Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1

Journal of Clinical Investigation

Volumn 99, Issue 6, 1997, Pages 1367-1379

  Cohn, Steven M ^a   Schloemann, Suzanne ^a   Tessner, Teresa ^a   Seibert, Karen ^b   Stenson, William F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

bromodeoxyuridine; epithelium; indomethacin; prostaglandin E2; wound healing

Indexed keywords

16,16 DIMETHYLPROSTAGLANDIN E2; CYCLOOXYGENASE 1; INDOMETACIN; MESSENGER RNA; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CRYPT CELL; ENZYME LOCALIZATION; FEMALE; GAMMA IRRADIATION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RADIATION INJURY; STEM CELL; WOUND HEALING;

EID: 0030895087     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119296     Document Type: Article

References (38)

1. Gordon, J.I., and M.L. Hermiston. 1994. Differentiation and self-renewal in the mouse gastrointestinal epithelium. Curr. Opin. Cell Biol. 6:795-803.
2. 2 increases survival of murine intestinal stem cells when given before photon radiation. Radiat. Res. 96:393-398.
3. Goodlad, R.A., C.Y. Lee, S. Levin, and N.A. Wright. 1991. Effects of the prostaglandin analogue misoprostol on cell proliferation in the canine small intestine. Exp. Physiol. 76:561-566.
4. Giovannucci, E., K.M., Egan, D.J. Hunter, M.J. Stampfer, G.A. Colditz, W.C. Willett, and F.E. Speizer. 1995. Aspirin and the risk of colorectal cancer in women. N. Engl. J. Med. 333:609-614.
5. Giovannucci, E., E.B. Rimm, M.J. Stampfer, G.A. Colditz, A. Ascherio, and W.C. Willett. 1994. Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann. Intern. Med. 121:241-246.
6. Cheng, H., and C.P. Leblond. 1974. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types. Am. J. Anal. 141:537-561.
7. Cohn, S.M., T.C. Simon, K.A. Roth, E.H. Birkenmeier, and J.I. Gordon. 1992. Use of transgenic mice to map cis-acting elements in the intestinal fatty acid binding protein gene (Fabpi) that control its cell lineage-specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium. J. Cell Biol. 119:27-44.
8. Schmidt, G.H., M.M. Wilkinson, and B.A.J. Ponder. 1985. Cell migration pathway in the intestinal epithelium: an in situ marker system using mouse aggregation chimeras. Cell. 40:425-429.
9. Winton, D.J., and B.A. Ponder. 1990. Stem-cell organization in mouse small intestine. Proc. R. Soc. Lond. B. Biol. Sci. 241:13-18.
10. Potten, C.S., and M. Loeffler. 1987. A comprehensive model of the crypts of the small intestine of the mouse provides insight into the mechanisms of cell migration and the proliferation hierarchy. J. Theor. Biol. 127:381-391.
11. Potten, C.S., and M. Loeffler. 1990. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development. (Camb.). 110:1001-1020.
12. Potten, C.S. 1990. A comprehensive study of the radiobiological response of the murine (BDF1) small intestine. Int. J. Radiat. Biol. 58:925-973.
13. Hauft, S.M., S.H. Kim, G.H. Schmidt, S. Pease, S. Rees, S. Harris, K.A. Roth, J.R. Hansbrough, S.M. Cohn, D.J. Ahnen, N.A. Wright, R.A. Goodlad, and J.I. Gordon. 1992. Expression of SV-40 T antigen in the small intestinal epithelium of transgenic mice results in proliferative changes in the crypt and reentry of villus-associated enterocytes into the cell cycle but has no apparent effect on cellular differentiation programs and does not cause neoplastic transformation. J. Cell Biol. 117:825-839.
14. Roberts, S.A., J.H. Hendry, and C.S. Potten. 1995. Deduction of the clonogen content of intestinal crypts: A direct comparison of two-dose and multiple-dose methodologies. Radiat. Res. 141:303-308.
15. Withers, H.R., and M.M. Elkind. 1970. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int. J. Radiat. Biol. 117: 261-267.
16. Dignass, A.U., S. Tsunekawa, and D.K. Podolsky. 1994. Fibroblast growth factors modulate intestinal epithelial cell growth and migration. Gastroenterology. 106:1254-1262.
17. 2 prostaglandins modulate cell proliferation in the small intestinal epithelium of the rat. Digestion. 52:157-164.
18. 2 prostaglandins and indomethacin. Digestion. 36:238-245.
