Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes

Immunity

Volumn 7, Issue 2, 1997, Pages 221-231

  Hu, Qinghui ^a,b   Bazemore Walker, Carthene R ^c   Girao, Cristina ^a   Opferman, Joseph T ^a,b   Sun, Jiling ^a,b   Shabanowitz, Jeffery ^c   Hunt, Donald F ^c,d   Ashton Rickardt, Philip G ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CELL SELECTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0343472103     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80525-7     Document Type: Article

References (47)

1. Anderson, G., Jenkinson, E.J., Moore, N.C., and Owen, J.J. (1993). MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature 362, 70-73.
2. + T cells in the thymus. Thymus 22, 111-115.
3. + T cells in the thymus. Cell 73, 1041-1049.
4. Ashton-Rickardt, P.G., Bandeira, A., Delaney, J.R., Van Kaer, L., Pircher, H.-P., Zinkernagel, R.M., and Tonegawa, S. (1994). Evidence for a differential avidity model of T cell selection in the thymus. Cell 76, 651-663.
5. Attaya, M., Jameson, S., Martinez, C.K., Hermel, E., Alrich, C., Forman, J., Fisher-Lindahl, K., Bevan, M.J., and Monaco, J.J. (1992). HAM-2 corrects the class I antigen-processing defect in RMA-S cells. Nature 355, 647-649.
6. Bevan, M.J. (1977). In a radiation chimera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 269, 417-418.
7. Bjorkman, P.J., Saper, M.A., Bennett, W.S., Strominger, J.L., and Wiley, D.C. (1987). Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329, 506-512.
8. Brinster, R.L., Chen, H.Y., Messing, A., van Dyke, T., Levine, A.J., and Palmiter, R.D. (1984).Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 37, 367-379.
9. Bruno, L., Kirberg, J., and von Boehmer, H. (1995). On the cellular basis of immunological T cell memory. Immunity 2, 37-43.
10. Ceredig, R., Jenkinson, E.J., Mac Donald, H.R., and Owen, J.J.T. (1982). Development of cytolytic T lymphocyte precursors in organcultured mouse embryonic thymus rudiments. J. Exp. Med. 155, 617-622.
11. Faas, S.J., Rothstein, J.L., Kreider, B.L., Rovera, G., and Knowles, B.B. (1993). Phenotypically diverse mouse thymic stromal cell lines which induce proliferation and differentiation of hematopoietic cells. Eur. J. Immunol. 23, 1201-1214.
12. Falk, K., Rotzachke, O., Stevanivic, O., Jung, G., and Rammensee, H.-G. (1991). Allele-specific motifs revealed by sequencing of self-peptides from MHC molecules. Nature 351, 290-296.
13. Fecker, L., Ekblom, P., Kurkinen, M., and Ekblom, M. (1990). A genomic clone encoding a novel proliferation-dependent histone H2A.1 mRNA enriched in the poly(A)+ fraction. Mol. Cell. Biol. 10, 2848-2854.
14. + T cells induced by major histocompatibility complex binding peptides in fetal thymus organ culture. J. Exp. Med. 177, 1464-1473.
15. Hogquist, K.A., Jameson, S.C., Heath, W.R., Howard, J.L., Bevan, M.J., and Carbone, F.R. (1994). T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27.
16. + T-cell memory determined by clonal burst size. Nature 369, 652-654.
17. Hunt, D.F., Yates, J.R.D., Shabanowitz, J., Winston, S., and Hauer, C.R. (1986). Protein sequencing by tandem mass spectrometry. Proc. Natl. Acad. Sci. USA 83, 6233-6237.
18. Hunt, D.F., Henderson, R.A., Shabanowitz, J., Sakaguchi, K., Michel, H., Seilir, N., Cox, A.L., Appella, E., and Engelhard, V.H. (1992). Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry. Science 255, 1261-1263.
19. Ignatowicz, L., Kappler, J., and Marrack, P. (1996). The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84, 521-529.
20. + thymocytes. Nature 333, 742-746.
21. Lau, L.L., Jamieson, B.D., Somasundaram, T., and Ahmed, R. (1994). Cytotoxic T-cell memory without antigen. Nature 369, 648-652.
22. Ljunggren, H.-G., and Karre, K. (1985). Host resistance directed selectively against H-2 deficient lymphoma varients: analysis of the mechanism. J. Exp. Med. 162, 1745-1754.
