Enhancer control of local accessibility to V(D)J recombinase

Molecular and Cellular Biology

Volumn 17, Issue 8, 1997, Pages 4553-4561

  McMurry, Michelle Taylor ^a   Hernandez Munain, Cristina ^a   Lauzurica, Pilar ^a,b   Krangel, Michael S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; RECOMBINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; ENHANCER REGION; ENZYME ANALYSIS; GENE LOCUS; GENETIC RECOMBINATION; INTRON; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE RECEPTOR GENE;

ANIMALIA;

EID: 0030853938     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.8.4553     Document Type: Article

References (62)

1. Alt, F. W., T. K. Blackwell, and G. D. Yancopoulos. 1987. Development of the primary antibody repertoire. Science (Washington, D.C.) 238:1079-1087.
2. Alt, F. W., E. M. Oltz, F. Young, J. Gorman, G. Taccioli, and J. Chen. 1992. VDJ recombination. Immunol. Today 13:306-314.
3. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. A. Smith, J. G. Seidman, and K. Struhl. 1987. Current protocols in molecular biology. Green Publishing Associates and John Wiley and Sons, New York, N.Y.
4. Blunt, T., N. J. Finnie, G. E. Taccioli, G. C. M. Smith, J. Demengeot, T. M. Gottlieb, R. Mizuta, A. J. Varghese, F. W. Alt, P. A. Jeggo, and S. P. Jackson. 1995. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80:813-823.
5. Bories, J.-C., J. Demengeot, L. Davidson, and F. W. Alt. 1996. Gene-targeted deletion and replacement of the T-cell receptor β-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc. Natl. Acad. Sci. USA 93:7871-7876.
6. Bouvier, G., F. Watrin, M. Naspetti, C. Verthuy, P. Naquet, and P. Ferrier. 1996. Deletion of the mouse T-cell receptor β gene enhancer blocks αβ T-cell development. Proc. Natl. Acad. Sci. USA 93:7877-7881.
7. Capone, M., F. Watrin, C. Fernex, B. Horvat, B. Krippl, L. Wu, R. Scollay, and P. Ferrier. 1993. TCRβ and TCRα gene enhancers confer tissue- and stage-specificity on V(D)J recombination events. EMBO J. 12:4335-4346.
8. Chen, E. Y., and P. H. Seeburg. 1985. Supercoil sequencing: a fast and simple method for sequencing plasmid DNA. Dev. Biol. 4:165-170.
9. Chen, J., F. Young, A. Bottaro, V. Stewart, R. K. Smith, and F. W. Alt. 1993. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J. 12:4635-4645.
10. Chien, Y.-H., M. Iwashima, D. A. Wettstein, K. B. Kaplan, J. F. Elliot, W. Born, and M. M. Davis. 1987. T-cell receptor δ gene rearrangements in early thymocytes. Nature (London) 330:722-727.
11. Eastman, Q. M., T. M. Leu, and D. G. Schatz. 1996. Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature (London) 380:85-88.
12. Elliot, J. F., E. P. Rock, P. A. Patten, M. M. Davis, and Y.-H. Chien. 1988. The adult T-cell receptor δ-chain is diverse and distinct from that of fetal thymocytes. Nature (London) 331:627-631.
13. Feinberg, A., and B. Vogelstein. 1983. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6-13.
14. Ferrier, P., B. Krippl, T. K. Blackwell, A. J. W. Furley, H. Suh, A. Winoto, W. D. Cook, L. Hood, F. Costantini, and F. W. Alt. 1990. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J. 9:117-125.
15. Forrester, W. C., C. van Genderen, T. Jenuwein, and R. Grosschedl. 1994. Dependence of enhancer-mediated transcription of the immunoglobulin μ gene on nuclear matrix attachment regions. Science (Washington, D.C.) 265:1221-1225.
16. Gellert, M. 1992. Molecular analysis of V(D)J recombination. Annu. Rev. Genet. 22:425-446.
17. Gorman, J. R., N. van der Stoep, R. Monroe, M. Cogne, L. Davidson, and F. W. Alt. 1996. The Igκ 3′ enhancer influences the ratio of Igκ versus Igλ B lymphocytes. Immunity 5:241-252.
