Regulation of AP-1 and NFAT transcription factors during thymic selection of T cells

Molecular and Cellular Biology

Volumn 16, Issue 3, 1996, Pages 1074-1084

  Rincón, Mercedes ^a   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; THYMUS;

ANIMALIA; MUS MUSCULUS;

EID: 0030059827     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.3.1074     Document Type: Article

References (68)

1. Angel, P., M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich, and M. Karin. 1987. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739.
2. Bendelac, A., P. Matzinger, R. A. Seder, W. E. Paul, and R. H. Schwartz. 1992 Activation events during thymic selection. J. Exp. Med. 175:731-742.
3. Berg, L. J., A. M. Pullen, B. Fazekas de St. Groth, D. Mathis, C. Benoist, and M. M. Davis. 1989. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 58:1035-1046.
4. Bogue, M., S. Gilfillan, C. Benoist, and D. Mathis. 1992. Regulation on N region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny. Proc. Natl. Acad. Sci. USA 89:11011-11015
5. Boise, L. H., B. Petrynyak, X. Mao, C. H. June, C.-Y. Wang, T. Lindsten, R. Bravo, K. Kovary, J. M. Leiden, and C. B. Thompson. 1993. The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB. Mol. Cell. Biol. 13:1911-1919.
6. Borgulya, P., H. Kishi, U. Müller, J. Kirberg, and H. von Boehmer. 1991. Development of the CD4 and CD8 lineage of T cells: instruction versus selection. EMBO J. 10:913-918.
7. Borgulya, P., H. Kishi, Y. Uematsu, and H. von Boehmer. 1992. Exclusion and inclusion of α and β T cell receptor alleles. Cell 69:529-537.
8. Boyd, R. L. 1991 Towards an integrated view of thymopoiesis. Immunol. Today 12:71-79.
9. Carding, S. R., A. C. Hayday, and K. Bottomly. 1991. Cytokines in T-cell development. Immunol. Today 12:239-245
10. Chan, S. H., D. Cosgrove, C. Waltzinger, C. Benoist, and D. Mathis. 1993. Another view of the selective model of thymocyte selection. Cell 73:225-236.
11. Chen, D., and E. V. Rothenberg. 1993. Molecular basis for developmental changes in interleukin-2 gene inducibility. Mol. Cell. Biol. 13:228-237.
12. Chen, J., V. Stewart, G. Spyrou, F. Hilberg, E. F. Wagner, and F. W. Alt. 1994. Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells. Immunity 1:65-72.
13. Cohen, D. R., and T. Curran. 1988 fra-1: a serum-inducible, cellular immediate-early gene that encodes a Fos-related antigen. Mol. Cell. Biol. 8:2063-2069.
14. Cosgrove, D., D. Gray, A. Dierich, J. Kaufman, M. Lemeur, C. Benoist, and D. Mathis. 1991 Mice lacking MHC class II molecules. Cell 66:1053-1066.
15. Crispe, I. N., and M. J. Bevan. 1987 Expression and functional significance of the J11d marker on mouse thymocytes. J. Immunol. 138:2012-2018.
16. Davis, C. B., N. Killeen, M. E. Casey Crooks, D. Raulet, and D. R. Littman. 1993. Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. Cell 73:237-247.
17. Durand, D. B., J. P. Shaw, M. R. Bush, R. E. Replogle, R. Belageje, and G. R. Crabtree. 1988. Characterization of antigen receptor response elements within the interleukin 2 enhancer. Mol. Cell. Biol. 8:1715-1724.
18. Fischer, M., I. MacNeil, T. Suda, J. E. Cupp, K. Shortman, and A. Zlotnik. 1991. Cytokine production by mature and immature thymocytes. 146:3452-3456.
19. Flanagan, W. F., B. Corthesy, R. J. Bram, and G. R. Crabtree. 1991. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature (London) 352:803-807.
20. Geiger, T., L. R. Gooding, and R. A. Flavell. 1992. T-cell responsiveness to an oncogenic peripheral protein and spontaneous autotmmunity in transgenic mice. Proc. Natl. Acad. Sci. USA 89:2985-2989.
21. Gillis, S., M. N. Ferm, and K. A. Smith. 1978. T cell growth factor: parameters of production and quantitative microassay for activity. J. Immunol. 120:1109-1113.
