Prostanoids synthesized by cyclo-oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability

British Journal of Pharmacology

Volumn 122, Issue 8, 1997, Pages 1593-1604

  Willingale, H L ^a   Gardiner, N J ^a   McLymont, N ^a   Giblett, S ^a   Grubb, B D ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

COX 1; COX 2; Cyclo oxygenase; Hyperexcitability; Nociception; NSAID; Prostaglandin; Spinal cord

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; 6 OXOPROSTAGLANDIN F1 ALPHA; ICOSANOID; INDOMETACIN; MECLOFENAMIC ACID; PROSTACYCLIN; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROSTANOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; CYTOPLASM; DOSE RESPONSE; ELECTROSTIMULATION; GRAY MATTER; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUMBAR SPINAL CORD; MALE; MECHANICAL STIMULATION; MOTONEURON; NERVE EXCITABILITY; NERVE FIBER; NERVE FIBER C; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL ANESTHESIA; SPINAL CORD DORSAL HORN; SPINAL CORD VENTRAL HORN; SPINAL GANGLION; SURAL NERVE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ELECTROPHYSIOLOGY; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MALE; NEURONS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; RATS; RATS, WISTAR; REFLEX; SPINAL CORD;

EID: 0031463351     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701548     Document Type: Article

References (64)

