Identification of a naturally occurring ligand for thymic positive selection

Immunity

Volumn 6, Issue 4, 1997, Pages 389-399

  Hogquist, Kristin A ^a   Tomlinson, Andy J ^b   Kieper, William C ^a   McGargill, Maureen A ^a   Hart, Marilyn C ^c   Naylor, Stephen ^b   Jameson, Stephen C ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OVALBUMIN; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; FETUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS;

EID: 0030950405     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80282-4     Document Type: Article

References (58)

1. Alam, S.M., Travers, P.J., Wung, J.L., Nasholds, W., Redpath, S., Jameson, S.C., and Gascoigne, N.R.J. (1996). T-cell receptor affinity and thymocyte positive selection. Nature 381, 616-620.
2. Alexander-Miller, M.A., Burke, K., Koszinowski, U.H., Hansen, T.H., and Connolly, J.M. (1993). Alloreactive cytotoxic T lymphocytes generated in the presence of viral-derived peptides show exquisite peptide and MHC specificity. J. Immunol. 151, 1-10.
3. Ashton-Rickardt, P.G., Bandeira, A., Delaney, J.R., Van Kaer, L., Pircher, H.-P., Zinkernagel, R.M., and Tonegawa, S. (1994). Evidence for a differential avidity model of T cell selection in the thymus. Cell 76, 651-663.
4. Barnden, M.J., Heath, W.R., Rodda, S., and Carbone, F.R. (1994). Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion. Eur. J. Immunol. 24, 2452-2456.
5. Bevan, M.J., Hogquist, K.A., and Jameson, S.C. (1994). Selecting the T cell receptor repertoire. Science 264, 796-797.
6. Chen, W., McCluskey, J., Rodda, S., and Carbone, F.R. (1993). Changes at peptide residues buried in the major histocompatibility complex (MHC) class I binding cleft influence T cell recognition: a possible role for indirect conformational alterations in the MHC class I or bound peptide in determining T cell recognition. J. Exp. Med. 177, 869-873.
7. Engelhard, V.H. (1994). Structure of peptides associated with class I and class II MHC molecules. Annu. Rev. Immunol. 12, 181-207.
8. Evavold, B.D., Sloan-Lancaster, J., Wilson, K.J., Rothbard, J.B., and Allen, P.M. (1995). Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity 2, 655-663.
9. Falk, K., and Rotzschke, O. (1996). Consensus motifs and peptide ligands of MHC class I molecules. Semin, Immunol. 5, 81-94.
10. Falk, K., Rotzschke, O., Stevanovic, S., Jung, G., and Rammensee, H.G. (1991). Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351, 290-296.
11. Fink, P.J., and Bevan, M.J. (1978). H-2 antigens of the thymus determine lymphocyte specificity. J. Exp. Med. 148, 766-775.
12. Fremont, D.H., Stura, E.A., Matsumura, M., Peterson, P.A., and Wilson, I.A. (1995). Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove. Proc. Natl. Acad. Sci. USA 92, 2479-2483.
13. Fung-Leung, W.-P., Surh, C.D., Lilgedahl, M., Pang, J., Leturcq, D., Peterson, P.A., Webb, S.R., and Karlsson, L. (1996). Antigen presentation and T cell development in H2-M deficient mice. Science 271, 1278-1281.
14. Grossman, A., and Paul, W.E. (1992). Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses. Proc. Natl. Acad. Sci. USA 89, 10365-10369.
15. Hogquist, K.A., Grandea, A.G., III, and Bevan, M.J. (1993). Peptide variants reveal how antibodies recognize major histocompatibility complex class I. Eur. J. Immunol. 23, 3028-3036.
16. Hogquist, K.A., Jameson, S.C., Heath, W.R., Howard, J.L., Bevan, M.J., and Carbone, F.R. (1994). T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27.
17. Hogquist, K.A., Jameson, S.C., and Bevan, M.J. (1995). Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells. Immunity, 3, 79-86.
18. Hunt, D.F., Henderson, R.A., Shabanowitz, J., Sakaguchi, K., Michel, H., Sevilir, N., Cox, A.L., Appella, E., and Engelhard, V.H. (1992). Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 255, 1261-1263.
19. Ignatowicz, L., Kappler, J., and Marrack, P. (1996). The repertoire of T cells shaped by a single MHC-peptide ligand.Cell 84, 521-529.
20. Jameson, S.C., and Bevan, M.J. (1992). Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a Kb-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifs. Eur. J. Immunol. 22, 2663-2667.
21. Jameson, S.C., Carbone, F.R., and Bevan, M.J. (1993). Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J. Exp. Med. 177, 1541-1550.
22. Jameson, S.C., Hogquist, K.A., and Bevan, M.J. (1994). Specificity and flexibility in thymic selection. Nature 369, 750-752.
23. Janeway, C.A., Jr. (1995). Ligands for the T-cell receptor: hard times for avidity models. Immunol. Today 16, 223-225.
24. Kelly, J.M., Sterry, S.J., Cose, S., Turner, S.J., Fecondo, J., Rodda, S., Fink, P.J., and Carbone, F.R. (1993). Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide sidechains from an MHC class I-bound determinant. Eur. J. Immunol. 23, 3318-3326.
25. Kisielow, P., and von Boehmer, H. (1995). Development and selection of T cells: facts and puzzles. Adv. Immunol. 58, 87-209.
26. Koller, B.H., Marrack, P., Kappler, J.W., and Smithies, O. (1990). Normal development of mice deficient in β2M, MHC class I proteins, and CD8+ T cells. Science 248, 1227-1230.