19. Kujubu, D.A., B.S. Fletcher, B.C. Varnum, R.W. Lim, and H.R. Herschman. 1991. TIS10, a phorbol ester tumor promoter-inducible mRNA from swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J. Biol. Chem. 266:12866-12872.
20. Maier, J.A.M., T. Hla, and T. Maciag. 1990. Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. J. Biol. Chem. 265:10805-10808.
21. Masferrer, J.L., K. Seibert, B. Zweifel, and P. Needleman. 1992. Endogenous glucocoricoids regulate an inducible cyclooxygenase enzyme. Proc. Natl. Acad. Sci. USA. 89:3917-3921.
22. Dubois, R.N., J. Awad, J. Morrow, L.J. Roberts, and P.R. Bishop. 1994. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-α and phorbol ester. J. Clin. Invest. 93:493-498.
23. Meade, E.A., W.L. Smith, and D.L. Dewitt. 1993. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 268:6610-6614.
24. Seibert, K., Y. Zhang, K. Leahy, S. Hauser, J. Masferrer, W. Perkins, L. Lee, and P. Isakson. 1994. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA. 91:12013-12017.
25. Gierse, J.K., S.D. Hauser, D.P. Creely, C. Koboldt, S.H. Rangwala, P.C. Isakson, and K. Seibert. 1995. Expression and selective inhibition of the constituative and inducible forms of human cyclo-oxygenase. Biochem. J. 385:479-484.
26. Cohn, S.M., and M.W. Lieberman. 1984. The use of antibodies to 5-bromo-2′-deoxyuridine for the isolation of DNA sequences containing excision-repair sites. J. Biol. Chem. 259:12456-12462.
27. Masferrer, J.L., S.T. Reddy, B.S. Zweifel, K. Seibert, P. Needleman, R.S. Gilbert, and H.R. Herschman. 1995. In vivo glucocorticoids regulate cyclooxygenase-2 but not cyclooxygenase-1 in peritoneal macrophages. J. Pharm. Exp. Therapeutics. 270:1340-1344.
28. Masferrer, J.L., B.S. Zweifel, P.T. Manning, S.D. Hauser, K.M. Leahy, W.G. Smith, P.C. Isakson, and K. Seibert. 1994. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. USA. 91:3228-3232.
29. Reitz, D.B., J.J. Li, M.B. Norton, E.J. Reinhard, J.T. Collins, G.D. Anderson, S.A. Gregory, C.M. Koboldt, W.E. Perkins, K. Seibert, and P.C. Isakson. 1994. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active Cox-2 inhibitors. J. Med. Chem. 37:3878-3881.
30. Iseki, S. 1995. Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach. Histochem. J. 27:323-328.
31. Langenbach, R., S.G. Morham, H.F. Tiano, C.D. Loftin, B.I. Ghanayem, P.C. Chulada, J.F. Mahler, C.A. Lee, E.H. Goulding, K.D. Kluckman, H.S. Kim, and O. Smithies. 1995. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 83:483-492.
32. Weichselbaum, R.R., D. Hallahan, Z. Fuks, and D. Kufe. 1994. Radiation induction of immediate early genes: Effectors of the radiation-stress response. Int. J. Radiat. Oncol. Biol. Phys. 30:229-234.
33. Witte, L., Z. Fuks, A. Haimovitz-Friedman, I. Vlodavsky, D.S. Goodman, and A. Eldor. 1989. Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells. Cancer Res. 49: 5066-5072.
34. Murakami, M., R. Matsumoto, Y. Urade, K.F. Austen, and J.P. Arm. 1995. cKIT ligand mediates increased expression of cytosolic phospholipase A2, prostaglandin endoperoxide synthase-1, and hematopoietic prostaglandin D2 synthase and increased IgE-dependent Prostaglandin D2 generation in immature mouse mast cells. J. Biol. Chem. 270:3239-3246.
35. Samet, J.M., M.B. Fasano, A.N. Foneth, and F.H. Chilton. 1995. Selective induction of Prostaglandin G/H synthase I by stem cell factor and dexamethasone in mast cells. J. Biol. Chem. 270:8044-8049.
36. Kawaguchi, H., C.C. Pilbeam, G. Gronowicz, C. Abreu, B.S. Fletcher, H.R. Herschman, L.G. Raisz, and M.M. Hurley. 1995. Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor. Am. Soc. Clin. Invest. 96:923-930.
37. Sugimoto, Y., T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, and S. Narumiya. 1994. Distinct cellular localization of mRNAs for three subtypes of prostaglandin E receptor in kidney. Am. J. Physiol. 823-827.
38. Morham, S.G., R. Langenbach, C.D. Loftin, H.F. Tiano, N. Vouloumanos, J.C. Jennette, J.F. Mahler, K.D. Kluckman, A. Ledford, C.A. Lee, and O. Smithies. 1995. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell. 83:473-482.