The Cbl protooncogene product: From an enigmatic oncogene to center stage of signal transduction

Critical Reviews in Oncogenesis

Volumn 8, Issue 2-3, 1997, Pages 189-218

  Miyake, Sachiko ^a   Lupher Jr , Mark L ^a   Andoniou, Christopher E ^a   Lill, Nancy L ^a   Ota, Satoshi ^a   Douillard, Patrice ^a   Rao, Navin ^a   Band, Hamid ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Oncogenesis; Phosphotyrosine binding domains; Protein tyrosine kinase; Protooncogenes; Ras; Receptors; Src homology domains

Indexed keywords

MUTANT PROTEIN; ONCOPROTEIN; PROTEIN TYROSINE KINASE; RAS PROTEIN;

AMINO TERMINAL SEQUENCE; AUTOPHOSPHORYLATION; CAENORHABDITIS ELEGANS; DROSOPHILA; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; NONHUMAN; PROTEIN DOMAIN; PROTO ONCOGENE; REVIEW; SIGNAL TRANSDUCTION;

EID: 0031433275     PISSN: 08939675     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevOncog.v8.i2-3.30     Document Type: Review

References (202)

1. Aaronson, S. A.: Growth factors and cancer. [Review]. Science, 254:1146-1153 (1991).
2. Anderson, S. M., E. A. Burton, and B. L. Koch: Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase. J. Biol. Chem., 272:739-745 (1997).
3. Andoniou, C. E., C. B. Thien, and W. Y. Langdon: Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J., 13:4515-4523 (1994).
4. Andoniou, C. E., C. B. Thien, and W. Y. Langdon: The two major sites of cbl tyrosine phosphorylation in abl- transformed cells select the crkL SH2 domain. Oncogene, 12:1981-1989 (1996).
5. Barber, D. L., J. M. Mason, T. Fukazawa, K. A. Reedquist, B. J. Druker, H. Band, and A. D. D'Andrea: Erythropoietin and interleukin-3 activate tyrosine phosphorylation of cbl and association with crk adaptor proteins. Blood, 89:3166-3174(1997).
6. Baserga, R.: Oncogenes and the strategy of growth factors. [Review]. Cell, 79:927-930 (1994)
7. Beckwith, M., G. Jorgensen, and D. L. Longo: The protein product of the protooncogene c-cbl forms a complex with phosphatidylinositol 3-kinase p85 and CD19 in anti-IgM-stimulated human B-lymphoma cells. Blood, 88:3502-3507 (1996).
8. Bhat, A., K. Kolibaba, T. Oda, S. Ohno-Jones, C. Heaney, and B. J. Druker: Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells. J. Biol. Chem., 272:16170-16175 (1997).
9. Binstadt, B. A., K. M. Brumbaugh, C. J. Dick, A. M. Scharenberg, B. L. Williams, M. Colonna, L. L. Lanier, J. P. Kinet, R. T. Abraham, and P. J. Leibson: Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits KIR-initiated tyrosine kinase activation. Immunity, 5:629-638 (1996).
10. Birge, R. B., J. E. Fajardo, C. Reichman, S. E. Shoelson, Z. Songyang, L. C. Cantley, and H. Hanafusa: Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Mol. Cell. Biol., 13: 4648-4656 (1993).
11. Blake, T. J., M. Shapiro, H. C. Morse, 3d, and W. Y. Langdon: The sequences of the human and mouse c-cbl protooncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene, 6:653-657 (1991).
12. Blake, T. J., K. G. Heath, and W. Y. Langdon: The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation. EMBO J., 12:2017-2026 (1993).
13. Boll, W., A. Gallusser, and T. Kirchhausen: Role of the regulatory domain of the EGF-receptor cytoplasmic tail in selective binding of the clathrin-associated complex AP-2. Curr. Biol., 5:1168-1178 (1995).
14. Bonita, D. P., S. Miyake, M. L. Lupher, Jr., W. Y. Langdon, and H. Band: Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity. Mol. Cell. Biol., 17:4597-4610 (1997).
15. Bos, J. L.: Ras-like GTPases. [Review] Biochim. Biophys. Acta, 1333:M19-31 (1997).
16. Bos, J. L., B. Franke, L. M'Rabet, K. Reedquist, and F. Zwartkruis: In search of a function for the Ras-like GTPase Rap1. [Review] FEBS Lett., 410:59-62 (1997).
17. Boussiotis, V. A., G. J. Freeman, A. Berezovskaya, D. L. Barber, and L. M. Nadler: Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science, 278:124-128 (1997).
18. Bowtell D, D. D. and W. Y. Langdon: The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation. Oncogene, 11:1561-1567 (1995).
19. Brizzi, M. F., P. Dentelli, L. Lanfrancoise, A. Rosso, P. G. Pelicci, and L. Pegoraro: Discrete protein interactions with the GRB2/c-cbl complex in SCF- and TPO-mediated myeloid cell proliferation. Oncogene, 13:2067-2076 (1996).
20. Broome, M. A. and T. Hunter: Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling. J. Biol. Chem., 271:16798-16806 (1996).
21. Buday, L., A. Khwaja, S. Sipeki, A. Farago, and J. Downward: Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation. J. Biol. Chem., 271:6159-6163 (1996).
22. Bunnell, S. C, P. A. Henry, R. Kolluri, T. Kirchhausen, R. J. Rickles, and L. J. Berg: Identification of Itk/Tsk Src homology 3 domain ligands. J. Biol. Chem., 271:25646-25656 (1996).
