Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 3, 1997, Pages 1226-1230

  Arboix, Margarita ^a,b   Paz, Odalys Gonzalez ^a   Colombo, Tina ^a   D'Incalci, Maurizio ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CYCLOSPORIN A; GLYCOPROTEIN P; QUINIDINE; TRIFLUOPERAZINE; VINBLASTINE; VINBLASTINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG LIVER LEVEL; DRUG METABOLISM; DRUG PENETRATION; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TESTIS;

ANIMALS; BRAIN; CYCLOSPORINE; DRUG RESISTANCE, MULTIPLE; MALE; MICE; P-GLYCOPROTEIN; TESTIS; TRIFLUOPERAZINE; VINBLASTINE;

EID: 0030922974     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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