1. ABDEL-HALIM, M.S. & ÄNGGÄRD, E. (1979). Regional and species differences in endogenous prostaglandin biosynthesis by brain homogenates. Prostaglandins, 17, 411-418.
2. 2 as a major prostaglandin in homogenates of rat brain. Prostaglandins, 14, 633-643.
3. AMRUTHESH, S.C., BOERSCHEL, M.F., MCKINNEY, J.S., WILLOUGHBY, K.A. & ELLIS, E.F. (1993). Metabolism of arachidonic acid to epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and prostaglandins in cultured rat hippocampal astrocytes. J. Neurochem., 61, 150-159.
4. BAUER, M.K.A., LIEB, K., SCHULTZE-OSTHOFF, K., BERGER, M., GEBICKE-HAERTER, P.J. & FIEBICH, B.L. (1997). Expression and regulation of cyclooxygenase-2 in rat microglia. Eur. J. Biochem., 243, 726-731.
5. BEICHE, F., SCHEUERER, S., BRUNE, K., GEISSLINGER, G. & GOPPELT-STRUEBE, M. (1996). Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation. FEBS Lett., 390, 165-169.
6. BISHAI, I. & COCEANI, F. (1992). Eicosanoid formation in the rat cerebral cortex. Mol. Chem. Neuropathol., 17, 219-237.
7. BREDER, C.D., SMITH, W.L., RAZ, A., MASFERRER, J., SEIBERT, K., NEEDLEMAN, P. & SAPER, C.B. (1992). Distribution and characterization of cyclooxygenase immunoreactivity in the ovine brain. J. Comp. Neurol., 322, 409-438.
8. BREDER, C.D., DEWITT, D. & KRAIG, R.P. (1995). Characterization of inducible cyclooxygenase in rat brain. J. Comp. Neurol., 355, 296-315.
9. CHAPMAN, V. & DICKENSON, A.H. (1992). The spinal and peripheral roles of bradykinin and prostaglandins in nociceptive processing in the rat. Eur. J. Pharmacol., 219, 427-433.
10. CLARKE, R.W. & MATTHEWS, B. (1990). The thresholds of the jaw-opening reflex and trigeminal brainstem neurons to tooth-pulp stimulation in acutely and chronically prepared cats. Neuroscience, 36, 105-114.
11. DAVIES, S.N. & LODGE, D. (1987). Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat. Brain Res., 424, 402-406.
12. DICKENSON, A.H. & AYDAR, E. (1991). Antagonism at the glycine site on the NMDA receptor reduces spinal nociception in the rat. Neurosci. Lett., 121, 263-266.
13. FENG, L., SUN, W., XIA, Y., TANG, W.W., CHANMUGAM, P., SOYOOLA, E., WILSON, C.B. & HWANG, D. (1993). Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. Arch. Biochem. Biophys., 307, 361-368.
14. FLETCHER, B.S., KUJUBU, D.A., PERRIN, D.M. & HERSCHMAN H.R. (1992). Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. J. Biol. Chem., 267, 4338-4344.
15. GARDINER, N.J., GIBLETT, S.J. & GRUBB B.D. (1997). Cyclooxygenases in rat spinal cord: selective induction of cox-2 during peripheral inflammation. Br. J. Pharmacol. 120, 71P.
16. GAUDET, R.J., ALAM, I. & LEVINE, L. (1980). Accumulation of cyclooxygenase products of arachidonate metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlusion. J. Neurochem., 35, 653-658.
17. GIERSE, J.K., HAUSER, S.D., CREELY, D.P., KOBOLDT, C., RANGWALA, S.H., ISAKSON, P.C. & SEIBERT, K. (1996). Expression and selective inhibition of the constitutive and inducible forms of human cyclooxygenase. Biochem. J., 385, 479-484.
18. 2 in the sensitizalion of joint mechanoreceptors in normal and inflamed ankle joints of the rat. Exp. Brain Res., 84, 383-392.
19. GRUBB, B.D., STILLER, R.U. & SCHAIBLE, H.-G. (1993). Dynamic changes in the receptive field properties of spinal cord neurons with ankle input in rats with chronic unilateral inflammation in the ankle region. Exp. Brain Res., 92, 441-452.
20. GUILBAUD, G. & IGGO, A. (1985). The effect of lysine acetylsalicylate on joint capsule mechanoreceptors in rats with polyarthritis. Exp. Brain Res., 61, 164-168.
21. HABIB, A., CRÉMINON, C., FROBERT, Y., GRASSI, J., PRADELLES, P. & MACLOUF, J. (1993). Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxy-terminal region of cyclooxygenase-2. J. Biol. Chem., 268, 23448-23454.
