Proto-Oncoprotein Vav Interacts with c-Cbl in Activated Thymocytes and Peripheral T Cells

Journal of Immunology

Volumn 159, Issue 1, 1997, Pages 70-76

  Marengére, Luc E M ^a   Mirtsos, Christine ^a   Kozieradzki, Ivona ^a   Veillette, André ^b   Mak, Tak W ^a   Penninger, Josef M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; CBL PROTEIN, HUMAN; CBL PROTEIN, MOUSE; CELL CYCLE PROTEIN; ONCOPROTEIN; UBIQUITIN PROTEIN LIGASE; VAV PROTEIN; VAV1 PROTEIN, HUMAN; VAV1 PROTEIN, MOUSE;

ANIMAL; ARTICLE; HUMAN; IMMUNOLOGY; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; MOUSE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMUS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MICE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS C-VAV; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND; UBIQUITIN-PROTEIN LIGASES;

EID: 0031178960     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Weiss, A., and D. R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263.
2. Chan, A. C., D. M. Desui, and A. Weiss. 1994. The role of protein lyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction, Annu. Rev. Immunol. 12:555.
3. Donovan, J. A., R. L. Wange, W. Y. Langdon, and L. E. Samelson. 1994. The protein product of the c-cbl proio-oncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J. Biol. Chem. 269:22921.
4. Fukazawa, T., K. A. Reedquist, T. Trub, S. Soltolf, G. Panchamoorthy, B. Druker, L. Cantley, S. E. Shoelson, and H. Bund. 1995. The SH3 domain-binding T cell tyrosyl phosphoprotein p120: demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. J. Biol. Chem. 270.-19141.
5. Langdon, W. Y., J. W. Hartley, S. P. Klinken, S. K. Ruscetti, and H. C. Morse. 1989. v-cbl. an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc. Natl. Acad. Sci. USA 86:1168.
6. Blake, T. J., M. Shupiro, H. C. Morse, and W. Y. Langdon. 1991. The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene 6:653.
7. Panchamoorthy, G., T, Fukazawa, S. Miyake, S. Soltoff, B. Druker, S. Shoelson, L. Cantley, and H. Band. 1996. P120(cbl) is a major substrate of tyrosine phosphorylation upon B-cell antigen receptor stimulation and interacts in-vivo with fyn and SYK tyrosine kinases, Grb2. and SHC adapters, and the p85 subunit of phosphatidylinositol 3-kinase. J. Biol. Chem. 271:3187.
8. Marcilla, A., O. M. Rivero Lezcano, A. Agarwal, and K. C. Robbins. 1995. Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of Fc gamma receptors. J. Biol. Chem. 270:9115.
9. Bowtell, D. D. L., and W. Y. Langdon. 1995. The protein product of the c-cbl oncogene rapidly complexes with the EOF receptor and is tycosine phosphorylated following EGF stimulation, Oncogene 11:1561.
10. Odai, H., K. Sasaki, A. Iwamatsu, Y. Hanazono, T. Tanaka, K. Mitani, Y. Yazaki, and H. Hirai. 1995. The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells. J. Biol. Chem. 270: 10800.
11. Wang, Y., G. Yeung, W. Y. Langdon, and E. R. Stanley. 1996. c-Cbl is transiently tyrosine phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 stimulation of macrophages. J. Biol. Chem. 271:17.
12. c-cbl in T lymphocytes. J. Exp. Med. 183:301.
13. Meisner, H., B. R. Conway, D. Hartley, and M. P. Czech. 1995. Interactions of Cbl with Grb2 and phosphatidylinositol 3′-kinase in activated Jurkat cells. Mol. Cell. Biol. 15:3571.
14. Rivero-Lezcano. O. M., J. H. Sameshima, A. Marcilla, and K. C. Robbins. 1994. Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene. J. Biol. Chem. 269:17363.
15. fyn in T-cells. J. Biol. Chem. 269:7792.
