Complex complexes: Signaling at the TCR

Immunity

Volumn 5, Issue 3, 1996, Pages 197-205

  Wange, Ronald L ^a   Samelson, Lawrence E ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; T LYMPHOCYTE RECEPTOR;

CYTOSKELETON; HUMAN; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0030250114     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80315-5     Document Type: Review

References (80)

1. + thymic selection in humans lacking ZAP-70 kinase. Cell 76, 947-958.
2. Ashwell, J.D., and Klausner, R.D. (1990). Genetic and mutational analysis of the T-cell antigen receptor. Annu. Rev. Immunol. 8, 139-167.
3. Bolen, J.B. (1993). Nonreceptor tyrosine protein kinases. Oncogene 8, 2025-2031.
4. Buday, L., Egan, S.E., Rodriguez Viciana, P., Cantrell, D.A., and Downward, J. (1994). A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J. Biol. Chem. 269, 9019-9023.
5. Bustelo, X.R., Ledbetter, J.A., and Barbacid, M. (1992). Product of the Vav protooncogene defines a new class of tyrosine protein kinase substrates. Nature 356, 68-74.
6. Cambier, J.C. (1995). Antigen and Fc receptor signaling: the awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J. Immunol. 155, 3281-3285.
7. Cambier, J.C., and Johnson, S.A. (1995). Differential binding activity of ARH1/TAM motifs. Immunol. Lett. 44, 77-80.
8. Cantrell, D. (1996). T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14, 259-274.
9. Caplan, S., Zeliger, S., Wang, L., and Baniyash, M. (1995). Cell-surface expressed T-cell antigen-receptor ε chain is associated with the cytoskeleton. Proc. Natl. Acad. Sci. USA 92, 4768-4772.
10. Chan, A.C., Iwashima, M., Turck, C.W., and Weiss, A. (1992). ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCRζ chain. Cell 71, 649-662.
11. Chan, A.C., Kadlecek, T.A., Elder, M.E., Filipovich, A.H., Kuo, W. L., Iwashima, M., Parslow, T.G., and Weiss, A. (1994). ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 264, 1599-1601.
12. Chan, A.C., Dalton, M., Johnson, R., Kong, G.H., Wang, T., Thoma, R., and Kurosaki, T. (1995). Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J. 14, 2499-2508.
13. Cheng, A.M., Rowley, B., Pao, W., Hayday, A., Bolen, J.B., and Pawson, T. (1995). Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378, 303-306.
14. Desiderio, S., and Siliciano, J.D. (1994). The Itk/Btk/Tec family of protein-tyrosine kinases. Chem. Immunol. 59, 191-208.
15. Donovan, J.A., Wange, R.L., Langdon, W.Y., and Samelson, L.E. (1994). The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J. Biol. Chem. 269, 22921-22924.
16. Downward, J. (1994). The GRB2/Sem-5 adaptor protein. FEBS Lett. 338, 113-117.
17. Elder, M.E., Lin, D., Clever, J., Chan, A.C., Hope, T.J., Weiss, A., and Parslow, T.G. (1994). Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase. Science 264, 1596-1599.
18. Exley, M., Varticovsky, L., Peter, M., Sancho, J., and Terhorst, C. (1994). Association of phosphatidylinositol-3-kinase with a specific sequence of the T cell receptor ζ chain is dependent on T cell activation. J. Biol. Chem. 269, 15140-15146.
19. Fantl, W.J., Johnson, D.E., and Williams, L.T. (1993). Signalling by receptor tyrosine kinases. Annu. Rev. Biochem. 62, 453-481.
20. Fargnoli, J., Burkhardt, A.L., Laverty, M., Kut, S.A., van Oers, N.S., Weiss, A., and Bolen, J.B. (1995). Syk mutation in Jurkat E6-derived clones results in lack of p72syk expression. J Biol. Chem. 270, 26533-26537.
21. + T cells. Science 277, 1276-1278.
22. c-cbl in T lymphocytes. J. Exp. Med. 183, 301-306.
