required for lymphoid lineage commitment. Curr. Opin. Immunol. 9, 222-227.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 222-227
    • Georgopoulos, K.1
  • 54
    • 0027237601 scopus 로고
    • Coding end sequence can markedly affect the initiation of V(D)J recombination
    • Gerstein, R. M., and Lieber, M. R. (1993). Coding end sequence can markedly affect the initiation of V(D)J recombination. Genes Dev. 7, 1459-1469.
    • (1993) Genes Dev , vol.7 , pp. 1459-1469
    • Gerstein, R.M.1    Lieber, M.R.2
  • 55
    • 0027452074 scopus 로고
    • Mice lacking TdT: Mature animals with an immature lymphocyte repertoire
    • Gilfillan, S., Dierich, A., Lemeur, M., Benoist, C., and Mathis, D. (1993). Mice lacking TdT: Mature animals with an immature lymphocyte repertoire. Science 261, 1175-1178.
    • (1993) Science , vol.261 , pp. 1175-1178
    • Gilfillan, S.1    Dierich, A.2    Lemeur, M.3    Benoist, C.4    Mathis, D.5
  • 57
    • 0026093419 scopus 로고
    • A transcriptional enhancer of the mouse T cell receptor δ gene locus
    • Gill, L. L., Zaninetta, D., and Karjalainen, K. (1991). A transcriptional enhancer of the mouse T cell receptor δ gene locus, Eur. J. Immunol. 21, 807-810.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 807-810
    • Gill, L.L.1    Zaninetta, D.2    Karjalainen, K.3
  • 58
    • 0027400624 scopus 로고
    • Ordered rearrangement of variable region genes of the T cell receptor γ locus correlates with transcription of the unrearranged genes
    • Goldman, J. P., Spencer, D. M., and Raulet, D. H. (1993). Ordered rearrangement of variable region genes of the T cell receptor γ locus correlates with transcription of the unrearranged genes. J. Exp. Med. 177, 729-739.
    • (1993) J. Exp. Med. , vol.177 , pp. 729-739
    • Goldman, J.P.1    Spencer, D.M.2    Raulet, D.H.3
  • 59
    • 0024472824 scopus 로고
    • Immunoglobulin Κ light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement
    • Goodhardt, M., Babinet, C., Lutfalla, G., Kallenbach, S., Cavelier, P., and Rougeon, F. (1989). Immunoglobulin Κ light chain gene promoter and enhancer are not responsible for B-cell restricted gene rearrangement. Nucleic Acids Res. 17, 7403-7415.
    • (1989) Nucleic Acids Res , vol.17 , pp. 7403-7415
    • Goodhardt, M.1    Babinet, C.2    Lutfalla, G.3    Kallenbach, S.4    Cavelier, P.5    Rougeon, F.6
  • 60
    • 0027301927 scopus 로고
    • Methylation status of immunoglobulin K gene segments correlates with their recombination potential
    • Goodhardt, M., Cavelier, P., Doyen, N., Kallenbach, S.,, Babinet, C., and Rougeon, F. (1993). Methylation status of immunoglobulin K gene segments correlates with their recombination potential. Eur. J. Immunol. 23, 1789-1795.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1789-1795
    • Goodhardt, M.1    Cavelier, P.2    Doyen, N.3    Kallenbach, S.4    Babinet, C.5    Rougeon, F.6
  • 61
    • 0030222767 scopus 로고    scopus 로고
    • The Igκ 3' enhancer influences the ratio of Igκ versus Igλ B lymphocytes
    • Gorman, J. R., van der Stoep, N., Monroe, R., Cogné, M., Davidson, L., and Alt, F. W. (1996). The Igκ 3' enhancer influences the ratio of Igκ versus Igλ B lymphocytes. Immunity 5, 241-252.
    • (1996) Immunity , vol.5 , pp. 241-252
    • Gorman, J.R.1    van der Stoep, N.2    Monroe, R.3    Cogné, M.4    Davidson, L.5    Alt, F.W.6
  • 63
    • 0030795764 scopus 로고    scopus 로고
    • A complex of RAG-1 and RAG-2 proteins persists on DNA after single-strand cleavage at V(D)J recombination signal sequences
    • Grawunder, U., and Lieber, M. R. (1997). A complex of RAG-1 and RAG-2 proteins persists on DNA after single-strand cleavage at V(D)J recombination signal sequences. Nucleic Acids Res. 25, 1375-1382.
    • (1997) Nucleic Acids Res , vol.25 , pp. 1375-1382
    • Grawunder, U.1    Lieber, M.R.2
  • 64
    • 0030743386 scopus 로고    scopus 로고
    • Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
    • Grawunder, U., Wilm, M., Wu, X., Kulesza, P., Wilson, T. E., Mann, M., and Lieber, M. R. (1997). Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature (London) 388, 492-495.
    • (1997) Nature (London) , vol.388 , pp. 492-495
    • Grawunder, U.1    Wilm, M.2    Wu, X.3    Kulesza, P.4    Wilson, T.E.5    Mann, M.6    Lieber, M.R.7
  • 65
    • 0021714531 scopus 로고
    • Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody
    • Grosschedl, R., Weaver, D., Baltimore, D., and Costantini, F. (1984). Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody. Cell (Cambridge, Mass.) 38, 647-640.
    • (1984) Cell (Cambridge, Mass.) , vol.38 , pp. 647-1640
    • Grosschedl, R.1    Weaver, D.2    Baltimore, D.3    Costantini, F.4
  • 66
    • 0024397326 scopus 로고
    • T cell receptor β gene has two downstream DNase I hypersensitive r e g i o n s
    • Hashimoto, Y. (1989). T cell receptor β gene has two downstream DNase I hypersensitive r e g i o n s. J. Exp. Med. 169, 2097-2107.
    • (1989) J. Exp. Med. , vol.169 , pp. 2097-2107
    • Hashimoto, Y.1
  • 67
    • 0026429190 scopus 로고
    • Introduction of a subtle mutation in the Hox-2.6 locus in embryonic stem cells
    • Hasty, P. R., Ramirez-Solis, R., Krumlauf, R., and Bradley, A. (1991). Introduction of a subtle mutation in the Hox-2.6 locus in embryonic stem cells. Nature (London) 350, 243-246.
