Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): Rationale for selective inhibition and progress to date

Medicinal Research Reviews

Volumn 16, Issue 2, 1996, Pages 181-206

  Griswold, Don E ^a   Adams, Jerry L ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 1 (3 TRIFLUOROMETHYLPHENYL) 2 PYRAZOLINE; 4 (3,5 DI TERT BUTYL 4 HYDROXYPHENYL) 2 METHYL 1,2 OXAZIN 3 ONE; 4' ACETYL 2' (2,4 DIFLUOROPHENOXY)METHANESULFONANILIDE; 5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; 6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; ACETYLSALICYLIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; DIFLUMIDONE; ETODOLAC; FLOSULIDE; FLURBIPROFEN; IGURATIMOD; INDOMETACIN; INDOXOLE; ISOENZYME; MEFENAMIC ACID; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NABUMETONE; NAPROXEN; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OXAPROZIN; PIROXICAM; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROSTANOID; RADICICOL; TENIDAP; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; BLOOD VESSEL; CLINICAL TRIAL; DIGESTIVE SYSTEM ULCER; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYMOLOGY; GENE EXPRESSION; HUMAN; LEUKOCYTE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROSTAGLANDIN METABOLISM; REVIEW; RHEUMATIC DISEASE; SMOOTH MUSCLE; STOMACH LESION;

ANIMALS; CYCLOOXYGENASE INHIBITORS; ENZYME INDUCTION; HUMANS; ISOENZYMES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0029983843     PISSN: 01986325     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1128(199603)16:2<181::AID-MED3>3.0.CO;2-X     Document Type: Review

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