23. Bustelo, X. R., P. Crespo, M. Lopezbarahona, J. S. Gutkind, and M. Barbacid: Cbl-b, a member of the SLI-1/c-Cbl protein family, inhibits VAV-mediated c-jun N-terminal kinase activation. Oncogene, 15:2511-2520 (1997).
24. Cantley, L. C., K. R. Auger, C. Carpenter, B. Duckworth, A. Graziani, R. Kapeller, and S. Soltoff: Oncogenes and signal transduction [published erratum appears in Cell 1991 May 31;65(5):following 914]. [Review]. Cell, 64:281-302 (1991).
25. Cantley, L. C. and Z. Songyang: Specificity in recognition of phosphopeptides by src-homology 2 domains. J. Cell Sci. (Suppl.), 18:121-126 (1994).
26. Cantley, L. C. and Z. Songyang: Specificity in proteintyrosine kinase signaling. [Review]. Advances in Second Messenger &. Phosphoprotein Res., 31:41-48 (1997).
27. Cantrell, D. A.: T cell antigen receptor signal transduction pathways. Cancer Surveys, 27:165-175 (1996).
28. Chan, A. C., D. M. Desai, and A. Weiss: The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. [Review]. Annu. Rev. Immunol., 12:555-592 (1994a).
29. Chan, A. C., N. S. van Oers, A. Tran, L. Turka, C. L. Law, J. C. Ryan, E. A. Clark, and A. Weiss: Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J. Immunol., 152:4758-4766 (1994b).
30. Chan, A. C., M. Dalton, R. Johnson, G. H. Kong, T. Wang, R. Thoma, and T. Kurosaki: Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J., 14:2499-2508 (1995).
31. Chan, A.C. and A. S. Shaw: Regulation of antigen receptor signal transduction by protein tyrosine kinases [review]. Curr. Opin. Immunol., 8:394-401 (1996).
32. Chiarugi, P., P. Cirri, G. Raugei, G. Camici, F. Dolfi, A. Berti, and G. Ramponi: PDGF receptor as a specific in vivo target for low M(r) phosphotyrosine protein phosphatase. FEBS Lett., 372:49-53 (1995).
33. Chin, H., T. Saito, A. Arai, K. Yamamoto, R. Kamiyama, N. Miyasaka, and O. Miura: Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with She, SHP-2, and Cbl in hematopoietic cells. Biochem. Biophys. Res. Commun., 239:412-417 (1997).
34. Claesson-Welsh, L.: Mechanism of action of platelet-derived growth factor. [Review]. Int. J. Biochem. Cell Biol., 28:373-385 (1996).
35. Cory, G. O., R. C. Lovering, S. Hinshelwood, L. MacCarthy-Morrogh, R. J. Levinsky, and C. Kinnon: The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. J. Exp. Med., 182:611-615 (1995).
36. Darnell, J. E., Jr.: The JAK-STAT pathway: summary of initial studies and recent advances. [Review]. Recent Progr. Horm. Res., 51:391-403 (1996).
37. de Jong, R., J. ten Hoeve, N. Heisterkamp, and J. Groffen: Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia. J. Biol. Chem., 270:21468-21471 (1995).
38. Dombrosky-Ferlan, P. M. and S. J. Corey: Yeast two-hybrid in vivo association of the Src kinase Lyn with the protooncogene product Cbl but not with the p85 subunit of PI 3-kinase. Oncogene, 14:2019-2024(1997).
39. Donovan, J. A., R. L. Wange, W. Y. Langdon, and L. E. Samelson: The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J. Biol. Chem., 269:22921-22924(1994).
40. Donovan, J. A., Y. Ota, W. Y. Langdon, and L. E. Samelson: Regulation of the association of p120cbl with Grb2 in Jurkat T cells. J. Biol. Chem., 271:26369-26374(1996).
41. Erpel, T. and S. A. Courtneidge: Src family protein tyrosine kinases and cellular signal transduction pathways. [Review]. Curr. Opin. Cell Biol., 7:176-182 (1995).
42. Fantl, W. J., D. E. Johnson, and L. T. Williams: Signalling by receptor tyrosine kinases. [Review]. Annu. Rev. Biochem., 62:453-481 (1993).
43. Fields, P. E., T. F. Gajewski, and F. W. Fitch: Blocked Ras activation in anergic CD4+ T cells. Science, 271:1276-1278 (1996).
44. Fitzer-Attas, C. J., D. G. Schindler, T. Waks, and Z. Eshhar: Direct T cell activation by chimeric single chain Fv-Syk promotes Syk-Cbl association and Cbl phosphorylation. J. Biol. Chem., 272:8551-8557 (1997).
45. Fixman, E. D., M. Holgado-Madruga, L. Nguyen, D. M. Kamikura, T. M. Fournier, A. J. Wong, and M. Park: Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gabi. J. Biol. Chem., 272:20167-20172 (1997).
46. Fournel, M., D. Davidson, R. Weil, and A. Veillette: Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes. J. Exp. Med., 183:301-306 (1996).
47. Fry, A. M., L. L. Lanier, and A. Weiss: Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. J. Exp. Med., 184:295-300 (1996).
48. Fukazawa, T., K. A. Reedquist, G. Panchamoorthy, S. Soltoff, T. Trub, B. Druker, L. Cantley, S. E. Shoelson, and H. Band: T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/ phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38. J. Biol. Chem., 270:20177-20182 (1995a).
49. Fukazawa, T., K. A. Reedquist, T. Trub, S. Soltoff, G. Panchamoorthy, B. Druker, L. Cantley, S. E. Shoelson, and H. Band: The SH3 domain-binding T cell tyrosyl phosphoprotein p 120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. J. Biol. Chem., 270:19141-19150 (1995b).