    • (1991) Nature (London) , vol.350 , pp. 243-246
    • Hasty, P.R.1    Ramirez-Solis, R.2    Krumlauf, R.3    Bradley, A.4
  • 68
    • 0030045374 scopus 로고    scopus 로고
    • Regulation of T cell receptor δ gene rearrangement by c-Myb
    • Hernández-Munain, C., Lauzurica, P., and Krangel, M. S. (1996). Regulation of T cell receptor δ gene rearrangement by c-Myb. J. Exp. Med. 183, 289-293.
    • (1996) J. Exp. Med. , vol.183 , pp. 289-293
    • Hernández-Munain, C.1    Lauzurica, P.2    Krangel, M.S.3
  • 69
    • 0029610034 scopus 로고
    • The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: A B cell-specific trans-activator that describes a new DNA-binding protein family
    • Herrscher, R. F., Kaplan, M. H., Lelsz, D. L., Das, C., Scheuermann, R., and Tucker, P. W. (1995). The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: A B cell-specific trans-activator that describes a new DNA-binding protein family. Genes Dev. 9, 3067-3082.
    • (1995) Genes Dev , vol.9 , pp. 3067-3082
    • Herrscher, R.F.1    Kaplan, M.H.2    Lelsz, D.L.3    Das, C.4    Scheuermann, R.5    Tucker, P.W.6
  • 70
    • 0024691453 scopus 로고
    • V(D)J recombination: A functional definition of the joining signals
    • Hesse, J. E., Lieber, M. R., Mizuuchi, K., and Gellert, M. (1989). V(D)J recombination: A functional definition of the joining signals. Genes Dev. 3, 1053-1061.
    • (1989) Genes Dev , vol.3 , pp. 1053-1061
    • Hesse, J.E.1    Lieber, M.R.2    Mizuuchi, K.3    Gellert, M.4
  • 71
    • 0030964130 scopus 로고    scopus 로고
    • A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
    • Hiom, K., and Gellert, M. (1997). A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage. Cell (Cambridge, Mass.) 88, 65-72.
    • (1997) Cell (Cambridge, Mass.) , vol.88 , pp. 65-72
    • Hiom, K.1    Gellert, M.2
  • 73
    • 0030938918 scopus 로고    scopus 로고
    • A targeted mutation at the T-cell receptor α/δ locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dadl
    • Hong, N. A., Cado, D., Mitchell, J., Ortiz, B. D., Hsieh, S. N., and Winoto, A. (1997). A targeted mutation at the T-cell receptor α/δ locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dadl. Mol. Cell. Biol. 17, 2151-2157.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2151-2157
    • Hong, N.A.1    Cado, D.2    Mitchell, J.3    Ortiz, B.D.4    Hsieh, S.N.5    Winoto, A.6
  • 74
    • 0029113706 scopus 로고
    • Human and mouse T-cell receptor loci: Genomics, evolution, diversity, and serendipity
    • Hood, L., Rowen, L., and Koop, B. F. (1995). Human and mouse T-cell receptor loci: Genomics, evolution, diversity, and serendipity. Ann. N. Y. Acad. Sci. 758, 390-412.
    • (1995) Ann. N. Y. Acad. Sci. , vol.758 , pp. 390-412
    • Hood, L.1    Rowen, L.2    Koop, B.F.3
  • 75
    • 0026755207 scopus 로고
    • V(D)J recombination on minichromosomes is not affected by transcription
    • Hsieh, C. -L., McCloskey, R. P., and Lieber, M. R. (1992). V(D)J recombination on minichromosomes is not affected by transcription. J. Biol. Chem. 267, 15613-15619.
    • (1992) J. Biol. Chem. , vol.267 , pp. 15613-15619
    • Hsieh, C.-L.1    McCloskey, R.P.2    Lieber, M.R.3
  • 77
    • 0030871428 scopus 로고    scopus 로고
    • Identification of a DNA segment exhibiting rearrangement modifying effects upon transgenic delta-deleting elements
    • Janowski, K. M., Ledbetter, S., Mayo, M. S., and Hockett, R. D. (1997). Identification of a DNA segment exhibiting rearrangement modifying effects upon transgenic delta-deleting elements. J. Exp. Med. 186, 91-100.
    • (1997) J. Exp. Med. , vol.186 , pp. 91-100
    • Janowski, K.M.1    Ledbetter, S.2    Mayo, M.S.3    Hockett, R.D.4
  • 78
    • 0027487392 scopus 로고
    • The immunoglobulin μ enhancer core establishes local factor access in nuclear chromatin independant of transcriptional stimulation
    • Jenuwein, T., Forrester, W. C, Qiu, R.-G., and Grosschedl, R. (1993). The immunoglobulin μ enhancer core establishes local factor access in nuclear chromatin independant of transcriptional stimulation. Genes Dev. 7, 2016-2032.
    • (1993) Genes Dev , vol.7 , pp. 2016-2032
    • Jenuwein, T.1    Forrester, W.C.2    Qiu, R.-G.3    Grosschedl, R.4
  • 79
    • 0027168861 scopus 로고
    • The intronic immunoglobulin Κ gene enhancer acts independently on rearrangement and transcription
    • Kallenbach, S., Babinet, C., Pournin, S., Cavelier, P., Goodhardt, M., and Rougeon, F. (1993). The intronic immunoglobulin Κ gene enhancer acts independently on rearrangement and transcription. Eur. J. Immunol. 23, 1917-1921.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1917-1921
    • Kallenbach, S.1    Babinet, C.2    Pournin, S.3    Cavelier, P.4    Goodhardt, M.5    Rougeon, F.6
  • 80
    • 0027422291 scopus 로고
    • Site-specific recombinases: Tools for genome engineering
    • Kilby, N. J., Snaith, M. R., and Murray, J. A. H. (1993). Site-specific recombinases: Tools for genome engineering. Trends Genet. 9, 413-421.
    • (1993) Trends Genet , vol.9 , pp. 413-421
    • Kilby, N.J.1    Snaith, M.R.2    Murray, J.A.H.3
  • 81
    • 0026704374 scopus 로고
    • Inactivation of the human β-globin gene by targeted insertion into the β-globin locus control region
    • Kim, C. G., Epner, E. M., Forrester, W. C, and Groudine, M. (1992). Inactivation of the human β-globin gene by targeted insertion into the β-globin locus control region. Genes Dev. 6, 928-938.
