Structural basis for selective inhibition of cyciooxygenase-2 by anti-inflammatory agents

Nature

Volumn 384, Issue 6610, 1996, Pages 644-648

  Kurumbail, Ravi G ^a   Stevens, Anna M ^a   Gierse, James K ^a   McDonald, Joseph J ^a   Stegeman, Roderick A ^a   Pak, Jina Y ^a   Gildehaus, Daniel ^a   Miyashiro, Julie M ^b   Penning, Thomas D ^b   Seibert, Karen ^a   Isakson, Peter C ^a   Stallings, William C ^a  

^a G D Searie   (United States)

^b G D Searie   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ARTICLE; DRUG MECHANISM; ENZYME INHIBITION; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHEEP; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; FLURBIPROFEN; INDOMETHACIN; ISOENZYMES; MICE; MODELS, MOLECULAR; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN CONFORMATION; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030461132     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/384644a0     Document Type: Article

References (30)

1. Smith, W. L. & Mamett, L. J. in Metal Ions in Biological Systems (eds Sigel, H. & Sigel, A.) 163-199 (Marcel Dekker, New York, 1994).
2. Otto, J. C. & Smith, W. L. J. Lipid Mediat. Cell Signal. 12, 139-156 (1995).
3. Vane, J. R. et al. Proc. Natl Acad. Sci. USA 91, 2046-2050 (1994).
4. DeWitt, D. L. et al. J. Biol. Chem. 265, 5192-5196 (1990).
5. Herschman, H. R. Biochim. Biophys. Acta 1299, 125-140 (1996).
6. Seibert, K. et al. Proc. Natl Acad. Sci. USA 91, 12013-12017 (1994).
7. Masferrer, J. L. et al. Proc. Natl Acad. Sci. USA 91, 3228-3232 (1994).
8. Picot, D., Loll, P. J. & Garavito, R. M. Nature 367, 243-249 (1994).
9. Loll, P. J., Picot, D. & Garavito, R. M. Nature Struct. Biol. 2, 637-643 (1995).
10. Loll, P. J., Picot, D., Ekabo, O. & Garavito, R. M. Biochemistry 35, 7330-7340 (1996).
11. Mamett, L J. & Maddipati, K. R. in Peroxidases in Chemistry and Biology Vol 1 (eds Everse, K. E. & Grisham, M. B.) 293-334 (CRC Press, Boca Raton, FL, 1991).
12. Mitchell, J. A., Akarasereenont, P., Thiemermann, C., Flower, R. J. & Vane, J. R. Proc. Natl Acad. Sci. USA 90, 11693-11697 (1993).
13. Laneuville, O. et al. J. Pharmacol. Exp. Ther. 271, 927-934 (1994).
14. Gans, K. R. et al. J. Pharmacol. Exp. Ther. 254, 180-187 (1990).
15. Futaki, N. et al. Prostaglandins 47, 55-59 (1994).
16. Smith, W. L., Eling, T.E., Kulmacz, R. J., Mamett, L. J. & Tsai, A. Biochemistry 31, 3-7 (1992).
17. Dietz, R., Nastainczyk, W. & Ruf, H. H. Eur. J. Biochem. 171, 320-327 (1988).
18. Van, J. R. Nature New. Biol. 231, 232-235 (1971).
19. Hoogsteen, K. & Trenner, N. R. J. Org. Chem. 35, 521 (1970).
20. Black, W. C. et al. Bioorg. Med. Chem. Lett. 6, 725-730 (1996).
21. Gierse, J. K. et al. J. Biol. Chem. 271, 15810-15814 (1996).
22. Bertenshaw, S. R. et al. Bioorg. Med. Chem. Lett. 5, 2919-2922 (1995).
23. Kulmacz, R. J. & Lands, W. E. M. J. Biol. Chem. 260, 12572-12578 (1985).
24. Bhattacharyya, D. K., Lecomte, M., Rieke, C. J., Garavito, R. M. & Smith, W. L. J. Biol. Chem. 271, 2179-2184 (1996).
25. Copeland, R. A. et al. Proc. Natl Acad. Sci. USA 91, 11202-11206 (1994).
26. Gierse, J. K. et al. Biochem. J. 305, 479-484 (1995).
27. Otwinowski, Z. & Minor, W. in Data Collection and Processing (eds Sawyer, L. Isaacs, N. & Bailey, S.) 556-562 (SERC Daresbuty Laboratory, Warrington, UK, 1993).
28. Fitzgerald, P. M. D. J. Appl. Crystallogr. 21, 273-278 (1988).
29. Brunger, A. T. XPLOR (Version 3.1): A System for X-ray Crystallography and NMR (Yale Univ. Press, New Haven, CT, 1993).
30. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgarrd, M. Acta Crystallogr. A47, 110-119 (1991).