Thymocyte selection: Not by TCR alone

Immunological Reviews

Volumn 165, Issue , 1998, Pages 209-229

  Amsen, Derk ^a   Kruisbeek, Ada M ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CALCINEURIN; CD38 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CELL SURFACE RECEPTOR; CYCLOSPORIN A; GLUCOCORTICOID; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN BCL 2; PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TACROLIMUS; TRANSCRIPTION FACTOR;

ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; APOPTOSIS; CELL SELECTION; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR OCCUPANCY; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE; TRANSCRIPTION REGULATION; TRANSGENE;

EID: 0031727316     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1998.tb01241.x     Document Type: Review

References (202)

1. Bevan MJ. In thymic selection, peptide diversity gives and takes away. Immunity 1997;7:175-178.
2. Jameson SC, Bevan MJ. T-cell selection. Curr Opin Immunol 1998;10:214-219.
3. Wilkinson RW, Anderson G, Owen JJT, Jenkinson EJ. Positive selection of thymocytes involves sustained interactions with the thymic microenvironment. J Immunol 1995;155:5234-5240.
4. Kisielow P, Miazek A. Positive selection of T cells: rescue from programmed cell death and differentiation require continual engagement of the T cell receptor. J Exp Med 1995;181:1975-1984.
5. Huesmann M, Scott B, Kisielow P, Von Boehmer H. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell 1991;66:533-540.
6. Ernst B, Surh CD, Sprent J. Thymic selection and cell division. J Exp Med 1995;182:961-972.
7. Kishimoto H, Sprent J. Negative selection in the thymus includes semi-mature T cells. J Exp Med 1997;185:263-272.
8. Robey E, Fowlkes BJ. Selective events in T cell development. Annu Rev Immunol 1994;12:675-705.
9. Zerrahn J, Held W, Raulet DH. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 1997;88:626-636.
10. Merkenschlager M, Graf D, Lovatt M, Bommhardt U, Zamoyska R, Fisher A. How many thymocytes audition for selection? J Exp Med 1997;186:1149-1158.
11. Surh CD, Sprent J. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 1994;372:100-103.
12. Sebzda E, Wallace VA, Mayer J, Yeung RSM, Mak TW, Ohashi PS. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 1994;263:1615-1618.
13. Munir Alam S, et al. T-cell-receptor affinity and thymocyte positive selection. Nature 1996;381:616-620.
14. McKeithan TW. Kinetic proofreading in T-cell receptor signal transduction. Proc Natl Acad Sci USA 1995;92:5042-5046.
15. Rabinowitz JD, Beeson C, Lyons DS, Davis MM, McConnell HM. Kinetic discrimination in T-cell activation. Proc Natl Acad Sci USA 1996;93:1401-1405.
16. Girao C, Hu Q, Sun J, Ashton-Rickardt PG. Limits to the differential affinity model of T cell selection in the thymus. J Immunol 1997;159:4205-4211.
17. d resulting in positive versus negative selection of the 2C transgenic T cell receptor in vivo. Immunity 1997;7:233-241.
18. Chidgey A, Boyd R. Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 coreceptor expression. Int Immunol 1997;9:1527-1536.
19. Hogquist KA, Jameson SC, Bevan MJ. Specificity and flexibility in thymic selection. Immunity 1995;3:79-86.
20. Jameson SC, Hogquist KA, Bevan MJ. Specificity and flexibility in thymic selection. Nature 1994;369:750-752.
21. Nakano N, Rooke R, Benoist C, Mathis D. Positive selection of T cells induced by viral delivery of neopeptides to the thymus. Science 1997;275:678-683.
22. Sebzda E, Choi M, Fung-Leung WP, Mak TW, Ohashi PS. Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner. Immunity 1997;6:643-653.
23. Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR. T cell receptor antagonist peptides induce positive selection. Cell 1994;76:17-27.