    • (1992) Genes Dev , vol.6 , pp. 928-938
    • Kim, C.G.1    Epner, E.M.2    Forrester, W.C.3    Groudine, M.4
  • 82
    • 0029917808 scopus 로고    scopus 로고
    • Regions of RAG1 protein critical for V(D)J recombination
    • Kirch, S. A., Sudarsanam, P., and Oettinger, M. A. (1996). Regions of RAG1 protein critical for V(D)J recombination. Eur. J. Immunol. 26, 886-891.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 886-891
    • Kirch, S.A.1    Sudarsanam, P.2    Oettinger, M.A.3
  • 83
    • 0031170828 scopus 로고    scopus 로고
    • Lymphocyte-specific genomic instability and risk of lymphoid malignancy
    • Kirsch, I. R., and Lista, F. (1997). Lymphocyte-specific genomic instability and risk of lymphoid malignancy. Semin. Immunol. 9, 207-215.
    • (1997) Semin. Immunol. , vol.9 , pp. 207-215
    • Kirsch, I.R.1    Lista, F.2
  • 84
    • 0028872616 scopus 로고
    • Development and selection of T cells: Facts and puzzles
    • Kisielow, P., and von Boehmer, H. (1995). Development and selection of T cells: Facts and puzzles. Adv. Immunol. 58, 87-208.
    • (1995) Adv. Immunol. , vol.58 , pp. 87-208
    • Kisielow, P.1    von Boehmer, H.2
  • 85
    • 0026689409 scopus 로고
    • Altering genes in animals by gene targeting
    • Koller, B. H., and Smithies, O. (1992). Altering genes in animals by gene targeting. Annu. Rev. Immunol. 10, 705-730.
    • (1992) Annu. Rev. Immunol. , vol.10 , pp. 705-730
    • Koller, B.H.1    Smithies, O.2
  • 86
    • 0027369562 scopus 로고
    • Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes
    • Komori, T., Okada, A., Stewart, V., and Alt, F. W. (1993). Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science 261, 1171-1174.
    • (1993) Science , vol.261 , pp. 1171-1174
    • Komori, T.1    Okada, A.2    Stewart, V.3    Alt, F.W.4
  • 87
    • 0027963488 scopus 로고
    • Striking sequences similarity over almost 100 kilobases of human and mouse T-cell receptor DNA
    • Koop, B. F., and Hood, L. (1994). Striking sequences similarity over almost 100 kilobases of human and mouse T-cell receptor DNA. Nat. Genet. 7, 48-53.
    • (1994) Nat. Genet. , vol.7 , pp. 48-53
    • Koop, B.F.1    Hood, L.2
  • 88
    • 0026637284 scopus 로고
    • A survey of protein-DNA interaction sites within the murine immunoglobulin heavy chain locus reveals a complex pattern around the DQ52 element
    • Kottmann, A. H., Brack, C., Eibel, H., and Köhler, G. (1992). A survey of protein-DNA interaction sites within the murine immunoglobulin heavy chain locus reveals a complex pattern around the DQ52 element. Eur. J. Immunol. 22, 2113-2120.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2113-2120
    • Kottmann, A.H.1    Brack, C.2    Eibel, H.3    Köhler, G.4
  • 89
    • 0028329398 scopus 로고
    • A second promoter and enhancer element within the immunoglobulin heavy chain locus
    • Kottmann, A. H., Zevnik, B., Welte, M., Nielsen, P. J., and Köhler, G. (1994). A second promoter and enhancer element within the immunoglobulin heavy chain locus. Eur. J. Immunol. 24, 817-821.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 817-821
    • Kottmann, A.H.1    Zevnik, B.2    Welte, M.3    Nielsen, P.J.4    Köhler, G.5
  • 91
    • 0343035756 scopus 로고    scopus 로고
    • Advances in gene targeting methods
    • Kühn, R., and Schwenk, F. (1997). Advances in gene targeting methods. Curr. Opin. Immunol. 9, 183-188.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 183-188
    • Kühn, R.1    Schwenk, F.2
  • 92
    • 0027485507 scopus 로고
    • Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene
    • Lauster, R., Reynaud, C.-A., Martensson, L., Peter, A., Bucchini, D., Jami, J., and Weill, J. C. (1993). Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene. EMBO J. 12, 4615-4623.
    • (1993) EMBO J , vol.12 , pp. 4615-4623
    • Lauster, R.1    Reynaud, C.-A.2    Martensson, L.3    Peter, A.4    Bucchini, D.5    Jami, J.6    Weill, J.C.7
  • 93
    • 0028012025 scopus 로고
    • Enhancer-dependant and -independant steps in the rearrangement of a human T cell receptor 5 transgene
    • Lauzurica, P., and Krangel, M. S. (1994a). Enhancer-dependant and -independant steps in the rearrangement of a human T cell receptor 5 transgene. J. Exp. Med. 179, 43-55.
    • (1994) J. Exp. Med. , vol.179 , pp. 43-55
    • Lauzurica, P.1    Krangel, M.S.2
  • 94
    • 0028276377 scopus 로고
    • Temporal and lineage-specific control of T Cell Receptor α/δ gene rearrangement by T Cell Receptor α and δ enhancers
    • Lauzurica, P., and Krangel, M. S. (1994b). Temporal and lineage-specific control of T Cell Receptor α/δ gene rearrangement by T Cell Receptor α and δ enhancers. J. Exp. Med. 179, 1913-1921.
    • (1994) J. Exp. Med. , vol.179 , pp. 1913-1921
    • Lauzurica, P.1    Krangel, M.S.2
  • 95
    • 0030984563 scopus 로고    scopus 로고
    • Regulation of T cell receptor 5 gene rearrangement by CBF/PEBP2
    • Lauzurica, P., Zhong, X. P., Krangel, M. S., and Roberts, J. L. (1997). Regulation of T cell receptor 5 gene rearrangement by CBF/PEBP2. J. Exp. Med. 185, 1193-1201.
    • (1997) J. Exp. Med. , vol.185 , pp. 1193-1201
    • Lauzurica, P.1    Zhong, X.P.2    Krangel, M.S.3    Roberts, J.L.4
  • 96
    • 0027465001 scopus 로고
    • Transcriptional regulation of T cell receptor genes
    • Leiden, J. M. (1993). Transcriptional regulation of T cell receptor genes. Annu. Rev. Immunol. 11, 539-570.