22. HANESCH, U., PFOMMER, U., GRUBB, B.D. & SCHAIBLE, H.-G. (1993). Acute and chronic phases of unilateral inflammation in rat's ankle are associated with an increase in the proportion of calcitonin gene-related peptide-immunoreactive dorsal root ganglion cells. Eur. J. Neurosci., 5, 154-161.
23. HARTELL, N.A. & HEADLEY, P.M. (1989). Comparison of the spinal reflex depression and behavioural sedation caused by four anaesthetics in the rat. J. Physiol., 420, 29P.
24. HARTELL, N.A. & HEADLEY, P.M. (1990). Eletrophysiological techniques for monitoring spinal reflex responses to noxious stimuli in acutely prepared anaesthetized rats and in chronically prepared conscious rats. J. Physiol., 425, 10P.
25. HARTELL, N.A. & HEADLEY, P.M. (1991). Preparative surgery enhances the direct spinal actions of three injectable anaesthetics in the anaesthetized rat. Pain, 46, 75-80.
26. HAY, C.M., TREVETHICK, M.A., WHEELDON, A., BOWERS, J.S. & DE BELLEROCHE, J.S. (1997). The potential role of spinal cord cyclooxygenase-2 in the development of Freund's complete adjuvant-induced changes in hyperalgesia and allodynia. Neuroscience, 78, 843-850.
27. HEPPELMANN, B., PFEFFER, A., SCHAIBLE, H.-G. & SCHMIDT, R.F. (1986). Effects of acetylsalicylic acid and indomethacin on single groups III and IV sensory units from acutely inflamed joints. Pain, 26, 337-351.
28. HERRERO, J.F. & CERVERO, F. (1996a). Changes in nociceptive reflex facilitation during carrageenan-induced arthritis. Brain Res., 717, 62-68.
29. HERRERO, J.F. & CERVERO, F. (1996b). Supraspinal influences on the facilitation of rat nociceptive reflexes induced by carrageenan monoarthritis. Neurosci. Lett., 209, 21-24.
30. HLA, T. & NEILSON, K. (1992). Human cyclooxygenase-2 cDNA. Proc. Natl. Acad. Sci. USA, 89, 7384-7388.
31. HLA, T., RISTIMÄKI, A., APPLEBY, S. & BARRIOCANAL, J. (1993). Cox gene expression in inflammation and angiogenesis. Ann. N. Y. Acad. Sci., 696, 197-204.
32. 2 in cerebrospinal fluid of fetal and newborn sheep: central versus peripheral source. Biol. Neonate, 66, 339-351.
33. KAUFMANN, W.E., WORLEY, P.F., PEGG, J., BREMER, M. & ISAKSON, P. (1996). Cox-2, a synaptically induced enzyme, is expressed by excitatory neurones at postsynaptic sites in rat cerebral cortex. Proc. Natl. Acad. Sci. U.S.A., 93, 2317-2321.
34. LAWSON, S.N., PERRY, M.J., PRABHAKAR, P. & MCCARTHY, P.W. (1993). Primary sensory neurones: neurofilament, neuropeptides, and conduction velocity. Brain Res. Bull., 30, 239-243.
35. LAZAREWICZ, J.W. & SALIÑSKA, E. (1995). N-methyl-D-aspartate-evoked release of cyclo-oxygenase products in rabbit hippocampus: an in vivo microdialysis study. J. Neurosci. Res., 40, 660-666.
36. MALMBERG, A.B. & YAKSH, T.L. (1992). Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J. Pharmacol. Exp. Ther., 263, 136-146.
37. 2 release in spinal cord slices: relative effect of cyclooxygenase inhibitors. Eur. J. Pharmacol., 271, 293-299.
38. MARSALA, M., MALMBERG, A.B. & YAKSH, T.L. (1995). The spinal loop dialysis catheter: characterisation of use in the unanesthetised rat. J. Neurosci. Meth., 62, 43-53.
39. MCCORMACK, K. & BRUNE, K. (1991). Dissociation between the antinociceptive and anti-inflammatory effects of the nonstcroidal anti-inflammatory drugs. Drugs. 41, 533-547.
40. MCCORMACK, K. & URQUART, E. (1995). Correlation between nonsteroidal anti-inflammatory drug efficacy in a clinical pain model and the dissociation of their anti-inflammatory and analgesic properties in animal models. Clin. Drug Invest., 9, 88-97.
41. MITCHELL, J.A., LARKIN, S. & WILLIAMS, T.J. (1995). Cox-2: regulation and relevance in inflammation. Biochem. Pharmacol., 50, 1535-1542.
42. MORITA, I., SCHINDLER, M., REGIER, M.K., OTTO, J.C., HORI, T., DEWITT, D.L. & SMITH, W.L. (1995). Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J. Biol. Chem., 270, 10902-10907.
43. NEUGEBAUER, V. & SCHAIBLE, H.-G. (1990). Evidence for a central component in the sensitization of spinal neurons with joint input during the development of acute arthritis in cat's knee. J. Neurophysiol., 64, 299-311.