50. Fukazawa, T., S. Miyake, V. Band, and H. Band: Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. J. Biol. Chem., 271:14554-14559 (1996).
51. Furlong, M. T., A. M. Mahrenholz, K. H. Kim, C. L. Ashendel, M. L. Harrison, and R. L. Geahlen: Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase syk. Biochim. Biophys. Acta, 1355: 177-190 (1997).
52. Galisteo, M. L., I. Dikic, A. G. Batzer, W. Y. Langdon, and J. Schlessinger: Tyrosine phosphorylation of the c-cbl protooncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. J. Biol. Chem., 270:20242-20245 (1995).
53. Galisteo, M. L., J. Chernoff, Y. C. Su, E. Y. Skolnik, and J. Schlessinger: The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J. Biol. Chem., 271:20997-21000 (1996).
54. Gotoh, T., S. Hattori, S. Nakamura, H. Kitayama, M. Noda, Y. Takai, K. Kaibuchi, H. Matsui, O. Hatase, H. Takahashi et al.: Identification of Rap1 as a tar-get for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol. Cell. Biol., 15:6746-6753 (1995).
55. Hartley, D., H. Meisner, and S. Corvera: Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the protooncogene c-cbl. J. Biol. Chem., 270:18260-18263 (1995).
56. Hartley, D. and S. Corvera: Formation of c-Cbl. phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p561ck-independent mechanism. J. Biol. Chem., 271:21939-21943 (1996).
57. Hasegawa, H., E. Kiyokawa, S. Tanaka, K. Nagashima, N. Gotoh, M. Shibuya, T. Kurata, and M. Matsuda: DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol. Cell. Biol., 16:1770-1776 (1996).
58. Hegen, M., J. Kameoka, R. P. Dong, S. F. Schlossman, and C. Morimoto: Cross-linking of cd26 by antibody induces tyrosine phosphorylation and activation of mitogen-activated protein kinase. Immunology, 90:257-264 (1997).
59. Heldin, C. H.: Dimerization of cell surface receptors in signal transduction. [Review]. Cell, 80:213-223 (1995).
60. Hime, G. R., M. P. Dhungat, A. Ng, and D. D. Bowtell: D-Cbl, the Drosophila homologue of the c-Cbl protooncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites. Oncogene, 14:2709-2719 (1997).
61. Hunter, S., B. L. Koch, and S. M. Anderson: Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase. Mol. Endocrinol., 11:1213-1222 (1997).
62. Hunter, T.: Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. [Review]. Cell, 80:225-236 (1995).
63. Hunter, T.: Oncoprotein networks. [Review]. Cell, 88:333-346 (1997).
64. Husson, H., B. Mograbi, H. Schmidantomarchi, S. Fischer, and B. Rossi: CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, CRK-II and GRB2. Oncogene, 14: 2331-2338 (1997).
65. Ichiba, T., Y. Kuraishi, O. Sakai, S. Nagata, J. Groffen, T. Kurata, S. Hattori, and M. Matsuda: Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk, CrkL, and Grb2. J. Biol. Chem., 272:22215-22220 (1997).
66. Ingham, R. J., D. L. Krebs, S. M. Barbazuk, C. W. Turck, H. Hirai, M. Matsuda, and M. R. Gold: B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins. J. Biol. Chem., 271:32306-32314 (1996).
67. Ishiki, M., T. Sasaoka, H. Ishihara, T. Imamura, I. Usui, Y. Takata, and M. Kobayashi: Evidence for functional roles of Crk-II in insulin and epidermal growth factor signaling in Rat-1 fibroblasts overexpressing insulin receptors. Endocrinology, 138:4950-4958 (1997).
68. Jain, S. K., W. Y. Langdon, and L. Varticovski: Tyrosine phosphorylation of p120(cbl) in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase. Oncogene, 14:2217-2228 (1997).
69. Jiao, H., K. Berrada, W. Yang, M. Tabrizi, L. C. Platanias, and T. Yi: Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol. Cell. Biol., 16: 6985-6992 (1996).
70. Joly, M., A. Kazlauskas, F. S. Fay, and S. Corvera: Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science, 263:684-687 (1994).
71. Joly, M., A. Kazlauskas, and S. Corvera: Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking. J. Biol. Chem., 270:13225-13230 (1995a).
72. Joly, M., A. Kazlauskas, and S. Corvera: Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking. J. Biol. Chem., 270:13225-13230 (1995b).
73. Jongeward, G. D., T. R. Clandinin, and P. W. Sternberg: sli-1, a negative regulator of let-23-mediated signaling in C. elegans. Genetics, 139:1553-1566 (1995).
74. Kanagasundaram, V., A. Jaworowski, and J. A. Hamilton: Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages. Biochem. J., 320:69-77 (1996).
75. Kavanaugh, W. M., C. W. Turck, and L. T. Williams: PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine. Science, 268:1177-1179 (1995).
76. Keane, M. M., O. M. Rivero-Lezcano, J. A. Mitchell, K. C. Robbins, and S. Lipkowitz: Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl protooncogene. Oncogene, 10:2367-2377 (1995).
77. Khwaja, A., B. Hallberg, P. H. Warne, and J. Downward: Networks of interaction of p120(cbl) and p130(cas) with Crk and GRB2 adaptor proteins. Oncogene, 12: 2491-2498 (1996).
78. Kim, T. J., Y. T. Kim, and S. Pillai: Association of activated phosphatidylinositol 3-kinase with p120cbl in antigen receptor-ligated B cells. J. Biol. Chem., 270:27504-27509 (1995).
79. Kitanaka, A., C. Ito, H. Nishigaki, and D. Campana: CD38-mediated growth suppression of b-cell progenitors requires activation of phosphatidylinositol 3-kinase and involves its association with the protein product of the c-cbl protooncogene. Blood, 88:590-598 (1996).