22. Groettrup, M., A. Baron, G. Griffiths, R. Palacios, and H. von Boehmer. 1992 T cell receptor β chain homodimers on the surface of immature but not mature α, γ and δ chain deficient T cell lines. EMBO J. 11:2735-2746.
23. Groettrup, M., K. Ungewiss, O. Azogui, R. Palacios, M. J. Owen, A. C. Hayday, and H. von Boehmer. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor b chain and a 33 kd glycoprotein. Cell 75:283-294.
24. Groettrup, M., and H. von Boehmer. 1993. A role of a pre-T-cell receptor in T-cell development. Immunol. Today. 14:610-614.
25. Halazonetis, T. D., K. Georgopoulos, M. E. Greenberg, and P. Leder. 1988. c-Jun dimerizes with itself and with c-Fos forming complexes of different DNA binding affinities. Cell 55:917-924.
26. Hirai, S.-I., R.-P. Ryseck, F. Mechta, R. Bravo, and M. Yaniv. 1989. Characterization of JunD: a new member of jun proto-oncogene family. EMBO J. 8:1433-1439.
27. Hogan, B., F. Constantini, and E. Lacy. 1986. Manipulating the mouse embryo, p. 89-203. Cold Spring Harbor Laboratory, Cold Spring Harbor, N Y
28. Huesmann, M., B. Scott, P. Kisielow, and H. von Boehmer. 1991 Kinetics and efficacy of positive selection in thymus of normal and T cell receptor transgenic mice. Cell 66:533-540.
29. Ivanov, V., and R. Ceredig. 1992. Transcription factors in mouse fetal thymus development Int. Immunol 4:729-737.
30. Jain, J., P. G. McCaffrey, A. Miner, T. K. Kerppola, J. N. Lambert, G. L. Verdine, T. Curran, and A. Rao. 1993. The T-cell transcription factor NFATp is a substrate tor calcineurin and interacts with Fos and Jun. Nature (London) 365:352-355.
31. Jain, J., P. G. McCaffrey, V. E. Valge-Archer, and A. Rao. 1992 Nuclear factor of activated T cells contains Fos and Jun. Nature (London) 356:801-804.
32. Kaye, J., M.-L. Hsu, M.-E. Sauron, S. C. Jameson, N. R. J. Gascoigne, and S. M. Hedrick. 1989 Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor Nature (London) 341:746-749.
33. Kisielow, P., H. S. Teh, H. Bluthmann, and H. von Boehmer. 1988. Positive selection of antigen-specific T cells m thymus by restricting MHC molecules Nature (London) 335:730-733
34. Kizaki, H., T. Tadakuma, C. Odaka, J. Muramatsu, and Y. Ishimura. 1989. Activation of a suicide process of thymocytes through DNA fragmentation by calcium ionophores and phorbol esters. J. Immunol. 143:1790-1794
35. Lee, W., P. Mitchell, and R. Tjian. 1987. Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements Cell 49:741-752
36. Lugo, J. P., S. N. Krishnan, R. Diamond Sailor, and E. V. Rothenberg. 1986. Early precursor thymocytes can produce interleukin-2 upon stimulation with calcium ionophore and phorhol ester. Proc. Natl. Acad. Sci. USA 83:1862-1866.
37. McCaffrey, P. G., C. Luo, T. K. Kerppola, J. Jain, T. M. Badalian, A. M. Ho, E. Burgeon, W. S. Lane, J. N. Lambert, T. Curran, G. L. Verdine, A. Rao, and P. G. Hogan. 1993. Isolation of cyclosporin-sensitive T cell transcription factor NFATp. Science 262:750-754.
38. Montgomery, R. A., and M. J. Dallman. 1991. Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. J. Immunol. 147:554-560.
39. Montminy, M. R., and L. M. Bilezikijan. 1986 Binding of nuclear protein to the cyclic-AMP response element of the somatostatin gene Nature (London) 328:175-178.
40. Nakabeppu, Y., K. Ryder, and D. Nathans. 1988. DNA binding activities of three murine jun proteins stimulation by fos Cell 55:907-915.
41. Nikolic-Zugic, J. 1991. Phenotypic and functional stages in the intrathymic development of ab cells. Immunol Today 12:65-70.
42. Northrop, J. P., S. N. Ho, L. Chen, D. J. Thomas, G. P. Nolan, A. Admon, and G. R. Crabtree. 1994. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (London) 369:497-502.
43. Northrop, J. P., K. S. Ullman, and G. R. Crabtree. 1993. Characterization of nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT). J. Biol Chem. 268:2917-2923.
