Transcription factors required for lymphoid lineage commitment

Current Opinion in Immunology

Volumn 9, Issue 2, 1997, Pages 222-227

  Georgopoulos, Katia ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

CELL DIFFERENTIATION; CELL LINEAGE; GENE; GENE EXPRESSION REGULATION; GENE REPRESSION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; T LYMPHOCYTE;

EID: 0030993348     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(97)80139-2     Document Type: Article

References (40)

1. of outstanding interest Shortman K, Wu L. Early T lymphocyte progenitors. Annu Rev Immunol. 14:1996;29-47 The most current extensive overview of the early steps in T cell development. It discusses in depth both cellular and molecular aspects of the early events in the pathway.
2. of outstanding interest Zuñiga-Pflucker JC, Lenardo MJ. Regulation of thymocyte development from immature progenitors. of special interest Curr Opin Immunol. 8:1996;215-224 Similar to [1] but more comprehensive.
3. of special interest Owen MJ, Venkitaramen AR. Signaling in lymphocyte development. Immunology. 8:1996;191-198 Excellent review on signaling control of lymphoid development.
4. Arroyo AG, Yang JT, Rayburn H, Hynes RO. Differential requirements for α4 integrins during fetal and adult hematopoiesis. Cell. 85:1996;997-1006.
5. 1 integrins. Nature. 380:1996;171-175.
6. Wu L, Scollay R, Egerton M, Pearse M, Spangrude GJ, Shortman K. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature. 349:1991;71-74.
7. of outstanding interest Li Y, Wassermann R, Hayakawa K, Hardy RR. Identification of the earliest B lineage stage in mouse bone marrow. Immunity. 5:1996;527-535 This paper is a hallmark in the delineation of the earliest stages of B cell development. A combination of cell surface and molecular markers is used to dissect and characterize the pro-B cell window.
8. Hardy RR, Camack CE, Shinton SA, Kemp JD, Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell states in normal mouse bone marrow. J Exp Med. 173:1991;1213-1225.
9. Lemischka IR. The haematopoietic stem cell and its clonal progeny: mechanisms regulating the hierarchy of primitive haematopoietic cells. Cancer Surv. 15:1992;3-18.
10. Taccioli GE, Rathbun G, Shinkai Y, Oltz EM, Cheng H, Whitmore G, Stamato T, Jeggo P, Alt FW. Activities involved in V(D)J recombination. Curr Top Microbiol Immunol. 182:1992;107-114.
11. Grosschedl R. Higher-order nucleoprotein complexes in transcription: analogies with site-specific recombination. Curr Opin Cell Biol. 7:1995;362-370.
12. of special interest Clevers H, Grosschedl R. Transcriptional control of lymphoid development: lessons from gene targeting. Immunol Today. 17:1996;336-343 A comprehensive up-to-date review of the transcription factors relevant to lymphoid development.
13. of outstanding interest Wang J, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity. 5:1996;537-549 The role of Ikaros in the development of the fetal and adult lymphoid systems is described. This study in combination with a previous one [17] on an Ikaros dominant negative mutation reveals that this gene acts in a complex with other family members during T cell specification in the adult hemopoietic system.
14. Scott E, Simon M, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 265:1994;1573-1577.
15. of outstanding interest McKercher SR, Torbett BE, Anderson KL, Henkel GW, Vestal DJ, Baribault H, Klemsz M, Feeney AJ, Wu GE, Paige CJ, Maki RA. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15:1996;5647-5658 A study on a second inactivating PU.1 mutation (see [14] for the first) that does not cause embryonic lethalities. The study describes the effects of the mutation on the postnatal hemopoietic system.
16. of outstanding interest Ting C, Olsen MC, Barton KP, Leiden JM. Transcription factor GATA-3 is required for development of the T-cell lineage. Nature. 384:1996;474-478 This paper describes the severe effects that GATA-3 inactivation has at the earliest stages of T cell commitment. The B cell lineage develops normally.
