Intrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate

Inflammation Research

Volumn 45, Issue 10, 1996, Pages 499-502

  Ferreira, S H ^a   Lorenzetti, B B ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Glutamate; Nitric oxide analgesia; NMDA receptor; Primary afferent neuron; Prostaglandin E2; Spinal hyperalgesia

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; GLUTAMIC ACID; METHYLENE BLUE; MORPHINE; N ACETYL S NITROSOPENICILLAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N(G) METHYLARGININE; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ETIOLOGY; HYPERALGESIA; INTRATHECAL DRUG ADMINISTRATION; MALE; NONHUMAN; SENSORY NERVE; SPINAL NERVE;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; DINOPROSTONE; GLUTAMIC ACID; HYPERALGESIA; INJECTIONS, SPINAL; MALE; NEURONS, AFFERENT; OMEGA-N-METHYLARGININE; PENICILLAMINE; RATS; RATS, WISTAR; S-NITROSO-N-ACETYLPENICILLAMINE; SPINAL CORD;

EID: 0029823291     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02311085     Document Type: Article

References (15)

1. Ramwell PW, Shaw JE, Jessup R. Spontaneous release of prostaglandins from frog spinal cord. Am J Physiol 1966;998-1004.
2. 2 to conscious mice. Pain 1994;57:217-23.
3. 2-induced hyperalgesia in conscious mice. Brain Res 1995;677:138-44.
4. Duarte IDG, Lorenzetti BB, Ferreira SH. Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Eur J Pharmacol 1990;186:289-93.
5. Ferreira SH, Lorenzetti BB. Glutamate spinal retrograde sensitization of primary sensory neurons associated with nociception. Neuropharmacology 1993;33:1479-85.
6. Malmherg AB, Yaksh TL. Hyperalgesia medicated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science 1992;257:1276-9.
7. Ferreira SH, Lorenzetti BB, Correa FMA. Central and peripheral antialgesic action of aspirin-like drugs. Eur J Pharmacol 1978;53:39-48.
8. Papir-Kricheli D, Frey J, Laufer R, Gilon C, Chorev M, Selinger Z, et al. Behavioural effects of receptor-specific substance P agonists. Pain 1987;31:263-76.
9. Yamamoto T, Yaksh TL. Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists. Pain 1992;49:121-8.
10. Haley JE, Sullivan AF, Dickenson AH. Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Res 1990;518:218-26.
11. Sher GD, Mitchell D. Intrathecal N-methyl-D-aspartate induces hyperexcitability in rat dorsal horn corvergent neurones. Neurosci Lett 1990;119:199-202.
12. Duarte IDG, Santos IR, Lorenzetti BB, Ferreira SH. Analgesia by direct antagonism of nociceptor sensitization involves the arginine-nitric oxide-cGMP pathway. Eur J Pharmacol 1992;217:225-7.
13. Mayer B, Brunner F, Schmidt K. Inhibition of nitric oxide synthesis by methylene blue. Biochem Pharmacol 1993;45: 367-74.
14. Coderre TJ, Melzack R. The role of NMDA receptor-operated calcium channels in persistent nociception after formalin-induced tissue injury. J Neurosci 1992;12:3671-5.
15. Jeftinija S, Jeftinija K, Liu F, Skilling SR, Smullin DH, Larson AA. Excitatory amino acids are released from rate primary afferent neurons in vitro. Neurosci Lett 1991;125: 191-4.