44. NEUGEBAUER, V., SCHAIBLE, H.-G., HE, X., LÜCKE, T., GÜNDLING, P. & SCHMIDT, R.F. (1994). Electrophysiological evidence for a spinal antinociceptive action of dipyrone. Agents Actions, 41, 62-70.
45. NEUGEBAUER, V . GEISSLINGER, G., RÜMENAPP, P., WEIRETTER, F., SZELENYI, I., BRUNE, K. & SCHAIBLE, H.-G. (1995). Antinociceptive effects of R( - )- and S( + )-flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation. J. Pharmacol. Exp. Ther., 275, 618-628.
46. 2 increases calcium conductance and stimulates release of substance P in avian sensory neurons. J. Neurosci., 12, 1917-1927.
47. O'BANION, M.K., SADOWSKI, H.B., WINN, V. & YOUNG, D.A. (1991). A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J. Biol. Chem., 266, 23261-23267.
48. O'NEILL, G.P. & FORD-HUTCHINSON, A.W. (1993). Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett., 330, 156-160.
49. 2α in the cerebrospinal fluid of anesthetized rats. Biochem. Biophys. Res. Commun., 213, 625-629.
50. PERCIVAL, D.M., OUELLET, M., VINCENT, C.J., YERGEY, J.A., KENNEDY, B.P. & O'NEILL, G.P. (1994). Purification and characterization of recombinant human cyclooxygenase-2. Arch. Biochem. Biophys., 315, 111-118.
51. PETRONI, A., BERTAZZO, A., SARTI, S. & GALLI, C. (1989). Accumulation of arachidonic acid cyclo- and lipoxygenase products in rat brain during ischemia and reperfusion: effects of treatment with GM1-lactone. J. Neurochem., 53, 747-752.
52. RODRIGUEZ Y BAENA, R., GAETANI, P. & PAOLETTI, P. (1988). A study on cisternal CSF levels of arachidonic acid metabolites after aneurysmal subarachnoid hemmorhage. J. Neurol. Sci., 84, 329-335.
53. SANO, H., HLA, T., MAIER, J.A.M., CROFFORD, L.J., CASE, J.P., MARIAG, T. & WILDER, R.L. (1992). In vivo cox expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. J. Clin. Invest., 89, 97-108.
54. 2. J. Physiol., 403, 91-104.
55. SEIBERT, K., ZHANG, Y., LEAHY, K., HAUSER, S., MASFERRER, J., PERKINS, W., LEE, E. & ISAKSON, P. (1994). Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci., 91, 12013-12017.
56. SORKIN, L.S. & MOORE, J.H. (1996). Evoked release of amino acids and prostanoids in spinal cords of anesthetized rats: changes during peripheral inflammation and hyperalgesia. Am. J. Ther., 3, 268-275.
57. THOMPSON, S.W.N., KING, A.E. & WOOLF, C.J. (1990). Activity-dependent changes in rat ventral horn neurons in vitro: summation of prolonged afferent evoked postsynaptic depolarizations produce a D-2-amino-5-phosphonovaleric acid sensitive wind-up. Eur. J. Neurosci., 2, 638-649.
58. URADE, Y., FUJIMOTO, N., KANEKO, T., KONISHI, A., AMIZUNO, J. & HAYAISHI, O. (1989). Postnatal changes in the localization of prostaglandin D synthetase from neurones to oligodendrocytes in the rat brain. J. Biol. Chem., 262, 15132-15136.
59. VASKO, M.R., ZIRKELBACH, S.L. & WAITE, K.J. (1993). Prostaglandins stimulate the release of substance P from rat spinal cord slices. Prog. Pharmacol. Clin. Pharmacol., 10, 69-89.
60. 2 by motoneurons and dorsal horn microneurons: a biochemical and high resolution immunocytochemical study in chick spinal cord. Neuroscience, 69, 967-975.
61. WILLINGALE, H.L. & GRUBB, B.D. (1996). Evidence that prostaglandins may modulate wind-up in a spinal nociceptive reflex in anaesthetised rats. Br. J. Pharmacol., 118, 49P.
62. WOOLF, C.J. (1983). Evidence for a central component of post-injury pain hypersensitivity. Nature, 306, 686-688.
63. WOOLF, C.J. & THOMPSON, S.W.N. (1991). The induction and maintenance of central sensitization is dependent on NMDA receptor activation: implications for the treatment of post-injury pain hypersensitivity states. Pain, 44, 293-299.
64. YAMAMOTO, T. & NOZAKI-TAGUCHI, N. (1996). Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor, and NS 398, a COX-2 selective inhibitor. Brain Research, 739, 104-110.