The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins

Leukemia

Volumn 11, Issue 3, 1997, Pages 376-385

  Uemura, N ^a   Salgia, R ^a   Li, J L ^a   Pisick, E ^a   Sattler, M ^a   Griffin, J D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Adapter proteins; BCR ABL; Chronic myelogenous leukemia; CRK; CRKL; Signal transduction

Indexed keywords

BCR ABL PROTEIN; CELL PROTEIN; PHOSPHOPROTEIN; PHOSPHOTYROSINE;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CHIMERA; CHRONIC MYELOID LEUKEMIA; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MOUSE; NEUTROPHIL; NONHUMAN; ONCOGENE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; PROTO ONCOGENE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

EID: 0030892028     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2400590     Document Type: Article

References (6)

1. Muller AJ, Young JC, Pendergast AM et al. BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Mol Cell Biol 1991 ; 11: 1785-1792.
2. McWhirter JR, Wang JY. An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias. EMBO J 1993; 12: 1533-1546.
3. Van Etten RA, Jackson PK, Baltimore D, Sanders MC, Matsudaira PT, Janmey PA. The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity (published erratum appears in J Cell Biol 1994; 124: 865). J Cell Biol 1994; 124: 325-340.
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5. Salgia R, Uemura N, Okuda K et al. CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. J Biol Chem 1995; 270: 29145-29150.
6. Oda T, Heaney C, Hagopian JR, Okuda K, Griffin JD, Druker BJ. Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. J Biol Chem 1994; 269: 22925-22928.