23. Fukazawa, T., Reedquist, K.A., Trub, T., Soltoff, S., Panchamoorthy, G., Druker, B., Cantley, L., Shoelson, S.E., and Band, H. (1995). The SH3 domain-binding T cell tyrosyl phosphoprotein p120. J. Biol. Chem. 270, 19141-19150.
24. Fusaki, N., Matsuda, S., Nishizumi, H., Umemori, H., and Yamamoto, T. (1996). Physical and functional interactions of protein tyrosine kinases, p59fyn and ZAP-70, in T cell signaling. J. Immunol. 156, 1369-1377.
25. Gibson, S., August, A., Kawakami, Y., Kawakami, T., Dupont, B., and Mills, G.B. (1996). The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling. J. Immunol. 156, 2716-2722.
26. Guanghui, K., Dalton, M., Wardenburg, J.B., Straus, D., Kurosaki, T., and Chan, A.C. (1996). Distinct tyrosine phosphorylation sites within ZAP-70 mediate activation and negative regulation of antigen receptor function. Mol. Cell. Biol., in press.
27. Harrison, M.L., Isaacson, C.C., Burg, D.L., Geahlen, R.L., and Low, P.S. (1994). Phosphorylation of human erythrocyte band 3 by endogenous p72syk. J. Biol. Chem. 269, 955-959.
28. Hatada, M.H., Lu, X., E.R., L., Green, J., Morgenstern, J.P., Lou, M., Marr, C.S., Phillips, T.B., Ram, M.K., Theriault, K., Zoller, M., and Karas, J.L. (1995). Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 377, 32-38.
29. Holsinger, L.J., Spencer, D.M., Austin, D.J., Schreiber, S.L., and Crabtree, G.R. (1995). Signal transduction in T lymphocytes using a conditional allele of Sos. Proc. Natl. Acad. Sci. USA 92, 9810-9814.
30. Huby, R.D.J., Carlile, G.W., and Ley, S.C. (1995). Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells. J. Biol. Chem. 270, 30241-30244.
31. Irving, B.A., Chan, A.C., and Weiss, A. (1993). Functional characterization of a signal transducing motif present in the T cell antigen receptor ζ chain. J. Exp. Med. 777, 1093-1103.
32. Isakov, N., Wange, R.L., Burgess, W.H., Watts, J.D., Aebersold, R., and Samelson, L.E. (1995). ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity. J. Exp. Med. 181, 375-380.
33. Isakov, N., Wange, R.L., Watts, J.D., Aebersold, R., and Samelson, L.E. (1996). Purification and characterization of human ZAP-70 protein tyrosine kinase from a baculovirus expression system. J. Biol. Chem. 277, 15753-15761.
34. Iwashima, M., Irving, B.A., van Oers, N.S., Chan, A.C., and Weiss, A. (1994). Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263, 1136-1139.
35. Jackman, J.K., Motto, D.G., Sun, Q., Tanemoto, M., Turck, C.W., Peltz, G.A., Koretzky, G.A., and Findell, P.R. (1995). Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J. Biol. Chem. 270, 7029-7032.
36. Jayaraman, T., Ondrias, K., Ondriasova, E., and Marks, A.R. (1996). Regulation of the inositol 1,4,5-trisphosphate receptor by tyrosine phosphorylation. Science 272, 1492-1494.
37. Katzav, S., Sutherland, M., Packham, G., Yi, T., and Weiss, A. (1994). The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-vav. J. Biol. Chem. 269, 32579-32585.
38. Kon-Kozlowski, M., Pani, G., Pawson, T., and Siminovitch, K.A. (1996). The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells. J. Biol. Chem. 277, 3856-3862.
39. Ley, S.C., Verbi, W., Pappin, D.J.C., Druker, B., Davies, A.S., and Crumpton, M.J. (1994). Tyrosine phosphorylation of a tubulin in human T lymphocytes. Eur. J. Immunol. 24, 99-106.
40. + T cells. Science 277, 1272-1276.
41. Liao, X.C., and Littman, D. (1995). Altered T cell receptor signaling and disrupted T cell development in mice lacking ltk. Immunity 3, 757-769.