24. Lyons DS, et al. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity 1996;5:53-61.
25. Hogquist KA, et al. Identification of a naturally occurring ligand for thymic positive selection. Immunity 1997;6:389-399.
26. Hu Q, et al. Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes. Immunity 1997;7:221-231.
27. Ignatowicz L, Kappler J, Marrack P. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 1996;84:521-529.
28. + thymocyte selection by a single MHC class II/peptide ligand affected by its expression level in the thymus. Immunity 1997;6:401-410.
29. Ignatowicz L, et al. T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. Immunity 1997;7:179-186.
30. 0/0 mice. Immunity 1997;7:187-195.
31. Grubin CE, Kovats S, De Roos P, Rudensky AY. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 1997;7:197-208.
32. + T cells. Immunity 1997;7:209-219.
33. Sant'Angelo DB, et al. The imprint of intrathymic self-peptides on the mature T cell receptor repertoire. Immunity 1997;7:517-524.
34. Ding Y-H, Smith KJ, Garboczi DN, Utz U, Biddison WE, Wiley DC. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 1998;8:403-111.
35. Janeway CA Jr. A tale of two cells. Immunity 1998;8:391-394.
36. Alberola-Ila J, Takaki S, Kerner JD, Perlmutter RM. Differential signaling by lymphocyte antigen receptors. Annu Rev Immunol 1997;15:125-154.
37. Van Oers NSC, Tao W, Watts JD, Johnson P, Aebersold R, Teh H-S. Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) ζ subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR ζ. Mol Cell Biol 1993;13:5771-5780.
38. + thymocytes results in tyrosine phosphorylation of the T-cell receptor ζ chain. Nature 1989;341:651-653.
39. Van Oers NSC, Killeen N, Weiss A. ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells. Immunity 1994;1:675-685.
40. Van Oers NSC, Killeen N, Weiss A. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. J Exp Med 1996;183:1053-1062.
41. Killeen N, Irving BA, Pippig S, Zingler K. Signaling checkpoints during the development of T lymphocytes. Curr Opin Immunol 1998;10:360-367.
42. Negishi I, et al. Essential role for ZAP-70 in both positive and negative selection. Nature 1995;376:435-438.
43. lck tyrosine kinase activation in T cell receptor-mediated thymic selection. J Exp Med 1996;184:931-943.
44. lck. J Immunol 1996;157:5359-5366.
45. fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of signalling motif. Mol Cell Biol 1994;14:3729-3741.
46. fyn. Cell 1992;70:751-763.
47. Van Oers NSC, Lowin-Kropf B, Finlay D, Connolly K, Weiss A. αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity 1996;5:429-436.
48. Groves T, Smiley P, Cooke MP, Forbush K, Perlmutter RM, Guidos CJ. Fyn can partially substitute for Lck in T lymphocyte development. Immunity 1996;5:417-428.
49. + thymocytes, and in B cell maturation. J Exp Med 1996;183:1707-1718.
50. Wallace VA, et al. Alterations in the level of CD45 surface expression affect the outcome of thymic selection. J Immunol 1997;158:3205-3214.
51. Stone JD, et al. Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of LCk, Fyn, TCR-ζ, and ZAP-70. J Immunol 1997;158:5773-5782.
52. Combadière B, Freedman M, Chen L, Shores EW, Love P, Lenardo MJ. Qualitative and quantitative contributions of the T cell receptor ζ chain to mature T cell apoptosis. J Exp Med 1996;183:2109-2117.
53. Shores EW, Tran T, Grinberg A, Sommers CL, Shen H, Love PE. Role of the multiple T cell receptor (TCR)-ζ chain signaling motifs in selection of the T cell repertoire. J Exp Med 1997;185:893-900.
54. -/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex. J Exp Med 1997;185:707-715.
55. Dave VP, et al. CD3δ deficiency arrests development of the αβ but not the γδ cell lineage. EMBO J 1997;16:1360-1370.
56. Haks MC, Krimpenfort P, Borst J, Kruisbeek AM. The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages. EMBO J 1998;17:1871-1882.
