The protein product of the proto-oncogene c-cbl forms a complex with phosphatidylinositol 3-kinase p85 and CD19 in anti-IgM-stimulated human B- lymphoma cells

Blood

Volumn 88, Issue 9, 1996, Pages 3502-3507

  Beckwith, Margaret ^a   Jorgensen, Gitte ^b   Longo, Dan L ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CELL SURFACE RECEPTOR; IMMUNOGLOBULIN M ANTIBODY; IMMUNOGLOBULIN RECEPTOR; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; B CELL LYMPHOMA; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

EID: 0029907533     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.9.3502.bloodjournal8893502     Document Type: Article

References (33)

1. ++ stores in B lymphocytes. J Immunol 137:708, 1986
2. Chen ZZ, Coggeshall KM, Cambier JC: Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes. J Immunol 136:2300, 1986
3. Gold MR, Law DA, DeFranco AL: Stimulation of protein tyrosine phosphorylation by the B lymphocyte antigen receptor. Nature 345:810, 1990
4. Lane PJL, Ledbetter JA, McConnell FM, Draves K, Deans J, Schieven GL, Clark EA: The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. J Immunol 146:715, 1991
5. Gold MR, Jakway JP, DeFranco AL: Involvement of a guanine nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown. J Immunol 139:3604, 1987
6. Graziadei L, Riabowol K, Bar-Sagi D: Co-capping of ras proteins with surface immunoglobulins in B lymphocytes. Nature 347:396, 1990
7. rasl. J Immunol 151:4513, 1993
8. Kapeller R, Cantley LC: Phosphatidylinositol 3-kinase. Bioessays 16:565, 1994
9. Thompson PA, Gutkind JS, Robbins KC, Ledbetter JA, Bolen JB: Identification of distinct populations of PI-3 kinase activity following T-cell activation. Oncogene 7:719, 1992
10. Gold MR, Chan VWF, Turck CW, DeFranco AL: Membrane Ig cross-linking regulates phosphatidylinositol-3-kinase in B lymphocytes. J Immunol 148:2012, 1992
11. Prasad KVS, Cai YC, Raab M, Duckworth B, Cantley LC, Shoelson SE, Rudd CE: T-cell antigen CD28 interacts with the lipid kinae phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc Natl Acad Sci USA 91:2834, 1994
12. Truitt KE, Hicks CM, Imboden JB: Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. J Exp Med 179:1071, 1994
13. Tuveson DA, Carter RH, Soltoff SP, Fearon DT: CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science 260:986, 1993
14. Fearon DT, Carter RH: The CD 19/CR2/TAPA-1 complex of B lymphocytes: Linking natural to acquired immunity. Annu Rev Immunol 13:127, 1995
15. Carter RH, Fearon DT: CD 19: Lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256:105, 1992
16. van Noesel CJM, Lankester AC, van Schijndel GMW, van Lier RAW: The CR2/CD19 complex on human B cells contains the src-family kinase Lyn. Int Immunol 5:699, 1993
17. Chalupny NJ, Aruffo A, Esselstyn JM, Chan P-Y, Bajorath J, Blake J, Gilliland LK, Ledbetter JA, Tepper MA: Specific binding of fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD 19 through their src homology 2 domains. Eur J Immunol 25:2978, 1995
18. Meisner H, Conway BR, Hartley D, Czech MP: Interactions of cbl with grb2 and phosphatidylinositol 3′-kinase in activated Jurkat cells. Mol Cell Biol 15:3571, 1995
19. Cory GOC, Lovering RC, Hinshelwood S, MacCarthy-Morrogh L, Levinsky RJ, Kinnon C: The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. J Exp Med 182:611, 1995
20. Donavan JA, Wange RL, Langdon WY, Samelson LE: The protein product of the c-cbl protooncogene is the 120-kDa tyrosinephosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J Biol Chem 269:22921, 1994
21. Blake TJ, Shapiro M, Morse III HC, Langdon WY: The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domin and a leucine zipper-like motif. Oncogene 6:653, 1991
22. Blake TJ, Heath KG, Langdon WY: The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation. EMBO J 12:2017, 1993
23. Beckwith M, Urba WJ, Ferris DK, Freter CE, Kuhns DB, Moratz CM, Longo DL: Anti-IgM-mediated growth inhibition of a human B lymphoma cell line is independent of phosphatidylinositol turnover and protein kinase C activation and involves tyrosine phosphorylation. J Immunol 147:2411, 1991
24. Beckwith M, Fenton RG, Katona IM, Longo DL: Phosphatidylinositol 3-kinase activity is required for the anti-Ig-mediated growth inhibition of a human B lymphoma cell line. Blood 87:202, 1996
25. Lankester AC, van Schijndel GMW, Rood PML, Verhoeven AJ, van Lier RAW: B cell antigen receptor cross-linking induces tyrosine phosphorylation and membrane translocation of a multimeric Shc complex that is augmented by CD19 co-ligation. Eur J Immunol 24:2818, 1994
26. Weng W-K, Jarvis L, LeBien, TW: Signaling through CD19 activates vav/mitogen-activated protein kinase pathway and induces formation of a CD19/vav/phosphatidylinositol 3-kinase complex in human B cell precursors. J Biol Chem 269:32514, 1994
27. Rivero-Lezcano OM, Sameshima JH, Marcilla A, Robbins KC: Physical association between src homology 3 elements and protein product of the c-cbl proto-oncogene. J Biol Chem 269:17363, 1994
28. c-fgr. Mol Cell Biol 8:259, 1988
29. Stahl ML, Ferenz CR, Kelleher KL, Kriz RW, Knopf JL: Sequence similarity of phospholipase C with the non-catalytic region of src. Nature 332:269, 1988
30. Nakanishi H, Brewer KA, Exton JH: Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 208:13, 1993
31. S6K activation mediated by phosphatidylinositol-3-kinase. Nature 370:71, 1994
32. Franke TF, Yang S-I, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN: The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727, 1995
33. Schu PV, Takegawa K, Fry MJ, Waterfield JH, Emr SD: Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene is essential for protein sorting. Science 260:88, 1993