42. Liu, Y.-C., Elly, C., Yoshida, H., Bonnefoy-Berard, N., and Altman, A. (1996). Activation-modulated association of 14-3-3 proteins with Cbl in T cells. J. Biol. Chem. 277, 14591-14595.
43. Madrenas, J., Wange, R.L., Wang, J.L., Isakov, N., Samelson, L.E., and Germain, R.N. (1995). ζ phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267, 515-518.
44. Marengere, L.E., Waterhouse, P., Duncan, G.S., Mittrucker, H.W., Feng, G.S., and Mak, T.W. (1996). Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272, 1170-1173.
45. McFarland, E.C., Flores, E., Matthews, R.J., and Thomas, M.L. (1994). Protein tyrosine phosphatases involved in lymphocyte signal transduction. Chem. Immunol. 59, 40-61.
46. Meisner, H., Conway, B.R., Hartley, D., and Czech, M.P. (1995). Interaction of Cbl with Grb2 and phosphatidylinositol-3′-kinase in activated Jurkat cells. Mol. Cell. Biol. 75, 3571-3578.
47. Motto, D.G., Ross, S.E., Jackman, J.K., Sun, Q., Olson, A.L., Findell, P.R., and Koretzky, G.A. (1994). In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase. J. Biol. Chem. 269, 21608-21613.
48. Motto, D.G., Ross, S.E., Wu, J., Hendricks-Taylor, L.R., and Koretzky, G.A. (1996). Implications of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production. J. Exp. Med. 183, 1937-1943.
49. Negishi, I., Motoyama, N., Nakayama, K., Nakayama, K., Senju, S., Hatakeyama, S., Zhang, Q., Chan, A.C., and Loh, D.Y. (1995). Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376, 435-438.
50. Neumeister, E.N., Zhu, Y., Richard, S., Terhorst, C., Chan, A.C., and Shaw, A.S. (1995). Binding of ZAP-70 to phosphorylated T-cell receptor ζ and η enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol. Cell. Biol. 15, 3171-3178.
51. Osman, N., Lucas, S.C., Turner, H., and Cantrell, D. (1995). A comparison of the interaction of Shc and the tyrosine kinase ZAP-70 with the T cell antigen receptor ζ chain tyrosine-based activation motif. J. Biol. Chem. 270, 13981-13986.
52. Osman, N., Turner, H., Lucas, S., Reif, K., and Cantrell, D.A. (1996). The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor ζ subunits and the CD3 γ, δ and ∈ chains. Eur. J. Immunol. 26, 1063-1068
53. Pawson, T. (1995). Protein modules and signaling networks. Nature 373, 573-580.
54. Peri, K.G., and Veillette, A. (1994). Tyrosine protein kinases in T lymphocytes. Chem. Immunol. 59, 19-39.
55. Perlmutter, R.M., Levin, S.D., Appleby, M.W., Anderson, S.J., and Alberola-lla, J. (1993). Regulation of lymphocyte function by protein phosphorylation. Annu. Rev. Immunol. 11, 451-499.
56. Peters, J.D., Furlong, M.T., Asai, D.J., Harrison, M.L., and Geahlen, R.L. (1996). Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates α-tubulin on tyrosine. J. Biol. Chem. 271, 4755-4762.
57. Plas, D.R., Johnson, R., Pingel, J.T., Matthews, R.J., Dalton, M., Roy, G., Chan, A.C., and Thomas, M.L. (1996). Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 272, 1173-1176.
58. Qian, D., Mollenaver, M.N., and Weiss, A. (1996). Dominant-negative ζ-associated protein 70 inhibits T cell antigen receptor signaling. J. Exp. Med. 183, 611-620.
59. Ravichandran, K.S., Lorenz, U., Shoelson, S.E., and Burakoff, S.J. (1995). Interaction of Shc with Grb2 regulates association of Grb2 with mSOS. Mol. Cell. Biol. 15, 593-600.
