Selective inhibition of cyclooxygenase-1 and -2 using intact insect cell assays

Biochemical Pharmacology

Volumn 52, Issue 11, 1996, Pages 1777-1785

  Cromlish, Wanda A ^a   Kennedy, Brian P ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

arachidonic acid; baculovirus; cyclooxygenase; drug inhibition; NSAID; prostaglandins

Indexed keywords

6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DICLOFENAC; FENCLOFENAC; FENOPROFEN; FLOSULIDE; FLUFENAMIC ACID; FLURBIPROFEN; IBUPROFEN; INDOMETACIN; ISOENZYME; ISOXICAM; KETOPROFEN; L 190090; L 612835; L 659528; L 740516; L 742436; MEFENAMIC ACID; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NAPROXEN; NIFLUMIC ACID; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PHENYLBUTAZONE; PIROXICAM; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; SALICYLIC ACID; SULINDAC SULFIDE; TENOXICAM; TOLMETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACULOVIRUS; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELECTIVITY; ENZYME INHIBITION; EXPRESSION VECTOR; GENE EXPRESSION; HUMAN; INSECT; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STOMACH LESION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; CYCLOOXYGENASE INHIBITORS; ISOENZYMES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECOMBINANT PROTEINS; SPODOPTERA;

EID: 0030582843     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(96)00599-0     Document Type: Article

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