80. Kizaka-Kondoh, S., M. Matsuda, and H. Okayama: CrkII signals from epidermal growth factor receptor to Ras. Proc. Natl. Acad. Sci. U.S.A., 93:12177-12182 (1996).
81. Kong, G., M. Dalton, J. B. Wardenburg, D. Straus, T. Kurosaki, and A. C. Chan: Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function. Mol. Cell. Biol., 16:5026-5035 (1996).
82. Kontani, K., I. Kukimoto, H. Nishina, S. Hoshino, O. Hazeki, Y. Kanaho, and T. Katada: Tyrosine phosphorylation of the c-cbl protooncogene product mediated by cell surface antigen CD38 in HL-60 cells. J. Biol. Chem., 271: 1534-1537 (1996).
83. Kornilova, E., T. Sorkina, L. Beguinot, and A. Sorkin: Lysosomal targeting of epidermal growth factor receptors via a kinase-dependent pathway is mediated by the receptor carboxyl-terminal residues 1022-1123. J. Biol. Chem., 271:30340-30346 (1996).
84. Lamaze, C. and S. L. Schmid: Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase. J. Cell Biol., 129:47-54 (1995).
85. Landschulz, W. H., P. F. Johnson, and S. L. McKnight: The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science, 240:1759-1764(1988).
86. Langdon, W. Y., J. W. Hartley, S. P. Klinken, S. K. Ruscetti, and H. C. Morse, 3d: v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas. Proc. Natl. Acad. Sci. U.S.A., 86: 1168-1172 (1989).
87. Langdon, W. Y.: The cbl oncogene: a novel substrate of protein tyrosine kinases. [Review]. Australian & New Zealand J. Med., 25:859-864 (1995).
88. Latour, S., L. M. L. Chow, and A. Veillette: Differential intrinsic enzymatic activity of Syk and Zap-70 proteintyrosinekinases.y. Biol. Chem., 271:22782-22790 (1996).
89. Lee, C. H., W. Li, R. Nishimura, M. Zhou, A. G. Batzer, M. G. Myers, Jr., M. F. White, J. Schlessinger, and E. Y. Skolnik: Nek associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc. Natl. Acad. Sci. U.S.A., 90:11713-11717 (1993).
90. Levkowitz, G., L. N. Klapper, E. Tzahar, A. Freywald, M. Sela, and Y. Yarden: Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins. Oncogene, 12:1117-1125 (1996).
91. Li, S. C., Z. Songyang, S. J. Vincent, C. Zwahlen, S. Wiley, L. Cantley, L. E. Kay, J. Forman-Kay, and T. Pawson: High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif. Proc. Natl. Acad. Sci. U.S.A., 94:7204-7209 (1997).
92. Li, W., P. Hu, E. Y. Skolnik, A. Ullrich, and J. Schlessinger: The SH2 and SH3 domain-containing Nek protein is oncogenic and a common target for phosphorylation by different surface receptors. Mol. Cell. Biol., 12:5824-5833 (1992).
93. Liu, Y. C., C. Elly, H. Yoshida, N. Bonnefoy-Berard, and A. Altman: Activation-modulated association of 14-3-3 proteins with Cbl in T cells. J. Biol. Chem., 271:14591-14595 (1996).
94. Liu, Y. C., C. Elly, W. Y. Langdon, and A. Altman: Rasdependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells. J. Biol. Chem., 272:168-173 (1997a).
95. Liu, Y. C., Y. Liu, C. Elly, H. Yoshida, S. Lipkowitz, and A. Altman: Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif. J. Biol. Chem., 272:9979-9985 (1997b).
96. Lupher, M. L., Jr., C. E. Andoniou, D. P. Bonita, S. Miyake, and H. Band: Molecules in focus: the c-Cbl oncoprotein. Int. J. Biochem. Cell Biol., in press (1998).
97. Lupher, M. L., Jr., S. Y. Zhou, S. E. Shoelson, L. C. Cantley, and H. Band: The Cbl phosphotyrosine-binding domain selects a D(N/D)XPY motif and binds to the Tyr(292) negative regulatory phosphorylation site of ZAP-70. J. Biol. Chem., 272:33140-33144 (1997).
98. Lupher, M. L., Jr., K. A. Reedquist, S. Miyake, W. Y. Langdon, and H. Band: A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells. J. Biol. Chem., 271:24063-24068 (1996).
99. Manie, S. N., M. Sattler, A. Astier, J. S. Phifer, T. Canty, C. Morimoto, B. J. Druker, R. Salgia, J. D. Griffin, and A. S. Freedman: Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation [published erratum appears in Experimental Hematology, 1997 Feb;25(2):177]. Exp. Hematol., 25:45-50 (1997).
100. Marcilla, A., O. M. Rivero-Lezcano, A. Agarwal, and K. C. Robbins: Identification of the major tyrosine kinase substrate in signaling complexes formed after engage- ment of Fc gamma receptors. J. Biol. Chem., 270:9115-9120 (1995).
101. Marengere, L. E., P. Waterhouse, G. S. Duncan, H. W. Mittrucker, G. S. Feng, and T. W. Mak: Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science, 272:1170-1173 (1996).
102. Marengere, L. E., C. Mirtsos, I. Kozieradzki, A. Veillette, T. W. Mak, and J. M. Penninger: Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells. J. Immunol., 159:70-76 (1997).
103. Marshall, C. J.: Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. [Review]. Cell, 80:179-185 (1995).
104. Matsuda, M., S. Ota, R. Tanimura, H. Nakamura, K. Matuoka, T. Takenawa, K. Nagashima, and T. Kurata: Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. J. Biol. Chem., 271:14468-14472 (1996).