60. Reedquist, K.A., Fukazawa, T., Panchamoorthy, G., Langdon, W.Y., Shoelson, S.E., Druker, B.J., and Band, H. (1996). Stimulation through the T cell receptor induces Cbl association with Crk proteins and guanine nucleotide exchange protein C3G. J. Biol. Chem. 271, 8435-8442.
61. Reif, K., Buday, L., Downward, J., and Cantrell, D.A. (1994) SH3 domains of the adapter molecule Grb2 compete with two proteins in T cells: the guanine nucleotide exchange protein SOS and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. J. Biol. Chem. 269, 14081-14087.
62. Rozdzial, M.M., Malissen, B., and Finkel, T.H. (1995). Tyrosine-phosphorylated T cell receptor ζ chain associates with actin cytoskeleton upon activation of mature T lymphocytes. Immunity 3, 623-633.
63. Shiue, L., Zoller, M.J., and Brugge, J.S. (1995). Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE. J. Biol. Chem. 270, 10498-10502.
64. Sloan-Lancaster, J., Shaw, A.S., Rothbard, J.B., and Allen, P.M. (1995). Partial T cell signaling: altered phospho-ζ and lack of ZAP-70 recruitment in APL-induced T cell anergy. Cell 79, 913-922.
65. Thome, M., Duplay, P., Guttinger, M., and Acuto, O. (1995). Syk and ZAP-70 mediate recruitment of p56/ck/CD4 to the activated T cell receptor/CD3/ζ complex. J. Exp. Med. 787, 1997-2006.
66. Turner, M., Mee, P.J., Costello, P.S., Williams, O., Price, A.A., Duddy, L.P., Furlong, M.T., Geahlen, R.L., and Tybulewicz, V.L. (1995). Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378, 298-302.
67. Ullrich, A., and Schlessinger, J. (1990). Signal transduction by receptors with tyrosine kinase activity. Cell 67, 203-212
68. van Oers, N.S., Tao, W., Watts, J.D., Johnson, P., Aebersold, R., and Teh, H.S. (1993). Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) ζ subunit: regulation of TCR-associated protein tyrosine kinase activity by TCRζ. Mol. Cell. Biol. 13, 5771-5780.
69. van Oers, N.S., Killeen, N., and Weiss, A. (1996). Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. J. Exp. Med. 183, 1053-1062.
70. Vogel, L.B., and Fujita, D.J. (1993). The SH3 domain of p56/ck is involved in binding to phosphatidylinositol 3′-kinase from T lymphocytes. Mol. Cell. Biol. 13, 7408-7417.
71. Wange, R.L., Malek, S.N., Desiderio, S., and Samelson, L.E. (1993). Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor ζ and CD3∈ from activated Jurkat T cells. J. Biol. Chem. 268, 19797-19801.
72. Wange, R.L., Guitian, R., Isakov, N., Watts, J.D., Aebersold, R., and Samelson, L.E. (1995a). Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J. Biol. Chem. 270, 18730-18733.
73. 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling. J. Biol. Chem. 270, 944-948.
74. Wardenburg, J.B., Fu, C., Jackman, J.K., Flotow, H., Wilkinson, S.E., Williams, D.H., Johnson, R., Kong, G., and Chan, A.C. (1996). Phosphorylation of SLP-76 by the ZAP-70 protein tyrosine kinase is required for T cell receptor function. J. Biol. Chem., in press.
75. Watts, J.D., Affolter, M., Krebs, D.L., Wange, R.L., Samelson, L.E., and Aebersold, R. (1994). Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70. J. Biol. Chem. 269, 29520-29529.
76. Weiss, A., and Littman, D.R. (1994). Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274.
77. Weissman, A.M. (1994). The T-cell antigen receptor: a multisubunit signaling complex. Chem. Immunol. 59, 1-18.
78. + thymocytes as a consequence of intrathymic interactions that diminish available p56lck. Immunity 4, 495-504.
79. Wu, J., Katzav, S., and Weiss, A. (1995). A functional T-cell receptor signaling pathway is required for p95vav activity. Mol. Cell. Biol. 15, 4337-4346.
80. Wu, J., Motto, D.G., Koretzky, G.A., and Weiss, A. (1996). Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity 4, 593-602.