57. Malissen M, et al. Altered T cell development in mice with a targeted mutation of the CD3-ε gene. EMBO J 1995;14:4641-4653.
58. Peterson EJ, Clements JL, Fang N, Koretzky GA. Adaptor proteins in lymphocyte antigen-receptor signaling. Curr Opin Immunol 1998;10:337-344.
59. McCormick F. How receptors turn Ras on. Nature 1993;363:15-18.
60. Marengére LEM, Mirtsos C, Kozieradzki I, Veillette A, Mak TW, Penninger JM. Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells. J Immunol 1997;159:70-76.
61. Turner M, et al. A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity 1997;7:451-460.
62. Tarakhovsky A, et al. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 1995;374:467-470.
63. + thymocytes. Nature 1995;374:474-477.
64. Crespo P, Schuebel KE, Ostrom AM, Gutkind JS, Bustelo XR. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP. Nature 1997;385:169-172.
65. Fischer K-D, et al. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol 1998;8:554-562.
66. Holsinger LJ, et al. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr Biol 1998;8:563-572.
67. Zhang W, Sloan-Lancaster J, Samelson LE. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 1998;92:83-92.
68. Heyeck SD, Wilcox HM, Bunnell SC, Berg LJ. Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. J Biol Chem 1997;272:25401-25406.
69. Gibson S, August A, Branch D, Dupont B, Mills GB. Functional LCK is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK. J Biol Chem 1996;271:7079-7083.
70. Gibson S, August A, Kawakami Y, Kawakami T, Dupont B, Mills GB. The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling. LCK is required for optimal activation of EMT. J Immunol 1996;156:2716-2722.
71. Liu K-Q, Bunnell SC, Gurniak CB, Berg LJ. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. J Exp Med 1998;187:1721-1727.
72. Liao XC, Littman DR. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity 1995;3:757-769.
73. Crabtree GR, Clipstone NA. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu Rev Biochem 1994;63:1045-1083.
74. + thymocyte negative selection. J Immunol 1996;156:4594-4601.
75. Vasquez NJ, Kane LP, Hedrick SM. Intracellular signals that mediate thymic negative selection. Immunity 1994;1:45-56.
76. 2+ response amplitude and duration. Nature 1997;386:855-858.
77. Clipstone NA, Crabtree GR. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 1992;357:695-698.
78. + thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection. J Exp Med 1995;181:927-941.
79. Urdahl KB, Pardoll DM, Jenkins MK. Cyclosporin A inhibits positive selection and delays negative selection in αβ TCR transgenic mice. J Immunol 1994;152:2853-2862.
80. + thymocytes in vitro. J Immunol 1995;154:3636-3643.
81. Gao E-K, Lo D, Cheney R, Kanagawa O, Sprent J. Abnormal differentiation of thymocytes in mice treated with cyclosporin A. Nature 198;336:176-178.
82. Jenkins MK, Schwartz RH, Pardoll DH. Effects of cyclosporin A on T cell development and clonal deletion. Science 1988;241:1655-1657.
83. Kosugi A, Zúñiga-Pflücker JC, Sharrow SO, Kruisbeek AM, Shearer GM. Effects of cyclosporin A on lymphopoiesis. II. Developmental defects in immature and mature thymocytes in fetal thymus organ cultures treated with cyclosporin A. J Immunol 1989;143:3134-3140.
84. Zhang W, et al. T cell responses in calcineurin Aα-deficient mice. J Exp Med 1996;183:413-420.
85. Henning SW, Cantrell DA. GTPases in antigen receptor signalling. Curr Opin Immunol 1998;10:322-329.
86. Cantrell DA. T cell antigen receptor signal transduction pathways. Annu Rev Immunol 1996;14:259-274.
87. Hill CS, Treisman R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 1995;80:199-211.
88. Alberola-Ila J, Forbush KA, Seger R, Krebs EG, Perlmutter RM. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 1995;373:620-623.