27. Laufer, T.M., DeKoning, J., Markowitz, J.S., Lo, D., and Glimcher, L.H. (1996). Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature 383, 81-85.
28. Lee, N.A., Loh, D.Y., and Lacy, E. (1992). CD8 surface levels alter the fate of α/β T cell receptor-expressing thymocytes in transgenic mice. J. Exp. Med. 175, 1013-1025.
29. + thymocyte differentiation. Immunity 4, 461-477.
30. Margulies, D.H. (1996). An affinity for learning. Nature 381, 558-559.
31. Marrack, P., Ignatowicz, L., Kappler, J.W., Boymel, J., and Freed, J.H. (1993). Comparison of peptides bound to spleen and thymus class II. J. Exp. Med. 178, 2173-2183.
32. Martin, W.D., Hicks, G.G., Mendiratta, S.K., Leva, H.I., Ruley, H.E., and Van Kaer, L. (1996). H-2M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84, 542-550.
33. Miyazaki, T., Wolf, P., Tourne, S., Waltzinger, C., Dierich, A., Barois, N., Benoist, C., and Mathis, D. (1996). Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 84, 531-541.
34. Nanda, N.K., Arzoo, K.K., Geysen, H.M., Sette, A., and Sercarz, E.E. (1995). Recognition of multiple peptide cores by a single T cell receptor. J. Exp. Med. 182, 531-539.
35. Nikolic Zugic, J., and Bevan, M.J. (1990). Role of self-peptides in positively selecting the T-cell repertoire. Nature 344, 65-77.
36. Page, D.M., Kane, L.P., Allison, J.P., and Hedrick, S.M. (1993). Two signals are required for negative selection of CD4+CD8+ thymocytes. J. Immunol. 151, 1868-1880.
37. Pawlowski, T.J., Singleton, M.D., Loh, D.Y., Berg, R., and Staerz, U.D. (1996). Permissive recognition during positive selection. Eur. J. Immunol. 26, 851-857.
38. Pircher, H., Rohrer, U.H., Moskophidis, D., Zinkernagel, R.M., and Hengartner, H. (1991). Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature 351, 482-485.
39. Robey, E.A., Fowlkes, B.J., Gordon, J.W., Kioussis, D., von Boehmer, H., Ramsdell, F., and Axel, R. (1991). Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell 64, 99-107.
40. Robey, E.A., Ramsdell, F., Kioussis, D., Sha, W., Loh, D., Axel, R., and Fowlkes, B.J. (1992). The level of CD8 expression can determine the outcome of thymic selection. Cell 69, 1089-1096.
41. Schafer, D.A., Korshunova, Y.O., Schroer, T.A., and Cooper, J.A. (1994). Differential localization and sequence analysis of capping protein b-subunit isoforms of vertebrates. J. Cell Biol. 127, 453-465.
42. Schafer, D.A., Jennings, P.B., and Cooper, J.A. (1996). Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. J. Cell Biol. 135, 169-179.
43. Schumacher, T.N., and Ploegh, H.L. (1994). Are MHC-bound peptides a nuisance for positive selection? Immunity 1, 721-723.
44. Sebzda, E., Wallace, V.A., Mayer, J., Yeung, R.S.M., Mak, T.W., and Ohashi, P.S. (1994). Positive and negative thymocyte selection induced by different concentration of a single peptide. Science 263, 1615-1618.
45. Sebzda, E., Kundig, T.M., Thomson, C.T., Aoki, K., Mak, S.-Y., Mayer, J.P., Zamborelli, T., Nathenson, S.G., and Ohashi, P.S. (1996). Mature T cell reactivity altered by peptide agonist that induces positive selection. J. Exp. Med. 183, 1093-1104.
46. b molecule by the side chains of three amino acids and the main chain atoms of the amino terminus. Proc. Natl. Acad. Sci. USA 89, 3135-3139.
47. Swat, W., Ignatowicz, L., von Boehmer, H., and Kisielow, P. (1991). Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature 351, 150-153.
48. Tallquist, M.D., Yun, T.J., and Pease, L.R. (1996). A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity. J. Exp. Med. 184, 1017-1026.
49. Tomlinson, A.J., and Naylor, S. (1995a). A strategy for sequencing peptides from dilute mixtures at the low femtomole level using membrane preconcentration-capillary electrophoresis-tandem mass spectrometry (MPC-CE-MS/MS). J. Liq. Chromatogr. 18, 3591-3615.
50. Tomlinson, A.J., and Naylor, S. (1995b). Systematic development of on-line membrane preconcentration-capillary electrophoresis-mass spectrometry for the analysis of peptide mixtures. J. Cap. Elec. 2, 225-230.
51. Tomlinson, A.J., Benson, L.M., Braddock, W.D., Oda, R.P., and Naylor, S. (1994). On-line preconcentration-capillary electrophoresis-mass spectrometry (PC-CE-MS). J. High Resol. Chromatogr. 17, 729-732.
52. Tomlinson, A.J., Jameson, S., and Naylor, S. (1996). Strategy for isolating and sequencing biologically derived MHC class I peptides. J. Chromatogr. A744, 273-278.
53. + T cells. Cell 71, 1205-1214.
54. 2-microglobulin transgene. J. Exp. Med. 181, 787-792.
55. Vasquez, N.J., Kaye, J., and Hedrick, S.M. (1992). In vivo and in vitro clonal deletion of double-positive thymocytes. J. Exp. Med. 175, 1307-1316.
56. Vukmanovic, S., Grandea, A.G., III, Faas, S.J., Knowles, B.B., and Bevan, M.J. (1992). Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line. Nature 359, 729-732.
57. Wucherpfennig, K.W., and Strominger, J.L. (1995). Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80, 695-705.
58. Yates, J.R., Eng, J.K., McCormack, A.L., and Schieltz, D. (1995). Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database. Anal. Chem. 67, 1426-1432.