16. Smit, L., G. van der Horst, and J. Borst. 1996. Formation of SHC/Grb-2- and Crk adapter complexes containing tyrosine-phosphorylated Cbl upon stimulation to the B-cell antigen receptor. J. Biol. Chem. 271:85649.
17. Pratt, J., C. K. S. Ravichandran, S. Sawasdikosol, J.-H. Chang, and S. J. Burakoff. 1996. Multifunctional roles of adapter proteins in T-cell signaling. Immunologist 4:122.
18. Matsuda, M., Y. Hashimoto, K. Muroya, H. Hasegawa, T. Kurata, S. Tanaka. S. Nakamura, and S. Hatorri. 1994. Crk protein hinds to 2 guanine-releasing proteins for the ras family and modulates nerve growth factor-induced activation of ras in PC12 cells. Mol. Cell. Biol. 14:5495.
19. Reedquist, K. A., T. Fukuzaka, G Panchamoorthy, W. Y. Langdon, S. E. Shoelson, B. J. Druker, and H. Band. 1996. Stimulation through the T-cell receptor induces Cbl association with Crk proteins and the guanine-nucleotide exchange protein C3G. J. Biol. Chem. 271:8435.
20. Sawasdikosol, S., J. H. Chang, J. C. Pratt, G. Wolf, S. E. Shoelson, and S. J. Burakoff. 1996. Tyrosine-phosphorylated Cbl binds to Crk after T cell activation. J. Immunol. 157:110.
21. de Jong, R., J. Tenhoeve, N. Heisterkamp, and J. Groffen. 1995. Crk-L is complexed with tyrosine-phosphorylated Cbl in pH-positive leukemia. J. Biol. Chem. 270:21468.
22. Egan, S. E., B. W. Giddings, M. W. Brooks, L. Buday, A. M. Sizeland, and R. A. Weinberg. 1993. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363:45.
23. Tanaka, S., S. Hattori, T. Kurata, K. Nagashima, Y. Fukui, S. Nakamura, and M. Matsuda. 1994. Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells. Mol. Cell. Biol. 13:4409.
24. Katzav, S., D. Martin-Zanka, and M. Barbacid. 1989. Vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 8:2283.
25. Adams, J. M., H. Houston, J. Allen, T. Lints, and R. Harvey. 1992. The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. Oncogene 7:611.
26. Ramos-Morales, F., B. J. Druker, and S. Fischer. 1994. Vav binds to several SH2/SH3 containing proteins in activated lymphocytes. Oncogene 9:1917.
27. Wu, J., D. G. Motto, G. A. Koretzky, and A. Weiss. 1996. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity 4:593.
28. Bustelo, X. R., J. A. Ledbetter, and M. Barbacid. 1992. Product of vav protooncogene defines a new class of tyrosine protein kinase substrates. Nature 356: 68.
29. Margolis, B., P. Hu, S. Katzav, W. Li, J. M. Oliver, A. Ullrich, A. Weiss, and J. Schlessinger. 1992. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 356:71.
30. Tarakhovsky, A., M. Turner, S. Schaal, P. J. Mee, L. P. Duddy, K. Rajewsky, and V. L. Tybulewicz. 1995. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374:467.
31. Zhang, R., F. Alt, L. Davidson, S. H. Orkin, and W. Swat. 1995. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature 374:470.
32. + thymocytes. Nature 374:474.
33. Wu, J., S. Katzav, and A. Weiss. 1995. A functional T-cell receptor signaling pathway is required for p95Vav activity. Mol. Cell. Biol. 15:4337.
34. Tuosto, L., F. Michel, and O. Acuto. 1996. p95Vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. J. Exp. Med. 184:1161.
35. Decken, M., S. Tartare-Deckert, C. Couture, T. Mustelin, and A. Altman. 1996. Functional and physical interactions of Syk family kinases with the Vav protooncogene product. Immunity 5:591.
36. Gulbins, E., K. Schlottmann, B. Brenner, F. Lang, and K. M. Coggeshall. 1995. Molecular analysis of Ras activation by tyrosine phosphorylated Vav. Biochem. Biophys. Res. Commun. 217:876.