    • (1993) Annu. Rev. Immunol. , vol.11 , pp. 539-570
    • Leiden, J.M.1
  • 97
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
    • Lewis, S. M. (1994). The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56, 29-150.
    • (1994) Adv. Immunol. , vol.56 , pp. 29-150
    • Lewis, S.M.1
  • 99
    • 0028328632 scopus 로고
    • B-cell specific demethylation: A novel role for the intronic Κ chain enhancer sequence
    • Lichtenstein, M., Keini, G., Cedar, H., and Bergman, Y. (1994). B-cell specific demethylation: A novel role for the intronic Κ chain enhancer sequence. Cell (Cambridge, Mass.) 76, 913-923.
    • (1994) Cell (Cambridge, Mass.) , vol.76 , pp. 913-923
    • Lichtenstein, M.1    Keini, G.2    Cedar, H.3    Bergman, Y.4
  • 100
    • 0011139791 scopus 로고
    • The role of site-directed recombinases in physiologic and pathologic chromosomal rearrangements
    • I. R. Kirsch, ed.),. CRC Press, Ann Arbor, MI
    • Lieber, M. R. (1993). The role of site-directed recombinases in physiologic and pathologic chromosomal rearrangements. In "The Causes and Consequences of Chromosomal Aberrations" (I. R. Kirsch, ed.), pp. 239-275. CRC Press, Ann Arbor, MI.
    • (1993) The Causes and Consequences of Chromosomal Aberrations , pp. 239-275
    • Lieber, M.R.1
  • 101
    • 0031059531 scopus 로고    scopus 로고
    • Tying loose ends: Roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks
    • Lieber, M. R., Grawunder, U., Wu, X., and Yaneva, M. (1997). Tying loose ends: Roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Curr. Opin. Genet. Dev. 7, 99-104.
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 99-104
    • Lieber, M.R.1    Grawunder, U.2    Wu, X.3    Yaneva, M.4
  • 102
    • 0025969990 scopus 로고
    • An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus
    • Lieberson, R., Giannini, S. L., Birshtein, B. K., and Eckhardt, L. A. (1991). An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus. Nucleic Acids Res. 19, 933-937.
    • (1991) Nucleic Acids Res , vol.19 , pp. 933-937
    • Lieberson, R.1    Giannini, S.L.2    Birshtein, B.K.3    Eckhardt, L.A.4
  • 103
    • 0029416912 scopus 로고
    • Immunoglobulin gene transcription ceases upon deletion of a distant enhancer
    • Lieberson, R., Ong, J., Shi, X., and Eckhardt, L. A. (1995). Immunoglobulin gene transcription ceases upon deletion of a distant enhancer. EMBO J. 14, 6229-6238.
    • (1995) EMBO J , vol.14 , pp. 6229-6238
    • Lieberson, R.1    Ong, J.2    Shi, X.3    Eckhardt, L.A.4
  • 104
    • 0030069149 scopus 로고    scopus 로고
    • T-cell receptor α locus V(D)J recombination byproducts are abundant in thymocytes and mature T cells
    • Livak, F., and Schatz, D. G. (1996). T-cell receptor α locus V(D)J recombination byproducts are abundant in thymocytes and mature T cells. Mol. Cell. Biol. 16, 609-618.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 609-618
    • Livak, F.1    Schatz, D.G.2
  • 105
    • 0029054748 scopus 로고
    • In-frame TCR 6 gene rearrangements play a critical role in the αβ/γδ T cell lineage decision
    • Livak, F., Petrie, H. T., Crispe, I. N., and Schatz, D. G. (1995). In-frame TCR 6 gene rearrangements play a critical role in the αβ/γδ T cell lineage decision. Immunity 2, 617-627.
    • (1995) Immunity , vol.2 , pp. 617-627
    • Livak, F.1    Petrie, H.T.2    Crispe, I.N.3    Schatz, D.G.4
  • 106
    • 0030579607 scopus 로고    scopus 로고
    • X-chromosome inaetivation-Pinpointing the centre
    • Lyon, M. F. (1996). X-chromosome inaetivation-Pinpointing the centre. Nature (London) 379, 116-117.
    • (1996) Nature (London) , vol.379 , pp. 116-117
    • Lyon, M.F.1
  • 109
    • 0030219342 scopus 로고    scopus 로고
    • Regulation of β-globin gene expression: Straightening out the locus
    • Martin, D. I. K., Fiering, S., and Groudine, M. (1996). Regulation of β-globin gene expression: Straightening out the locus. Curr. Opin. Genet. Dev. 6, 488-495.
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 488-495
    • Martin, D.I.K.1    Fiering, S.2    Groudine, M.3
  • 111
    • 0030807246 scopus 로고    scopus 로고
    • An upstream, DNase I hypersensitive region of the hematopoietic- Expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice
    • McDevitt, M. A., Fujiwara, Y., Shivdasani, R. A., and Orkin, S. H. (1997). An upstream, DNase I hypersensitive region of the hematopoietic- expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 94, 7976-7981.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 7976-7981
    • McDevitt, M.A.1    Fujiwara, Y.2    Shivdasani, R.A.3    Orkin, S.H.4
  • 112
    • 0024281597 scopus 로고
    • A transcription enhancer 3' of Cβ2 in the T cell receptor β locus
    • McDougall, S., Peterson, C. L., and Calame, K. (1988). A transcription enhancer 3' of Cβ2 in the T cell receptor β locus. Science 241, 205-208.
