메뉴 건너뛰기




Volumn 9, Issue 3, 1997, Pages 149-159

V(D)J recombination moves in vitro

Author keywords

RAG1; RAG2; Site specific recombination; V(D)J recombination

Indexed keywords

PROTEIN;

EID: 0031171937     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1997.0068     Document Type: Article
Times cited : (41)

References (67)
  • 1
    • 0011118362 scopus 로고
    • Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions
    • 1. Hozumi N, Tonegawa S (1976) Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc Natl Acad Sci USA 73:3628-3632
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 3628-3632
    • Hozumi, N.1    Tonegawa, S.2
  • 3
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses
    • 3. Lewis SM (1994) The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv Immunol 56:27-150
    • (1994) Adv Immunol , vol.56 , pp. 27-150
    • Lewis, S.M.1
  • 4
    • 0024442890 scopus 로고
    • The mechanism of antigen receptor gene assembly
    • 4. Lewis S, Gellert M (1989) The mechanism of antigen receptor gene assembly. Cell 59:585-588
    • (1989) Cell , vol.59 , pp. 585-588
    • Lewis, S.1    Gellert, M.2
  • 5
    • 0028801363 scopus 로고
    • Formation and resolution of double-strand break intermediates in V(D)J rearrangement
    • 5. Ramsden DA, Gellert M (1995) Formation and resolution of double-strand break intermediates in V(D)J rearrangement. Genes Dev 9:2409-2420
    • (1995) Genes Dev , vol.9 , pp. 2409-2420
    • Ramsden, D.A.1    Gellert, M.2
  • 6
    • 0023801238 scopus 로고
    • The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
    • 6. Lieber MR, Hesse JE, Lewis S, Bosma GC, Rosenberg N, Mizuuchi K, Bosma MJ, Gellert M (1988) The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination. Cell 55:7-16
    • (1988) Cell , vol.55 , pp. 7-16
    • Lieber, M.R.1    Hesse, J.E.2    Lewis, S.3    Bosma, G.C.4    Rosenberg, N.5    Mizuuchi, K.6    Bosma, M.J.7    Gellert, M.8
  • 7
    • 0027491330 scopus 로고
    • Characterization of broken DNA molecules associated with V(D)J recombination
    • 7. Roth DB, Zhu CM, Gellert M (1993) Characterization of broken DNA molecules associated with V(D)J recombination. Proc Natl Acad Sci USA 90:10788-10792
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10788-10792
    • Roth, D.B.1    Zhu, C.M.2    Gellert, M.3
  • 8
    • 0028958942 scopus 로고
    • Characterization of coding ends in thymocytes of seid mice - Implications for the mechanism of V(D)J recombination
    • 8. Zhu CM, Roth DB (1995) Characterization of coding ends in thymocytes of seid mice - implications for the mechanism of V(D)J recombination. Immunity 2:101-112
    • (1995) Immunity , vol.2 , pp. 101-112
    • Zhu, C.M.1    Roth, D.B.2
  • 9
    • 0030069149 scopus 로고    scopus 로고
    • T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells
    • 9. Livak F, Schatz DG (1996) T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol Cell Biol 16:609-618
    • (1996) Mol Cell Biol , vol.16 , pp. 609-618
    • Livak, F.1    Schatz, D.G.2
  • 10
    • 0029395076 scopus 로고
    • Menage a trois - Double strand break repair, V(D)J recombination and DNA-PK
    • 10. Taccioli GE, Jackson SP (1995) Menage a trois - double strand break repair, V(D)J recombination and DNA-PK. Bioessays 17:949-957
    • (1995) Bioessays , vol.17 , pp. 949-957
    • Taccioli, G.E.1    Jackson, S.P.2
  • 11
    • 0029117310 scopus 로고
    • What to do at an end - DNA double-strand-break-repair
    • 11. Weaver DT (1995) What to do at an end - DNA double-strand-break-repair. Trends Genet 11:388-392
    • (1995) Trends Genet , vol.11 , pp. 388-392
    • Weaver, D.T.1
  • 12
    • 0029302857 scopus 로고
    • Repair and recombination - How to make ends meet
    • 12. Roth DB, Lindahl T, Gellert M (1995) Repair and recombination - how to make ends meet. Curr Biol 5:496-499