105. Matsuda, M. and T. Kurata: Emerging components of the Crk oncogene product: the first identified adaptor protein. [Review]. Cell. Signalling, 8:335-340 (1996).
106. Matsuo, T., K. Hazeki, O. Hazeki, T. Katada, and M. Ui: Specific association of phosphatidylinositol 3-kinase with the protooncogene product Cbl in Fc gamma receptor signaling. FEBS Lett., 382:11-14 (1996a).
107. Matsuo, T., K. Hazeki, N. Tsujimoto, S. Inoue, H. Kurosu, K. Kontani, O. Hazeki, M. Ui, and T. Katada: Association of phosphatidylinositol 3-kinase with the protooncogene product Cbl upon CD38 ligation by a specific monoclonal antibody in THP-1 cells. FEBS Lett., 397:113-116 (1996b).
108. Mayer, B. J., H. Hirai, and R. Sakai: Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases. Curr. Biol., 5:296-305 (1995).
109. Mege, D., V. Di Bartolo, V. Germain, L. Tuosto, F. Michel, and O. Acuto: Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways. J. Biol. Chem., 271:32644-32652 (1996).
110. Meisner, H., B. R. Conway, D. Hartley, and M. P. Czech: Interactions of Cbl with Grb2 and phosphatidylinositol 3′-kinase in activated Jurkat cells. Mol. Cell. Biol., 15: 3571-3578 (1995).
111. Meisner, H., A. Daga, J. Buxton, B. Fernandez, A. Chawla, U. Banerjee, and M. P. Czech: Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol. Cell. Biol., 17:2217-2225 (1997).
112. Meisner, H. and M. P. Czech: Coupling of the protooncogene product c-Cbl to the epidermal growth factor receptor. J. Biol Chem., 270:25332-25335 (1995).
113. Morita, H., T. Tahara, A. Matsumoto, T. Kato, H. Miyazaki, and H. Ohashi: Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation. FEBS Lett., 395:228-234 (1996).
114. Myers, M. G., Jr., J. M. Backer, X. J. Sun, S. Shoelson, P. Hu, J. Schlessinger, M. Yoakim, B. Schaffhausen, and M. F. White: IRS-1 activates phosphatidylinositol 3′-kinase by associating with src homology 2 domains of p85. Proc. Natl. Acad. Sci. U.S.A., 89:10350-10354 (1992).
115. Nishimura, R., W. Li, A. Kashishian, A. Mondino, M. Zhou, J. Cooper, and J. Schlessinger: Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor. Mol. Cell. Biol., 13:6889-6896 (1993).
116. Nishizumi, H., I. Taniuchi, Y. Yamanashi, D. Kitamura, D. Ilic, S. Mori, T. Watanabe, and T. Yamamoto: Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity, 3:549-560 (1995).
117. Oda, A., K. Ozaki, B. J. Druker, Y. Miyakawa, H. Miyazaki, M. Handa, H. Morita, H. Ohashi, and Y. Ikeda: P120(c-cbl) is present in human blood platelets and is differentially involved in signaling by thrombopoietin and thrombin. Blood, 88:1330-1338 (1996).
118. Odai, H., K. Sasaki, Y. Hanazono, H. Ueno, T. Tanaka, K. Miyagawa, K. Mitani, Y. Yazaki, and H. Hirai: c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in vsrc-transformed fibroblasts. Jpn. J. Cancer Res., 86:1119-1126 (1995a).
119. Odai, H., K. Sasaki, A. Iwamatsu, Y. Hanazono, T. Tanaka, K. Mitani, Y. Yazaki, and H. Hirai: The protooncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells. J. Biol. Chem., 270:10800-10805 (1995b).
120. Ohtsuka, T., K. Shimizu, B. Yamamori, S. Kuroda, and Y. Takai: Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein. J. Biol. Chem., 271: 1258-1261 (1996).
121. Ojaniemi, M., S. S. Martin, F. Dolfi, J. M. Olefsky, and K. Vuori: The protooncogene product p120(cbl) links c-Src and phosphatidylinositol 3′-kinase to the integrin signaling pathway. J. Biol. Chem., 272:3780-3787 (1997).
122. Okada, S. and J. E. Pessin: Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor. J. Biol. Chem., 271:25533-25538 (1996).
123. Okada, S. and J. E. Pessin: Insulin and epidermal growth factor stimulate a conformational change in Rap1 and dissociation of the CrkII-C3G complex. J. Biol. Chem., 272:28179-28182 (1997).
124. Okuda, K., T. R. Golub, D. G. Gilliland, and J. D. Griffin: P210bcr/abl, p190bcr/abl, and tel/abl activate similar signal transduction pathways in hematopoietic cell lines. Oncogene, 13:1147-1152 (1996).
125. Opresko, L. K., C. P. Chang, B. H. Will, P. M. Burke, G. N. Gill, and H. S. Wiley: Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain. J. Biol. Chem., 270:4325-4333 (1995).
126. Osman, N., S. C. Lucas, H. Turner, and D. Cantrell: A comparison of the interaction of She and the tyrosine kinase ZAP-70 with the T cell antigen receptor zeta chain tyrosine-based activation motif. J. Biol. Chem., 270:13981-13986 (1995).
127. Ota, Y., L. O. Beitz, A. M. Scharenberg, J. A. Donovan, J. P. Kinet, and L. E. Samelson: Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells. J. Exp. Med., 184:1713-1723 (1996).
128. Ota, Y. and L. E. Samelson: The product of the protooncogene c-cbl-a negative regulator of the syk tyrosine kinase. Science, 276:418-420 (1997).