89. O'Shea CC, Crompton T, Rosewell IR, Hayday AC, Owen MJ. Raf regulates positive selection. Eur J Immunol 1996;26:2350-2355.
90. Swan KA, et al. Involvement of p21ras distinguishes positive and negative selection in thymocytes. EMBO J 1995;14:276-285.
91. Alberola-Ila J, Hogquist KA, Swan KA, Bevan MJ, Perlmutter RM. Positive and negative selection invoke distinct signaling pathways. J Exp Med 1996;184:9-18.
92. Su B, Karin M. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr Opin Immunol 1996;8:402-411.
93. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995;270:1326-1340.
94. Su B, Jacinto E, Hibi M, Kallunki T, Karin M, Ben-Neriah Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994;77:727-736.
95. Amsen D, Kruisbeek AM. CD28-B7 interactions function to co-stimulate clonal deletion of double-positive thymocytes. Int Immunol 1996;8:1927-1936.
96. Nishina H, et al. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J Exp Med 1997;186:941-953.
97. Osborne BA, Smith SW Liu Z-G, McLaughlin KA, Grimm L, Schwartz LM. Identification of genes induced during apoptosis in T lymphocytes. Immunol Rev 1994;142:301-320.
98. Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 1997;15:707-747.
99. Hodge MR, Ranger AM, Charles de la Brousse F, Hoey T, Grusby MJ, Glimcher LH. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity 1996;4:397-405.
100. Rincón M, Flavell RA. Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells. Mol Cell Biol 1996;16:1074-1084.
101. Amasaki Y, Masuda ES, Imamura R, Arai K-I, Arai N. Distinct NFAT family proteins are involved in the nuclear NFA-DNA binding complexes from human thymocyte subsets. J Immunol 1998;160:2324-2333.
102. Frantz B, et al. Calcineurin acts in synergy with PMA to inactivate IκB/MAD3, an inhibitor of NF-κB. EMBO J 1994;13:861-870.
103. Baeuerle PA, Baltimore D. N-κB: ten years after. Cell 1996;87:13-20.
104. Sen J, et al. Expression and induction of nuclear factor-κ-related proteins in thymocytes. J Immunol 1995;154:3213-3221.
105. Königen F, et al. Mice lacking the c-rel protooncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev 1995;9:1965-1977.
106. Sha WC, Liou H-C, Tuomanen EI, Baltimore D. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell 1995;80:321-330.
107. Weih F, et al. Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, A member of the NF-κB/Rel family. Cell 1995;80:331-340.
108. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 1995;376:167-169.
109. Caamaño JH, et al. Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses. J Exp Med 1998;187:185-196.
110. Boothby MR, Mora AL, Scherer DC, Brockman JA, Ballard D. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB. J Exp Med 1997;185:1897-1907.
111. Esslinger CW, Wilson A, Sordat B, Beermann F, Jongeneel CV. Abnormal T lymphocyte development induced by targeted overexpression of IκBα. J Immunol 1997;158:5075-5078.
112. Laufer TM, DeKoning J, Markowitz JS, Lo D, Glimcher LH. Unopposed positive selection and autoreactivity in mice expressing class II MHC only in thymic cortex. Nature 1996;383:81-85.
113. Burkly L, et al. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 1995;373:531-534.
114. Calnan BJ, Szychowski S, Chan K-M, Cado D, Winoto A. A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity 1995;3:273-282.
115. Zhou T, et al. Inhibition of Nur77/Nur1 leads to inefficient clonal deletion of self-reactive T cells. J Exp Med 1996;183:1879-1892.
116. Lee SL, Wesselschmidt RL, Linette GP, Kanagawa O, Russell JH, Milbrandt J. Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGH-B (Nur77). Science 1995;269:532-535.
117. Cheng LE-C, Chan FK-M, Cado D, Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J 1997;16:1865-1875.
118. Weih F, Ryseck R-P, Chen L, Bravo R. Apoptosis of nur77/B10-transgenic thymocytes involves the Fas/Fas ligand pathway. Proc Natl Acad Sci USA 1996;93:5533-5538.