    • (1995) Curr Biol , vol.5 , pp. 496-499
    • Roth, D.B.1    Lindahl, T.2    Gellert, M.3
  • 13
    • 0027369562 scopus 로고
    • Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes
    • 13. Komori T, Okada A, Stewart V, Alt FW (1993) Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science 261:1171-1175
    • (1993) Science , vol.261 , pp. 1171-1175
    • Komori, T.1    Okada, A.2    Stewart, V.3    Alt, F.W.4
  • 14
    • 0027452074 scopus 로고
    • Mice lacking TdT: Mature animals with an immature lymphocyte repertoire
    • 14. Gilfillan S, Dierich A, Lemeur M, Benoist C, Mathis D (1993) Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science 261:1175-1178
    • (1993) Science , vol.261 , pp. 1175-1178
    • Gilfillan, S.1    Dierich, A.2    Lemeur, M.3    Benoist, C.4    Mathis, D.5
  • 15
    • 0024281350 scopus 로고
    • Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts
    • 15. Schatz DG, Baltimore D (1988) Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts. Cell 53:107-115
    • (1988) Cell , vol.53 , pp. 107-115
    • Schatz, D.G.1    Baltimore, D.2
  • 16
    • 0024846088 scopus 로고
    • The V(D)J recombination activating gene (Rag-1)
    • 16. Schatz DG, Oettinger MA, Baltimore D (1989) The V(D)J recombination activating gene (RAG-1). Cell 59:1035-1048
    • (1989) Cell , vol.59 , pp. 1035-1048
    • Schatz, D.G.1    Oettinger, M.A.2    Baltimore, D.3
  • 17
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • 17. Oettinger MA, Schatz DG, Gorka C, Baltimore D (1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517-1523
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 18
    • 0027197151 scopus 로고
    • Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid-V(D)J recombination
    • 18. Silver DP, Spanopoulou E, Mulligan RC, Baltimore D (1993) Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid-V(D)J recombination. Proc Natl Acad Sci USA 90:6100-6104
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6100-6104
    • Silver, D.P.1    Spanopoulou, E.2    Mulligan, R.C.3    Baltimore, D.4
  • 19
    • 0027770854 scopus 로고
    • Expression and V(D)J recombination activity of mutated Rag-1 proteins
    • 19. Sadofsky MJ, Hesse JE, McBlane JF, Gellert M (1993) Expression and V(D)J recombination activity of mutated RAG-1 proteins. Nucleic Acids Res 22:5644-5650
    • (1993) Nucleic Acids Res , vol.22 , pp. 5644-5650
    • Sadofsky, M.J.1    Hesse, J.E.2    McBlane, J.F.3    Gellert, M.4
  • 20
    • 0029083695 scopus 로고
    • Rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent
    • 20. Leu TMJ, Schatz DG (1995) Rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent. Mol Cell Biol 15:5657-5670
    • (1995) Mol Cell Biol , vol.15 , pp. 5657-5670
    • Leu, T.M.J.1    Schatz, D.G.2
  • 21
    • 0028307661 scopus 로고
    • Analysis of regions of Rag-2 important for V(D)J recombination
    • 21. Cuomo CA, Oettinger MA (1994) Analysis of regions of RAG-2 important for V(D)J recombination. Nucleic Acids Res 22:1810-1814
    • (1994) Nucleic Acids Res , vol.22 , pp. 1810-1814
    • Cuomo, C.A.1    Oettinger, M.A.2
  • 22
    • 0028237683 scopus 로고
    • Definition of a core region of Rag-2 that is functional in V(D)J recombination
    • 22. Sadofsky MJ, Hesse JE, Gellert M (1994) Definition of a core region of RAG-2 that is functional in V(D)J recombination. Nucleic Acids Res 22:1805-1809
    • (1994) Nucleic Acids Res , vol.22 , pp. 1805-1809
    • Sadofsky, M.J.1    Hesse, J.E.2    Gellert, M.3
  • 23
    • 0026762509 scopus 로고
    • V(D)J recombination in mouse thymocytes - Double-stranded breaks near T-cell receptor delta rearrangement signals
    • 23. Roth DB, Nakajima PB, Menetski JP, Bosma MJ, Gellert M (1992) V(D)J recombination in mouse thymocytes - double-stranded breaks near T-cell receptor delta rearrangement signals. Cell 69:41-53
