Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity

FEBS Letters

Volumn 413, Issue 1, 1997, Pages 142-146

  Taguchi, Yoshitomo ^a   Morishima, Masaki ^a   Komano, Tohru ^a   Ueda, Kazumitsu ^a  

^a Grad Sch Pharmaceutical Sci   (Japan)

Author keywords

ABC transporter; Multidrug resistance; P Glycoprotein; Substrate specificity

Indexed keywords

ANTIBIOTIC G 418; COLCHICINE; DOXORUBICIN; ETOPOSIDE; GLYCOPROTEIN P; VINBLASTINE;

AMINO ACID SUBSTITUTION; ARTICLE; CELL CULTURE; CELL STRAIN KB; CONTROLLED STUDY; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MULTIDRUG RESISTANCE; MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN;

ALANINE; ARGININE; CELL MEMBRANE; CELLS, CULTURED; COLCHICINE; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; ETOPOSIDE; GLYCINE; HISTIDINE; HUMANS; IMMUNOBLOTTING; ISOLEUCINE; LEUCINE; P-GLYCOPROTEIN; SUBSTRATE SPECIFICITY; VINBLASTINE;

EID: 0030796990     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00899-5     Document Type: Article

References (24)

1. Endicott J.A., Ling V. Annu. Rev. Biochem. 58:1989;137-171.
2. Gottesman M.M., Pastan I. Annu. Rev. Biochem. 62:1993;385-427.
3. Loo T.W., Clarke D.M. J. Biol. Chem. 268:1993;3143-3149.
4. Devine S.E., Ling V., Melera P.W. Proc. Natl. Acad. Sci. USA. 89:1992;4564-4568.
5. Loo T.W., Clarke D.M. J. Biol. Chem. 268:1993;19965-19972.
6. Loo T.W., Clarke D.M. Biochemistry. 33:1994;14049-14057.
7. Gros P., Dhir R., Croop J., Talbot F. Proc. Natl. Acad. Sci. USA. 88:1991;7289-7293.
8. Kajiji S., Talbot F., Grizzuti K., Dyke-Philips V.V., Agresti M., Safa A.R., Gros P. Biochemistry. 32:1993;4185-4194.
9. Hanna M., Brault M., Kwan T., Kast C., Gros P. Biochemistry. 35:1996;3625-3635.
10. Choi K., Chen C., Kriegler M., Roninson I.B. Cell. 53:1988;519-529.
11. Kioka N., Tsubota J., Kakehi Y., Komano T., Gottesman M.M., Pastan I., Ueda K. Biochem. Biopys. Res. Commun. 162:1989;224-231.
12. Loo T.W., Clarke D.M. J. Biol. Chem. 269:1994;7243-7248.
13. Taguchi, Y., Kino, K., Morishima, M., Kane, S.E., Komano, T. and Ueda, K. (1997) Biochemistry (in press).
14. Zamora J.M., Pearce H.L., Beck W.T. Mol. Pharmacol. 33:1988;454-462.
15. Tang-Wai D.F., Brossi A., Arnold L.D., Gros P. Biochemistry. 32:1993;6470-6476.
16. Welsh M.J., et al. Neuron. 8:1992;821-829.
17. Riordan J.R. Annu. Rev. Physiol. 55:1993;609-630.
18. Anderson M.P., Gregory R.J., Thompson S., Souza D.W., Paul S., Mulligan R.C., Smith A.E., Welsh M.J. Science. 253:1991;202-205.
19. Akabas M.H., Kaufmann C., Cook T.A., Archdeacon P. J. Biol. Chem. 269:1994;14865-14868.
20. Ueda K., Okamura N., Hirai M., Tanigawara Y., Saeki T., Kioka N., Komano T., Hori R. J. Biol. Chem. 267:1992;24248-24252.
21. Loo T.W., Clarke D.M. J. Biol. Chem. 271:1996;15414-15419.
22. Gottesman M.M., Pastan I. J. Biol. Chem. 263:1988;12163-12166.
23. Juranka P.F., Zastawny R.L., Ling V. FASEB J. 3:1989;2583-2592.
24. Loo T.M., Clarke D.M. J. Biol. Chem. 270:1995;843-848.