37. Gulbins, E., C. Langlet, G. Baier, N. Bonnefoy-Berard, E. Hebert, A. Altman, and K. M. Coggeshall. 1994. Tyrosine phosphorylation and activation of Vav GTP/ GDP exchange activity in antigen receptor-triggered B cells. J. Immunol. 152: 2123.
38. Zheng, L., A. Sjolander, J. Eckerdal, and T. Andersson. 1996, Antibody-induced engagement of β2 integrins on adherent human neutrophils triggers activation of p21Ras through tyrosine phosphorylation of the protooncogene product Vav. Proc. Natl. Acad. Sci. USA 93:8431.
39. Marengère, L. E. M., P. S. Waterhouse, G. Duncan, H. W. Mittrücker, G. S. Feng, and T. W. Mak. 1996. Regulation of T-cell receptor signaling by tyrosine phosphatase syp associated with CTLA-4. Science 272:1170.
40. Waterhouse, P., L. E. M. Marengere, H.-W. Miltrucker, and T. W. Mak. 1996. CTLA-4, a negative regulator of T-lymphocyte activation. Immunol. Rev. 153: 183.
41. Feng. G. S., C. C. Hui, and T. Pawson. 1993. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinase. Science 259:1607.
42. Lee, J. M., M. Fournel, A. Veillette, and P. E. Branton. 1996. Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines. Oncogene 12:253.
43. lck regulates interactions with tyrosine protein phosphatases in T lymphocytes. Mol. Cell. Biol. 15:2393.
44. Imbert, V., J. F. Peyron, D. Fahari Far, B. Mari, P. Auberger, and B. Rossi. 1994. Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, and inhibitor of protein tyrosine phosphatases. Biochem. J. 297:163.
45. Liu, X., L. E. M. Marengère, C. A. Koch, and T. Pawson. 1993. The v-Src SH3 domain binds phosphatidylinositol 3′-kinase. Mol. Cell. Biol. 13:5225.
46. Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270:985.
47. Lowenstein, E. J., R. J. Daly, A. G. Batzer, W. Li, B. Margolis, R. Lammers, A. Ullrich, E. Y. Skolnik, D. Bar-Sagi, and J. Schlessinger. 1992. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70:431.
48. Songyang, Z., S. E. Shoelson, J. McGlade, P. Olivier, T. Pawson, X. R. Bustelo, M. Barbacid, H. Sabe, H. Hanafusa, T. Yi, R. Ren, D. Baltimore, S. Ratnofsky, R. A. Feldman, and L. C. Cantley. 1994. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol. Cell. Biol. 14:2777.
49. Panayotou, G., G. Gish, P. End, O. Truong, I. Gout, R. Dhand, M. J. Fry, I. Hiles, T. Pawson, and M. D. Waterfield. 1993. Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor β-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach. Mol. Cell. Biol. 13:3567.
50. src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. Proc. Natl. Acad. Sci. USA 90:4902.
51. Crespo, P., K. E. Schuebel, A. A. Ostrom, J. S. Gutkind, and X. R. Bustelo. 1997. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385:169.
52. Hartley, D., H. Meisner, and S. Corvera. 1995. Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3-kinase with the proto-oncogene c-Cbl. J. Biol. Chem. 270:18260.
53. Negishi, I., N. Motoyama, K. Nakayama, K. Nakayama, S. Senju, S. Hatakeyama, Q. Zhang, A. C. Chan, and D. Y. Loh. 1995. Essential role for zap-70 in both positive and negative selection of thymocytes. Nature 376:435.
54. Yoon, C. H., J. H. Lee, G. D. Jongeward, and P. W. Sternberg. 1995. Similarity of sli-1, a regulator of vulva development in C. elegans, to the mammalian protooncogene c-cbl. Science 269:1102.
55. Blake, T. J., and W. Y. Langdon. 1992. A rearrangement of the c-cbl protooncogene in HUT78 T-lymphoma cells results in a truncated protein. Oncogene 7:757.
56. Andoniou, C. E., C. B. F. Thien, and W. Y. Langdon. 1994. Tumor-induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J. 13:4515.