Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 272, Issue 6 41-6, 1997, Pages

  Cao, Chunyu ^a   Matsumura, Kiyoshi ^a,b   Yamagata, Kanato ^c   Watanabe, Yasuyoshi ^a,b  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Lipopolysaccharide; Prostaglandin; Tolerance

Indexed keywords

ANTIPYRETIC ANALGESIC AGENT; CYCLOOXYGENASE 2; HEAT SHOCK PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROSTAGLANDIN E2; URETHAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BODY TEMPERATURE; BRAIN BLOOD VESSEL; ENZYME LOCALIZATION; FEVER; IN SITU HYBRIDIZATION; MALE; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; RAT; TELENCEPHALON; THERMOREGULATION;

EID: 0030787985     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1997.272.6.r1712     Document Type: Article

References (14)

1. 1. Agents Actions Suppl. 45: 59-64, 1995.
2. Bernheim, H. A., T. M. Gilbert, and J. T. Stitt. Prostaglandin E levels in third ventricular cerebrospinal fluid of rabbits during fever and changes in body temperature. J. Physiol. (Lond.) 301: 69-78, 1980.
3. Blatteis, C. M. Neural mechanisms in the pyrogenic and acute-phase responses to interleukin-1. Int. J. Neurosci. 38: 223-232, 1988.
4. Breder, C. D., D. Dewitt, and R. P. Kraig. Characterization of inducible cyclooxygenase in rat brain. J. Comp. Neural. 355: 296-315, 1995.
5. Breder, C. D., and C. B. Saper. Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide. Brain Res. 713: 64-69, 1996.
6. Cao, C., K. Matsumura, K. Yamagata, and Y. Watanabe. Induction by lipopolysaccaride of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response. Brain Res. 697: 187-196, 1995.
7. Cao, C., K. Matsumura, K. Yamagata, and Y. Watanabe. Endothelial cells of the rat brain vasculacture express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever. Brain Res. 733: 263-272, 1996.
8. 2 in the genesis of pyrogen fever. Am. J. Physiol. 254 (Regulatory Integrative Comp. Physiol. 23): R463-R469, 1988.
9. Cranston, W. I., and M. D. Rawlins. Effects of intracerebral micro-injection of sodium salicylate on temperature regulation in the rabbit. J. Physiol. (Lond.) 222: 257-266, 1972.
10. Cunningham, J. E. T., and E. B. De Souza. Interleukin 1 receptors in the brain and endocrine tissues. Immunol. Today 14: 171-176, 1993.
11. De Vries, H. E., K. H. Hoogendoorn, J. van Dijk, F. J. Zijlstra, A.-M. van Dam, D. D. Breimer, T. J. C. van Berkel, A. G. de Boer, and J. Kuiper. Eicosanoid production by rat cerebral endothelial cells: stimulation by lipopolysaccharide, interleukin-1 and interleukin-6. J. Neuroimmunol. 59: 1-8, 1995.
12. Futaki, N., I. Arai, Y. Hamasaka, S. Takahashi, S. Higuchi, and S. Otomo. Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation. J. Pharm. Pharmacol. 45: 753-755, 1993.
13. Futaki, N., S. Takahashi, M. Yokoyama, I. Arai, S. Higuchi, and S. Otomo. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47: 55-59, 1994.
14. Futaki, N., K. Yoshikawa, Y. Hamasaka, I. Arai, S. Higuchi, H. Iizuka, and S. Otomo. NS-389, a novel non-steroidal antiinflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen. Pharmacol. 24: 105-110, 1993.