23. Lo, D., and Sprent, J. (1986). Identity of cells that imprint H-2 restricted T cell specificity in the thymus. Nature 319, 672-675.
24. Mamalaki, C., Norton, T., Tanaka, Y., Townsend, A.R., Simpson, E., and Kioussis, D. (1992). Thymic deletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA. 89, 11342-11346.
25. + T cells in the absence of a functional transporter. J. Exp. Med 181, 757-792.
26. Mombaerts, P., Iacomini, J., Johnson, R.S., Herrup, K., Tonegawa, S., and Papaioannou, V.E. (1992). RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877.
27. Owen, J.A., Allouche, M., and Doherty, P.C. (1984). Frequency of influenza-responsive cytolytic T-lymphocyte precursors in the thymus and spleen of unprimed mice. Cell. Immunol. 84, 403-408.
28. Ozato, K., Mayer, N.M., and Sachs, D.H. (1982). Monoclonal antibodies to mouse major histocompatibility complex antigens. Transplantation 34, 113-120.
29. Pircher, H.-P., Baenziger, J., Schilham, M., Sado, T., Kamisaku, H., Hengartner, H., and Zinkernagel, R.M. (1987). Characterization of virus-specific cytotoxic T cell clones from allogeneic bone marrow chimeras. Eur. J. Immunol. 17, 159-166.
30. Pircher, H.-P., Burki, K., Lang, R., Hengartner, H., and Zinkernagel, R.M. (1989). Tolerance induction in double specific T cell receptor transgenic mice varies with antigen. Nature 342, 559-561.
31. Pircher, H.-P., Moskophidis, D., Rohrer, U., Burki, K., Hengartner, H., and Zinkernagel, R.M. (1990). Viral escape by selection of cytotoxic T cell-resistant virus varients in vivo. Nature 346, 624-632.
32. Schumacher, T.N., and Ploegh, H.L. (1994). Are MHC-bound peptides a nuisance for positive selection? Immunity 1, 721-723.
33. Schwartz, R. (1989). Acquisition of immunological self-tolerance. Cell 57, 1073-1081.
34. Sebzda, E., Wallace, V.A., Mayer, J., Yeung, R.S., Mak, T.W., and Ohashi, P.S. (1994). Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263, 1615-1618.
35. Shepherd, J.C., Schumacher, T.N.M., Ashton-Rickardt, P.G., Imaeda, S., Ploegh, H.L., Janeway, C.A.J., and Tonegawa, S. (1993). TAP1 dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell 74, 577-584.
36. b-binding peptides from influenza virus: effect of non-anchor residues on stability and immunodominance. Mol. Immunol. 32, 623-632.
37. Thelander, L., and Berg, P. (1986). Isolation and characterization of expressible cDNA clones encoding the M1 and M2 subunits of mouse ribonucleotide reuctase. Mol. Cell. Biol. 6, 3433-3442.
38. Thelander, L., Eriksson, S., and Akerman, M. (1980). Ribonucleotide Reductase from calf thymus. J. Biol. Chem. 255, 7426-7432.
39. Townsend, A., Rothbard, J., Gotch, F.M., Bahadur, G., Wraith, D., and McMicheal, A.J. (1986). The epitopes of influenza nucleoprotien recognized by cyotoxic T cells can be defined with short synthetic peptides. Cell 44, 959-968.
40. Townsend, A., Ohlen, C., Bastin, J., Ljunggren, H.-G., Foster, L., and Karre, K. (1989). Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 340, 443-448.
41. + T cells. Cell 71, 1205-1214.
42. von Boehmer, H., and Hafen, K. (1984). Thymocytes appear to ignore class I major histocompatibility antigens expressed on thymus epithelial cells. Eur. J. Immunol. 14, 1048-1052.
43. von Boehmer, H., Teh, H.S., and Kisielow, P. (1989). The thymus selects the useful, neglects the useless and destroys the harmful, Immunol. Today 10, 57-61.
44. Vukmanovic, S., Grandea, A.G., Faas, S.J., Knowles, B.B., and Bevan, M.J. (1992). Positive selection of T-lymphocytes induced by intrathymic injection of a thymic epithelial cell line. Nature 359, 729-732.
45. b at 2.4 Å resolution: implications for antigen-determinant selection. Cell 76, 39-50.
46. + cytotoxic T cells. Nature 344, 742-746.
47. Zinkernagel, R.M., and Doherty, P.C. (1974). Restriction of in vitro T cell mediated cytotoxicity in lymphocytic choriomeningitis within a syneneic or semi-allogeneic system. Nature 248, 701-702.