    • (1988) Science , vol.241 , pp. 205-208
    • McDougall, S.1    Peterson, C.L.2    Calame, K.3
  • 113
    • 0030811531 scopus 로고    scopus 로고
    • A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity
    • McMahan, C. J., Difilippantonio, M. J., Rao, N., Spanopoulou, E., and Schatz, D. G. (1997). A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity. Mol. Cell. Biol. 17, 4544-4552.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4544-4552
    • McMahan, C.J.1    Difilippantonio, M.J.2    Rao, N.3    Spanopoulou, E.4    Schatz, D.G.5
  • 115
    • 0026317875 scopus 로고
    • Creation of a large genomic deletion at the T-cell antigen receptor β-subunit locus in mouse embryonic stem cells by gene targeting
    • Mombaerts, P., Clarke, A. R., Hooper, M., and Tonegawa, S. (1991). Creation of a large genomic deletion at the T-cell antigen receptor β-subunit locus in mouse embryonic stem cells by gene targeting. Proc. Natl. Acad. Sci. U.S.A. 88, 3084-3087.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 3084-3087
    • Mombaerts, P.1    Clarke, A.R.2    Hooper, M.3    Tonegawa, S.4
  • 118
    • 0030929878 scopus 로고    scopus 로고
    • Nucleotide deletion and P addition in V(D)J recombination: A determinant role of the coding-end sequence
    • Nadel, B., and Feeney, A. J. (1997). Nucleotide deletion and P addition in V(D)J recombination: A determinant role of the coding-end sequence. Mol. Cell. Biol. 17, 3768-3778.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3768-3778
    • Nadel, B.1    Feeney, A.J.2
  • 119
    • 0028453266 scopus 로고
    • Mechanisms that control antigen receptor variable region gene assembly
    • Okada, A., and Alt, F. W. (1994). Mechanisms that control antigen receptor variable region gene assembly. Semina. Immunol. 6, 185-196.
    • (1994) Semina. Immunol. , vol.6 , pp. 185-196
    • Okada, A.1    Alt, F.W.2
  • 120
    • 0028223482 scopus 로고
    • Differential activation of transcription versus recombination of transgenic T cell receptor β variable region gene segments in B and T lineage cells
    • Okada, A., Mendelsohn, M., and Alt, F. (1994). Differential activation of transcription versus recombination of transgenic T cell receptor β variable region gene segments in B and T lineage cells. J. Exp. Med. 180, 261-272.
    • (1994) J. Exp. Med. , vol.180 , pp. 261-272
    • Okada, A.1    Mendelsohn, M.2    Alt, F.3
  • 121
    • 0029993449 scopus 로고    scopus 로고
    • Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF4
    • Olson, E. N., Arnold, H.-H., Rigby, P. W., and Wold, B. J. (1996). Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell (Cambridge, Mass.) 85, 1-4.
    • (1996) Cell (Cambridge, Mass.) , vol.85 , pp. 1-4
    • Olson, E.N.1    Arnold, H.-H.2    Rigby, P.W.3    Wold, B.J.4
  • 122
    • 0030789734 scopus 로고    scopus 로고
    • Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues
    • Ortiz, B. D., Cado, D., Chen, V., Diaz, P. W., and Winoto, A. (1997). Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues. EMBO J. 16, 5037-5045.
    • (1997) EMBO J , vol.16 , pp. 5037-5045
    • Ortiz, B.D.1    Cado, D.2    Chen, V.3    Diaz, P.W.4    Winoto, A.5
  • 123
    • 85084933400 scopus 로고    scopus 로고
    • Selective alteration in the antibody repertoire in DHQ52 deficient mice
    • abstr., 13th Eur. Immunol. Meet
    • Pelkonen, J., Kestler, J., Pelkonen, S., and Nitschke, L. (1997). Selective alteration in the antibody repertoire in DHQ52 deficient mice. Immunol. Lett. 56, 10-11 (abstr., 13th Eur. Immunol. Meet.).
    • (1997) Immunol. Lett. , vol.56 , pp. 10-11
    • Pelkonen, J.1    Kestler, J.2    Pelkonen, S.3    Nitschke, L.4
  • 126
    • 0027970838 scopus 로고
    • Chromosomal translocations in human cancer
    • Rabbitts, T. H. (1994). Chromosomal translocations in human cancer. Nature (London) 372, 143-149.
    • (1994) Nature (London) , vol.372 , pp. 143-149
    • Rabbitts, T.H.1
  • 127
    • 0028801363 scopus 로고
    • Formation and resolution of double-strand break intermediates in V(D)J rearrangement
    • Ramsden, D. A., and Gellert, M. (1995). Formation and resolution of double-strand break intermediates in V(D)J rearrangement. Genes Dev. 9, 2409-2420.
    • (1995) Genes Dev , vol.9 , pp. 2409-2420
    • Ramsden, D.A.1    Gellert, M.2
  • 128
    • 0029891597 scopus 로고    scopus 로고
    • Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage
    • Ramsden, D. A., McBlane, J. F., Van Gent, D. C., and Gellert, M. (1996). Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage. EMBO J. 15, 3197-3206.
    • (1996) EMBO J , vol.15 , pp. 3197-3206
    • Ramsden, D.A.1    McBlane, J.F.2    van Gent, D.C.3    Gellert, M.4
  • 131
    • 0030871602 scopus 로고    scopus 로고
    • Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1
    • Roman, C. A., Cherry, S. R., and Baltimore, D. (1997). Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1. Immunity 7, 13-24.
    • (1997) Immunity , vol.7 , pp. 13-24
    • Roman, C.A.1    Cherry, S.R.2    Baltimore, D.3
  • 132
    • 0027770854 scopus 로고
    • Expression and V(D)J recombination activity of mutated RAG-1 proteins
    • Sadofsky, M. J., Hesse, J. E., McBlane, J. F., and Gellert, M. (1993). Expression and V(D)J recombination activity of mutated RAG-1 proteins. Nucleic Acids Res. 21, 5644-5650.
    • (1993) Nucleic Acids Res , vol.21 , pp. 5644-5650
    • Sadofsky, M.J.1    Hesse, J.E.2    McBlane, J.F.3    Gellert, M.4
  • 133
    • 0028237683 scopus 로고
    • Definition of a core region of RAG-2 that is functional in V(D)J recombination
    • Sadofsky, M. J., Hesse, J. E., and Gellert, M. (1994). Definition of a core region of RAG-2 that is functional in V(D)J recombination. Nucleic Acids Res. 22, 1805-1809.
    • (1994) Nucleic Acids Res , vol.22 , pp. 1805-1809
    • Sadofsky, M.J.1    Hesse, J.E.2    Gellert, M.3
  • 134
    • 0030980386 scopus 로고    scopus 로고
    • V(D)J recombination: Modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending p r o t e i n s
    • Sawchuk, D. J., Weis-Garcia, F., Malik, S., Besmer, E., Bustin, M., Nussenzweig, M. C., and Cortes, P. (1997). V(D)J recombination: Modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending p r o t e i n s. J. Exp. Med. 185, 2025-2032.