129. Panchamoorthy, G., T. Fukazawa, S. Miyake, S. Soltoff, K. Reedquist, B. Druker, S. Shoelson, L. Cantley, and H. Band: p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and She adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. J. Biol. Chem., 271:3187-3194 (1996).
130. Pawson, T.: Protein modules and signalling networks. [Review]. Nature, 373:573-580 (1995).
131. Pawson, T. and J. D. Scott: Signaling through scaffold, anchoring, and adaptor proteins [Review]. Science, 278: 2075-2080 (1997).
132. Peri, K. G. and A. Veillette: Tyrosine protein kinases in T lymphocytes. [Review]. Chem. Immunol., 59:19-39 (1994).
133. Plas, D. R., R. Johnson, J. T. Pingel, R. J. Matthews, M. Dalton, G. Roy, A. C. Chan, and M. L. Thomas: Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science, 272:1173-1176 (1996).
134. Qian, D., M. N. Mollenauer, and A. Weiss: Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling. J. Exp. Med., 183:611-620 (1996).
135. Qian, D. and A. Weiss: T cell antigen receptor signal transduction. [Review] [71 refs]. Curr. Opin. Cell Biol., 9:205-212 (1997).
136. Quilliam, L. A., Q. T. Lambert, L. A. Mickelsonyoung, J. K. Westwick, A. B. Sparks, B. K. Kay, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, and C. J. Der: Isolation of a Nek-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J. Biol. Chem., 271:28772-28776 (1996).
137. Ravichandran, K. S., K. K. Lee, Z. Songyang, L. C. Cantley, P. Burn, and S. J. Burakoff: Interaction of She with the zeta chain of the T cell receptor upon T cell activation. Science, 262:902-905 (1993).
138. Ravichandran, K. S., U. Lorenz, S. E. Shoelson, and S. J. Burakoff: Interaction of She with Grb2 regulates the Grb2 association with mSOS. Ann. NY Acad. Sci., 766:202-203 (1995).
139. Reedquist, K. A., T. Fukazawa, B. Druker, G. Panchamoorthy, S. E. Shoelson, and H. Band: Rapid T-cell receptor-mediated tyrosine phosphorylation of p 120, an Fyn/Lck Src homology 3 domain-binding protein. Proc. Natl. Acad. Sci. U.S.A., 91:4135-4139 (1994).
140. Reedquist, K. A., T. Fukazawa, G. Panchamoorthy, W. Y. Langdon, S. E. Shoelson, B. J. Druker, and H. Band: Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J. Biol. Chem., 271:8435-8442 (1996).
141. Ribon, V., S. Hubbell, R. Herrera, and A. R. Saltiel: The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner. Mol. Cell. Biol., 16:45-52 (1996).
142. Ribon, V. and A. R. Saltiel: Insulin stimulates tyrosine phosphorylation of the protooncogene product of c-Cbl in 3T3-L1 adipocytes. Biochem. J., 324:839-845 (1997).
143. Rivero-Lezcano, O. M., J. H. Sameshima, A. Marcilla, and K. C. Robbins: Physical association between Src homology 3 elements and the protein product of the c-cbl protooncogene. J. Biol. Chem., 269:17363-17366 (1994).
144. Robertson, H., W. Y. Langdon, C. B. F. Thien, and D. D. L. Bowtell: A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components. Biochem. Biophys. Res. Commun., 240:46-50 (1997).
145. Rodriguez-Viciana, P., P. H. Warne, R. Dhand, B. Vanhaesebroeck, I. Gout, M. J. Fry, M. D. Waterfield, and J. Downward: Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature, 370:527-532 (1994).
146. Rodriguez-Viciana, P., P. H. Warne, B. Vanhaesebroeck, M. D. Waterfield, and J. Downward: Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J., 15:2442-2451 (1996).
147. Salgia, R., E. Pisick, M. Sattler, J. L. Li, N. Uemura, W. K. Wong, S. A. Burky, H. Hirai, L. B. Chen, and J. D. Griffin: p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene. J. Biol. Chem., 271:25198-25203 (1996a).
148. Salgia, R., M. Sattler, E. Pisick, J. L. Li, and J. D. Griffin: P210(BCR/abl) induces formation of complexes containing focal adhesion proteins and the protooncogene product p 120(c-cbl). Exp. Hematol., 24:310-313 (1996b).
149. Salojin, K., J. Zhang, M. Cameron, B. Gill, G. Arreaza, A. Ochi, and T. L. Delovitch: Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice. J. Exp. Med., 186:887-897 (1997).
150. Sasaki, K., H. Odai, Y. Hanazono, H. Ueno, S. Ogawa, W. Y. Langdon, T. Tanaka, K. Miyagawa, K. Mitani, Y. Yazaki, and H. Hirai: TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including protooncogene products, Vav and c-Cbl, and Ras signaling molecules. Biochem. Biophys. Res. Commun., 216:338-347 (1995).
151. Sattler, M., R. Salgia, K. Okuda, N. Uemura, M. A. Durstin, E. Pisick, G. Xu, J. L. Li, K. V. Prasad, and J. D. Griffin: The protooncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p21OBCR/ABL to the phosphatidylinositol-3′ kinase pathway. Oncogene, 12:839-846 (1996).
152. Sattler, M., R. Salgia, M. A. Durstin, K. V. Prasad, and J. D. Griffin: Thrombopoietin induces activation of the phosphatidylinositol-3′ kinase pathway and formation of a complex containing p85(pi3k) and the protooncoprotein p120(cbl). J. Cell. Physiol., 171:28-33 (1997a).
