Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 → Arg and Ile523 → Val mutation

Journal of Biological Chemistry

Volumn 272, Issue 14, 1997, Pages 9280-9286

  Wong, Elizabeth ^a   Bayly, Christopher ^a   Waterman, Heather L ^a   Riendeau, Denis ^a   Mancini, Joseph A ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC; INDOMETACIN; L 745296; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN G; PROSTAGLANDIN H; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG MECHANISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ARGININE; BINDING SITES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; HISTIDINE; HUMANS; ISOENZYMES; ISOLEUCINE; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIOPHENES; VALINE;

EID: 0030964929     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.14.9280     Document Type: Article

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