Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1

Journal of Biological Chemistry

Volumn 271, Issue 4, 1996, Pages 2179-2184

  Bhattacharyya, Dipak K ^a   Lecomte, Marc ^a   Rieke, Caroline Jill ^a   Garavito, R Michael ^a   Smith, William L ^a  

^a Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; ARGININE; GLUTAMIC ACID; HYDRATROPIC ACID; IBUPROFEN; TYROSINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; MONKEY; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY;

AMINO ACID SEQUENCE; ANIMALS; ARACHIDONIC ACID; ARGININE; BASE SEQUENCE; BINDING SITES; CYCLOOXYGENASE INHIBITORS; DNA PRIMERS; ENZYME INHIBITORS; FLURBIPROFEN; GLUTAMATES; IBUPROFEN; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENYLPROPIONATES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

ANIMALIA; OVIS;

EID: 0030068054     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.4.2179     Document Type: Article

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