119. Singer CG, Abbas AK. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1994;1:365-371.
120. Sidman CL, Marshall JD, Von Boehmer H. Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice. Eur J Immunol 1992;22:499-504.
121. Nagata S. Apoptosis by death factor. Cell 1997;88:355-365.
122. Newton K, Harris AW, Bath ML, Smith KGC, Strasser A. A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J 1998;17:706-718.
123. Walsh CM, Wen BG, Chinnaiyan AM, O'Rourke K, Dixit VM, Hedrick SM. A role for FADD in T cell activation and development. Immunity 1998;8:439-444.
124. Zhang J, Cado D, Chen A, Kabra NH, Winoto A. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 1998;392:296-300.
125. Yang X, Khosravi-Far R, Chang HY, Baltimore D. Daxx, a novel fas-binding protein that activates JNK and apoptosis. Cell 1997;89:1067-1076.
126. Stanger BZ, Leder P, Lee T-H, Kim E, Seed B. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 1995;81:513-523.
127. Duan H, Dixit VM. RAIDD is a new "death" adaptor molecule. Nature 1997;385:86-89.
128. + T cells mediated by MHC class-II bearing stromal cell in the thymic cortex. Nature 1989;341:649-651.
129. Benoist C, Mathis D. Positive selection of the T cell repertoire: where and when does it occur? Cell 1989;58:1027-1033.
130. Berg LJ, Pullen AM, Fazekas de St. Groth B, Mathis D, Benoist C, Davis MM. Antigen/MHC-speafic T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 1989;58:1035-1046.
131. Brocker T, Riedinger M, Karjalainen K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J Exp Med 1997;185:541-550.
132. + T cells. Int Immunol 1992;4:707-710.
133. Bix M, Raulet D. Inefficient positive selection of T cells directed by haematopoietic cells. Nature 1992;359:330-333.
134. Hugo P, Kappler JW, McCormack JE, Marrack P. Fibroblasts can induce thymocyte positive selection in vivo. Proc Natl Acad Sci USA 1993;90:10335-10339.
135. Pawlovski T, Elliott JD, Loh DY, Staerz UD. Positive selection of T lymphocytes on fibroblasts. Nature 1993;364:642-645.
136. Vukmanovic S, Jameson SC, Bevan MJ. A thymic epithelial cell line induces both positive and negative selection in the thymus. Int Immunol 1994;6:239-246.
137. Hugo P, Kappler JW, Godfrey DI, Marrack P. A cell line that can induce thymocyte positive selection. Nature 1992;360:679-682.
138. Vukmanovic S, Grandea III AG, Faas SJ, Knowles BB, Bevan MJ. Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line. Nature 1992;359:729-732.
139. + thymocytes in vitro. J Exp Med 1994;179:2027-2031.
140. Ernst BB, Surh CD, Sprent J. Bone marrow-derived cells fail to induce positive selection thymus reaggregation cultures. J Exp Med 1996;183:1235-1240.
141. Carlow DA, Van Oers NSC, Teh S-J, Teh H-S. Deletion of antigen-specific immature thymocytes by dendritic cells requires LFA-1/ICAM interactions. J Immunol 1992;148:1595-1603.
142. Jenkinson EJ, Anderson G, Owen JJT. Studies on T cell maturation on defined thymic stromal cell populations in vitro. J Exp Med 1992;176:845-855.
143. Sprent J, Kosak H, Gao E-K, Surh CD, Webb SR. Intrathymic and extrathymic tolerance in bone marrow chimeras. Immunol Rev 1993;11:151-176.
144. Bonomo A, Matzinger P. Thymus epithelium induces tissue-specific tolerance. J Exp Med 1993;177:1153-1164.
145. Speiser DE, Pircher H, Ohashi PS, Kyburz D, Hengartner H, Zinkernagel RM. Clonal deletion induced by either radioresistant thymic host cells or lymphohemopoietic donor cells at different stages of class I-restricted T cell ontogeny. J Exp Med 175;1992:1277-1283.