153. Sattler, M., R. Salgia, G. Shrikhande, S. Verma, E. Pisick, K. V. Prasad, and J. D. Griffin: Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL). J. Biol. Chem., 272:10248-10253 (1997b).
154. Sattler, M., R. Salgia, G. Shrikhande, S. Verma, N. Uemura, S. F. Law, E. A. Golemis, and J. D. Griffin: Differential signaling after betal integrin
155. Saurin, A. J., K. L. Borden, J. B. Bohlen, and P. S. Freemont: Does this have a familiar RING? Trends Biol. Sci., 21:208-214 (1996).
156. Savage, P. D., M. Shapiro, W. Y. Langdon, A. D. Geurts van Kessel, H. N. Seuanez, Y. Akao, C. Croce, H. C. Morse, 3d, and J. H. Kersey: Relationship of the human protooncogene CBL2 on 11q23 to the t(4; 11), t(11;22), and t(11;14) breakpoints. Cytogenet. Cell Genet., 56: 112-115 (1991).
157. Sawasdikosol, S., J. H. Chang, J. C. Pratt, G. Wolf, S. E. Shoelson, and S. J. Burakoff: Tyrosine-phosphorylated Cbl binds to Crk after T cell activation. J. Immunol., 157:110-116 (1996).
158. Schlottmann, K. E., E. Gulbins, S. M. Lau, and K. M. Coggeshall: Activation of Src-family tyrosine kinases during Fas-induced apoptosis. J. Leukocyte Biol., 60: 546-554 (1996).
159. Smit, L., G. van der Horst, and J. Borst: Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and CrkL adaptors. J. Biol Chem., 271:8564-8569 (1996a).
160. Smit, L., G. Vanderhorst, and J. Borst: Formation of Chc/ GRB2- and Crk adaptor complexes containing tyrosine phosphorylated Cbl upon stimulation of the B-cell antigen receptor. Oncogene, 13:381-389 (1996b).
161. Soltoff, S. P. and L. C. Cantley: p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells. J. Biol. Chem., 271:563-567 (1996).
162. Songyang, Z., S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, R. J. Lechleider et al.: SH2 domains recognize specific phosphopeptide sequences. Cell, 72:767-778 (1993).
163. Songyang, Z., S. E. Shoelson, J. McGlade, P. Olivier, T. Pawson, X. R. Bustelo, M. Barbacid, H. Sabe, H. Hanafusa, T. Yi et al.: Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol. Cell. Biol., 14:2777-2785 (1994).
164. Songyang, Z., B. Margolis, M. Chaudhuri, S. E. Shoelson, and L. C. Cantley: The phosphotyrosine interaction domain of She recognizes tyrosine-phosphorylated NPXY motif. J. Biol. Chem., 270:14863-14866 (1995).
165. Sorkin, A. and C. M. Waters: Endocytosis of growth factor receptors. Bioessays, 15:375-382 (1993).
166. Sternberg, P. W., G. Lesa, J. Lee, W. S. Katz, C. Yoon, T. R. Clandinin, L. S. Huang, H. M. Chamberlin, and G. Jongeward: LET-23-mediated signal transduction during Caenorhabditis elegans development. [Review]. Mol. Reproduct. Dev., 42:523-528 (1995).
167. Streuli, M.: Protein tyrosine phosphatases in signaling. [Review]. Curr. Opin. Cell Biol., 8:182-188 (1996).
168. Su, Y. C., J. Han, S. Xu, M. Cobb, and E. Y. Skolnik: NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J., 16:1279-1290 (1997).
169. Swieter, M., E. H. Berenstein, and R. P. Siraganian: Protein tyrosine phosphatase activity associates with the high affinity IgE receptor and dephosphorylates the receptor subunits, but not Lyn or Syk. J. Immunol., 155:5330-5336 (1995).
170. Tanaka, S., L. Neff, R. Baron, and J. B. Levy: Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways. J. Biol. Chem., 270:14347-14351 (1995).
171. Tanaka, S., M. Amling, L. Neff, A. Peyman, E. Uhlmann, J. B. Levy, and R. Baron: c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption. Nature, 383:528-531 (1996).
172. Tashiro, M., Y. Kawakami, R. Abe, W. Han, D. Hata, K. Sugie, L. Yao, and T. Kawakami: Increased secretion of TNF-alpha by costimulation of mast cells via CD28 and Fc epsilon RI. J. Immunol., 158:2382-2389 (1997).
173. Tezuka, T., H. Umemori, N. Fusaki, T. Yagi, M. Takata, T. Kurosaki, and T. Yamamoto: Physical and functional association of the cbl protooncogen product with an srcfamily protein tyrosine kinase, p53/561yn, in the B cell antigen receptor-mediated signaling. J. Exp. Med., 183:675-680 (1996).
174. Thien, C. B. and W. Y. Langdon: EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene. Oncogene, 14:2239-2249 (1997).
175. Thien, C. B. F. and W. Y. Langdon: Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl. Oncogene, 15:2909-2919 (1997).
176. Toker, A. and L. C. Cantley: Signalling through the lipid products of phosphoinositide-3-OH kinase. [Review]. Nature, 387:673-676 (1997).
177. Tonks, N. K. and B. G. Neel: From form to function: signaling by protein tyrosine phosphatases. [Review]. Cell, 87:365-368 (1996).
178. Trub, T., W. E. Choi, G. Wolf, E. Ottinger, Y. Chen, M. Weiss, and S. E. Shoelson: Specificity of the PTB domain of She for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine. J. Biol. Chem., 270:18205-18208 (1995).
179. Tsygankov, A. Y., S. Mahajan, J. E. Fincke, and J. B. Bolen: Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cells. J. Biol. Chem., 271:27130-27137 (1996).