    • (1997) J. Exp. Med. , vol.185 , pp. 2025-2032
    • Sawchuk, D.J.1    Weis-Garcia, F.2    Malik, S.3    Besmer, E.4    Bustin, M.5    Nussenzweig, M.C.6    Cortes, P.7
  • 135
    • 0031171937 scopus 로고    scopus 로고
    • V(D)J recombination moves in vitro
    • Schatz, D. G. (1997). V(D)J recombination moves in vitro. Semin. Immunology 9, 149-159.
    • (1997) Semin. Immunology , vol.9 , pp. 149-159
    • Schatz, D.G.1
  • 136
  • 137
    • 0024710470 scopus 로고
    • A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer
    • Scheuermann, R. H., and Chen, U. (1989). A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer. Genes Dev. 3, 1255-1266.
    • (1989) Genes Dev , vol.3 , pp. 1255-1266
    • Scheuermann, R.H.1    Chen, U.2
  • 138
    • 0024435908 scopus 로고
    • Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription
    • Schlissel, M. S., and Baltimore, D. (1989). Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription. Cell (Cambridge, Mass.) 58, 1001-1007.
    • (1989) Cell (Cambridge, Mass.) , vol.58 , pp. 1001-1007
    • Schlissel, M.S.1    Baltimore, D.2
  • 139
    • 0027192988 scopus 로고
    • V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer
    • Serwe, M., and Sablitzky, F. (1993). V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J. 12, 2321-2327.
    • (1993) EMBO J , vol.12 , pp. 2321-2327
    • Serwe, M.1    Sablitzky, F.2
  • 140
    • 0025729069 scopus 로고
    • Deletions of immunoglobulin C kappa region characterized by the circular excision products in mouse splenocytes
    • Shimizu, T., Iwasato, T., and Yamagishi, H. (1991). Deletions of immunoglobulin C kappa region characterized by the circular excision products in mouse splenocytes. J. Exp. Med. 173, 1065-1072.
    • (1991) J. Exp. Med. , vol.173 , pp. 1065-1072
    • Shimizu, T.1    Iwasato, T.2    Yamagishi, H.3
  • 141
    • 0027509564 scopus 로고
    • Mouse germline transcript of TCR α joining region and temporal expression in ontogeny
    • Shimizu, T., Takeshita, S., Muto, M., Kubo, E., Sado, T., and Yamagishi, H. (1993). Mouse germline transcript of TCR α joining region and temporal expression in ontogeny. Int. Immunol. 5, 155-160.
    • (1993) Int. Immunol. , vol.5 , pp. 155-160
    • Shimizu, T.1    Takeshita, S.2    Muto, M.3    Kubo, E.4    Sado, T.5    Yamagishi, H.6
  • 142
    • 0031569608 scopus 로고    scopus 로고
    • CS in equine SCID results in defective coding and signal joint formation
    • CS in equine SCID results in defective coding and signal joint formation. J. Immunol. 158, 3565-3569.
    • (1997) J. Immunol. , vol.158 , pp. 3565-3569
    • Shin, E.K.1    Perryman, L.E.2    Meek, K.3
  • 144
    • 0029876726 scopus 로고    scopus 로고
    • The transcriptional control of hematopoiesis
    • Shivdasani, R. A., and Orkin, S. H. (1996). The transcriptional control of hematopoiesis. Blood 87, 4025-4039.
    • (1996) Blood , vol.87 , pp. 4025-4039
    • Shivdasani, R.A.1    Orkin, S.H.2
  • 145
    • 0028866095 scopus 로고
    • A δ T-cell receptor deleting element transgenic reporter construct is rearranged in αβ but not γδ T-cell lineages
    • Shutter, J., Cain, J. A., Ledbetter, S., Rogers, M. D., and Hockett, R. D., Jr. (1995). A δ T-cell receptor deleting element transgenic reporter construct is rearranged in αβ but not γδ T-cell lineages. Mol. Cell. Biol. 15, 7022-7031.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 7022-7031
    • Shutter, J.1    Cain, J.A.2    Ledbetter, S.3    Rogers, M.D.4    Hockett, R.D.5
  • 146
    • 0031149162 scopus 로고    scopus 로고
    • DNA methylation: A molecular clock
    • Siegfried, Z., and Cedar, H. (1997). DNA methylation: A molecular clock. Curr. Biol. 7, R305-R307.
    • (1997) Curr. Biol. , vol.7 , pp. R305-R307
    • Siegfried, Z.1    Cedar, H.2
  • 147
    • 0027197151 scopus 로고
    • Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
    • Silver, D. P., Spanopoulou, E.,, Mulligan, R. C, and Baltimore, D. (1993). Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination. Proc. Natl. Acad. Sci. U.S.A. 90, 6100-6104.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 6100-6104
    • Silver, D.P.1    Spanopoulou, E.2    Mulligan, R.C.3    Baltimore, D.4
  • 148
    • 0029983727 scopus 로고    scopus 로고
    • Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements
    • Sleckman, B. P., Gorman, J. R., and Alt, F. W. (1996). Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements. Annu. Rev. Immunol. 14, 459-481.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 459-481
    • Sleckman, B.P.1    Gorman, J.R.2    Alt, F.W.3
  • 151
    • 0026073338 scopus 로고
    • Identification of a T-cell-specific transcriptional enhancer located 3' of Cγl in the murine T-cell receptor γ locus
    • Spencer, D. M., Hsiang, Y. H., Goldman, J. P., and Raulet, D. H. (1991). Identification of a T-cell-specific transcriptional enhancer located 3' of Cγl in the murine T-cell receptor γ locus. Proc. Natl. Acad. Sci. U.S.A. 88, 800-804.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 800-804
    • Spencer, D.M.1    Hsiang, Y.H.2    Goldman, J.P.3    Raulet, D.H.4
  • 153
    • 0025817426 scopus 로고
    • Immunoglobulin gene transcription
    • Staudt, L. M., and Lenardo, M. J. (1991). Immunoglobulin gene transcription. Annu. Rev. Immunol. 9, 373-398.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 373-398
    • Staudt, L.M.1    Lenardo, M.J.2
  • 154
    • 0030155949 scopus 로고    scopus 로고
    • The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo
    • Steen, S. B., Gomelsky, L., and Roth, D. B. (1996). The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo. Genes Cells 1, 543-553.