146. Hoffman MW, Heath WR, Ruschmeyer D, Miller JF. Deletion of high-avidity T cells by thymic epithelium. Proc Natl Acad Sci USA 1996;92:9851-9855.
147. + T cells by transgenic I-E restricted to thymic medullary epithelium. J Immunol 1993;151:3954-3960.
148. + thymocytes. Nature 1988;333:742-746.
149. lo thymocytes in vivo. Science 1990;250:1720-1723.
150. Martin S, Bevan MJ. Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection. Eur J Immunol 1997;27:2726-2736.
151. Kishimoto H, Surh CD, Sprent J. A role for Fas in negative selection of thymocytes in vivo. J Exp Med 1998;187:1427-1438.
152. Oehen S, Feng L, Xia Y, Suh CD, Hedrick SM. Antigen compartmentation and T helper cell tolerance induction. J Exp Med 1996;183:2617-2626.
153. Killeen N, Littman DR. The regulation and function of the CD4 coreceptor during T lymphocyte development. Curr Top Microbiol Immunol 1996;205:89-106.
154. Robey EA, et al. The level of CD8 expression can determine the outcome of thymic selection. Cell 1992;69:1089-1096.
155. Lee NA, Loh DY, Lacy E. CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes in transgenic mice. J Exp Med 1992;175:1013-1025.
156. Sherman LA, Hesse SV, Irwin MJ, La Face D, Peterson P. Selecting T cell receptors with high affinity for self-MHC by decreasing the contribution of CD8. Science 1992;258:815-817.
157. Sligh JE Jr, et al. Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1. Proc Natl Acad Sci USA 1993;90:8529-8533.
158. + T cells. Blood 1997;89:1308-1318.
159. -/- mice show augmented TCR signaling and impaired differentiation. Curr Biol 1997;7:705-708.
160. Tarakhovsky A, et al. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 1995;269:535-539.
161. Noda S, Kosugi A, Saitoh S-I, Narumiya S, Hamaoka T. Protection from anti-TCR/CD3-induced apoptosis in immature thymocytes by a signal through thymic shared antigen-1/stem cell antigen-2. J Exp Med 1996;183:2355-2360.
162. + thymocytes. J Immunol 1993;151:1868-1880.
163. + thymocytes by T cell receptor-induced apoptosis requires a co-stimulatory signal that can be provided by CD28. J Exp Med 1994;179:709-713.
164. Kishimoto H, Cai Z, Brunmark A, Jackson MR, Peterson PA, Sprent J. Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes. J Exp Med 1996;184:531-537.
165. Gross JA, Callas E, Allison JP. Identification and distribution of the costimulatory receptor CD28 in the mouse. J Immunol 1992;149:380-382.
166. Jones LA, Izon DJ, Nieland JD, Linsley PS, Kruisbeek AM. CD28-B7 interactions are not required for intrathymic clonal deletion. Int Immunol 1993;5:503-512.
167. Nelson AJ, Hosier S, Brady W, Linsley PS, Farr AG. Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro. J Immunol 1993;151:2453-2462.
168. Shahinian A, et al. Differential T cell co-stimulatory requirements in CD28-deficient mice. Science 1993;261:609-612.
169. Lucas PJ, Negishi I, Nakayama K, Fields LE, Loh DY. Naive CD28-deficient mice can initiate but not sustain an in vitro antigen specific immune response. J Immunol 1995;154:5757-5768.
170. Walunas TL, Sperling AI, Khattri R, Thompson CB, Bluestone JA. CD28 expression is not essential for positive and negative selection of thyrhocytes or peripheral T cell tolerance. J Immunol 1995;156:1006-1014.
171. + thymocytes by two distince mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus. J Exp Med 1997;186:1911-1922.