180. Twamley-Stein, G. M., R. Pepperkok, W. Ansorge, and S. A. Courtneidge: The Src family tyrosine kinases are required for platelet-derived growth factor-mediated sig- nal transduction in NIH 3T3 cells. Proc. Natl. Acad. Sci. U.S.A., 90:7696-7700 (1993).
181. Uddin, S., C. Gardziola, A. Dangat, T. Yi, and L. C. Platanias: Interaction of the c-cbl protooncogene product with the Tyk-2 protein tyrosine kinase. Biochem. Biophys. Res. Commun., 225:833-838 (1996).
182. Uddin, S., D. A. Sher, Y. Alsayed, S. Pons, O. R. Colamonici, E. N. Fish, M. F. White, and L. C. Platanias: Interaction of p59fyn with interferon-activated Jak kinases. Biochem. Biophys. Res. Commun., 235:83-88 (1997).
183. Uemura, N., R. Salgia, J. L. Li, E. Pisick, M. Sattler, and J. D. Griffin: The BCR-abl oncogene alters interaction of the adapter proteins Crkl and Crk with cellular proteins. Leukemia, 11:376-385 (1997).
184. Ueno, H., K. Sasaki, K. Miyagawa, H. Honda, K. Mitani, Y. Yazaki, and H. Hirai: Antisense repression of protooncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling. J. Biol. Chem., 272:8739-8743.(1997).
185. Ueno, H., K. Sasaki, H. Honda, T. Nakamoto, T. Yamagata, K. Miyagawa, K. Mitani, Y. Yazaki, and H. Hirai: C-Cbl is tyrosine phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3′-kinase pathway. Blood, 91:46-53 (1998).
186. van der Geer, P., T. Hunter, and R. A. Lindberg: Receptor protein-tyrosine kinases and their signal transduction pathways. [Review]. Annu. Rev. Cell Biol., 10:251-337 (1994).
187. van der Geer, P., S. Wiley, G. D. Gish, V. K. Lai, R. Stephens, M. F. White, D. Kaplan, and T. Pawson: Identification of residues that control specific binding of the She phosphotyrosine-binding domain to phosphotyrosine sites. Proc. Natl. Acad. Sci. U.S.A., 93:963-968 (1996).
188. van der Geer, P. and T. Pawson: The PTB domain: a new protein module implicated in signal transduction. [Review]. Trends Biochem. Sci., 20:277-280 (1995).
189. Vieira, A. V., C. Lamaze, and S. L. Schmid: Control of EGF receptor signaling by clathrin-mediated endocytosis. Science, 274:2086-2089 (1996).
190. Vossler, M. R., H. Yao, R. D. York, M. G. Pan, C. S. Rim, and P. J. Stork: cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell, 89:73-82 (1997).
191. Wang, Y., Y. G. Yeung, W. Y. Langdon, and E. R. Stanley: c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated, and membrane-targeted following CSF-1 Stimulation of macrophages. J. Biol. Chem., 271:17-20 (1996).
192. Wang, Z. and M. F. Moran: Requirement for the adapter protein GRB2 in EgF receptor endocytosis. Science, 272:1935-1939(1996).
193. Wange, R. L., R. Guitian, N. Isakov, J. D. Watts, R. Aebersold, and L. E. Samelson: Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J. Biol. Chem., 270:18730-18733 (1995).
194. Wange, R. L. and L. E. Samelson: Complex complexes: signaling at the TCR. [Review]. Immunity, 5:197-205 (1996).
195. Watanabe, S. and K-I. Arai: Roles of the JAK-STAT system in signal transduction via cytokine receptors. [Review]. Curr. Opin. Genet. Dev., 6:587-596 (1996).
196. Watts, J. D., M. Affolter, D. L. Krebs, R. L. Wange, L. E. Samelson, and R. Aebersold: Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70. J. Biol. Chem., 269:29520-29529 (1994).
197. Wisniewski, D., A. Strife, and B. Clarkson: c-kit ligand stimulates tyrosine phosphorylation of the c-Cbl protein in human hematopoietic cells. Leukemia, 10:1436-1442 (1996).
198. Wolf, G., T. Trub, E. Ottinger, L. Groninga, A. Lynch, M. F. White, M. Miyazaki, J. Lee, and S. E. Shoelson: PTB domains of 1RS-1 and She have distinct but overlapping binding specificities. J. Biol. Chem., 270:27407-27410 (1995).
199. Yoon, C. H., J. Lee, G. E. Jongeward, and P. W. Sternberg: Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian protooncogene c-cbl. Science, 269:1102-1105 (1995).
200. Zhou, M. M., J. E. Harlan, W. S. Wade, S. Crosby, K. S. Ravichandran, S. J. Burakoff, and S. W. Fesik: Binding affinities of tyrosine-phosphorylated peptides to the COOH-terminal SH2 and NH2-terminal phosphotyrosine binding domains of Shc. J. Biol. Chem., 270: 31119-31123 (1995a).
201. Zhou, M. M., K. S. Ravichandran, E. F. Olejniczak, A. M. Petros, R. P. Meadows, M. Sattler, J. E. Harlan, W. S. Wade, S. J. Burakoff, and S. W. Fesik: Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature, 378:584-592 (1995b).
202. Zubiaur, M., M. Izquierdo, C. Terhorst, F. Malavasi, and J. Sancho: CD38 ligation results in activation of the Raf1/mitogen-activated protein kinase and the CD3-zeta/ zeta-associated protein-70 signaling pathways in Jurkat T lymphocytes. J. Immunol., 159:193-205.(1997).