    • (1996) Genes Cells , vol.1 , pp. 543-553
    • Steen, S.B.1    Gomelsky, L.2    Roth, D.B.3
  • 155
    • 0030959068 scopus 로고    scopus 로고
    • Initiation of V(D)J recombination in vivo: Role of recombination signal sequences in formation of single and paired double-strand breaks
    • Steen, S. B., Gomelsky, L., Speidel, S. L., and Roth, D. B. (1997). Initiation of V(D)J recombination in vivo: Role of recombination signal sequences in formation of single and paired double-strand breaks. EMBO J. 16, 2656-2664.
    • (1997) EMBO J , vol.16 , pp. 2656-2664
    • Steen, S.B.1    Gomelsky, L.2    Speidel, S.L.3    Roth, D.B.4
  • 156
    • 0025370215 scopus 로고
    • The immunoglobulin heavy-chain enhancer functions as the promoter for Iμ sterile transcription
    • Su, L.-K., and Kadesh, T. (1990). The immunoglobulin heavy-chain enhancer functions as the promoter for Iμ sterile transcription. Mol. Cell. Biol. 10, 2619-2624.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 2619-2624
    • Su, L.-K.1    Kadesh, T.2
  • 158
    • 0031137016 scopus 로고    scopus 로고
    • Developmentally ordered V-J recombination in mouse T cell receptor y locus is not perturbed by targeted deletion of the Vγ4 gene
    • Sunaga, S., Maki, K., Komagata, Y., Miyazaki, J., and Ikuta, K. (1997). Developmentally ordered V-J recombination in mouse T cell receptor y locus is not perturbed by targeted deletion of the Vγ4 gene. J. Immunol. 158, 4223-4228.
    • (1997) J. Immunol. , vol.158 , pp. 4223-4228
    • Sunaga, S.1    Maki, K.2    Komagata, Y.3    Miyazaki, J.4    Ikuta, K.5
  • 159
    • 0027189754 scopus 로고
    • Deletion of the immunoglobulin Κ chain intron enhancer abolishes Κ chain gene rearrangement in cis but not λ chain gene rearrangement in trans
    • Takeda, S., Zou, Y.-R., Bluethmann, H., Kitamura, D., Muller, U., and Rajewsky, K. (1993). Deletion of the immunoglobulin Κ chain intron enhancer abolishes Κ chain gene rearrangement in cis but not λ chain gene rearrangement in trans. EMBO J. 12, 2329-2336.
    • (1993) EMBO J , vol.12 , pp. 2329-2336
    • Takeda, S.1    Zou, Y.-R.2    Bluethmann, H.3    Kitamura, D.4    Muller, U.5    Rajewsky, K.6
  • 160
    • 0025324784 scopus 로고
    • Chromosomal translocations in lymphoid neoplasia: A reappraisal of the recombinase model
    • Tycko, B., and Sklar, J. (1990). Chromosomal translocations in lymphoid neoplasia: A reappraisal of the recombinase model. Cancer Cells 2, 1-8.
    • (1990) Cancer Cells , vol.2 , pp. 1-8
    • Tycko, B.1    Sklar, J.2
  • 161
    • 0026100231 scopus 로고
    • Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells
    • Valancius, V., and Smithies, O. (1991). Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells. Mol. Cell. Biol. 11, 1402-1410.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1402-1410
    • Valancius, V.1    Smithies, O.2
  • 162
    • 0030009253 scopus 로고    scopus 로고
    • The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
    • Van Gent, D. C, Ramsden, D. A., and Gellert, M. (1996). The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell (Cambridge, Mass.) 85, 107-113.
    • (1996) Cell (Cambridge, Mass.) , vol.85 , pp. 107-113
    • van Gent, D.C.1    Ramsden, D.A.2    Gellert, M.3
  • 163
    • 0030994385 scopus 로고    scopus 로고
    • Stimulation of V(D)J cleavage by high mobility group proteins
    • Van Gent, D. C, Hiom, K., Paull, T. T., and Gellert, M. (1997). Stimulation of V(D)J cleavage by high mobility group proteins. EMBO J. 16, 2665-2670.
    • (1997) EMBO J , vol.16 , pp. 2665-2670
    • van Gent, D.C.1    Hiom, K.2    Paull, T.T.3    Gellert, M.4
  • 164
    • 0027296085 scopus 로고
    • Organization of murine T-cell receptor γ locus
    • Vernooij, B. T. M., Lenstra, J. A., Wang, K., and Hood, L. (1993). Organization of murine T-cell receptor γ locus. Genomics 17, 566-574.
    • (1993) Genomics , vol.17 , pp. 566-574
    • Vernooij, B.T.M.1    Lenstra, J.A.2    Wang, K.3    Hood, L.4
  • 165
    • 0030273709 scopus 로고    scopus 로고
    • Selective defect in rearrangement of the most 5' TCR-Jα gene segments evidenced by targeted deletion of the TEA (T early α) element: Implications for regulation of DNA accessibility within the TCR-α locus
    • Villey, I., Caillol, D., Selz, F., Ferrier, P., and De Villartay, J. P. (1996). Selective defect in rearrangement of the most 5' TCR-Jα gene segments evidenced by targeted deletion of the TEA (T early α) element: Implications for regulation of DNA accessibility within the TCR-α locus. Immunity 5, 331-342.
    • (1996) Immunity , vol.5 , pp. 331-342
    • Villey, I.1    Caillol, D.2    Selz, F.3    Ferrier, P.4    de Villartay, J.P.5
  • 166
    • 0030873630 scopus 로고    scopus 로고
    • Germ-line transcription and methylation status of the TCR-Jα locus in its accessible configuration
    • Villey, I., Quartier, P., Selz, F., and De Villartay, J. P. (1997). Germ-line transcription and methylation status of the TCR-Jα locus in its accessible configuration. Eur. J. Immunol. 27, 1619-1625.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1619-1625
    • Villey, I.1    Quartier, P.2    Selz, F.3    de Villartay, J.P.4
  • 167
    • 0028929565 scopus 로고
    • Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
    • von Freeden-Jeffry, U., Vieira, P., Lucian, L. A., McNeil, T., Burdach, S. E., and Murray, R. (1995). Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J. Exp. Med. 181, 1519-1526.