18. Han, S., B. Zheng, D. G. Schatz, E. Spanopoulou, and G. Kelsoe. 1996. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science (Washington, D.C.) 274:2094-2097.
19. Hendrickson, E. A., V. F. Liu, and D. T. Weaver. 1991. Strand breaks without DNA rearrangement in V(D)J recombination. Mol. Cell. Biol. 11:3155-3162.
20. Hernandez-Munain, C., P. Lauzurica, and M. S. Krangel. 1996. Regulation of T cell receptor δ gene rearrangement by c-Myb. J. Exp. Med. 183:289-293.
21. Hikida, M., M. Mori, T. Takai, K.-I. Tomochika, K. Hamatani, and H. Ohmori. 1996. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science (Washington, D.C.) 274:2092-2094.
22. Jackson, S. P., and P. A. Jeggo. 1995. DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends Biochem. Sci. 20: 412-416.
23. Jenuwein, T., W. C. Forrester, R.-G. Qiu, and R. Grosschedl. 1993. The immunoglobulin μ enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation. Genes Dev. 7:2016-2032.
24. Kirchgessner, C. U., C. K. Patil, J. W. Evans, C. A. Cuomo, L. M. Fried, T. Carter, M. A. Oettinger, and J. M. Brown. 1995. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science (Washington, D.C.) 267:1178-1183.
25. Krangel, M. S., H. Yssel, C. Brocklehurst, and H. Spits. 1990. A distinct wave of human T cell receptor γ/δ lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. J. Exp. Med. 172:847-859.
26. Lauster, R., C.-A. Reynaud, I.-L. Martensson, A. Peter, D. Bucchini, J. Jami, and J.-C. Weill. 1993. Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene. EMBO J. 12:4615-4623.
27. Lauzurica, P., and M. S. Krangel. 1994. Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor δ transgene. J. Exp. Med. 179:43-55.
28. Lauzurica, P., and M. S. Krangel. 1994. Temporal and lineage-specific control of T cell receptor α/δ gene rearrangement by T cell receptor α and δ enhancers. J. Exp. Med. 179:1913-1921.
29. Lauzurica, P., X.-P. Zhong, M. S. Krangel, and J. L. Roberts. 1997. Regulation of T cell receptor δ gene rearrangement by CBF/PEBP2. J. Exp. Med. 185:1193-1201.
30. Lewis, S. M. 1994. The mechanism of V(D)J joining: lessons from molecular, immunological and comparative analyses. Adv. Immunol. 56:27-150.
31. Lewis, S. M., and J. E. Hesse. 1991. Cutting and closing without recombination in V(D)J joining. EMBO J. 10:3631-3639.
32. Loh, E. Y., S. Cwirla, A. T. Serafini, J. H. Phillips, and L. L. Lanier. 1988. Human T-cell-receptor δ chain: genomic organization, diversity, and expression in populations of cells. Proc. Natl. Acad. Sci. USA 85:9714-9718.
33. McBlane, J. F., D. C. van Gent, D. A. Ramsden, C. Romeo, C. A. Cuomo, M. Gellert, and M. A. Oettinger. 1995. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83:387-395.
34. Mombaerts, P., J. Iacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869-877.
35. Mueller, P. R., and B. Wold. 1989. In vivo footprinting of a muscle specific enhancer by ligation mediated PCR. Science (Washington, D.C.) 246:780-786.
36. Nussenzweig, A., C. Chen, V. da Costa Soares, M. Sanchez, K. Sokol, M. C. Nussenzweig, and G. C. Li. 1996. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature (London) 382:551-555.
37. Oettinger, M. A., D. G. Schatz, C. Gorka, and D. Baltimore. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science (Washington, D.C.) 248:1517-1523.
38. Okada, A., M. Mendelsohn, and F. Alt. 1994. Differential activation of transcription versus recombination of transgenic T cell receptor β variable region gene segments in B and T lineage cells. J. Exp. Med. 180:261-272.
39. Oltz, E. M., F. W. Alt, W.-C. Lin, J. Chen, G. Taccioli, S. Desiderio, and G. Rathbun. 1993. A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol. Cell. Biol. 13:6223-6230.