    • (1992) Cell , vol.69 , pp. 41-53
    • Roth, D.B.1    Nakajima, P.B.2    Menetski, J.P.3    Bosma, M.J.4    Gellert, M.5
  • 24
    • 0027769386 scopus 로고
    • Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, Rag-dependent, and cell cycle regulated
    • 24. Schlissel M, Constantinescu A, Morrow T, Baxter M, Peng A (1993) Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev 7:2520-2532
    • (1993) Genes Dev , vol.7 , pp. 2520-2532
    • Schlissel, M.1    Constantinescu, A.2    Morrow, T.3    Baxter, M.4    Peng, A.5
  • 25
    • 0026792892 scopus 로고
    • V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
    • 25. Roth DB, Menetski JP, Nakajima PB, Bosma MJ, Gellert M (1992) V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70:983-991
    • (1992) Cell , vol.70 , pp. 983-991
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.B.3    Bosma, M.J.4    Gellert, M.5
  • 26
    • 0024691453 scopus 로고
    • V(D)J recombination: A functional definition of the joining signals
    • 26. Hesse JE, Lieber MR, Mizuuchi K, Gellert M (1989) V(D)J recombination: a functional definition of the joining signals. Genes Dev 3:1053-1061
    • (1989) Genes Dev , vol.3 , pp. 1053-1061
    • Hesse, J.E.1    Lieber, M.R.2    Mizuuchi, K.3    Gellert, M.4
  • 27
    • 0030155949 scopus 로고    scopus 로고
    • The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo
    • 27. Steen SB, Gomelsky L, Roth DB (1996) The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo. Genes Cells 1:543-553
    • (1996) Genes Cells , vol.1 , pp. 543-553
    • Steen, S.B.1    Gomelsky, L.2    Roth, D.B.3
  • 28
  • 29
    • 0027491702 scopus 로고
    • A new protein motif found in DNA joining and DNA binding proteins
    • 29. Halligan BD (1993) A new protein motif found in DNA joining and DNA binding proteins. Nucleic Acids Res 21:5520-5521
    • (1993) Nucleic Acids Res , vol.21 , pp. 5520-5521
    • Halligan, B.D.1
  • 30
    • 0029967722 scopus 로고    scopus 로고
    • Similarities between initiation of V(D)J recombination and retroviral integration
    • 30. van Gent DC, Mizuuchi K, Gellert M (1996) Similarities between initiation of V(D)J recombination and retroviral integration. Science 271:1592-1594
    • (1996) Science , vol.271 , pp. 1592-1594
    • Van Gent, D.C.1    Mizuuchi, K.2    Gellert, M.3
  • 31
    • 0025899314 scopus 로고
    • Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: Evidence for a one-step transesterification mechanism
    • 31. Mizuuchi K, Adzuma K (1991) Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: Evidence for a one-step transesterification mechanism. Cell 66:129-140
    • (1991) Cell , vol.66 , pp. 129-140
    • Mizuuchi, K.1    Adzuma, K.2
  • 32
    • 0026330796 scopus 로고
    • HIV-I DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
    • 32. Engelman A, Mizuuchi K, Craigie R (1991) HIV-I DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer. Cell 67:1211-1221
    • (1991) Cell , vol.67 , pp. 1211-1221
    • Engelman, A.1    Mizuuchi, K.2    Craigie, R.3
  • 33
    • 0027508068 scopus 로고
    • The human immunodeficiency virus integrase protein
    • 33. Vink C, Plasterk RHA (1993) The human immunodeficiency virus integrase protein. Trends Genet 9:433-437
    • (1993) Trends Genet , vol.9 , pp. 433-437
    • Vink, C.1    Plasterk, R.H.A.2
  • 34
    • 0028317055 scopus 로고
    • Identification of residues in the Mu transposase essential for catalysis
    • 34. Baker TA, Luo L (1994) Identification of residues in the Mu transposase essential for catalysis. Proc Natl Acad Sci USA 91:6654-6658
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6654-6658
    • Baker, T.A.1    Luo, L.2
  • 35
    • 0029129435 scopus 로고
