The imprint of intrathymic self-peptides on the mature T cell receptor repertoire

Immunity

Volumn 7, Issue 4, 1997, Pages 517-524

  Sant'Angelo, Derek B ^a   Waterbury, P Greg ^a   Cohen, Beth E ^a   Martin, W David ^c,d   Van Kaer, Luc ^c   Hayday, Adrian C ^a,b   Janeway Jr , Charles A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; GENE SEQUENCE; IMMUNOGENETICS; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOLECULAR CLONING; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0030698234     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80373-8     Document Type: Article

References (33)

1. + T cells in the thymus. Cell 73, 1041-1049.
2. kb recognition. J. Immunol. 152, 1790-1801.
3. Dudley, E.C., Petrie, H.T., Shah, M.L., Owen, M.J., and Hayday, A.C. (1994). T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1, 83-93.
4. Evavold, B.D., Sloan-Lancaster, J., Wilson, K.J., Rothbard, J.B., and Allen, P.M. (1995). Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity 2, 655-663.
5. Fehling, H.J., Krotkova, A., Saint-Ruf, C., and von Boehmer, H. (1995). Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Science 375, 795-798.
6. Fung-Leung, W.P., Surh, C.D., Liljedahl, M., Pang, J., Leturcq, D., Peterson, P.A., Webb, S.R., and Karlson, L. (1996). Antigen presentation and T cell development in H2-M-deficient mice. Science 271, 1278-1281.
7. Ghosh, P., Amaya, M., Mellins, E., and Wiley, D.C. (1995). The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378, 457-462.
8. Grubin, C.E., Kovats, S., DeRoos, P., and Rudensky, A.Y. (1997). Deficient positive selection of CD4 T cells in mice displaying altered repertoires of self-peptides bound to MHC class II molecules. Immunity 7, 197-208.
9. Hoffman, E.S., Passoni, L., Crompton, T., Leu, T.M.J., Schatz, D.G., Koff, A., Owen, M.J., and Hayday, A.C. (1996). Productive T cell receptor beta chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 10, 948-962.
10. Hogquist, K.A., Jameson, S.C., Heath, W.R., Howard, J.L., Bevan, M. J., and Carbone, F.R. (1994). T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27.
11. Hogquist, K.A., Tomlinson, A.J., Kieper, W.C., McGargill, M.A., Hart, M.C., Naylor, S., and Jameson, S.C. (1997). Identification of a naturally occurring ligand for thymic positive selection. Immunity 6, 389-399.
12. Hong, S.-C., Chelouche, A., Lin, R.-h., Shaywitz, D., Braunstein, N.S., Glimcher, L., and Janeway, C.A., Jr. (1992). An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain. Cell 69, 999-1009.
13. Hsu, B.L., Evavold, B.D., and Allen, P.M. (1995). Modulation of T cell development by an endogenous altered peptide ligand. J. Exp. Med. 181, 805-810.
14. k determinant. J. Immunol. 157, 2291-2298.
15. Ignatowicz, L., Kappler, K., and Marrack, P. (1996). The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84, 521-529.
16. Jorgensen, J.L., Esser, U., Fazekas de St. Groth, B., Reay, P.A., and Davis, M.M. (1992). Mapping T cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 355, 224-230.
17. Mallick, C.A., Dudley, E.G., Viney, J.L., Owen, M.J., and Hayday, A.C. (1993). Rearrangement and diversity of T cell receptor β chain genes in thymocytes: a critical role for the β chain in development. Cell 73, 513-519.
18. Martin, W.D., Hicks, G.G., Mendiratta, S.K., Leva, H.I., Ruley, E.H., and Van Kaer, L. (1996). H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell 84, 543-550.
19. Merkenschlager, M., Benoist, C., and Mathis, D. (1994). MHC control of the naive TCRalpha-chain repertoire. J. Immunol. 153, 3005-3013.
20. Miyazaki, T., Wolf, P., Tourne, S., Waltzinger, C., Dierich, A., Barois, N., Ploegh, H., Benoist, C., and Mathis, D. (1996). Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell 84, 531-541.
21. Mombaerts, P., Clarke, A.R., Rudnicki, M.A., Iacomini, J., Itohara, S., Lafaille, J.J., Wang, L., Ichikawa, Y., Jaenisch, R., Hooper, M.L., and Tonegawa, S. (1992). Mutations in T cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature 360, 225-231.
22. Mori, L., Loetscher, H., Kakimoto, K., Bluethmann, H., and Steinmetz, M. (1992). Expression of a transgenic T cell receptor β chain enhances collagen-induced arthritis. J. Exp. Med. 176, 381-388.
23. Morkowski, S., Goldrath, A.W., Eastman, S., Ramachandra, L., Freed, D.C., Whiteley, P., and Rudensky, A.Y. (1995). T cell recognition of major histocompatibility complex II complexes with invariant chain processing intermediates. J. Exp. Med. 182, 1403-1413.
24. Nakano, N., Rooke, R., Benoist, C., and Mathis, D. (1997). Positive selection of T cells induced by viral delivery of neopeptides to the thymus. Science 275, 678-683.
25. Nikolić-Zugić, J., and Bevan, M.J. (1990). Role of self-peptides in positively selecting the T-cell receptor repertoire. Nature 344, 65-67.
26. Petrie, H.T., Livak, F., Burtrum, D., and Mazel, S. (1995). T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production. J. Exp. Med. 182, 121-127.
27. Sant'Angelo, D.B., Waterbury, G., Preston-Hurlburt, P., Yoon, ST., Medzhitov, R., Hong, S.-c., and Janeway, C.A., Jr. (1996). The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4, 367-376.
28. Schumacher, T.N.M., and Ploegh, H.L. (1994). Are MHC-bound peptides a nuisance for positive selection? Immunity 1, 721-723.
29. Sebzda, E., Wallace, V.A., Mayer, J., Yeung, R.S.M., Mak, T.W., and Ohashi, P.S. (1994). Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263, 1615-1618.
30. Shinkai, Y., Rathbun, G., Lan, K.-P., Otiz, E.M., Stewart, V., Mendelsohn, M., Young, F., Stall, A.M., and Alt, F.W. (1992). RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855-867.
31. Tourigny, M.R., Mazel, S., Burtrum, D.B., and Petrie, H.T. (1997). T cell receptor (TCR)-β gene recombination: dissociation from cell cycle regulation and developmental progression during T cell ontogeny. J. Exp. Med. 185, 1549-1556.
32. + T cells expressing identical endogenous TCR-α chains. J. Immunol. 157, 4726-4735.
33. Zerrahn, J., Held, W., and Raulet, D.H. (1997). The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88, 627-636.