40. Pikaart, M., J. Feng, and B. Villeponteau. 1992. The polyoma enhancer activates chromatin accessibility on integration into the HPRT gene. Mol. Cell. Biol. 12:5786-5792.
41. Roberts, J. L., P. Lauzurica, and M. S. Krangel. 1997. Developmental regulation of VDJ recombination by the core fragment of the T cell receptor α enhancer. J. Exp. Med. 185:131-140.
42. Roth, D. B., J. P. Menetski, P. B. Nakajima, M. J. Bosma, and M. Gellert. 1992. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70:983-991.
43. Roth, D. B., P. B. Nakajima, J. P. Menetski, M. J. Bosma, and M. Gellert. 1992. V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor δ rearrangement signals. Cell 69:41-53.
44. Roth, D. B., C. Zhu, and M. Gellert. 1993. Characterization of broken DNA molecules associated with V(D)J recombination. Proc. Natl. Acad. Sci. USA 90:10788-10792.
45. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
46. Schatz, D. G., M. A. Oettinger, and D. Baltimore. 1989. The V(D)J recombination activating gene, RAG-1. Cell 59:1035-1048.
47. Schatz, D. G., M. A. Oettinger, and M. S. Schlissel. 1992. V(D)J recombination: molecular biology and regulation. Annu. Rev. Immunol. 10:359-383.
48. Schlissel, M., A. Constantinescu, T. Morrow, M. Baxter, and A. Peng. 1993. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7:2520-2532.
49. Serwe, M., and F. Sablitzky. 1993. V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J. 12:2321-2327.
50. Sheehan, K. M., and M. R. Lieber. 1993. V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites. Mol. Cell. Biol. 13:1363-1370.
51. Shinkai, Y., G. Rathbun, K.-P. Lam, E. M. Oltz, V. E. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A. M. Stall, and F. W. Alt. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855-867.
52. Sleckman, B. P., J. R. Gorman, and F. W. Alt. 1996. Accessibility control of antigen receptor variable region gene assembly: role of cis-acting elements. Annu. Rev. Immunol. 14:459-481.
53. Smider, V., W. K. Rathmell, M. R. Lieber, and G. Chu. 1995. Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science (Washington, D.C.) 266:288-291.
54. Stanhope-Baker, P., K. M. Hudson, A. L. Shaffer, A. Constantinescu, and M. S. Schlissel. 1996. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell 85:887-897.
55. Taccioli, G. E., T. M. Gottlieb, T. Blunt, A. Priestly, J. Demengeot, R. Mizuta, A. Lehmann, F. W. Alt, S. P. Jackson, and P. A. Jeggo. 1994. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science (Washington, D.C.) 265:1442-1445.
56. Takeda, S., Y.-R. Zou, H. Bluethmann, D. Kitamura, U. Muller, and K. Rajewsky. 1993. Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans. EMBO J. 12:2329-2336.
57. van Gent, D. C., D. A. Ramsden, and M. Gellert. 1996. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell 85: 107-113.
58. Villey, I., D. Caillol, F. Selz, P. Ferrier, and J.-P. de Villartay. 1996. Defect in rearrangement of the most 5′ TCR-Jα following targeted deletion of T early α (TEA): implications for TCR α locus accessibility. Immunity 5:331-342.
59. Weaver, D. T. 1995. What to do at an end: DNA double-strand break repair. Trends Genet. 11:388-392.
60. Xu, Y., L. Davidson, F. W. Alt, and D. Baltimore. 1996. Deletion of the Igκ light chain intronic enhancer/matrix attachment region impairs but does not abolish VKJK rearrangement. Immunity 4:377-385.
61. Zhong, X.-P., and M. S. Krangel. 1997. An enhancer-blocking element between α and δ gene segments within the human T cell receptor α/δ locus. Proc. Natl. Acad. Sci. USA 94: 5219-5224.
62. Zhu, C., M. Bogue, D.-S. Lim, P. Hasty, and D. B. Roth. 1996. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86:379-389.