    • (1995) J. Exp. Med. , vol.181 , pp. 1519-1526
    • von Freeden-Jeffry, U.1    Vieira, P.2    Lucian, L.A.3    McNeil, T.4    Burdach, S.E.5    Murray, R.6
  • 168
    • 0021418251 scopus 로고
    • Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis
    • Wabl, M. R., and Burrows, P. D. (1984). Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis. Proc. Natl. Acad. Sci. U.S.A. 81, 2452-2455.
    • (1984) Proc. Natl. Acad. Sci. U.S.A. , vol.81 , pp. 2452-2455
    • Wabl, M.R.1    Burrows, P.D.2
  • 170
    • 1842346594 scopus 로고
    • B-lymphocyte-specific protein binding near an immunoglobulin κ-chain gene J segment
    • Weaver, D., and Baltimore, D. (1987). B-lymphocyte-specific protein binding near an immunoglobulin κ-chain gene J segment. Proc. Natl. Acad. Sci. U.S.A. 84, 1516-1520.
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 1516-1520
    • Weaver, D.1    Baltimore, D.2
  • 171
    • 0028853297 scopus 로고
    • V(D)J recombination and double-strand break repair
    • Weaver, D. T. (1995). V(D)J recombination and double-strand break repair. Adv. Immunol. 58, 29-85.
    • (1995) Adv. Immunol. , vol.58 , pp. 29-85
    • Weaver, D.T.1
  • 172
    • 0030581173 scopus 로고    scopus 로고
    • X chromosome inactivation, XIST, and pursuit of the X-inactivation center
    • Willard, H. F. (1996). X chromosome inactivation, XIST, and pursuit of the X-inactivation center. Cell (Cambridge, Mass.) 86, 5-7.
    • (1996) Cell (Cambridge, Mass.) , vol.86 , pp. 5-7
    • Willard, H.F.1
  • 173
    • 0030019723 scopus 로고    scopus 로고
    • T cell receptor S gene rearrangement and T early α (TEA) expression in immature αβ lineage thymocytes: Implications for αβ/γδ lineage commitment
    • Wilson, A., De Villartay, J. P., and MacDonald, H. R. (1996). T cell receptor S gene rearrangement and T early α (TEA) expression in immature αβ lineage thymocytes: Implications for αβ/γδ lineage commitment. Immunity 4, 37-45.
    • (1996) Immunity , vol.4 , pp. 37-45
    • Wilson, A.1    de Villartay, J.P.2    MacDonald, H.R.3
  • 174
    • 0024445797 scopus 로고
    • Αβ lineage-specific expression of the α T cell receptor gene by nearby silencers
    • Winoto, A., and Baltimore, D. (1989a). αβ lineage-specific expression of the α T cell receptor gene by nearby silencers. Cell (Cambridge, Mass.) 59, 649-655.
    • (1989) Cell (Cambridge, Mass.) , vol.59 , pp. 649-655
    • Winoto, A.1    Baltimore, D.2
  • 175
    • 0024426027 scopus 로고
    • A novel, inducible and T cell-specific enhancer located at 3' end of the T cell receptor α locus
    • Winoto, A., and Baltimore, D. (1989b). A novel, inducible and T cell-specific enhancer located at 3' end of the T cell receptor α locus. EMBO J. 8, 729-733.
    • (1989) EMBO J , vol.8 , pp. 729-733
    • Winoto, A.1    Baltimore, D.2
  • 176
    • 0029967078 scopus 로고    scopus 로고
    • Deletion of the Igκ light chain intronic enhancer/matrix attachment region impairs but does not abolish VΚJκ rearrangement
    • Xu, Y., Davidson, L., Alt, F. W., and Baltimore, D. (1996). Deletion of the Igκ light chain intronic enhancer/matrix attachment region impairs but does not abolish VΚJκ rearrangement. Immunity 4, 377-385.
    • (1996) Immunity , vol.4 , pp. 377-385
    • Xu, Y.1    Davidson, L.2    Alt, F.W.3    Baltimore, D.4
  • 178
    • 0022346560 scopus 로고
    • Deletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expression
    • Zaller, D. M., and Eckhardt, L. A. (1985). Deletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expression. Proc. Natl. Acad. Sci. U.S.A. 82, 5088-5092.
    • (1985) Proc. Natl. Acad. Sci. U.S.A. , vol.82 , pp. 5088-5092
    • Zaller, D.M.1    Eckhardt, L.A.2
  • 179
    • 0029811475 scopus 로고    scopus 로고
    • HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation
    • Zappavigna, V., Falciola, L., Citterich, M. H., Mavilio, F., and Bianchi, M. E. (1996). HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation. EMBOJ. 15, 4981-4991.
    • (1996) EMBOJ , vol.15 , pp. 4981-4991
    • Zappavigna, V.1    Falciola, L.2    Citterich, M.H.3    Mavilio, F.4    Bianchi, M.E.5
  • 180
    • 0030992767 scopus 로고    scopus 로고
    • An enhancer-blocking element between α and δ gene segments within the human T cell receptor odd locus
    • Zhong, X. P., and Krangel, M. S. (1997). An enhancer-blocking element between α and δ gene segments within the human T cell receptor odd locus. Proc. Natl. Acad. Sci. U.S.A. 94, 5219-5224.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 5219-5224
    • Zhong, X.P.1    Krangel, M.S.2
  • 181
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
    • Zhu, C. M., Bogue, M. A, Lim, D. S., Hasty, P., and Roth, D. B. (1996). Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates, Cell (Cambridge, Mass.) 86, 379-389.
    • (1996) Cell (Cambridge, Mass.) , vol.86 , pp. 379-389
    • Zhu, C.M.1    Bogue, M.A.2    Lim, D.S.3    Hasty, P.4    Roth, D.B.5
  • 182
    • 0028921810 scopus 로고
    • High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors
    • Zwilling, S., König, H., and Wirth, T. (1995). High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. EMBO J. 14, 1198-1208.
    • (1995) EMBO J , vol.14 , pp. 1198-1208
    • Zwilling, S.1    König, H.2    Wirth, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.