44. Ohashi, P. S., H. Pircher, K. Bürki, R. M. Zinkernagel, and H. Hengartner. 1990. Distinct sequence of negative or positive selection implied by thymocytes T-cell receptor densities. Nature (London) 346:861-863.
45. Pircher, H., K. Bürki, R. Lang, H. Hengartner, and R. M. Zinkemagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature (London) 342:559-561.
46. Rao, A. 1994. NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes. Immunol Today 15:274-281.
47. Riegel, J. S., B. Corthesy, W. M. Flanagan, and G. R. Crabtree. 1992. Regulation of interleukin-2 gene. Chem. Immunol. 51:266-298.
48. Riegel, J. S., E. R. Richie, and J. P. Allison. 1990. Nuclear events after activation of CD4+8+ thymocytes. J. Immunol. 144:3611-3618.
49. Rincón, M., and R. A. Flavell. 1994. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J. 13:4370-4381.
50. Robey, E. A., B. J. Fowlkes, J. W. Gordon, D. Kioussis, H. von Boehmer, F. Ramsdell, and R. Axel. 1991. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to CD4 or CD8 lineage. Cell 64:99-107.
51. Rüther, U., W. Muller, T. Sumida, T. Tokuhisa, K. Rajewsky, and E. F. Wagner. 1988 c-fos expression interferes with thymus development in transgenic mice. Cell 53:847-856.
52. Ryder, K., A. Lanahan, E. Perez-Albuerne, and D. Nathans. 1989. Jun-D: a third member of the Jun gene family. Proc. Natl. Acad Sci. USA 86:1500-1503.
53. Sawada, S., J. D. Scarborough, N. Killeen, and D. R. Littman. 1994. A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell 77:917-929.
54. Schreiber, E., P. Matthias, M, M. Muller, and W. Shaffner. 1989. Rapid detection of octamer binding proteins with 'mini'-extracts prepared from a small number of cells. Nucleic Acids Res. 17:6419.
55. Scott, B., H. Blüthmann, H. S. Teh, and H. von Boehmer. 1989. The generation of mature T cells requires interaction of αβ T-cell receptor with major compatibility antigens. Nature (London) 338:591-593
56. Sen, J., Y. Shinkai, F. W. Alt, R. Sen, and S. J. Burakoff. 1994. Nuclear factors that mediate intrathymic signals are developmentally regulated J. Exp. Med. 180:2321-2327.
57. Sha, W. C., C. A. Nelson, R. D. Newberry, D. M. Kranz, J. H. Rusell, and D. Y. Loh. 1988. Positive and negative selection of an antigen receptor on T cell in transgenic mice Nature (London) 336:73-76.
58. 2- thymocytes as post-selection intermediates leading to mature T cells. J. Exp. Med. 173:323-332.
59. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994 JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727-736
60. Swat, W., M. Dessing, A. Baron, P. Kisielow, and H. von Boehmer. 1992 Phenotypic changes accompanying positive selection of CD4+CD8+ thymocytes. Eur. J. Immunol. 22:2367-2372.
61. + thymocytes. Eur. J. Immunol 23:739-746
62. Teh, H. S., P. Kisilow, B. Scott, H. Kishi, Y. Uematsu, H. Blüthmann, and H. von Boehmer. 1988 Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/cd8 phenotype of T cells. Nature (London) 335:229-233.
63. Tugores, A., M. A. Alonso, F. Sánchez-Madrid, and M. O. de Landázuri. 1992. Human T cell activation through the activation-inducer molecule, CD69 enhances the activity of transcription factor AP-1. J. Immunol. 148: 2300-2306.
64. Vasquez, N. J., J. Kaye, and S. M. Hedrick. 1992. In vivo and in vitro clonal deletion of double-positive thymocytes. J. Exp. Med. 175:1307-1316.
65. Verweij, C. L., C. Guidos, and G. R. Crabtree. 1990. Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor. J. Biol. Chem. 265:15788-15795
66. von Boehmer, H. 1986 The selection of α, α heterodimeric T cell receptor for antigen. Immunol. Today 7:333-336.
67. Zerial, M., L. Toschi, R.-P. Ryseck, M. Schuermann, R. Müller, and R. Bravo. 1989. The product of a novel growth factor activated gene, fosB, interacts with JUN proteins enhancing their DNA binding activity. EMBO J 8:805-813.
68. neg thymocytes resembles antigen-activated mature T cell. J. Exp. Med. 178:1139-1149