172. Lesage S, Charron J, Winslow G, Hugo P. Induction of thymocyte deletion by purified single peptide/major histocompatibility complex ligands. J Immunol 1997;159:2078-2081.
173. + thymocytes. J Immunol 1994;152:3254-3263.
174. Wagner DH Jr, Hagman J, Linsley PS, Hodsdon W, Freed JH, Newell MK. Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2. J Exp Med 1996;184:1631-1638.
175. Chambers CA, Cado D, Truong T, Allison JP. Thymocyte development is normal in CTLA-4 deficient mice. Proc Natl Acad Sci USA 1997;94:9296-9301.
176. Gravestein LA, Nieland JD, Kruisbeek AM, Borst J. Novel mAbs reveal potent co-stimulatory activity of murine CD27. Int Immunol 1995;7:551-557.
177. Hough MR, Takei F, Humphries RK, Kay R. Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen. J Exp Med 1994;179:177-184.
178. Foy TM, et al. An essential role for gp39, the ligand for CD40, in thymic selection. J Exp Med 1995;182:1377-1388.
179. Ruggiero G, et al. CD40 expressed on thymic epithelial cells provides costimulation for proliferation but not for apoptosis of human thymocytes. J Immunol 1996;156:3737-3746.
180. Lenschow DJ, Walunas TL, Bluestone JA. CD28/B7 system of T cell costimulation. Annu Rev Immunol 1996;14:233-258.
181. Amakawa R, et al. Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell 1996;84:551-562.
182. Duckett CS, Thompson CB. CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival. Genes Dev 1997;11:2810-2821.
183. Lee SY, Park CG, Choi Y. T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors. J Exp Med 1996;183:669-674.
184. Page DM, Roberts EM, Peschon JJ, Hedrick SM. TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection. J Immunol 1998;160:120-133.
185. Anderson G, Jenkinson EJ, Moore NC, Owen JJT. MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature 1993;362:70-73.
186. Robey E, et al. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 1996;87:483-492.
187. Vacchio MS, Papadopoulos V, Ashwell JD. Steroid production in the thymus; implications for thymocyte selection. J Exp Med 1994;179:1835-1846.
188. Vacchio MS, Ashwell JD. Thymus-derived glucocorticoids regulate antigen-specific positive selection. J Exp Med 1997;185:2033-2038.
189. Philips A, et al. Antagonism between Nur77 and glucocorticoid receptor for control of transcription. Mol Cell Biol 1997;17:5952-5959.
190. D'Adamio F, et al. A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. Immunity 1997;7:803-812.
191. Nocentini G, et al. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA 1997;94:6216-6221.
192. Sloan-Lancaster J, Shaw AS, Rothbard JB, Allen PM. Partial T cell signaling: altered phospho-ζ and lack of Zap70 recruitment in APL induced T cell anergy. Cell 1994;79:913-922.
193. Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. ζ phosphorylation without ZAP70 activation induced by TCR antagonists or partial agonists. Science 1995;267:515-518.
194. Goldrath AW Hogquist KA, Bevan MJ. CD8 lineage commitment in the absence of CD8. Immunity 1997;6:633-642.
195. Germain RN, Levine EH, Madrenas J. The T-cell receptor as a diverse signal transduction machine. The Immunologist 1995;3/4:113-116.
196. Ashton-Rickardt PG, et al. Evidence for a differential avidity model of T cell selection in the thymus. Cell 1994;76:651-663.
197. Morisato D, Anderson KV. Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo. Annu Rev Genet 1995;29:371-399.
198. + T cells in the thymus. Cell 1993;73:1041-1049.
199. + T cells. Immunity 1995;3:79-86.
200. + thymocytes: increased synthesis of TCR-α
201. Cibotti R, Punt JA, Dash KS, Sharrow SO, Singer A. Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals. Immunity 1997;6:245-255.
202. + thymocytes in vitro induces early aspects of positive selection, but not apoptosis. J Immunol 1997;158:65-75.