Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)- ζ-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice

Journal of Experimental Medicine

Volumn 186, Issue 6, 1997, Pages 887-897

  Salojin, Konstantin ^a   Zhang, Jian ^a   Cameron, Mark ^a,b   Gill, Bruce ^a   Arreaza, Guillermo ^a   Ochi, Atsuo ^b   Delovitch, Terry L ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CELL MEMBRANE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOIMMUNE DISEASES; CELL MEMBRANE; CYTOSKELETON; DIABETES MELLITUS, TYPE 1; FEMALE; GRB2 ADAPTOR PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NOD; PHOSPHORYLATION; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS C-FYN; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RAS PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SELF TOLERANCE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TYROSINE; UBIQUITIN-PROTEIN LIGASES;

EID: 0030886815     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.6.887     Document Type: Article

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