Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter

Molecular Pharmacology

Volumn 49, Issue 6, 1996, Pages 962-971

  Stride, Brenda D ^a   Valdimarsson, Gunnar ^a   Gerlach, James H ^a   Wilson, Gerald M ^a   Cole, Susan P C ^a   Deeley, Roger G ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; MESSENGER RNA; VINCRISTINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER; CANCER COMBINATION CHEMOTHERAPY; HUMAN; HUMAN CELL; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CLONING, MOLECULAR; DRUG RESISTANCE, MULTIPLE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SOLUBILITY;

EID: 0029939542     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Endicott, J. A., and V. Ling. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem. 58:137-171 (1989).
2. Gottesman, M. M., and I. Pastan. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62:385-427 (1993).
3. Cole, S. P. C. Multidrug resistance in human lung cancer and topoisomerase II, in Lung Cancer: Principles and Practice (H. I. Pass, J. Mitchell, D. H Johnson, and A. T. Turrisi, eds.). J. B. Lippincott, Philadelphia, 169-204 (1996).
4. Cole, S. P. C., G. Bhardwaj, J. H. Gerlach, J. E. Mackie, C. E. Grant, K. C. Almquist, A. J. Stewart, E. U. Kurz, A. M. V. Duncan, and R. G. Deeley. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science (Washington D. C.) 258:1650-1654 (1992).
5. Grant, C. E., G. Valdimarsson, D. R. Hipfner, K. C. Almquist, S. P. C. Cole, and R. G. Deeley. Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res. 54:357-361 (1994).
6. Zaman, G. J. R., M. J. Flens, M. R. Van Leusden, M. de Haas, H. S. Mulder, J. Lankelma, H. M. Pinedo, R. J. Scheper, F. Baas, H. J. Broxterman, and P. Borst. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc. Natl. Acad. Sci. USA 91:8822-8826 (1994).
7. Cole, S. P. C., and R. G. Deeley. Multidrug resistance associated with Overexpression of MRP. Adv. Cancer Res. (1996).
8. Slapak, C. A., P M Fracasso, R. L. Martell, D. L. Toppmeyer, J.-M. Lecerf, and S. B. Levy. Overexpression of the multidrug resistance-associated protein (MRP) gene in vincristine but not doxorubicin-selected multidrug resistant murine erythroleukemia cells. Cancer Res. 54:5607-5613 (1994).
9. Slapak, C. A., N. Mizunuma, and D. W. Kufe. Expression of the multidrug resistance associated protein and P-glycoprotein in doxorubicin-selected human myeloid leukemia cells. Blood 84:3113-3121 (1994).
10. Brock, I., D. R. Hipfner, B. E. Nielsen, P. B. Jensen, R. G. Deeley, S. P. C. Cole, and M. Sehested. Sequential co-expression of the multidrug resistance genes, MRP and mdr1 and their products in VP-16 (etoposide) selected H69 small cell lung cancer cells. Cancer Res. 55:459-462 (1995).
11. Hasegawa, S., T. Abe, S. Naito, S. Kotoh, J. Kumazawa, D. R. Hipfner, R. G. Deeley, S. P. C. Cole, and M. Kuwano. Expression of multidrug resistance-associated protein (MRP), MDR1 and DNA topoisomerase II in human multidrug-resistant bladder cancer cell lines. Br. J. Cancer 71:907-913 (1995).
12. Bordow, S. B., M. Haber, J. Madafiglio, B. Cheung, G. M. Marshall, and M. D. Norris. Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. Cancer Res. 54:5036-5040 (1994).
13. Kuss, B. J., R. G. Deeley, S. P. C. Cole, C. L. Willman, K. J. Kopecky, S. R. Wolman, H. J. Eyre, S. A. Lane, J. K. Nancarrow, S. A. Whitmore, and D F. Callen. Deletion of gene for multidrug resistance in acute myeloid leukaemia with inversion in chromosome 16: prognostic implications. Lancet 343:1531-1534 (1994).
14. Higgins, C. F. ABC transporters: from microorganisms to man. Annu Rev. Cell Biol. 8:67-113 (1992).
15. Cole, S. P. C., K. E. Sparks, K. Fraser, D. W. Loe, C. E. Grant, G. M. Wilson, and R. G. Deeley. Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res. 54:5902-5910 (1994).
16. Almquist, K. C., D. W. Loe, D. R. Hipfner, J. E. Mackie, S. P. C. Cole, and R. G. Deeley. Characterization of the 190 kDa multidrug resistance protein (MRP) in drug-selected and transfected human tumor cells. Cancer Res. 55:102-110 (1995).
17. Ma, L., N. Krishnamachary, and M. S. Center. Phosphorylation of the multidrug resistance associated protein gene encoded protein P190. Biochemistry 34:3338-3343 (1995).
18. Jedlitschky, G., I. Leier, U. Buchholz, M. Center, and D. Keppler. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res. 54:4833-4836 (1994).
19. 4 and structurally related conjugates. J. Biol. Chem. 269: 27807-27810 (1994).
20. Muller, M., C. Meijer, G. J. R. Zaman, P. Borst, R. J. Scheper, N. H. Mulder, E. G. E. de Vries, and P. L. M. Jansen. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci. USA 91:13033-13037 (1994).
21. McGrath, T., C Latoud, S. T. Arnold, A. R. Safa, R. L. Felsted, and M. S. Center. Mechanisms of multidrug resistance in HL60 cells: analysis of resistance associated membrane proteins and levels of mdr gene expression. Biochem. Pharmacol. 38:3611-3619 (1989).
