Molecules in focus: The c-Cbl oncoprotein

International Journal of Biochemistry and Cell Biology

Volumn 30, Issue 4, 1998, Pages 439-444

  Lupher Jr , Mark L ^a   Andoniou, Christopher E ^a   Bonita, David ^a   Miyake, Sachiko ^a   Band, Hamid ^a  

^a Lymphocyte Biology Section   (United States)

Author keywords

Signal transduction

Indexed keywords

ADAPTOR PROTEIN; AMINO ACID; CELL SURFACE RECEPTOR; LEUCINE ZIPPER PROTEIN; MESSENGER RNA; ONCOPROTEIN; PHOSPHOTYROSINE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROLINE; PROTEIN TYROSINE KINASE; CBL PROTEIN; CBL PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE EXPRESSION; HUMAN; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTO ONCOGENE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; ANIMAL; CAENORHABDITIS ELEGANS; DROSOPHILA; PHYSIOLOGY; REVIEW;

CAENORHABDITIS ELEGANS; DROSOPHILA;

ANIMALS; CAENORHABDITIS ELEGANS; DROSOPHILA; HUMANS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

EID: 0032036763     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(97)00075-7     Document Type: Article

References (16)

1. Langdon W.Y. The cbl oncogene: a novel substrate of protein tyrosine kinases. Aust. NZ J. Med. 25:1995;859-864.
2. Lupher M.L., Reedquist K.A., Miyake S., Langdon W.Y., Band H. A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells. J. Biol. Chem. 271:1996;24063-24068.
3. Yoon C.H., Lee J., Jongeward G.D., Sternberg P.W. Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl. Science. 269:1995;1102-1105.
4. Meisner H., Daga A., Buxton J., Fernandez B., Chawla A., Czech U., Czech M.P. Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol. Cell. Biol. 17(4):1997;2217-2225.
5. Fukazawa T., Reedquist K.A., Trub T., Soltoff S., Panchamoorthy G., Druker B., Cantley L., Shoelson S.E., Band H. The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. J. Biol. Chem. 270:1995;19141-19150.
6. Andoniou C.E., Thien C.B., Langdon W.Y. The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain. Oncogene. 12:1996;1981-1989.
7. Rivero-Lezcano O.M., Sameshima J.H., Marcilla A., Robbins K.C. Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene. J. Biol. Chem. 269:1994;17363-17366.
8. Reedquist K.A., Fukazawa T., Druker B., Panchamoorthy G., Shoelson S.E., Band H. Rapid T-cell receptor-mediated tyrosine phosphorylation of p120 an Fyn/Lck Src homology 3 domain-binding protein. Proc. Natl Acad. Sci. USA. 91:1994;4135-4139.
9. D.P. Bonita, S. Miyake, M.L. Lupher, W.Y. Langdon, and H. Band, Phosphotyrosine binding (PTB) domain-dependent upregulation of the PDGFRalpha signaling cascade by transforming mutants of Cbl: Implications for Cbl's function and oncogenicity. Mol. Cell. Biol. 17 (1997) 4597-4610.
10. Reedquist K.A., Fukazawa T., Panchamoorthy G., Langdon W.Y., Shoelson S.E., Druker B.J., Band H. Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J. Biol. Chem. 271:1996;8435-8442.
11. Panchamoorthy G., Fukazawa T., Miyake S., Soltoff S., Reedquist K., Druker B., Shoelson S., Cantley L., Band H. p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. J. Biol. Chem. 271:1996;3187-3194.
12. Meisner H., Conway B.R., Hartley D., Czech M.P. Interactions of Cbl with Grb2 and phosphatidylinositol 3′-kinase in activated Jurkat cells. Mol. Cell. Biol. 15:1995;3571-3578.
13. Buday L., Khwaja A., Sipeki S., Farago A., Downward J. Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation. J. Biol. Chem. 271:1996;6159-6163.
14. Tanaka S., Amling M., Neff L., Peyman A., Uhlmann E., Levy J.B., Baron R. c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption. Nature. 383:1996;528-531.
15. Ojaniemi M., Martin S.S., Dolfi F., Olefsky J.M., Vuori K. The proto-oncogene product p120(Cbl) links c-Src and phosphatidylinositol 3′-kinase to the integrin signaling pathway. J. Biol. Chem. 272(6):1997;3780-3787.
16. Wange R.L., Samelson L.E. Complex complexes: signaling at the TCR. Immunity. 5:1996;197-205.