    • Structure of the bacteriophage Mu transposase core: A common structural motif for DNA transposition and retroviral integration
    • 35. Rice P, Mizuuchi K (1995) Structure of the bacteriophage Mu transposase core: A common structural motif for DNA transposition and retroviral integration. Cell 82:209-220
    • (1995) Cell , vol.82 , pp. 209-220
    • Rice, P.1    Mizuuchi, K.2
  • 36
    • 0028584269 scopus 로고
    • Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases
    • 36. Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR (1994) Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science 266:1981-1986
    • (1994) Science , vol.266 , pp. 1981-1986
    • Dyda, F.1    Hickman, A.B.2    Jenkins, T.M.3    Engelman, A.4    Craigie, R.5    Davies, D.R.6
  • 37
    • 0028867419 scopus 로고
    • New insights into V(D)J recombination and its role in the evolution of the immune system
    • 37. Thompson CB (1995) New insights into V(D)J recombination and its role in the evolution of the immune system. Immunity 3:531-539
    • (1995) Immunity , vol.3 , pp. 531-539
    • Thompson, C.B.1
  • 38
    • 0029553231 scopus 로고
    • Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins Rag1 and Rag2
    • 38. Spanopoulou E, Cortes P, Shih C, Huang CM, Silver DP, Svec P, Baltimore D (1995) Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2. Immunity 3:715-726
    • (1995) Immunity , vol.3 , pp. 715-726
    • Spanopoulou, E.1    Cortes, P.2    Shih, C.3    Huang, C.M.4    Silver, D.P.5    Svec, P.6    Baltimore, D.7
  • 39
    • 0031092628 scopus 로고    scopus 로고
    • Definition of a large region of Rag1 that is important for co-immunoprecipitation of Rag2
    • in press
    • 39. McMahan CJ, Sadofsky MJ, Schatz DG (1997) Definition of a large region of RAG1 that is important for co-immunoprecipitation of RAG2. J Immunol, in press
    • (1997) J Immunol
    • McMahan, C.J.1    Sadofsky, M.J.2    Schatz, D.G.3
  • 40
    • 0029092358 scopus 로고
    • Rag-1 mutations that affect the target specificity of V(D) J recombination - A possible direct role of Rag-1 in site recognition
    • 40. Sadofsky MJ, Hesse JE, Vangent DC, Gellert M (1995) RAG-1 mutations that affect the target specificity of V(D) J recombination - a possible direct role of RAG-1 in site recognition. Genes Dev 9:2193-2199
    • (1995) Genes Dev , vol.9 , pp. 2193-2199
    • Sadofsky, M.J.1    Hesse, J.E.2    Vangent, D.C.3    Gellert, M.4
  • 41
    • 0029966374 scopus 로고    scopus 로고
    • Genetic evidence that the Rag1 protein directly participates in V(D)J recombination through substrate recognition
    • 41. Roman CAJ, Baltimore D (1996) Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition. Proc Natl Acad Sci USA 93:2333-2338
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2333-2338
    • Roman, C.A.J.1    Baltimore, D.2
  • 42
    • 0030592523 scopus 로고    scopus 로고
    • The homeodomain of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination
    • 42. Spanopoulou E, Zaitseva F, Wang F-H, Santagata S, Baltimore D, Panayotou G (1996) The homeodomain of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination. Cell 87:263-276
    • (1996) Cell , vol.87 , pp. 263-276
    • Spanopoulou, E.1    Zaitseva, F.2    Wang, F.-H.3    Santagata, S.4    Baltimore, D.5    Panayotou, G.6
  • 43
    • 0001265782 scopus 로고    scopus 로고
    • Rag1 mediates signal sequence recognition and recruitment of Rag2 in V(D)J recombination
    • 43. Difilippantonio MJ, McMahan CJ, Eastman QM, Spanopoulou E, Schatz DG (1996) RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination. Cell 87:253-262
    • (1996) Cell , vol.87 , pp. 253-262
    • Difilippantonio, M.J.1    McMahan, C.J.2    Eastman, Q.M.3    Spanopoulou, E.4    Schatz, D.G.5
  • 44
    • 0029891597 scopus 로고    scopus 로고
    • Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage
    • 44. Ramsden DA, McBlane JF, van Gent DC, Gellert M (1996) Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage. EMBO J 15:3197-3206
    • (1996) EMBO J , vol.15 , pp. 3197-3206
    • Ramsden, D.A.1    McBlane, J.F.2    Van Gent, D.C.3    Gellert, M.4
  • 45
    • 0028118764 scopus 로고
    • Hin recombinase bound to DNA: The origin of specificity in major and minor groove interactions
    • 45. Feng J-A, Johnson RC, Dickerson RE (1994) Hin recombinase bound to DNA: The origin of specificity in major and minor groove interactions. Science 263:348-355
    • (1994) Science , vol.263 , pp. 348-355
    • Feng, J.-A.1    Johnson, R.C.2    Dickerson, R.E.3
  • 46
    • 0011080690 scopus 로고    scopus 로고
    • V(D)J recombination and site-specific DNA recognition by RAG1
    • (Grosschedl R, Singh H, eds), in press. Springer, Heidelberg
    • 46. Spanopoulou E, Schatz DG (1997) V(D)J recombination and site-specific DNA recognition by RAG1, in B Lymphocytes (Grosschedl R, Singh H, eds), in press. Springer, Heidelberg
    • (1997) B Lymphocytes
    • Spanopoulou, E.1    Schatz, D.G.2
  • 47
    • 0029864993 scopus 로고    scopus 로고
    • Initiation of V(D)J recombination in vitro obeying the 12/ 23 role
    • 47. Eastman QM, Leu TMJ, Schatz DG (1996) Initiation Of V(D)J recombination in vitro obeying the 12/ 23 role. Nature 380:85-88
    • (1996) Nature , vol.380 , pp. 85-88
    • Eastman, Q.M.1    Leu, T.M.J.2    Schatz, D.G.3
  • 48
    • 0030009253 scopus 로고    scopus 로고
    • The Rag1 and Rag2 proteins establish the 12/23 rule in V(D)J recombination
    • 48. van Gent DC, Ramsden DA, Gellert M (1996) The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85:107-113
    • (1996) Cell , vol.85 , pp. 107-113
    • Van Gent, D.C.1    Ramsden, D.A.2    Gellert, M.3
  • 49
    • 0027410476 scopus 로고
    • V(D)J recombination: Signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites
    • 49. Sheehan KM, Lieber MR (1993) V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites. Mol Cell Biol 13:1363-1370
    • (1993) Mol Cell Biol , vol.13 , pp. 1363-1370
    • Sheehan, K.M.1    Lieber, M.R.2
  • 50
    • 0029814965 scopus 로고    scopus 로고
    • DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences
    • 50. Cuomo CA, Mundy CL, Oettinger MA (1996) DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences. Mol Cell Biol 16:5683-5690
    • (1996) Mol Cell Biol , vol.16 , pp. 5683-5690
    • Cuomo, C.A.1    Mundy, C.L.2    Oettinger, M.A.3
  • 51
    • 0027237601 scopus 로고
    • Coding end sequence can markedly affect the initiation of V(D)J recombination
    • 51. Gerstein RM, Lieber MR (1993) Coding end sequence can markedly affect the initiation of V(D)J recombination. Genes Dev 7:1459-1469
    • (1993) Genes Dev , vol.7 , pp. 1459-1469
    • Gerstein, R.M.1    Lieber, M.R.2
  • 52
    • 0028961228 scopus 로고
    • Coding sequence composition flanking either signal element alters V(D)J recombination efficiency
    • 52. Boubnov NV, Wills ZP, Weaver DT (1995) Coding sequence composition flanking either signal element alters V(D)J recombination efficiency. Nucleic Acids Res 23:1060-1067
    • (1995) Nucleic Acids Res , vol.23 , pp. 1060-1067
    • Boubnov, N.V.1    Wills, Z.P.2    Weaver, D.T.3
  • 53
    • 0028956147 scopus 로고
    • Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination
    • 53. Ezekiel UR, Engler P, Stern D, Storb U (1995) Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination. Immunity 2:381-389
    • (1995) Immunity , vol.2 , pp. 381-389
    • Ezekiel, U.R.1    Engler, P.2    Stern, D.3    Storb, U.4
  • 54
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
    • 54. Zhu CM, Bogue MA, Lim DS, Hasty P, Roth DB (1996) Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86:379-389
    • (1996) Cell , vol.86 , pp. 379-389
