Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs

Journal of Physiology and Pharmacology

Volumn 48, Issue 4, 1997, Pages 623-631

  Patrignani, P ^a   Panara, M R ^a   Sciulli, M G ^a   Santini, G ^a   Renda, G ^a   Patrono, C ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

Human blood; Human platelets; Monocytes; Nonsteroidal anti inflammatory drugs; Prostaglandin endoperoxide synthases; Selective PGHS 2 inhibitors

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; 6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; 6 METHOXY 2 NAPHTHYLACETIC ACID; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; FLURBIPROFEN; IBUPROFEN; INDOMETACIN; ISOENZYME; KETOPROFEN; MELOXICAM; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NAPROXEN; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ARACHIDONIC ACID METABOLISM; CONFERENCE PAPER; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INACTIVATION; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; PROSTAGLANDIN SYNTHESIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD PLATELETS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; ENZYME INDUCTION; HUMANS; ISOENZYMES; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MONOCYTES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0031456454     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

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