17. Georgopoulos K, Bigby M, Wang J-H, Molnar A, Wu P, Winandy S, Sharpe A. The Ikaros gene is required for the development of all lymphoid lineages. Cell. 79:1994;143-156.
18. Cumano A, Dieterien-Lievre F, Godin I. Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura. Cell. 86:1996;907-916.
19. Medvinsky A, Dzierzak E. Definitive hematopoiesis is autonomously initiated by the AGM region. Cell. 86:1996;897-906.
20. + dendritic epidermal cells of adult mice from fetal thymic precursors. Nature. 344:1990;68-70.
21. Allison JP. Gamma delta T-cell development. Curr Biol. 5:1993;241-246.
22. + B cells. Immunol Rev. 137:1994;92-118.
23. Melchers F, Strasser A, Bauer SR, Kudo A, Thalmann P, Rolink A. B cell development in fetal liver. Adv Exp Med Biol. 292:1991;201-205.
24. Hardy RR, Hayakawa K. A developmental switch in B lymphopoiesis. Proc Natl Acad Sci USA. 88:1991;11550-11554.
25. Ardavin C, Wu L, Li C, Shortman K. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature. 362:1993;761-763.
26. Vremec D, Zorbas M, Scollay R, Saunders DJ, Ardavin CF, Wu L, Shortman K. The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J Exp Med. 176:1992;47-58.
27. Wu L, Vremec D, Ardavin K, Winkel G, Suess IL, Maraskovsky E, Cook W, Shortman K. Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation. Eur J Immunol. 25:1995;418-425.
28. Raulet DH, Spencer DM, Hsiang Y, Goldman JP, Bix M, Liao N, Zustra M, Jaenisch R, Correa I. Control of γδ T-cell development. Immunol Rev. 120:1991;185-204.
29. of outstanding interest Sun L, Liu A, Georgopoulos K. Zinc finger mediated Ikaros protein interactions modulate their activity in transcription: a putative on/off switch for lymphocyte proliferation. EMBO J. 15:1996;5358-5369 Delineation of the Ikaros protein interaction domain by in vitro and in vivo studies. In vivo expression studies showed that such protein-protein interactions determine the subcellular localization and transcriptional activity of the Ikaros protein complex.
30. of outstanding interest Morgan B, Sun L, Avitahl N, Andrikopoulos K, Gonzales E, Wu P, Neben S, Georgopoulos K. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 16:1997;101-110 Isolation and functional characterization of Aiolos, a lymphoid-restricted Ikaros homologue. In vivo and in vitro studies demonstrate that Aiolos and Ikaros work in the same complex within developing thymocytes.
31. of special interest Winandy S, Wu P, Georgopoulos K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell. 83:1995;289-299 Effects of a dominant-negative Ikaros mutation in the maturing T cell compartment. This study provides in vivo evidence that Ikaros proteins work in higher order complexes.
32. Molnar A, Georgopoulos K. The Ikaros gene encodes a family of functionally diverse zinc finger DNA binding proteins. Mol Cell Bio. 83:1994;785-794.
33. Kodandapani R, Pio F, Ni C, Piccialli G, Klemsz M, McKercher S, Maki RA, Ely KR. A new pattern for helix-turn-helix recognition by the PU.1 ETS-domain-DNA complex. Nature. 380:1996;456-460.
34. Weintraub H. The MyoD family and myogenesis: redundancy, networks, and thresholds. Cell. 75:1993;1241-1244.
35. Hromas R, Orazi A, Neiman RS, Maki R, Van Beveral C, Moore J, Klemsz M. Hematopoietic lineage- and stage-restricted expression of the ETS oncogene family member PU.1. Blood. 82:1993;2998-3004.
36. Clevers HC, Oosterwegal MA, Georgopoulos K. Transcription factors in early T-cell development. Immunol Today. 14:1993;591-596.
37. Bain G, Robanus Maandag EC, Izon DJ, Amsen D, Kruisbeek AM, Weintraub BC, Krop I, Schlissel MS, Feeney AM, Van Roon M. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell. 79:1994;885-892.
38. Zhuang Y, Soriano P, Weintraub H. The helix-loop-helix gene E2A is required for B cell formation. Cell. 79:1994;875-884.
39. of outstanding interest Shen CP, Kadesch T. B-cell specific DNA binding by E47 homodimer. Mol Cell Biol. 15:1995;4518-4524 An excellent study providing the molecular basis for the B cell specific effects of the ubiquitously expressed E2A proteins.
40. Sun XH. Constitutive expression of the Id1 gene impairs mouse B cell development. Cell. 87:1994;4025-4039.