    • Zhu, C.M.1    Bogue, M.A.2    Lim, D.S.3    Hasty, P.4    Roth, D.B.5
  • 55
    • 0028863006 scopus 로고
    • Disassembly of the Mu transposase tetramer by the Clpx chaperone
    • 55. Levchenko I, Luo L, Baker TA (1995) Disassembly of the Mu transposase tetramer by the ClpX chaperone. Genes Dev 9:2399-2408
    • (1995) Genes Dev , vol.9 , pp. 2399-2408
    • Levchenko, I.1    Luo, L.2    Baker, T.A.3
  • 56
    • 0030020897 scopus 로고    scopus 로고
    • ClpX protein of Escherichia coli activates bacteriophage Mu transposase in the strand transfer complex for initiation of Mu DNA synthesis
    • 56. Kruklitis R, Welty DJ, Nakai H (1996) ClpX protein of Escherichia coli activates bacteriophage Mu transposase in the strand transfer complex for initiation of Mu DNA synthesis. EMBO J 15:935-944
    • (1996) EMBO J , vol.15 , pp. 935-944
    • Kruklitis, R.1    Welty, D.J.2    Nakai, H.3
  • 57
    • 0026052160 scopus 로고
    • Cutting and closing without recombination in V(D)J joining
    • 57. Lewis SM, Hesse JE (1991) Cutting and closing without recombination in V(D)J joining. EMBO J 10:3631-3639
    • (1991) EMBO J , vol.10 , pp. 3631-3639
    • Lewis, S.M.1    Hesse, J.E.2
  • 59
    • 0029894165 scopus 로고    scopus 로고
    • Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vivo
    • 59. Stanhope-Baker P, Hudson KM, Shaffer AL, Constantinescu A, Schlissel MS (1996) Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vivo. Cell 85:887-897
    • (1996) Cell , vol.85 , pp. 887-897
    • Stanhope-Baker, P.1    Hudson, K.M.2    Shaffer, A.L.3    Constantinescu, A.4    Schlissel, M.S.5
  • 60
    • 0027296517 scopus 로고
    • Regulation of V(D)J recombination activator protein Rag-2 by phosphorylation
    • 60. Lin W, Desiderio S (1993) Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation. Science 260:953-959
    • (1993) Science , vol.260 , pp. 953-959
    • Lin, W.1    Desiderio, S.2
  • 61
    • 0028223271 scopus 로고
    • Cell cycle regulation of V(D)J recombination-activating protein Rag-2
    • 61. Lin WC, Desiderio S (1994) Cell cycle regulation of V(D)J recombination-activating protein RAG-2. Proc Natl Acad Sci USA 91:2733-2737
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2733-2737
    • Lin, W.C.1    Desiderio, S.2
  • 63
    • 0028291092 scopus 로고
    • Conservation of sequence in recombination signal sequence spacers
    • 63. Ramsden DA, Baetz K, Wu GE (1994) Conservation of sequence in recombination signal sequence spacers. Nucleic Acids Res 22:1785-1796
    • (1994) Nucleic Acids Res , vol.22 , pp. 1785-1796
    • Ramsden, D.A.1    Baetz, K.2    Wu, G.E.3
  • 64
    • 0031582059 scopus 로고    scopus 로고
    • Identification of V(D)J recombination coding end intermediates in normal thymocytes
    • in press
    • 64. Livak F, Schatz DG (1997) Identification of V(D)J recombination coding end intermediates in normal thymocytes. J Mol Biol, in press
    • (1997) J Mol Biol
    • Livak, F.1    Schatz, D.G.2
  • 65
    • 0025836948 scopus 로고
    • Site-specific recombination in the immune system
    • 65. Lieber MR (1991) Site-specific recombination in the immune system. FASEB J 5:2934-2944
    • (1991) FASEB J , vol.5 , pp. 2934-2944
    • Lieber, M.R.1
  • 66
    • 0028847473 scopus 로고
    • Influence of coding-end sequence on coding-end processing in V(D)J recombination
    • 66. Nadel B, Feeney AJ (1995) Influence of coding-end sequence on coding-end processing in V(D)J recombination. J Immunol 155:4322-4329
    • (1995) J Immunol , vol.155 , pp. 4322-4329
    • Nadel, B.1    Feeney, A.J.2
  • 67
    • 0026492714 scopus 로고
    • V(D)J recombination gets a break
    • 67. Gellert M (1992) V(D)J recombination gets a break. Immunol Today 8:408-412
    • (1992) Immunol Today , vol.8 , pp. 408-412
    • Gellert, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.