A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors

Journal of Biological Chemistry

Volumn 271, Issue 26, 1996, Pages 15810-15814

  Gierse, James K ^a,b   McDonald, Joseph J ^a   Hauser, Scott D ^a   Rangwala, Shaukat H ^a   Koboldt, Carol M ^a   Seibert, Karen ^a  

^a PFIZER INC   (United States)

^b Monsanto/Searle   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; ENZYME SPECIFICITY; INFLAMMATORY DISEASE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; ISOENZYMES; ISOLEUCINE; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SHEEP; STRUCTURE-ACTIVITY RELATIONSHIP; VALINE;

ANIMALIA; INSECTA;

EID: 0029899186     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.26.15810     Document Type: Article

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