22. Aguilar-Bryan, L., C. G. Nichols, S. W. Wechsler, J. P. Clement, A. E. Boyd, G. Gonzalez, H. Herrera-Sosa, K. Nguy, J. Bryan, and D. A. Nelson. Cloning of the β cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science (Washington. D. C.) 268:423-426 (1995).
23. Szczypka, M. S., J. A. Wemmie, W. S. Moye-Rowley, and D. J. Thiele. A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. J. Biol. Chem. 269:22853-22857 (1994).
24. Sambrook, J., E. F. Fritsch, and T. Maniatis. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1989)
25. Zhu, Q., and M. S. Center. Cloning and sequence analysis of the promoter region of the MRP gene of HL60 cells isolated for resistance to adriamycin. Cancer Res. 54:4488-4492 (1994).
26. Sanger, F., S. Nicklen, and A. R. Coulson. DNA sequencing with chain-terminating inhibitors. Proc. Natl Acad. Sci. USA 74:5463-5467 (1977).
27. Wilson, G. M., and R. G. Deeley. An episomal expression vector system for monitoring sequence-specific effects on mRNA stability in human cell lines. Plasmid 33:198-207 (1995).
28. Fourney, R. M., J. Miyakoshi, R. S. Day, and M. C. Paterson. Northern blotting: efficient RNA staining and transfer. Focus 10:5-7 (1988).
29. Gorman, C., R. Padmanabham, and B. H. Howard. High efficiency DNA-mediated transformation of primate cells. Science (Washington D. C.) 221:551-553 (1983).
30. Walker, J. E., M. Saraste, M. J. Runswick, and N. J. Gay. Distantly related sequences m the α- and β-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding-fold EMBO J. 1:945-951 (1982).
31. Becq, F., T. J. Jensen, X.-B. Chang, A. Savoia, J. M. Rommens, L.-C Tsui, M. Buchwald, J. R. Riordan, and J. W. Hanrahan. Phosphatase inhibitors activate normal and defective CFTR chloride channels. Proc. Natl. Acad Sci. USA 91:9160-9164 (1994).
32. Orr, G. A., E. K.-H. Han, P. C. Browne, E. Nieves, B. M. O'Connor, C.-P. H. Yang, and S. B. Horwitz. Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein: analysis of the protein kinase A and protein kinase C phosphorylation sites. J. Biol. Chem. 268:25054-25062 (1993).
33. Chambers, T. C., J. Pohl, R. L. Raynor, and J. F. Kuo. Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C J. Biol. Chem. 268:4592-4595 (1993).
34. Zaman, G. J. R., C. H. M. Versantvoort, J. J. M. Smit, E. W. H. M. Eijdems, M. de Haas, A. J. Smith, H. J. Broxterman, N. H. Mulder, E. G. E. de Vries, F. Baas, and P. Borst. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Res. 53:1747-1750 (1993).
35. 4 export carrier in mastocytoma cells. Eur. J. Biochem. 220:599-606 (1994).
36. Ruetz, S , and P. Gros. Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 77:1071-1081 (1994).
37. Oakberg, E. F. A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal. Am J. Anat. 99:391-413 (1956).
38. Clermont, Y. Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal. Physiol. Rev. 52:198-236 (1972).
39. Trezise, A. E. O., P. R. Romano, D. R. Gill, S. C. Hyde, F. V. Sepulveda, M. Buchwald, and C. F. Higgins. The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression. EMBO J. 11:4291-4303 (1992).
40. Trezise, A. E. O., C. C. Linder, D. Grieger, E. W. Thompson, H. Meunier, M. D. Griswold, and M. Buchwald. CFTR expression is regulated during both the cycle of the seminiferous epithelium and the oestrous cycle of rodents. Nature Genet. 3:157-164 (1993).
41. Sprando, R. L., and L. D. Russell. Comparative study of cytoplasmic elimination in spermatids of selected mammalian species. Am. J. Anat. 178:72-80 (1987)
42. Hardy, S. P., H. R. Goodfellow, M. A. Valverde, D. R. Gill, F V. Sepulveda, and C. F. Higgins. Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated channels. EMBO J. 14:68-75 (1995).
43. + channels and volume-regulated anion channels in multidrug-resistant small cell lung cancer cells. Cancer Res. 53:4156-4160 (1993).
44. Thomas, G. A., M. A. Barrand, S. Stewart, P. H. Rabbitts, E. D. Williams, and P. R. Twentyman. Expression of the multidrug resistance associated protein (MRP) gene in human lung tumours and normal tissue as determined by in situ hybridisation. Eur. J. Cancer 30A:1705-1709 (1994).
45. Feng, D.-F., and R. F. Doolittle. Progressive sequence alignment as a prerequisite to correct phylogenetic trees. J. Mol. Evol. 25:351-360 (1987).
46. Hammarstrom, S. Leukotrienes. Annu. Rev. Biochem. 52:355-377 (1983).
47. Papadopoulou, B., G. Roy, S. Dey, B. P. Rosen, and M. Ouellette. Contribution of the Leishmama P-glycoprotein-related gene ItpgpA to oxyanion resistance. J. Biol. Chem. 269:11980-11986 (1994).
48. Fasman, G. D., and W. A. Gilbert. The prediction of transmembrane protein sequences and their conformation: an evaluation. TIBS 15:89-92 (1990).
49. Jones, D. T., W. R. Taylor, and J. M. Thornton. A model recognition approach to the prediction of all-helical membrane protein structure and topology. Biochemistry 33:3038-3049 (1994).
50. Eisenberg, D., E. Schwarz, M. Komaromy, and R. Wall. Analysis of membrane and surface protein sequences with the hydrophobic moment plot. J. Mol. Biol. 179:125-142 (1984).