Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdrla P-glycoprotein

British Journal of Pharmacology

Volumn 119, Issue 5, 1996, Pages 1038-1044

  Mayer, Ulrich ^a,b   Wagenaar, Els ^a   Beijnen, Jos H ^c   Smit, Johan W ^d   Meijer, Dirk K F ^d   Van Asperen, Judith ^a   Borst, Piet ^a   Schinkel, Alfred H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b European Cancer Centre   (Netherlands)

^c SLOTERVAART HOSPITAL   (Netherlands)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Blood brain barrier; Drug disposition; Enterohepatic circulation; Intestinal mucosa; Knockout mice; Multidrug resistance; P glycoprotein

Indexed keywords

CARDIAC GLYCOSIDE; DIGOXIN; GLYCOPROTEIN P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; BLOOD BRAIN BARRIER; BRAIN; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BRAIN LEVEL; DRUG DISPOSITION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG URINE LEVEL; ENDOTHELIUM CELL; FEMALE; GENE DISRUPTION; INTESTINE MUCOSA; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0029860174     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15775.x     Document Type: Article

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